| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Parco M Siu, Stephen E Alwa. Age-related apoptotic responses to stretch-induced hypertrophy in quail slow-tonic skeletal muscle. American journal of physiology. Cell physiology. vol 289. issue 5. 2005-11-07. PMID:15972839. |
these data suggest that stretch overload-induced muscle hypertrophy is associated with changes in apoptosis in slow-tonic skeletal muscle. |
2005-11-07 |
2023-08-12 |
Not clear |
| Ryotaro Wake, Shokei Kim-Mitsuyama, Yasukatsu Izumi, Kaoru Yoshida, Yasuhiro Izumiya, Tokihito Yukimura, Masayuki Shiota, Minoru Yoshiyama, Junichi Yoshikawa, Hiroshi Iwa. Beneficial effect of candesartan on rat diastolic heart failure. Journal of pharmacological sciences. vol 98. issue 4. 2005-11-03. PMID:16079469. |
the improvement of dhf by candesartan was accompanied by the decrease in cardiac hypertrophy, fibrosis, and apoptosis, and the reduction of gene expression of brain natriuretic peptide, collagen i, and monocyte chemoattractant protein-1. |
2005-11-03 |
2023-08-12 |
rat |
| Takuma Aoyama, Takashi Matsui, Mikhail Novikov, Jongsun Park, Brian Hemmings, Anthony Rosenzwei. Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response. Circulation. vol 111. issue 13. 2005-10-28. PMID:15795328. |
because sgk1 is a pi 3-kinase-dependent kinase with structural homology to akt, we examined its regulation in the heart and its effects on cardiomyocyte (cm) apoptosis and hypertrophy in vitro. |
2005-10-28 |
2023-08-12 |
Not clear |
| Makoto Hase, Christophe Depre, Stephen F Vatner, Junichi Sadoshim. H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes. The Biochemical journal. vol 388. issue Pt 2. 2005-10-24. PMID:15656793. |
the hypertrophic effect of h11 at high doses was unmasked when apoptosis was inhibited by the caspase inhibitor devd-cho, suggesting that h11 stimulates both hypertrophy and apoptosis in parallel. |
2005-10-24 |
2023-08-12 |
rat |
| Makoto Hase, Christophe Depre, Stephen F Vatner, Junichi Sadoshim. H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes. The Biochemical journal. vol 388. issue Pt 2. 2005-10-24. PMID:15656793. |
in summary, h11 is a dual-function kinase in cardiac cells: it induces hypertrophy at low doses through kinase-independent activation of akt, whereas it causes apoptosis at high doses through protein kinase-dependent mechanisms, in particular by physical interaction with and subsequent inhibition of ck2. |
2005-10-24 |
2023-08-12 |
rat |
| Jishuai Zhang, Xiaohong Tan, Wenlong Li, Youliang Wang, Jian Wang, Xuan Cheng, Xiao Yan. Smad4 is required for the normal organization of the cartilage growth plate. Developmental biology. vol 284. issue 2. 2005-10-14. PMID:16023633. |
the abrogation of smad4 in chondrocytes resulted in dwarfism with a severely disorganized growth plate characterized by expanded resting zone of chondrocytes, reduced chondrocyte proliferation, accelerated hypertrophic differentiation, increased apoptosis and ectopic bone collars in perichondrium. |
2005-10-14 |
2023-08-12 |
mouse |
| A Cataldi, C Rapino, G Bianchi, L Centurione, M Zingariello, C Di Giulio, A Antonucc. Balance between hypertrophic and hypoxic stimulus in caspase-3 activation during rat heart development. Journal of molecular histology. vol 36. issue 3. 2005-10-11. PMID:15900413. |
in particular, the role played by hypertrophic and survival factors like nf-kb and iap-1 (inhibiting apoptosis protein) and by death factors ask-1 (apoptosis signal regulating kinase), jnk/sapk (jun-n-terminal-kinase/stress-activated protein kinase) pathways in regulating caspase-3 expression and activity has been evaluated by immunohistochemical and western blotting analyses, respectively. |
2005-10-11 |
2023-08-12 |
rat |
| Guoyan Wang, Frank Beie. Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 20. issue 6. 2005-10-03. PMID:15883643. |
rac1/cdc42 and rhoa gtpases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis. |
2005-10-03 |
2023-08-12 |
Not clear |
| Soochan Bae, Lubo Zhan. Prenatal cocaine exposure increases apoptosis of neonatal rat heart and heart susceptibility to ischemia-reperfusion injury in 1-month-old rat. British journal of pharmacology. vol 144. issue 7. 2005-09-29. PMID:15685203. |
the results suggest that prenatal cocaine exposure induces abnormal apoptosis and myocyte hypertrophy in postnatal heart, leading to an increased heart susceptibility to ischemic insults in postnatal life. |
2005-09-29 |
2023-08-12 |
rat |
| Judy B de Haan, Nada Stefanovic, David Nikolic-Paterson, Lyndee L Scurr, Kevin D Croft, Trevor A Mori, Paul Hertzog, Ismail Kola, Robert C Atkins, Gregory H Tesc. Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy. American journal of physiology. Renal physiology. vol 289. issue 3. 2005-09-27. PMID:15827346. |
at 4 mo, diabetic gpx1+/+ and -/- mice had equivalent levels of oxidative renal injury (increased kidney reactive oxygen species, kidney lipid peroxidation, urine isoprostanes, kidney deposition of advanced glycoxidation, and nitrosylation end products) and a similar degree of glomerular damage (hypertrophy, hypercellularity, sclerosis), tubular injury (apoptosis and vimentin expression), and renal fibrosis (myofibroblasts, collagen, tgf-beta excretion). |
2005-09-27 |
2023-08-12 |
mouse |
| M F Cesta, C J Baty, B W Keene, I W Smoak, D E Malarke. Pathology of end-stage remodeling in a family of cats with hypertrophic cardiomyopathy. Veterinary pathology. vol 42. issue 4. 2005-09-21. PMID:16006605. |
the pathogenesis of es-hcm is uncertain, but theories implicate occlusion of the coronary blood flow by thickening of the coronary vessels, coronary vascular thromboembolism or coronary vessel spasm, apoptosis of myocytes, and myocardial hypertrophy beyond the ability of the vasculature to supply blood. |
2005-09-21 |
2023-08-12 |
human |
| Yves Sabbagh, Thomas O Carpenter, Marie B Dema. Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 27. 2005-09-12. PMID:15976027. |
hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. |
2005-09-12 |
2023-08-12 |
mouse |
| Yves Sabbagh, Thomas O Carpenter, Marie B Dema. Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 27. 2005-09-12. PMID:15976027. |
studies in vitamin d receptor (vdr)-null mice have demonstrated that expansion of the late hypertrophic chondrocyte layer, characteristic of rickets, is secondary to impaired apoptosis of these cells. |
2005-09-12 |
2023-08-12 |
mouse |
| Yves Sabbagh, Thomas O Carpenter, Marie B Dema. Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 27. 2005-09-12. PMID:15976027. |
our studies demonstrate that normal phosphorus levels are required for growth plate maturation and implicate a critical role for phosphate-regulated apoptosis of hypertrophic chondrocytes via activation of the caspase-9-mediated mitochondrial pathway. |
2005-09-12 |
2023-08-12 |
mouse |
| Claire Linge, Janette Richardson, Charlotte Vigor, Elisabeth Clayton, Bushan Hardas, Kerstinj Rolf. Hypertrophic scar cells fail to undergo a form of apoptosis specific to contractile collagen-the role of tissue transglutaminase. The Journal of investigative dermatology. vol 125. issue 1. 2005-09-01. PMID:15982305. |
hypertrophic scar cells fail to undergo a form of apoptosis specific to contractile collagen-the role of tissue transglutaminase. |
2005-09-01 |
2023-08-12 |
Not clear |
| Claire Linge, Janette Richardson, Charlotte Vigor, Elisabeth Clayton, Bushan Hardas, Kerstinj Rolf. Hypertrophic scar cells fail to undergo a form of apoptosis specific to contractile collagen-the role of tissue transglutaminase. The Journal of investigative dermatology. vol 125. issue 1. 2005-09-01. PMID:15982305. |
failure of apoptosis has been postulated to cause the hypercellularity and thus excess scar-tissue formation of hypertrophic scars (hts). |
2005-09-01 |
2023-08-12 |
Not clear |
| Hiroaki Ushikoshi, Tomoyuki Takahashi, Xuehai Chen, Ngin Cin Khai, Masayasu Esaki, Kazuko Goto, Genzou Takemura, Rumi Maruyama, Shinya Minatoguchi, Takako Fujiwara, Satoshi Nagano, Kentaro Yuge, Takao Kawai, Yoshiteru Murofushi, Hisayoshi Fujiwara, Ken-ichiro Kosa. Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating noncardiomyocytes. Laboratory investigation; a journal of technical methods and pathology. vol 85. issue 7. 2005-08-23. PMID:15856048. |
overexpressed hb-egf had no cytoprotective or additive death-inducible effect on fas-induced apoptosis or oxidative stress injury in primary cultured mouse cardiomyocytes, although it significantly induced hypertrophy of cardiomyocytes and proliferation of cardiac fibroblasts. |
2005-08-23 |
2023-08-12 |
mouse |
| Hiroaki Ushikoshi, Tomoyuki Takahashi, Xuehai Chen, Ngin Cin Khai, Masayasu Esaki, Kazuko Goto, Genzou Takemura, Rumi Maruyama, Shinya Minatoguchi, Takako Fujiwara, Satoshi Nagano, Kentaro Yuge, Takao Kawai, Yoshiteru Murofushi, Hisayoshi Fujiwara, Ken-ichiro Kosa. Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating noncardiomyocytes. Laboratory investigation; a journal of technical methods and pathology. vol 85. issue 7. 2005-08-23. PMID:15856048. |
namely, it elevated the levels of apoptosis, fibrosis, and the accumulation of myofibroblasts and macrophages in the mi area, in addition to inducing left ventricular hypertrophy. |
2005-08-23 |
2023-08-12 |
mouse |
| Beth L Viviano, Laura Silverstein, Camila Pflederer, Stephenie Paine-Saunders, Kathy Mills, Scott Saunder. Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification. Developmental biology. vol 282. issue 1. 2005-08-23. PMID:15936336. |
these hypertrophic chondrocytes down-regulate type x collagen mrna expression and undergo apoptosis, suggesting a normal progression of hypertrophic chondrocyte cell fate. |
2005-08-23 |
2023-08-12 |
mouse |
| Julie Chao, Lee Cha. Kallikrein-kinin in stroke, cardiovascular and renal disease. Experimental physiology. vol 90. issue 3. 2005-08-11. PMID:15653716. |
moreover, kallikrein-kinin exhibited pleiotropic effects by inhibiting apoptosis, inflammation, hypertrophy and fibrosis, and promoting angiogenesis and neurogenesis in the heart, kidney, brain and blood vessel. |
2005-08-11 |
2023-08-12 |
human |