| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Terrence M Yau, Christopher Kim, Guangming Li, Yaoguang Zhang, Richard D Weisel, Ren-Ke L. Maximizing ventricular function with multimodal cell-based gene therapy. Circulation. vol 112. issue 9 Suppl. 2006-02-21. PMID:16159803. |
insulin-like growth factor i (igf-i) may induce hypertrophy and inhibit apoptosis. |
2006-02-21 |
2023-08-12 |
Not clear |
| Roberto Piñieiro, María J Iglesias, Sonia Eiras, Juan Viñuela, Francisca Lago, José R González-Juanate. Leptin does not induce hypertrophy, cell cycle alterations, or production of MCP-1 in cultured rat and mouse cardiomyocytes. Endocrine research. vol 31. issue 4. 2006-02-21. PMID:16433256. |
chf is generally preceded by myocardial remodeling involving hypertrophy, necrosis, and apoptosis. |
2006-02-21 |
2023-08-12 |
mouse |
| Denise Hilfiker-Kleiner, Andres Hilfiker, Karol Kaminski, Arnd Schaefer, Joon-Keun Park, Kim Michel, Anja Quint, Moshe Yaniv, Jonathan B Weitzman, Helmut Drexle. Lack of JunD promotes pressure overload-induced apoptosis, hypertrophic growth, and angiogenesis in the heart. Circulation. vol 112. issue 10. 2006-02-15. PMID:16129800. |
lack of jund promotes pressure overload-induced apoptosis, hypertrophic growth, and angiogenesis in the heart. |
2006-02-15 |
2023-08-12 |
mouse |
| Denise Hilfiker-Kleiner, Andres Hilfiker, Karol Kaminski, Arnd Schaefer, Joon-Keun Park, Kim Michel, Anja Quint, Moshe Yaniv, Jonathan B Weitzman, Helmut Drexle. Lack of JunD promotes pressure overload-induced apoptosis, hypertrophic growth, and angiogenesis in the heart. Circulation. vol 112. issue 10. 2006-02-15. PMID:16129800. |
the jun family of activator protein 1 (ap-1) transcription factors (c-jun, junb, and jund) is involved in fundamental biological processes such as proliferation, apoptosis, tumor angiogenesis, and hypertrophy. |
2006-02-15 |
2023-08-12 |
mouse |
| Lili A Barouch, Daqing Gao, Lei Chen, Karen L Miller, Wenhong Xu, Alexander C Phan, Michelle M Kittleson, Khalid M Minhas, Dan E Berkowitz, Chiming Wei, Joshua M Har. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circulation research. vol 98. issue 1. 2006-02-09. PMID:16339484. |
disruption of leptin signaling is associated with obesity, heart failure, and cardiac hypertrophy, but the role of leptin in cardiac myocyte apoptosis is unknown. |
2006-02-09 |
2023-08-12 |
mouse |
| Lili A Barouch, Daqing Gao, Lei Chen, Karen L Miller, Wenhong Xu, Alexander C Phan, Michelle M Kittleson, Khalid M Minhas, Dan E Berkowitz, Chiming Wei, Joshua M Har. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circulation research. vol 98. issue 1. 2006-02-09. PMID:16339484. |
we tested the hypothesis that apoptosis increases in leptin-deficient ob/ob and leptin-resistant db/db mice and is associated with aging and left ventricular hypertrophy, increased dna damage, and decreased survival. |
2006-02-09 |
2023-08-12 |
mouse |
| Xiong Z Ruan, Zac Varghese, Stephen H Powis, John F Moorhea. Nuclear receptors and their coregulators in kidney. Kidney international. vol 68. issue 6. 2006-02-01. PMID:16316322. |
since progression of renal diseases is almost always associated with inflammatory processes and/or involve metabolic disorders of lipid and glucose, cell proliferation, hypertrophy, apoptosis, and hypertension, the importance of nuclear receptors and their coregulators in these contexts will be addressed. |
2006-02-01 |
2023-08-12 |
Not clear |
| Christian Freund, Ruth Schmidt-Ullrich, Anthony Baurand, Sandra Dunger, Wolfgang Schneider, Peter Loser, Amina El-Jamali, Rainer Dietz, Claus Scheidereit, Martin W Bergman. Requirement of nuclear factor-kappaB in angiotensin II- and isoproterenol-induced cardiac hypertrophy in vivo. Circulation. vol 111. issue 18. 2006-01-13. PMID:15870116. |
in vitro experiments have proposed a role of nuclear factor-kappab (nf-kappab), a transcription factor, in cardiomyocyte hypertrophy and protection against apoptosis. |
2006-01-13 |
2023-08-12 |
Not clear |
| Hua Chen, Xueyin N Huang, Wen Yan, Ka Chen, Lida Guo, Lekha Tummalapali, Shoukat Dedhar, René St-Arnaud, Chuanyue Wu, Jorge L Sepulved. Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. Laboratory investigation; a journal of technical methods and pathology. vol 85. issue 11. 2006-01-05. PMID:16170337. |
in this study, we demonstrate that (1) ilk forms a complex with pinch1 and alpha-parvin proteins (ipap1 complex) in neonatal rat ventricular myocytes; (2) localization of ipap1 complex proteins to costameres in cardiac myocytes is stimulated by fn, pe and synergistically by the combination of fn and pe in an integrin beta1-dependent manner; (3) a dominant-negative mutant lacking the pinch-binding n-terminus of ilk (ilk-c) prevents costamere association of ilk and alpha-parvin, but not pinch1; (4) fn- and pe-induced hypertrophy, measured by increased protein/dna ratio, beating frequency and atrial natriuretic peptide expression, is stimulated by low levels of ilk-c but repressed by high ilk-c expression; and (5) overexpression of ilk-c, as well as deletion of the ilk gene in mouse neonatal ventricular myocytes, induces marked apoptosis of cardiac myocytes. |
2006-01-05 |
2023-08-12 |
mouse |
| Hua Chen, Xueyin N Huang, Wen Yan, Ka Chen, Lida Guo, Lekha Tummalapali, Shoukat Dedhar, René St-Arnaud, Chuanyue Wu, Jorge L Sepulved. Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. Laboratory investigation; a journal of technical methods and pathology. vol 85. issue 11. 2006-01-05. PMID:16170337. |
these results suggest that the ipap1 complex plays an important role in mediating integrin-signaling pathways that regulate cardiac myocyte hypertrophy and resistance to apoptosis. |
2006-01-05 |
2023-08-12 |
mouse |
| Shahrzad Abbasi, Bing Su, Rodney E Kellems, Jianhua Yang, Yang Xi. The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation. The Journal of biological chemistry. vol 280. issue 44. 2005-12-28. PMID:16126726. |
calcineurin is a serine/threonine protein phosphatase that plays a critical role in many physiologic processes, such as t-cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. |
2005-12-28 |
2023-08-12 |
mouse |
| Laimute Taraseviciene-Stewart, Robertas Scerbavicius, John M Stewart, Lajos Gera, Yoshiki Demura, Carlyne Cool, Michael Kasper, Norbert F Voelke. Treatment of severe pulmonary hypertension: a bradykinin receptor 2 agonist B9972 causes reduction of pulmonary artery pressure and right ventricular hypertrophy. Peptides. vol 26. issue 8. 2005-12-21. PMID:15878794. |
taken together our data suggest that a stable bradykinin b2 agonist b9972 demonstrates the capacity to reduce severe pulmonary hypertension, right ventricular hypertrophy and induce apoptosis of hyperproliferative cells in pre-capillary pulmonary arterioles. |
2005-12-21 |
2023-08-12 |
human |
| Paweł Niemiec, Iwona Za. [Vascular NAD(P)H oxidases--role in the pathogenesis of atherosclerosis]. Postepy biochemii. vol 51. issue 1. 2005-12-20. PMID:16209336. |
moreover, reactive oxygen species produced by nad(p)h oxidases may be involved in endothelial cells apoptosis, oxidation of low density lipoproteins and vascular myocytes hypertrophy and proliferation. |
2005-12-20 |
2023-08-12 |
Not clear |
| Antonis S Manolis, Stylianos Tzeis, Kostas Triantafyllou, John Michaelidis, Ioannis Pyrros, Nikolaos Sakellaris, Athanasios Kranidis, Helen Melit. Erythropoietin in heart failure and other cardiovascular diseases: hematopoietic and pleiotropic effects. Current drug targets. Cardiovascular & haematological disorders. vol 5. issue 5. 2005-12-15. PMID:16248829. |
long-standing anemia of any cause can cause left ventricular hypertrophy, which can lead to cardiac cell death through apoptosis and worsen chf. |
2005-12-15 |
2023-08-12 |
human |
| Yumei Zhan, Courtney Brown, Elizabeth Maynard, Aleksandra Anshelevich, Weihua Ni, I-Cheng Ho, Peter Oettge. Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling. The Journal of clinical investigation. vol 115. issue 9. 2005-12-14. PMID:16138193. |
expression of p21cip in vsmcs leads to cellular hypertrophy, whereas expression of p21cip in endothelial cells is associated with cell cycle arrest, apoptosis, and endothelial dysfunction. |
2005-12-14 |
2023-08-12 |
mouse |
| Daniela Schneiders, Jacqueline Heger, Patrick Best, Hans Michael Piper, Gerhild Taimo. SMAD proteins are involved in apoptosis induction in ventricular cardiomyocytes. Cardiovascular research. vol 67. issue 1. 2005-12-13. PMID:15949472. |
the transcription factor ap-1 is a mediator of hypertrophic growth and apoptosis in cardiomyocytes. |
2005-12-13 |
2023-08-12 |
rat |
| Robin Ray, Ajay M Sha. NADPH oxidase and endothelial cell function. Clinical science (London, England : 1979). vol 109. issue 3. 2005-12-13. PMID:16104842. |
more importantly, this enzyme system is activated by numerous stimuli and is involved in triggering diverse intracellular signalling pathways ('redox-sensitive' signalling pathways) that have a central role in conditions such as endothelial activation and inflammation, cell growth, apoptosis and hypertrophy. |
2005-12-13 |
2023-08-12 |
Not clear |
| Wei-Wen Kuo, Chia-Yih Chu, Chieh-Hsi Wu, James A Lin, Jer-Yuh Liu, Yi-Hsien Hsieh, Kwo-Chang Ueng, Shin-Da Lee, Dennis Jine-Yuan Hsieh, His-Hsien Hsu, Li-Mien Chen, Chih-Yang Huan. Impaired IGF-I signalling of hypertrophic hearts in the developmental phase of hypertension in genetically hypertensive rats. Cell biochemistry and function. vol 23. issue 5. 2005-12-09. PMID:15996002. |
these findings indicate that impaired igf-ir signalling occurs at early stages, and it may contribute, at least partially, to the development of hypertension and pathological cardiac hypertrophy and to cardiomyocyte apoptosis at later stages in shr and spshr. |
2005-12-09 |
2023-08-12 |
rat |
| Amelie Lupp, Elke Karge, Manfred Danz, Thomas Deufel, Herbert Oelschläger, Wolfgang Klinge. Single and chronic administration of ciprofibrate or of ciprofibrate-glycinate in male Fischer 344 rats: comparison of the effects on morphological and biochemical parameters in liver and blood. European journal of drug metabolism and pharmacokinetics. vol 30. issue 3. 2005-11-10. PMID:16250258. |
histologically, a hypertrophy, an eosinophilia, a reduced glycogen content and also an apoptosis of the hepatocytes was observed. |
2005-11-10 |
2023-08-12 |
rat |
| Parco M Siu, Stephen E Alwa. Age-related apoptotic responses to stretch-induced hypertrophy in quail slow-tonic skeletal muscle. American journal of physiology. Cell physiology. vol 289. issue 5. 2005-11-07. PMID:15972839. |
in the present study, we examined the responses of apoptosis and apoptotic regulatory factors to muscle hypertrophy induced by stretch overload in quail slow-tonic muscles. |
2005-11-07 |
2023-08-12 |
Not clear |