| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter M Kang, Seigo Izum. Apoptosis in heart: basic mechanisms and implications in cardiovascular diseases. Trends in molecular medicine. vol 9. issue 4. 2004-03-09. PMID:12727144. |
in addition, the effects of various hypertrophic signaling molecules on apoptosis have been characterized. |
2004-03-09 |
2023-08-12 |
Not clear |
| Peter M Kang, Seigo Izum. Apoptosis in heart: basic mechanisms and implications in cardiovascular diseases. Trends in molecular medicine. vol 9. issue 4. 2004-03-09. PMID:12727144. |
however, the significance of apoptosis to the overall pathogenesis of heart failure, and the relationship between cardiac hypertrophic signaling and apoptosis still needs further investigation. |
2004-03-09 |
2023-08-12 |
Not clear |
| Susan H Kwon, David R Pimentel, Andrea Remondino, Douglas B Sawyer, Wilson S Colucc. H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways. Journal of molecular and cellular cardiology. vol 35. issue 6. 2004-03-09. PMID:12788379. |
reactive oxygen species (ros) can act as signaling molecules to stimulate either hypertrophy or apoptosis in cardiac myocytes. |
2004-03-09 |
2023-08-12 |
rat |
| Susan H Kwon, David R Pimentel, Andrea Remondino, Douglas B Sawyer, Wilson S Colucc. H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways. Journal of molecular and cellular cardiology. vol 35. issue 6. 2004-03-09. PMID:12788379. |
thus, the concentration-dependent effects of ros on myocyte hypertrophy and growth are due, at least in part, to the differential activation of specific kinase signaling pathways that regulate hypertrophy and apoptosis. |
2004-03-09 |
2023-08-12 |
rat |
| Filippo Renò, Maurizio Sabbatini, Francesca Lombardi, Maurizio Stella, Carla Pezzuto, Gilberto Magliacani, Mario Canna. In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 11. issue 5. 2004-03-05. PMID:12950636. |
in vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars. |
2004-03-05 |
2023-08-12 |
Not clear |
| Filippo Renò, Maurizio Sabbatini, Francesca Lombardi, Maurizio Stella, Carla Pezzuto, Gilberto Magliacani, Mario Canna. In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 11. issue 5. 2004-03-05. PMID:12950636. |
in this study, apoptosis induction and release of interleukin-1beta (il-1beta) and tumor necrosis factor-alpha (tnf-alpha) were evaluated in normal (n = 3) and hypertrophic (=7) scars from burns after in vitro mechanical compression. |
2004-03-05 |
2023-08-12 |
Not clear |
| Filippo Renò, Maurizio Sabbatini, Francesca Lombardi, Maurizio Stella, Carla Pezzuto, Gilberto Magliacani, Mario Canna. In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 11. issue 5. 2004-03-05. PMID:12950636. |
in conclusion, in our in vitro model, mechanical compression resembling the clinical use of elastocompression was able to strongly increase apoptosis in the hypertrophic scar derma as observed during granulation tissue regression in normal wound healing. |
2004-03-05 |
2023-08-12 |
Not clear |
| Sathyamangla V Naga Prasad, Cinzia Perrino, Howard A Rockma. Role of phosphoinositide 3-kinase in cardiac function and heart failure. Trends in cardiovascular medicine. vol 13. issue 5. 2004-03-04. PMID:12837584. |
although pi3k has been the focus of intense study in various biologic processes including apoptosis, metastasis, and neuronal differentiation, it is only recently that the focus has shifted to understanding the role of pi3k in cardiac function, hypertrophy, and heart failure. |
2004-03-04 |
2023-08-12 |
Not clear |
| Siân V Griffin, Raimund Pichler, Mary Dittrich, Raghu Durvasula, Stuart J Shanklan. Cell cycle control in glomerular disease. Springer seminars in immunopathology. vol 24. issue 4. 2004-02-26. PMID:12778338. |
more recently a role for these proteins and their inhibitors has been appreciated in several diverse renal and non-renal cell processes, including proliferation, development, differentiation, hypertrophy and apoptosis. |
2004-02-26 |
2023-08-12 |
Not clear |
| Silviu Itescu, Michael D Schuster, Alfred A Koche. New directions in strategies using cell therapy for heart disease. Journal of molecular medicine (Berlin, Germany). vol 81. issue 5. 2004-02-04. PMID:12698252. |
in response to ischemic insult adult cardiomyocytes undergo cellular hypertrophy, nuclear ploidy, and a high degree of apoptosis. |
2004-02-04 |
2023-08-12 |
human |
| Kazuo Kuwata, Tomoharu Matumoto, Hong Cheng, Kuniaki Nagayama, Thomas L James, Heinrich Rode. NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106-126. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 25. 2004-01-23. PMID:14657385. |
prp106-126, a peptide corresponding to residues 107-127 of the human prion protein, induces neuronal cell death by apoptosis and causes proliferation and hypertrophy of glia, reproducing the main neuropathological features of prion-related transmissible spongiform encephalopathies, such as bovine spongiform encephalopathy and creutzfeldt-jakob disease. |
2004-01-23 |
2023-08-12 |
mouse |
| Boris Z Simkhovich, Paul Marjoram, Coralie Poizat, Larry Kedes, Robert A Klone. Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion. Archives of biochemistry and biophysics. vol 420. issue 2. 2004-01-22. PMID:14654066. |
in contrast, old hearts showed a unique injury-related response, which included up-regulation of mrnas for proteins associated with hypertrophy or apoptosis (including h36-alpha7 integrin, alpha-actin, tubulin, filamin, connective tissue growth factor, calcineurin, serine protease, and apoptosis inducing factor). |
2004-01-22 |
2023-08-12 |
rat |
| Martin U Braun, Palma Szalai, Ruth H Strasser, Mathias M Bors. Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes. Cardiovascular research. vol 59. issue 3. 2004-01-14. PMID:14499867. |
right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of pkc isozymes. |
2004-01-14 |
2023-08-12 |
Not clear |
| Martin U Braun, Palma Szalai, Ruth H Strasser, Mathias M Bors. Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes. Cardiovascular research. vol 59. issue 3. 2004-01-14. PMID:14499867. |
pressure overload induced by pulmonary artery banding (pab) leads to right ventricular (rv) hypertrophy and cardiomyocyte apoptosis. |
2004-01-14 |
2023-08-12 |
Not clear |
| R Tracy Ballock, Regis J O'Keef. Physiology and pathophysiology of the growth plate. Birth defects research. Part C, Embryo today : reviews. vol 69. issue 2. 2004-01-06. PMID:12955857. |
through a sequential process of cell proliferation, extracellular matrix synthesis, cellular hypertrophy, matrix mineralization, vascular invasion, and eventually apoptosis, the cartilage model is continually replaced by bone as length increases. |
2004-01-06 |
2023-08-12 |
human |
| Antonio Pacifico, Philip D Henr. Structural pathways and prevention of heart failure and sudden death. Journal of cardiovascular electrophysiology. vol 14. issue 7. 2004-01-05. PMID:12930259. |
the microscopic myocardial anatomy of scd is incompletely defined but may include prevalent changes of advanced myocardial disease, including cardiomyocyte hypertrophy, cardiomyocyte apoptosis, fibroblast hyperplasia, diffuse and focal matrix protein accumulation, and recruitment of inflammatory cells. |
2004-01-05 |
2023-08-12 |
Not clear |
| J O P Cheung, M E Grant, C J P Jones, J A Hoyland, A J Freemont, M C Hillarb. Apoptosis of terminal hypertrophic chondrocytes in an in vitro model of endochondral ossification. The Journal of pathology. vol 201. issue 3. 2004-01-05. PMID:14595763. |
apoptosis of terminal hypertrophic chondrocytes in an in vitro model of endochondral ossification. |
2004-01-05 |
2023-08-12 |
cattle |
| J O P Cheung, M E Grant, C J P Jones, J A Hoyland, A J Freemont, M C Hillarb. Apoptosis of terminal hypertrophic chondrocytes in an in vitro model of endochondral ossification. The Journal of pathology. vol 201. issue 3. 2004-01-05. PMID:14595763. |
it is widely accepted that growth plate chondrocytes undergo apoptosis when they reach the terminal hypertrophic stage of their differentiation during the process of endochondral ossification in vivo. |
2004-01-05 |
2023-08-12 |
cattle |
| J O P Cheung, M E Grant, C J P Jones, J A Hoyland, A J Freemont, M C Hillarb. Apoptosis of terminal hypertrophic chondrocytes in an in vitro model of endochondral ossification. The Journal of pathology. vol 201. issue 3. 2004-01-05. PMID:14595763. |
taken together, the results indicate that azacytidine-treated epiphyseal chondrocytes entered terminal hypertrophy from day 23 onwards in culture and died by apoptosis. |
2004-01-05 |
2023-08-12 |
cattle |
| Valentina Grishko, Viktor Pastukh, Viktoriya Solodushko, Mark Gillespie, Junichi Azuma, Stephen Schaffe. Apoptotic cascade initiated by angiotensin II in neonatal cardiomyocytes: role of DNA damage. American journal of physiology. Heart and circulatory physiology. vol 285. issue 6. 2003-12-24. PMID:12919932. |
angiotensin ii contributes to ventricular remodeling by promoting both cardiac hypertrophy and apoptosis; however, the mechanism underlying the latter phenomenon is poorly understood. |
2003-12-24 |
2023-08-12 |
Not clear |