| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paris Troyo Barrig. [Hypertrophy and ventricular remodeling in systemic arterial hypertension: role of AT1 receptors]. Archivos de cardiologia de Mexico. vol 73 Suppl 1. 2003-12-23. PMID:12966667. |
genetic information evokes different responses in the cardiac myocyte, altering its morphology, metabolism, protein synthesis and the bioavailability of some hormonal receptors, promoting compensatory hypertrophy or apoptosis. |
2003-12-23 |
2023-08-12 |
Not clear |
| A M Kat. Heart failure: a hemodynamic disorder complicated by maladaptive proliferative responses. Journal of cellular and molecular medicine. vol 7. issue 1. 2003-12-12. PMID:12767256. |
aldosterone antagonists exert beneficial effects on prognosis that are not easily explained by their diuretic effects, but instead can be explained by their ability to inhibit signaling pathways that stimulate maladaptive hypertrophy, remodeling, apoptosis and other deleterious responses that cause deterioration of the failing heart. |
2003-12-12 |
2023-08-12 |
Not clear |
| Gunter Wolf, Stuart J Shanklan. Cell cycle control in glomerular disease. Progress in cell cycle research. vol 5. 2003-12-11. PMID:14593702. |
the three resident glomerular cell types respond differently to injury, which includes proliferation, hypertrophy, apoptosis and de-differentiation. |
2003-12-11 |
2023-08-12 |
Not clear |
| Renate B Pilz, Darren E Castee. Regulation of gene expression by cyclic GMP. Circulation research. vol 93. issue 11. 2003-12-11. PMID:14645134. |
in this review, we discuss the role of cgmp-regulated gene expression in (patho)physiological processes most relevant to the cardiovascular system, such as regulation of vascular tone, cardiac hypertrophy, phenotypic modulation of vascular smooth muscle cells, and regulation of cell proliferation and apoptosis. |
2003-12-11 |
2023-08-12 |
Not clear |
| Yasuhiro Izumiya, Shokei Kim, Yasukatsu Izumi, Kaoru Yoshida, Minoru Yoshiyama, Atsushi Matsuzawa, Hidenori Ichijo, Hiroshi Iwa. Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling. Circulation research. vol 93. issue 9. 2003-12-04. PMID:14551246. |
apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin ii-induced cardiac hypertrophy and remodeling. |
2003-12-04 |
2023-08-12 |
mouse |
| Yasuhiro Izumiya, Shokei Kim, Yasukatsu Izumi, Kaoru Yoshida, Minoru Yoshiyama, Atsushi Matsuzawa, Hidenori Ichijo, Hiroshi Iwa. Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling. Circulation research. vol 93. issue 9. 2003-12-04. PMID:14551246. |
however, ang ii-induced cardiac hypertrophy and remodeling, including cardiomyocyte hypertrophy, cardiac hypertrophy-related mrna upregulation, cardiomyocyte apoptosis, interstitial fibrosis, coronary arterial remodeling, and collagen gene upregulation, was significantly attenuated in ask1-/- mice compared with wild-type mice. |
2003-12-04 |
2023-08-12 |
mouse |
| Amy L Howes, Jane F Arthur, Tong Zhang, Shigeki Miyamoto, John W Adams, Gerald W Dorn, Elizabeth A Woodcock, Joan Heller Brow. Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion. The Journal of biological chemistry. vol 278. issue 41. 2003-12-02. PMID:12900409. |
expression of the wild type alpha subunit of gq (gqwt) in cardiomyocytes induces hypertrophy, whereas a constitutively active g alpha q subunit (gqq209l) induces apoptosis. |
2003-12-02 |
2023-08-12 |
mouse |
| Gary Yee, Yan Yu, William Robert Walsh, Robert Lindeman, Michael Drury Pool. The immunolocalisation of VEGF in the articular cartilage of sheep mandibular condyles. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. vol 31. issue 4. 2003-11-20. PMID:12914710. |
vascular endothelial growth factor (vegf) has recently been found to be essential for hypertrophic chondrocyte apoptosis and angiogenesis at the growth plate of long bones, indicating a central role in endochondral ossification. |
2003-11-20 |
2023-08-12 |
human |
| K D Evans, S T Lau, A M Oberbauer, R B Marti. Alendronate affects long bone length and growth plate morphology in the oim mouse model for Osteogenesis Imperfecta. Bone. vol 32. issue 3. 2003-11-19. PMID:12667554. |
the high dosage of alendronate increased overall growth plate height, particularly within the hypertrophic zone, which suggests a failure of vascular invasion-induced apoptosis in the hypertrophic cells. |
2003-11-19 |
2023-08-12 |
mouse |
| Cecile Ancey, Emmanuelle Menet, Pierre Corbi, Sandra Fredj, Martine Garcia, Catherine Rücker-Martin, Jocelyn Bescond, Franck Morel, John Wijdenes, Jean-Claude Lecron, Daniel Potrea. Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation. Cardiovascular research. vol 59. issue 1. 2003-10-14. PMID:12829178. |
recent in vivo and in vitro studies in animals have demonstrated that cytokines of the il-6 family are involved in cardiac hypertrophy and in protection of cardiomyocytes against apoptosis. |
2003-10-14 |
2023-08-12 |
human |
| C Nediani, A Celli, L Formigli, A M Perna, C Fiorillo, V Ponziani, L Ibba-Manneschi, S Zecchi-Orlandini, D Nosi, G Liguri, P A Modesti, P Nass. Possible role of acylphosphatase, Bcl-2 and Fas/Fas-L system in the early changes of cardiac remodeling induced by volume overload. Biochimica et biophysica acta. vol 1638. issue 3. 2003-10-09. PMID:12878322. |
at 96 h, apoptosis appeared attenuated, while fas/fas-l expression was still higher than control values and cardiomyocyte hypertrophy became to develop. |
2003-10-09 |
2023-08-12 |
Not clear |
| Hideharu Tomita, Michael Nazmy, Katsuya Kajimoto, Ghassan Yehia, Carlos A Molina, Junichi Sadoshim. Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circulation research. vol 93. issue 1. 2003-09-26. PMID:12791704. |
inducible camp early repressor (icer) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. |
2003-09-26 |
2023-08-12 |
rat |
| Hideharu Tomita, Michael Nazmy, Katsuya Kajimoto, Ghassan Yehia, Carlos A Molina, Junichi Sadoshim. Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circulation research. vol 93. issue 1. 2003-09-26. PMID:12791704. |
although stimulation of the beta-adrenergic receptor increases levels of camp and activation of the camp response element (cre) in cardiac myocytes, the role of the signaling mechanism regulated by camp in hypertrophy and apoptosis is not well understood. |
2003-09-26 |
2023-08-12 |
rat |
| Hideharu Tomita, Michael Nazmy, Katsuya Kajimoto, Ghassan Yehia, Carlos A Molina, Junichi Sadoshim. Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circulation research. vol 93. issue 1. 2003-09-26. PMID:12791704. |
antisense inhibition of icer significantly enhanced beta-adrenergic hypertrophy, whereas it significantly inhibited beta-adrenergic cardiac myocyte apoptosis, suggesting that endogenous icer works as an important regulator of cardiac hypertrophy and apoptosis. |
2003-09-26 |
2023-08-12 |
rat |
| Hideharu Tomita, Michael Nazmy, Katsuya Kajimoto, Ghassan Yehia, Carlos A Molina, Junichi Sadoshim. Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circulation research. vol 93. issue 1. 2003-09-26. PMID:12791704. |
inhibition of cre-mediated transcription by dominant-negative cre binding protein inhibited cardiac hypertrophy, whereas it stimulated cardiac myocyte apoptosis, thereby mimicking the effect of icer. |
2003-09-26 |
2023-08-12 |
rat |
| Hideharu Tomita, Michael Nazmy, Katsuya Kajimoto, Ghassan Yehia, Carlos A Molina, Junichi Sadoshim. Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circulation research. vol 93. issue 1. 2003-09-26. PMID:12791704. |
these results suggest that icer is upregulated by cardiac hypertrophic stimuli increasing cre-mediated transcription in cardiac myocytes and acts as a negative regulator of hypertrophy and a positive mediator of apoptosis, in part through both inhibition of cre-mediated transcription and downregulation of bcl-2. |
2003-09-26 |
2023-08-12 |
rat |
| Antoine Vieillard-Baron, Eric Frisdal, Bernadette Raffestin, Andrew H Baker, Saadia Eddahibi, Serge Adnot, Marie-Pia D'Orth. Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats. Human gene therapy. vol 14. issue 9. 2003-09-26. PMID:12828857. |
rats treated with ad.htimp-1 had less severe pulmonary vascular remodeling evidenced by a decreased right ventricular hypertrophy, with decreased muscularization of peripheral pulmonary arteries and increased lung-cell apoptosis compared to controls. |
2003-09-26 |
2023-08-12 |
human |
| Shen Zhang, Ivana Fantozzi, Donna D Tigno, Eunhee S Yi, Oleksandr Platoshyn, Patricia A Thistlethwaite, Jolene M Kriett, Gordon Yung, Lewis J Rubin, Jason X-J Yua. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 285. issue 3. 2003-09-24. PMID:12740218. |
pulmonary vascular medial hypertrophy in primary pulmonary hypertension (pph) is mainly caused by increased proliferation and decreased apoptosis in pulmonary artery smooth muscle cells (pasmcs). |
2003-09-24 |
2023-08-12 |
human |
| Shen Zhang, Ivana Fantozzi, Donna D Tigno, Eunhee S Yi, Oleksandr Platoshyn, Patricia A Thistlethwaite, Jolene M Kriett, Gordon Yung, Lewis J Rubin, Jason X-J Yua. Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 285. issue 3. 2003-09-24. PMID:12740218. |
inhibition of bmp-induced pasmc apoptosis in pph patients may play an important role in the development of pulmonary vascular medial hypertrophy in these patients. |
2003-09-24 |
2023-08-12 |
human |
| Stéphanie Héon, Martin Bernier, Nicolas Servant, Stevan Dostanic, Chunlei Wang, Gordon M Kirby, Lesley Alpert, Lorraine E Chalifou. Dexrazoxane does not protect against doxorubicin-induced damage in young rats. American journal of physiology. Heart and circulatory physiology. vol 285. issue 2. 2003-08-21. PMID:12714334. |
we followed body weight gain with growth, measured cardiac hypertrophy after a 2-wk swim exercise program, markers of apoptosis (bcl-2, bax, bnip1, caspase 3 activation), oxidative stress (heme oxygenase 1, protein carbonyl levels), the chaperone protein clusterin, and the transcriptional activator early growth response gene-1 (egr-1) in hearts of nonexercised and exercised rats on neonate day 38. |
2003-08-21 |
2023-08-12 |
rat |