| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xueyan Zheng, Danyi Zhou, Chun Y Seow, Tony R Ba. Cardiotrophin-1 alters airway smooth muscle structure and mechanical properties in airway explants. American journal of physiology. Lung cellular and molecular physiology. vol 287. issue 6. 2005-01-12. PMID:15273080. |
data from our laboratory indicate that cardiotrophin-1 (ct-1) induces hypertrophy and inhibits apoptosis in isolated human asm cells. |
2005-01-12 |
2023-08-12 |
human |
| Krisztina Buzás, Klára Megyeri, Márta Hõgye, Miklós Csanády, Gábor Bogáts, Yvette Mánd. Comparative study of the roles of cytokines and apoptosis in dilated and hypertrophic cardiomyopathies. European cytokine network. vol 15. issue 1. 2004-12-15. PMID:15217753. |
comparative study of the roles of cytokines and apoptosis in dilated and hypertrophic cardiomyopathies. |
2004-12-15 |
2023-08-12 |
Not clear |
| Krisztina Buzás, Klára Megyeri, Márta Hõgye, Miklós Csanády, Gábor Bogáts, Yvette Mánd. Comparative study of the roles of cytokines and apoptosis in dilated and hypertrophic cardiomyopathies. European cytokine network. vol 15. issue 1. 2004-12-15. PMID:15217753. |
in order to gain more insight into the pathogenesis of dilated and hypertrophic cardiomyopathies (dcm and hcm, respectively), we investigated the roles of certain cytokines that regulate apoptosis. |
2004-12-15 |
2023-08-12 |
Not clear |
| James Scot. Pathophysiology and biochemistry of cardiovascular disease. Current opinion in genetics & development. vol 14. issue 3. 2004-12-08. PMID:15172670. |
neuro-humoral and biomechanical processes, as seen in hypertension, produce cardiac hypertrophy, which predisposes to hf through apoptosis. |
2004-12-08 |
2023-08-12 |
Not clear |
| P Andreka, Z Nadhazi, G Muzes, G Szantho, L Vandor, L Konya, M S Turner, Z Tulassay, N H Bishopri. Possible therapeutic targets in cardiac myocyte apoptosis. Current pharmaceutical design. vol 10. issue 20. 2004-12-07. PMID:15320755. |
recent progress includes a better understanding of the importance of mitochondria-initiated events in cardiac myocyte apoptosis, of factors inducing apoptosis in heart failure and during hypoxia, and of the dual pro-apoptotic and anti-apoptotic effects of hypertrophic stimuli such as beta-adrenoceptor agonists, angiotensin converting enzyme inhibitors, nitric oxide and calcineurin. |
2004-12-07 |
2023-08-12 |
Not clear |
| Anthony Shaw, Qingbo X. Biomechanical stress-induced signaling in smooth muscle cells: an update. Current vascular pharmacology. vol 1. issue 1. 2004-12-01. PMID:15320852. |
in this process mechanical force is an important modulator of vascular smooth muscle cell (vsmc) morphology and function, including apoptosis, hypertrophy and proliferation that contribute to the development of atherosclerosis, hypertension, and restenosis. |
2004-12-01 |
2023-08-12 |
Not clear |
| Paul S Modlinger, Christopher S Wilcox, Shakil Asla. Nitric oxide, oxidative stress, and progression of chronic renal failure. Seminars in nephrology. vol 24. issue 4. 2004-11-30. PMID:15252775. |
first, ros can inactivate mitochondrial enzymes, damage dna, or lead to apoptosis or cellular hypertrophy. |
2004-11-30 |
2023-08-12 |
human |
| Jian-Mei Li, Ajay M Sha. Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. American journal of physiology. Regulatory, integrative and comparative physiology. vol 287. issue 5. 2004-11-23. PMID:15475499. |
depending on the level of oxidants generated and the relative balance between pro- and antioxidant pathways, ros may be involved in cell growth, hypertrophy, apoptosis, endothelial activation, and adhesivity, for example, in diabetes, hypertension, atherosclerosis, heart failure, and ischemia-reperfusion. |
2004-11-23 |
2023-08-12 |
human |
| Osamu Yamaguchi, Tetsuya Watanabe, Kazuhiko Nishida, Kazunori Kashiwase, Yoshiharu Higuchi, Toshihiro Takeda, Shungo Hikoso, Shinichi Hirotani, Michio Asahi, Masayuki Taniike, Atsuko Nakai, Ikuko Tsujimoto, Yasushi Matsumura, Jun-ichi Miyazaki, Kenneth R Chien, Atsushi Matsuzawa, Chiharu Sadamitsu, Hidenori Ichijo, Manuela Baccarini, Masatsugu Hori, Kinya Ots. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. The Journal of clinical investigation. vol 114. issue 7. 2004-11-22. PMID:15467832. |
the raf/mek/extracellular signal-regulated kinase (erk) signaling pathway regulates diverse cellular processes such as proliferation, differentiation, and apoptosis and is implicated as an important contributor to the pathogenesis of cardiac hypertrophy and heart failure. |
2004-11-22 |
2023-08-12 |
mouse |
| Rajiv Kumar, Ward Lutz, Elena Frank, Hee-Jeong I. Immediate early gene X-1 interacts with proteins that modulate apoptosis. Biochemical and biophysical research communications. vol 323. issue 4. 2004-11-16. PMID:15451437. |
immediate early gene x-1 (iex-1) modulates apoptosis, cellular growth, mechanical strain-induced cardiac hypertrophy, and vascular intimal hyperplasia. |
2004-11-16 |
2023-08-12 |
human |
| V A Frolov, G A Drozdova, P Rieger, M L Blagonravo. Initial mechanisms of the development of hypertonic heart. Bulletin of experimental biology and medicine. vol 137. issue 3. 2004-11-10. PMID:15232622. |
activation of apoptosis was noted in cardiomyocytes of both ventricles, and its intensity correlated with the degree of myocardial hypertrophy. |
2004-11-10 |
2023-08-12 |
Not clear |
| V A Frolov, G A Drozdova, P Rieger, M L Blagonravo. Initial mechanisms of the development of hypertonic heart. Bulletin of experimental biology and medicine. vol 137. issue 3. 2004-11-10. PMID:15232622. |
it is hypothesized that apoptosis limits the development of hypertrophy in the myocardium. |
2004-11-10 |
2023-08-12 |
Not clear |
| Pal Aukrust, Arne Yndestad, Jan K Damås, Lars Gullesta. Therapeutic potential of anticytokine therapy in congestive heart failure. American journal of cardiovascular drugs : drugs, devices, and other interventions. vol 4. issue 3. 2004-11-06. PMID:15134469. |
accumulating evidence indicates that inflammatory cytokines play a pathogenic role in congestive heart failure (chf) by influencing heart contractility, inducing hypertrophy, and promoting apoptosis or fibrosis, contributing to the continuous myocardial remodeling process. |
2004-11-06 |
2023-08-12 |
Not clear |
| Hiroaki Yajima, Emiko Ikeshima, Maho Shiraki, Tomoka Kanaya, Daisuke Fujiwara, Hideharu Odai, Nobuyo Tsuboyama-Kasaoka, Osamu Ezaki, Shinichi Oikawa, Keiji Kond. Isohumulones, bitter acids derived from hops, activate both peroxisome proliferator-activated receptor alpha and gamma and reduce insulin resistance. The Journal of biological chemistry. vol 279. issue 32. 2004-10-25. PMID:15178687. |
furthermore, these animals showed increased liver fatty acid oxidation and a decrease in size and an increase in apoptosis of their hypertrophic adipocytes. |
2004-10-25 |
2023-08-12 |
mouse |
| David Duguay, Shant Der Sarkissian, Rémi Kouz, Brice Ongali, Réjean Couture, Denis deBloi. Kinin B2 receptor is not involved in enalapril-induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptor. British journal of pharmacology. vol 141. issue 4. 2004-10-14. PMID:14744816. |
kinin b2 receptor is not involved in enalapril-induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of b1 receptor. |
2004-10-14 |
2023-08-12 |
rat |
| David Duguay, Shant Der Sarkissian, Rémi Kouz, Brice Ongali, Réjean Couture, Denis deBloi. Kinin B2 receptor is not involved in enalapril-induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptor. British journal of pharmacology. vol 141. issue 4. 2004-10-14. PMID:14744816. |
treatment with enalapril induces smooth muscle cell apoptosis and regression of aortic hypertrophy in spontaneously hypertensive rats (shrs), whereas combined blockade of angiotensin ii at(1) and at(2) receptors does not. |
2004-10-14 |
2023-08-12 |
rat |
| David Duguay, Shant Der Sarkissian, Rémi Kouz, Brice Ongali, Réjean Couture, Denis deBloi. Kinin B2 receptor is not involved in enalapril-induced apoptosis and regression of hypertrophy in spontaneously hypertensive rat aorta: possible role of B1 receptor. British journal of pharmacology. vol 141. issue 4. 2004-10-14. PMID:14744816. |
aortic apoptosis induction and hypertrophy regression with enalapril do not involve kinin b(2) receptors in shr. |
2004-10-14 |
2023-08-12 |
rat |
| Danyi Zhou, Xueyan Zheng, Lu Wang, Gerald Stelmack, Andrew J Halayko, Delbert Dorscheid, Tony R Ba. Expression and effects of cardiotrophin-1 (CT-1) in human airway smooth muscle cells. British journal of pharmacology. vol 140. issue 7. 2004-10-13. PMID:14597603. |
cellular hypertrophy and/or a reduced rate of apoptosis could increase airway smooth muscle mass. |
2004-10-13 |
2023-08-12 |
human |
| Danyi Zhou, Xueyan Zheng, Lu Wang, Gerald Stelmack, Andrew J Halayko, Delbert Dorscheid, Tony R Ba. Expression and effects of cardiotrophin-1 (CT-1) in human airway smooth muscle cells. British journal of pharmacology. vol 140. issue 7. 2004-10-13. PMID:14597603. |
as cardiotrophin-1 (ct-1) induces hypertrophy and inhibits apoptosis in cardiomyocytes, we tested for the expression and effects of ct-1 in human bronchial smooth muscle cells (hbsmc). |
2004-10-13 |
2023-08-12 |
human |
| Danyi Zhou, Xueyan Zheng, Lu Wang, Gerald Stelmack, Andrew J Halayko, Delbert Dorscheid, Tony R Ba. Expression and effects of cardiotrophin-1 (CT-1) in human airway smooth muscle cells. British journal of pharmacology. vol 140. issue 7. 2004-10-13. PMID:14597603. |
by reducing the rates of apoptosis and inducing hypertrophy, ct-1 may contribute to increased smooth muscle mass in airway disease. |
2004-10-13 |
2023-08-12 |
human |