| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John W Savopoulos, Stephen Dowd, Carolyn Armour, Paul S Carter, Catherine J Greenwood, David Mills, David Powell, Gary R Pettman, Owen Jenkins, Frank S Walsh, Karen L Philpot. Expression and purification of functional JNK2beta2: perspectives on high-level production of recombinant MAP kinases. Protein expression and purification. vol 24. issue 1. 2002-10-03. PMID:11812219. |
of this family, the c-jun n-terminal kinases (jnks) are members which, depending on cell type, have been shown to activate the transcription of genes involved in the inflammatory response, apoptosis, and hypertrophy. |
2002-10-03 |
2023-08-12 |
Not clear |
| Megan M Donohue, Marie B Dema. Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytes. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193585. |
rickets in vdr null mice is secondary to decreased apoptosis of hypertrophic chondrocytes. |
2002-09-23 |
2023-08-12 |
mouse |
| Megan M Donohue, Marie B Dema. Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytes. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193585. |
we then addressed whether expansion of the hypertrophic chondrocyte layer was secondary to increased proliferation or decreased apoptosis. |
2002-09-23 |
2023-08-12 |
mouse |
| Megan M Donohue, Marie B Dema. Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytes. Endocrinology. vol 143. issue 9. 2002-09-23. PMID:12193585. |
brdu labeling failed to demonstrate an increase in chondrocyte proliferation in the vdr null mice; however, apoptosis was markedly diminished in the late hypertrophic chondrocytes of the vdr null mice, suggesting that impairment in programmed cell death of these cells leads to the characteristic findings of rickets. |
2002-09-23 |
2023-08-12 |
mouse |
| Rick B Vega, John Yang, Beverly A Rothermel, Rhonda Bassel-Duby, R Sanders William. Multiple domains of MCIP1 contribute to inhibition of calcineurin activity. The Journal of biological chemistry. vol 277. issue 33. 2002-09-20. PMID:12063245. |
calcineurin is a serine/threonine protein phosphatase that plays a critical role in many physiologic processes such as t-cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. |
2002-09-20 |
2023-08-12 |
Not clear |
| David C Cuellar, Juong Rhee, Natasha Kypriano. Alpha1-adrenoceptor antagonists radiosensitize prostate cancer cells via apoptosis induction. Anticancer research. vol 22. issue 3. 2002-09-13. PMID:12168853. |
recent evidence documented the ability of alpha-adrenoceptor antagonists, a widely used medical therapy for the treatment of benign prostatic hypertrophy (bph), to induce apoptosis in benign and malignant prostate cells. |
2002-09-13 |
2023-08-12 |
human |
| Wim Martinet, Michiel W M Knaapen, Guido R Y De Meyer, Arnold G Herman, Mark M Kock. Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques. Circulation. vol 106. issue 8. 2002-09-03. PMID:12186795. |
the formation of reactive oxygen species is a critical event in atherosclerosis because it promotes cell proliferation, hypertrophy, growth arrest, and/or apoptosis and oxidation of ldl. |
2002-09-03 |
2023-08-12 |
human |
| Junichi Sadoshima, Olivier Montagne, Qian Wang, Guiping Yang, Jill Warden, Jing Liu, Gen Takagi, Vijaya Karoor, Chull Hong, Gary L Johnson, Dorothy E Vatner, Stephen F Vatne. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. The Journal of clinical investigation. vol 110. issue 2. 2002-08-14. PMID:12122119. |
although previous studies using cultured cardiac myocytes have suggested that the mekk1-jnk pathway plays a key role in hypertrophy and apoptosis, its effects in cardiac hypertrophy and apoptosis are not fully understood in adult animals in vivo. |
2002-08-14 |
2023-08-12 |
mouse |
| Martin G Yussman, Tsuyoshi Toyokawa, Amy Odley, Roy A Lynch, Guangyu Wu, Melissa C Colbert, Bruce J Aronow, John N Lorenz, Gerald W Dor. Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nature medicine. vol 8. issue 7. 2002-08-05. PMID:12053174. |
we used microarray analysis to identify a genetic program for myocardial apoptosis in gq-mediated and pressure-overload cardiac hypertrophy. |
2002-08-05 |
2023-08-12 |
Not clear |
| Martin G Yussman, Tsuyoshi Toyokawa, Amy Odley, Roy A Lynch, Guangyu Wu, Melissa C Colbert, Bruce J Aronow, John N Lorenz, Gerald W Dor. Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nature medicine. vol 8. issue 7. 2002-08-05. PMID:12053174. |
thus, nix/bnip3l is upregulated in myocardial hypertrophy, and is both necessary and sufficient for gq-mediated apoptosis of cardiomyocytes and resulting hypertrophy decompensation. |
2002-08-05 |
2023-08-12 |
Not clear |
| Catherine Communal, Wilson S Colucci, Andrea Remondino, Douglas B Sawyer, J David Port, Scott E Wichman, Michael R Bristow, Krishna Sing. Reciprocal modulation of mitogen-activated protein kinases and mitogen-activated protein kinase phosphatase 1 and 2 in failing human myocardium. Journal of cardiac failure. vol 8. issue 2. 2002-07-31. PMID:12016632. |
because myocardial failure is associated with myocyte hypertrophy and apoptosis, mapks may play a pathophysiologic role in human myocardial failure. |
2002-07-31 |
2023-08-12 |
human |
| Stephen E Alway, Hans Degens, Gururaj Krishnamurthy, Cheryl A Smit. Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats. American journal of physiology. Cell physiology. vol 283. issue 1. 2002-07-16. PMID:12055074. |
potential role for id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats. |
2002-07-16 |
2023-08-12 |
rat |
| Q Wang, Z W. [A study on the detection of apoptosis of hypertrophic scar and its related modulating factors]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 17. issue 1. 2002-07-12. PMID:11876906. |
[a study on the detection of apoptosis of hypertrophic scar and its related modulating factors]. |
2002-07-12 |
2023-08-12 |
Not clear |
| Q Wang, Z W. [A study on the detection of apoptosis of hypertrophic scar and its related modulating factors]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 17. issue 1. 2002-07-12. PMID:11876906. |
to investigate the relationships between the development of hypertrophic scar (hs) and apoptosis of fibroblast and endothelial cell, and to elucidate the influence of related modulating factors. |
2002-07-12 |
2023-08-12 |
Not clear |
| A Ecarnot-Laubriet, M Assem, F Poirson-Bichat, M Moisant, C Bernard, S Lecour, E Solary, L Rochette, J-R Teyssie. Stage-dependent activation of cell cycle and apoptosis mechanisms in the right ventricle by pressure overload. Biochimica et biophysica acta. vol 1586. issue 3. 2002-07-02. PMID:11997075. |
hypertrophy, apoptosis and cell cycle events, as well as expression of their regulator genes were documented during a period of 31 days. |
2002-07-02 |
2023-08-12 |
rat |
| J Lemay, P Hamet, D deBloi. Losartan-induced apoptosis as a novel mechanism for the prevention of vascular lesion formation after injury. Journal of the renin-angiotensin-aldosterone system : JRAAS. vol 1. issue 1. 2002-06-06. PMID:11967799. |
smooth muscle cell (smc) apoptosis is transiently increased at the onset of the regression of aortic hypertrophy in spontaneously hypertensive rats (shr) treated with the angiotensin ii at(1) antagonist losartan. |
2002-06-06 |
2023-08-12 |
rat |
| G Gibson, D L Lin, X Wang, L Zhan. The release and activation of transforming growth factor beta2 associated with apoptosis of chick hypertrophic chondrocytes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 16. issue 12. 2002-06-03. PMID:11760849. |
the release and activation of transforming growth factor beta2 associated with apoptosis of chick hypertrophic chondrocytes. |
2002-06-03 |
2023-08-12 |
chicken |
| G Gibson, D L Lin, X Wang, L Zhan. The release and activation of transforming growth factor beta2 associated with apoptosis of chick hypertrophic chondrocytes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 16. issue 12. 2002-06-03. PMID:11760849. |
the apoptosis of hypertrophic chondrocytes at the interface between growth cartilage and invading vessels is at the center of a series of critical events in endochondral formation. |
2002-06-03 |
2023-08-12 |
chicken |
| G Gibson, D L Lin, X Wang, L Zhan. The release and activation of transforming growth factor beta2 associated with apoptosis of chick hypertrophic chondrocytes. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 16. issue 12. 2002-06-03. PMID:11760849. |
we have shown that the hypertrophy and apoptosis of chick chondrocytes in culture is associated with the release and activation of transforming growth factor beta2 (tgf-beta2). |
2002-06-03 |
2023-08-12 |
chicken |
| N H Bishopric, P Andreka, T Slepak, K A Webste. Molecular mechanisms of apoptosis in the cardiac myocyte. Current opinion in pharmacology. vol 1. issue 2. 2002-05-17. PMID:11714088. |
progress in the past year includes a better understanding of the importance of mitochondria-initiated events in cardiac myocyte apoptosis, of factors inducing apoptosis during hypoxia, and of the dual pro-apoptotic and anti-apoptotic effects of hypertrophic stimuli such as beta-adrenoceptor agonists, nitric oxide and calcineurin. |
2002-05-17 |
2023-08-12 |
human |