| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tong Zhang, Joan Heller Brow. Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. Cardiovascular research. vol 63. issue 3. 2004-10-07. PMID:15276473. |
the nuclear deltab isoform plays a key role in hypertrophic gene expression, whereas the cytoplasmic deltac isoform can affect excitation-contraction (e-c) coupling through phosphorylation of ca2+ regulatory proteins and may also transduce signals leading to apoptosis. |
2004-10-07 |
2023-08-12 |
Not clear |
| Tong Zhang, Joan Heller Brow. Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. Cardiovascular research. vol 63. issue 3. 2004-10-07. PMID:15276473. |
this review focuses on evidence that camkii plays an essential role in transcriptional activation associated with cardiac hypertrophy, as well as the aberrant ca2+ handling and apoptosis that may contribute to heart failure. |
2004-10-07 |
2023-08-12 |
Not clear |
| Vanessa P M van Empel, Leon J De Wind. Myocyte hypertrophy and apoptosis: a balancing act. Cardiovascular research. vol 63. issue 3. 2004-10-07. PMID:15276474. |
myocyte hypertrophy and apoptosis: a balancing act. |
2004-10-07 |
2023-08-12 |
Not clear |
| Elena E Brevnova, Oleksandr Platoshyn, Shen Zhang, Jason X-J Yua. Overexpression of human KCNA5 increases IK V and enhances apoptosis. American journal of physiology. Cell physiology. vol 287. issue 3. 2004-09-23. PMID:15140747. |
inhibited apoptosis and downregulated k+ channels in pulmonary artery smooth muscle cells (pasmc) have been implicated in development of pulmonary vascular medial hypertrophy and pulmonary hypertension. |
2004-09-23 |
2023-08-12 |
human |
| Masatoshi Takahara, Takuji Naruse, Michiaki Takagi, Hiroshi Orui, Toshihiko Ogin. Matrix metalloproteinase-9 expression, tartrate-resistant acid phosphatase activity, and DNA fragmentation in vascular and cellular invasion into cartilage preceding primary endochondral ossification in long bones. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 22. issue 5. 2004-09-16. PMID:15304278. |
recently it has been shown that matrix metalloproteinase-9 (mmp-9)/gelatinase b is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. |
2004-09-16 |
2023-08-12 |
Not clear |
| Norio Amizuka, David Davidson, Hanlong Liu, Gladys Valverde-Franco, Sen Chai, Takeyasu Maeda, Hidehiro Ozawa, Vicki Hammond, David M Ornitz, David Goltzman, Janet E Henderso. Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development. Bone. vol 34. issue 1. 2004-09-15. PMID:14751559. |
however, abnormalities such as the presence of nonhypertrophic cells among hypertrophic chondrocytes and excessive apoptosis seen in the hypertrophic zone of pthrp-/- mice were absent in the pthrp-/-/fgfr3-/- mice. |
2004-09-15 |
2023-08-12 |
mouse |
| Keisuke Kawai, Fuzhong Qin, Junya Shite, Weike Mao, Shuji Fukuoka, Chang-Seng Lian. Importance of antioxidant and antiapoptotic effects of beta-receptor blockers in heart failure therapy. American journal of physiology. Heart and circulatory physiology. vol 287. issue 3. 2004-09-10. PMID:15105169. |
administration of carvedilol and metoprolol, which had no effect in sham animals, attenuated cardiac ventricular remodeling, cardiac hypertrophy, oxidative stress, and myocyte apoptosis in chf. |
2004-09-10 |
2023-08-12 |
Not clear |
| Chunxia Huang, Yuequn Wang, Dali Li, Yongqing Li, Jian Luo, Wuzhou Yuan, Ying Ou, Chuanbing Zhu, Yuejuan Zhang, Zhi Wang, Mingyao Liu, Xiushan W. Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc finger protein ZNF394. Biochemical and biophysical research communications. vol 320. issue 4. 2004-09-10. PMID:15249231. |
zinc finger proteins play important roles in a variety of cellular functions, including cell growth, proliferation, apoptosis, and intracellular signal transduction, and the zinc finger-containing transcription factor has been implicated as a critical regulator of multiple cardiac-expressed genes as well as a regulator of inducible gene expression in response to hypertrophic stimulation. |
2004-09-10 |
2023-08-12 |
human |
| David Engel, Ronald Peshock, Robert C Armstong, Natarajan Sivasubramanian, Douglas L Man. Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression. American journal of physiology. Heart and circulatory physiology. vol 287. issue 3. 2004-09-10. PMID:15317679. |
to determine whether progressive cardiac myocyte apoptosis contributes to the transition from a hypertrophic to a dilated cardiac phenotype that is observed in transgenic myosin heavy chain secreted tnf (mhcstnf) mice with cardiac restricted overexpression of tumor necrosis factor (tnf), we assessed cardiac myocyte apoptosis (using a dna ligase technique) in mhcstnf mice and littermate control mice in relation to serial changes in lv structure, which was assessed using mri. |
2004-09-10 |
2023-08-12 |
mouse |
| David Engel, Ronald Peshock, Robert C Armstong, Natarajan Sivasubramanian, Douglas L Man. Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression. American journal of physiology. Heart and circulatory physiology. vol 287. issue 3. 2004-09-10. PMID:15317679. |
the prevalence of cardiac myocyte apoptosis increased progressively from 4 to 12 wk as the hearts of the mhcstnf mice underwent the transition from a concentric hypertrophic to a dilated cardiac phenotype. |
2004-09-10 |
2023-08-12 |
mouse |
| F Martínez-Díaz, M Bernal-Gilar, M Gómez-Zapata, A Lun. Expression and significance of cell immunohistochemical markers (HHF-35, CD-31, Bcl-2, P-53 and apopDETEC) in hypertrophic cardiomyopathy. Histology and histopathology. vol 19. issue 1. 2004-08-30. PMID:14702165. |
there are several hypotheses concerning the pathogenesis of hypertrophic cardiomyopathy (genetic, ischaemic, immune, inflammatory and apoptosis induction). |
2004-08-30 |
2023-08-12 |
Not clear |
| Isao Shiraishi, Jaime Melendez, Youngkeun Ahn, Maryanne Skavdahl, Elizabeth Murphy, Sara Welch, Erik Schaefer, Kenneth Walsh, Anthony Rosenzweig, Daniele Torella, Daria Nurzynska, Jan Kajstura, Annarosa Leri, Piero Anversa, Mark A Sussma. Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circulation research. vol 94. issue 7. 2004-08-23. PMID:14988230. |
collectively, these experiments show that targeting of akt to the nucleus mediates inhibition of apoptosis without hypertrophic remodeling, opening new possibilities for therapeutic applications of nuclear-targeted akt to inhibit cell death associated with heart disease. |
2004-08-23 |
2023-08-12 |
Not clear |
| Gunter Wolf, Ulrich O Wenze. Angiotensin II and cell cycle regulation. Hypertension (Dallas, Tex. : 1979). vol 43. issue 4. 2004-08-10. PMID:14967829. |
depending on the specific cell type and presence of other growth factors, angiotensin ii induces proliferation (replication of dna with subsequent successful division of cells), hypertrophy (increase in cell size, cell protein, and mrna content without dna replication), apoptosis (programmed cell death), or differentiation. |
2004-08-10 |
2023-08-12 |
Not clear |
| Peter M Kang, Patrick Yue, Zhilin Liu, Oleg Tarnavski, Natalya Bodyak, Seigo Izum. Alterations in apoptosis regulatory factors during hypertrophy and heart failure. American journal of physiology. Heart and circulatory physiology. vol 287. issue 1. 2004-07-23. PMID:15001440. |
alterations in apoptosis regulatory factors during hypertrophy and heart failure. |
2004-07-23 |
2023-08-12 |
rat |
| Peter M Kang, Patrick Yue, Zhilin Liu, Oleg Tarnavski, Natalya Bodyak, Seigo Izum. Alterations in apoptosis regulatory factors during hypertrophy and heart failure. American journal of physiology. Heart and circulatory physiology. vol 287. issue 1. 2004-07-23. PMID:15001440. |
we analyzed primary cultures of these hearts and found that only cardiomyocytes made hypertrophic by a pathological stimulus show increased sensitivity to apoptosis. |
2004-07-23 |
2023-08-12 |
rat |
| Peter M Kang, Patrick Yue, Zhilin Liu, Oleg Tarnavski, Natalya Bodyak, Seigo Izum. Alterations in apoptosis regulatory factors during hypertrophy and heart failure. American journal of physiology. Heart and circulatory physiology. vol 287. issue 1. 2004-07-23. PMID:15001440. |
therefore, we speculate that this increased sensitivity to apoptotic stimulation along with proapoptotic changes in the apoptosis program may contribute to the development of heart failure seen in pathological cardiac hypertrophy. |
2004-07-23 |
2023-08-12 |
rat |
| Ming Zheng, Qi-De Han, Rui-Ping Xia. Distinct beta-adrenergic receptor subtype signaling in the heart and their pathophysiological relevance. Sheng li xue bao : [Acta physiologica Sinica]. vol 56. issue 1. 2004-07-22. PMID:14985822. |
however, sustained beta-adrenergic stimulation promotes pathological cardiac remodeling such as myocyte hypertrophy, apoptosis and necrosis, thus contributing to the pathogenesis of chronic heart failure. |
2004-07-22 |
2023-08-12 |
mouse |
| Ming Zheng, Qi-De Han, Rui-Ping Xia. Distinct beta-adrenergic receptor subtype signaling in the heart and their pathophysiological relevance. Sheng li xue bao : [Acta physiologica Sinica]. vol 56. issue 1. 2004-07-22. PMID:14985822. |
chronic stimulation of beta(1)ar and beta(2)ar elicits opposing effects on the fate of cardiomyocytes: beta(1)ar induces hypertrophy and apoptosis; but beta(2)ar promotes cell survival. |
2004-07-22 |
2023-08-12 |
mouse |
| Ming Zheng, Qi-De Han, Rui-Ping Xia. Distinct beta-adrenergic receptor subtype signaling in the heart and their pathophysiological relevance. Sheng li xue bao : [Acta physiologica Sinica]. vol 56. issue 1. 2004-07-22. PMID:14985822. |
unexpectedly, beta(1)ar-induced myocyte hypertrophy and apoptosis are independent of the classic camp/pka pathway, but require activation of ca(2+)/calmodulin-dependent kinase ii (camk ii). |
2004-07-22 |
2023-08-12 |
mouse |
| Ashakumary Lakshmikuttyamma, Ponniah Selvakumar, Rakesh Kakkar, Rani Kanthan, Rui Wang, Rajendra K Sharm. Activation of calcineurin expression in ischemia-reperfused rat heart and in human ischemic myocardium. Journal of cellular biochemistry. vol 90. issue 5. 2004-07-20. PMID:14624458. |
calcineurin (can) has been reported as a critical mediator for cardiac hypertrophy and cardiac myocyte apoptosis. |
2004-07-20 |
2023-08-12 |
human |