| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul C Howard, Letha H Couch, Ralph E Patton, Robert M Eppley, Daniel R Doerge, Mona I Churchwell, M Matilde Marques, Carlin V Okerber. Comparison of the toxicity of several fumonisin derivatives in a 28-day feeding study with female B6C3F(1) mice. Toxicology and applied pharmacology. vol 185. issue 3. 2003-01-14. PMID:12498732. |
increased hepatocellular apoptosis, hepatocellular hypertrophy, kupffer cell hyperplasia, and macrophage pigmentation were detected in the mice consuming 72 and 143 micromol/kg fumonisin b(1). |
2003-01-14 |
2023-08-12 |
mouse |
| Ayako Nakazono-Kusaba, Fumi Takahashi-Yanaga, Sachio Morimoto, Masutaka Furue, Toshiyuki Sasagur. Staurosporine-induced cleavage of alpha-smooth muscle actin during myofibroblast apoptosis. The Journal of investigative dermatology. vol 119. issue 5. 2003-01-08. PMID:12445185. |
to examine the possibility that staurosporine is applicable for the treatment of abnormal scar formation such as hypertrophic scar and keloid, the cellular process during staurosporine-induced apoptosis was analyzed in myofibroblasts isolated from a rat granulation tissue pouch. |
2003-01-08 |
2023-08-12 |
rat |
| B C Zhao, L Qia. [Detection of apoptosis by in situ labeling and study on the expression of PCNA in hypertrophic scars and keloids]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 25. issue 1. 2003-01-07. PMID:12212258. |
[detection of apoptosis by in situ labeling and study on the expression of pcna in hypertrophic scars and keloids]. |
2003-01-07 |
2023-08-12 |
Not clear |
| B C Zhao, L Qia. [Detection of apoptosis by in situ labeling and study on the expression of PCNA in hypertrophic scars and keloids]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 25. issue 1. 2003-01-07. PMID:12212258. |
to investigate the involvement of apoptosis and proliferation in the lesions of hypertrophic scars and keloids, eighteen samples of hypertrophic scar and five samples of keloid were collected. |
2003-01-07 |
2023-08-12 |
Not clear |
| B C Zhao, L Qia. [Detection of apoptosis by in situ labeling and study on the expression of PCNA in hypertrophic scars and keloids]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 25. issue 1. 2003-01-07. PMID:12212258. |
results showed that in hypertrophic scar and keloid samples the rate of proliferating cells in dermis was higher than that of normal skin(p < 0.05), whereas the apoptosis index between scars and normal skin shows no statistical significance. |
2003-01-07 |
2023-08-12 |
Not clear |
| B C Zhao, L Qia. [Detection of apoptosis by in situ labeling and study on the expression of PCNA in hypertrophic scars and keloids]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 25. issue 1. 2003-01-07. PMID:12212258. |
it indicates that excessive proliferation and the lack of apoptosis of cells in dermis may cause the formation and development of hypertrophic scars and keloids. |
2003-01-07 |
2023-08-12 |
Not clear |
| Abraham Nyska, Cindy R Moomaw, Julie F Foley, Robert R Maronpot, David E Malarkey, Connie A Cummings, Shyamal Peddada, Carolyn F Moyer, David G Allen, Greg Travlos, Po C Cha. The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis, mitosis, S phase, and p53 and hepatocytic vascular endothelial growth factor expression after short-term exposure. Toxicology and applied pharmacology. vol 184. issue 3. 2002-12-19. PMID:12460743. |
following 30 doses of 1.0 and 2.5 mg/kg/day, hepatocytes exhibited reduced mitosis, fewer s-phase nuclei, increased hypertrophy, and fatty degeneration, while endothelial cells showed karyomegaly, cytomegaly, decreased apoptosis, more s-phase nuclei, and p53 positivity. |
2002-12-19 |
2023-08-12 |
mouse |
| Doris Jäger, Ursula Müller-Werdan, Klaus Pönicke, Jürgen Holtz, Karl Werdan, Sylvana P Mülle. The impact of insulin-like growth factor-1 on the pattern of cardiac elongation factor-2 variants in a model of overload. Molecular and cellular biochemistry. vol 229. issue 1-2. 2002-12-17. PMID:11936844. |
because of its key role in proteosynthesis, the total content of elongation factor-2 (ef-2) and the distribution of six main ef-2 variants were investigated after pseudomonas exotoxin a catalyzed [37p]adp-ribosylation using 1d-page and isoelectric focusing (ief) in a rat model of hemodynamic overload with variable degrees of cardiac hypertrophy: chronic no-synthase inhibition by l-name (n-omega-nitro-l-arginine-methyl-ester; 0.75 mg/ml drinking water) induced arterial hypertension without hypertrophy but myocardial apoptosis; additional treatment with igf-1 (osmotic micropumps) did not modify hypertension but reduced apoptosis allowing moderate hypertrophy of the left ventricles. |
2002-12-17 |
2023-08-12 |
rat |
| David J Galvin, R William G Watson, James I Gillespie, Hugh Brady, John M Fitzpatric. Mechanical stretch regulates cell survival in human bladder smooth muscle cells in vitro. American journal of physiology. Renal physiology. vol 283. issue 6. 2002-12-17. PMID:12388384. |
the purpose of this study was to investigate the effect of stretch on apoptosis, proliferation, cell hypertrophy, and growth factor production in human bladder smooth muscle cells in vitro. |
2002-12-17 |
2023-08-12 |
human |
| David J Galvin, R William G Watson, James I Gillespie, Hugh Brady, John M Fitzpatric. Mechanical stretch regulates cell survival in human bladder smooth muscle cells in vitro. American journal of physiology. Renal physiology. vol 283. issue 6. 2002-12-17. PMID:12388384. |
mechanical stretch regulates apoptosis, proliferation, and cell hypertrophy in human bladder smooth muscle cells. |
2002-12-17 |
2023-08-12 |
human |
| Gianluigi Condorelli, Carmine Morisco, Michael V G Latronico, Pier Paolo Claudio, Paul Dent, Philip Tsichlis, Gerolama Condorelli, Giacomo Frati, Alessandra Drusco, Carlo M Croce, Claudio Napol. TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 16. issue 13. 2002-12-16. PMID:12409315. |
cardiomyocyte hypertrophy and apoptosis have been implicated in the loss of contractile function during heart failure (hf). |
2002-12-16 |
2023-08-12 |
rat |
| Gianluigi Condorelli, Carmine Morisco, Michael V G Latronico, Pier Paolo Claudio, Paul Dent, Philip Tsichlis, Gerolama Condorelli, Giacomo Frati, Alessandra Drusco, Carlo M Croce, Claudio Napol. TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 16. issue 13. 2002-12-16. PMID:12409315. |
however, the multiple signal transduction pathways generating from the tnf-alpha receptor in cardiomyocytes and leading preferentially to apoptosis or hypertrophy are still unknown. |
2002-12-16 |
2023-08-12 |
rat |
| Gianluigi Condorelli, Carmine Morisco, Michael V G Latronico, Pier Paolo Claudio, Paul Dent, Philip Tsichlis, Gerolama Condorelli, Giacomo Frati, Alessandra Drusco, Carlo M Croce, Claudio Napol. TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 16. issue 13. 2002-12-16. PMID:12409315. |
altogether, the data presented evidence the role of akt and jun in tnf-alpha-induced cardiomyocyte hypertrophy and apoptosis. |
2002-12-16 |
2023-08-12 |
rat |
| L Peng, C Bradeley, J Li. [Investigation of inhibitory effect of ramipril on apoptosis in spontaneously hypertensive rats]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao. vol 30. issue 1. 2002-12-11. PMID:12205919. |
these studies demonstrate that ramipril can prevent the development of hypertension and myocardial hypertrophy and can inhibit the increase in the apoptosis of shr cardiac myocytes, suggesting that apoptosis may be involved in the pathogenesis of genetic hypertension. |
2002-12-11 |
2023-08-12 |
rat |
| Mehran Mandegar, Carmelle V Remillard, Jason X-J Yua. Ion channels in pulmonary arterial hypertension. Progress in cardiovascular diseases. vol 45. issue 2. 2002-12-02. PMID:12411972. |
dysfunctional k(+) channels have also been linked to inhibition of apoptosis and contribute further to the medial hypertrophy. |
2002-12-02 |
2023-08-12 |
human |
| Jun Agata, Lee Chao, Julie Cha. Kallikrein gene delivery improves cardiac reserve and attenuates remodeling after myocardial infarction. Hypertension (Dallas, Tex. : 1979). vol 40. issue 5. 2002-11-08. PMID:12411458. |
this study indicates that the kallikrein-kinin system plays an important role in preventing the progression of heart failure by attenuating cardiac hypertrophy and fibrosis, improving endothelial function, and inhibiting myocardial apoptosis through the akt-mediated signaling pathway. |
2002-11-08 |
2023-08-12 |
human |
| Mandeep R Mehra, Patricia A Ube. Emergence of Laplace therapeutics: declaring an end to end-stage heart failure. Congestive heart failure (Greenwich, Conn.). vol 8. issue 4. 2002-11-04. PMID:12147947. |
the weight of evidence regarding mechanical unloading using assist devices suggests that hemodynamic restoration is accompanied by regression of cellular hypertrophy, normalization of the neuroendocrine axis, improved expression of contractile proteins, enhanced cellular respiratory control, and decreases in markers of apoptosis and cellular stress. |
2002-11-04 |
2023-08-12 |
Not clear |
| Kaitkanoke Sirinarumitr, Theerapol Sirinarumitr, Shirley D Johnston, Dipak K Sarkar, Margaret V Root Kustrit. Finasteride-induced prostatic involution by apoptosis in dogs with benign prostatic hypertrophy. American journal of veterinary research. vol 63. issue 4. 2002-10-21. PMID:11939309. |
finasteride-induced prostatic involution by apoptosis in dogs with benign prostatic hypertrophy. |
2002-10-21 |
2023-08-12 |
Not clear |
| Kaitkanoke Sirinarumitr, Theerapol Sirinarumitr, Shirley D Johnston, Dipak K Sarkar, Margaret V Root Kustrit. Finasteride-induced prostatic involution by apoptosis in dogs with benign prostatic hypertrophy. American journal of veterinary research. vol 63. issue 4. 2002-10-21. PMID:11939309. |
to determine the effect of finasteride on programmed cell death (apoptosis) of prostatic cells during prostatic involution in dogs with benign prostatic hypertrophy (bph). |
2002-10-21 |
2023-08-12 |
Not clear |
| G Nickeni. Central role of the AT(1)-receptor in atherosclerosis. Journal of human hypertension. vol 16 Suppl 3. 2002-10-08. PMID:12140725. |
at(1)-receptor activation is not only involved in vasoconstriction, water and salt homoeostasis and control of other neurohumoral systems, but also induces reactive oxygen species production, cellular hypertrophy and hyperplasia and apoptosis. |
2002-10-08 |
2023-08-12 |
Not clear |