| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Singh, L Xiao, A Remondino, D B Sawyer, W S Colucc. Adrenergic regulation of cardiac myocyte apoptosis. Journal of cellular physiology. vol 189. issue 3. 2002-01-03. PMID:11748583. |
overexpression of wildtype alpha1b-ar does not result in apoptosis, whereas overexpression of g(alpha)q results in myocyte hypertrophy and/or apoptosis depending on the level of expression. |
2002-01-03 |
2023-08-12 |
mouse |
| K Singh, L Xiao, A Remondino, D B Sawyer, W S Colucc. Adrenergic regulation of cardiac myocyte apoptosis. Journal of cellular physiology. vol 189. issue 3. 2002-01-03. PMID:11748583. |
differential activation of the members of the mitogen-activated protein kinase (mapk) superfamily and production of reactive oxygen species appear to play a key role in mediating the actions of adrenergic pathways on myocyte apoptosis and hypertrophy. |
2002-01-03 |
2023-08-12 |
mouse |
| X Wang, J Lu. [The role of beta-ray induced fibroblasts apoptosis on the inhibition of hypertrophic scar]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. vol 16. issue 2. 2001-12-14. PMID:11593620. |
[the role of beta-ray induced fibroblasts apoptosis on the inhibition of hypertrophic scar]. |
2001-12-14 |
2023-08-12 |
Not clear |
| X Wang, J Lu. [The role of beta-ray induced fibroblasts apoptosis on the inhibition of hypertrophic scar]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. vol 16. issue 2. 2001-12-14. PMID:11593620. |
to investigate the role of beta-ray induced apoptosis of the fibroblasts on the inhibition of hypertrophic scar. |
2001-12-14 |
2023-08-12 |
Not clear |
| T Yamauchi, J Kamon, H Waki, K Murakami, K Motojima, K Komeda, T Ide, N Kubota, Y Terauchi, K Tobe, H Miki, A Tsuchida, Y Akanuma, R Nagai, S Kimura, T Kadowak. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. The Journal of biological chemistry. vol 276. issue 44. 2001-12-07. PMID:11533050. |
moreover, although heterozygous ppargamma deficiency and tzd have opposite effects on total wat mass, heterozygous ppargamma deficiency decreases lipogenesis in wat, whereas tzd stimulate adipocyte differentiation and apoptosis, thereby both preventing adipocyte hypertrophy, which is associated with alleviation of insulin resistance presumably due to decreases in free fatty acids, and tumor necrosis factor alpha, and up-regulation of adiponectin, at least in part. |
2001-12-07 |
2023-08-12 |
Not clear |
| B Nedelec, H Shankowsky, P G Scott, A Ghahary, E E Tredge. Myofibroblasts and apoptosis in human hypertrophic scars: the effect of interferon-alpha2b. Surgery. vol 130. issue 5. 2001-12-07. PMID:11685189. |
myofibroblasts and apoptosis in human hypertrophic scars: the effect of interferon-alpha2b. |
2001-12-07 |
2023-08-12 |
human |
| M Flesch, K B Margulies, H C Mochmann, D Engel, N Sivasubramanian, D L Man. Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading. Circulation. vol 104. issue 19. 2001-12-04. PMID:11696464. |
we examined functional parameters that are linked to mapk activation, namely cardiac myocyte hypertrophy and apoptosis. |
2001-12-04 |
2023-08-12 |
human |
| M C Heidkamp, A L Bayer, J L Martin, A M Samare. Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytes. Circulation research. vol 89. issue 10. 2001-12-04. PMID:11701615. |
whereas neither adv induced nrvm hypertrophy, adv-capkcdelta, but not adv-capkcepsilon, induced nrvm apoptosis. |
2001-12-04 |
2023-08-12 |
rat |
| J Lemay, B S Tea, P Hamet, D deBloi. Regression of neointimal lesions in the carotid artery of nifedipine-treated SHR and WKY rats: possible role of apoptosis. Journal of vascular research. vol 38. issue 5. 2001-10-25. PMID:11561148. |
we previously observed that nifedipine reduces aortic hypertrophy in spontaneously hypertensive rats (shr) partly by inducing smooth muscle cell (smc) apoptosis. |
2001-10-25 |
2023-08-12 |
rat |
| J Díez, B López, A González, N Ardanaz, M A Fortuñ. [Genetics and molecular biology in cardiology (IV). Myocardial response to biomechanical stress]. Revista espanola de cardiologia. vol 54. issue 4. 2001-10-18. PMID:11282056. |
as a result some myocardial phenotypic changes develop that are initially compensatory (i.e., hypertrophy) but which may mediate the eventual decline in myocardial function that occurs with the transition from hypertrophy to failure in conditions of persistent stress (i.e., apoptosis and fibrosis). |
2001-10-18 |
2023-08-12 |
Not clear |
| T Aizawa, T Kon, T A Einhorn, L C Gerstenfel. Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 19. issue 5. 2001-10-04. PMID:11562122. |
although cell killing and ice induction were higher in the more hypertrophic cells, tnf-alpha induced apoptosis in both hypertrophic and non-hypertrophic chondrocyte populations. |
2001-10-04 |
2023-08-12 |
human |
| T Aizawa, T Kon, T A Einhorn, L C Gerstenfel. Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 19. issue 5. 2001-10-04. PMID:11562122. |
these results demonstrate that apoptosis may be induced in both hypertrophic and non-hypertrophic chondrocytes through both fas and tnf-alpha receptor mediated signaling, and suggest that chondrocytes are more sensitive to apoptotic effects of tnf-alpha within the skeletal lineage than are osteoblasts. |
2001-10-04 |
2023-08-12 |
human |
| V Nag. [Left ventricular hypertrophy: pathogenesis, diagnosis and therapy]. Orvosi hetilap. vol 142. issue 26. 2001-09-27. PMID:11478033. |
because the structural changes in the interstitial tissue followed by the alterations of heart myocytes hypertrophy, hyperplasy and apoptosis of myocytes, as well as the interstitial and perivascular fibrosis, coronary remodelling and necrosis in the consequence of insufficient blood circulation can be widely observed. |
2001-09-27 |
2023-08-12 |
Not clear |
| D R Pimentel, J K Amin, L Xiao, T Miller, J Viereck, J Oliver-Krasinski, R Baliga, J Wang, D A Siwik, K Singh, P Pagano, W S Colucci, D B Sawye. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circulation research. vol 89. issue 5. 2001-09-20. PMID:11532907. |
we investigated whether oxidative stress mediates hypertrophy and apoptosis in cyclically stretched ventricular myocytes. |
2001-09-20 |
2023-08-12 |
rat |
| D R Pimentel, J K Amin, L Xiao, T Miller, J Viereck, J Oliver-Krasinski, R Baliga, J Wang, D A Siwik, K Singh, P Pagano, W S Colucci, D B Sawye. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circulation research. vol 89. issue 5. 2001-09-20. PMID:11532907. |
in contrast to hypertrophy, only high-amplitude stretch increased myocyte apoptosis, as reflected by increased dna fragmentation on gel electrophoresis and an approximately 3-fold increase in the number of tunel-positive myocytes. |
2001-09-20 |
2023-08-12 |
rat |
| M Izumi, Y Fujio, K Kunisada, S Negoro, E Tone, M Funamoto, T Osugi, Y Oshima, Y Nakaoka, T Kishimoto, K Yamauchi-Takihara, H Hirot. Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway. The Journal of biological chemistry. vol 276. issue 33. 2001-09-06. PMID:11408477. |
interestingly, bmp-2 promoted survival and inhibited apoptosis of serum-deprived myocytes, although it did not strongly induce hypertrophic growth. |
2001-09-06 |
2023-08-12 |
rat |
| M Izumi, Y Fujio, K Kunisada, S Negoro, E Tone, M Funamoto, T Osugi, Y Oshima, Y Nakaoka, T Kishimoto, K Yamauchi-Takihara, H Hirot. Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway. The Journal of biological chemistry. vol 276. issue 33. 2001-09-06. PMID:11408477. |
overall, our findings suggest that bmp-2 prevents apoptosis of myocytes by induction of bcl-x(l) via a smad1 pathway and might be a novel survival factor without any hypertrophic effect on myocytes. |
2001-09-06 |
2023-08-12 |
rat |
| B Newman, L I Gigout, L Sudre, M E Grant, G A Walli. Coordinated expression of matrix Gla protein is required during endochondral ossification for chondrocyte survival. The Journal of cell biology. vol 154. issue 3. 2001-09-06. PMID:11489922. |
treatment of the atdc5 cultures with mgp antiserum during the proliferative phase leads to their apoptosis before maturation, whereas treatment during the hypertrophic phase has no effect on chondrocyte viability or mineralization. |
2001-09-06 |
2023-08-12 |
mouse |
| B Newman, L I Gigout, L Sudre, M E Grant, G A Walli. Coordinated expression of matrix Gla protein is required during endochondral ossification for chondrocyte survival. The Journal of cell biology. vol 154. issue 3. 2001-09-06. PMID:11489922. |
after stable transfection of atdc5 cells with inducible sense or antisense mgp cdna constructs, we found that overexpression of mgp in maturing chondrocytes and underexpression of mgp in proliferative and hypertrophic chondrocytes induced apoptosis. |
2001-09-06 |
2023-08-12 |
mouse |
| B Nadal-Ginar. [Generation of new cardiomyocytes in the adult heart: Prospects of myocardial regeneration as an alternative to cardiac transplantation]. Revista espanola de cardiologia. vol 54. issue 5. 2001-08-30. PMID:11412743. |
moreover, the elucidation of mechanisms responsible for the hypertrophic response indicate similarity and overlap with the mechanisms involved in cell death by apoptosis as well as cell growth. |
2001-08-30 |
2023-08-12 |
mouse |