| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Zhu, S McElwee-Witmer, M Perrone, K L Clark, A Zilberstei. Phenylephrine protects neonatal rat cardiomyocytes from hypoxia and serum deprivation-induced apoptosis. Cell death and differentiation. vol 7. issue 9. 2000-11-14. PMID:11042672. |
these results suggest that alpha-adrenergic activation protects cardiomyocytes against hypoxia and serum deprivation-induced apoptosis through regulating the expression of mitochondrion-associated apoptosis regulatory genes, preventing activation of mitochondrial damage-induced apoptosis pathway (cytochrome c-caspase-9), and activating hypertrophic growth. |
2000-11-14 |
2023-08-12 |
rat |
| J C Tiffee, J P Griffin, L F Coope. Immunolocalization of stress proteins and extracellular matrix proteins in the rat tibia. Tissue & cell. vol 32. issue 2. 2000-10-12. PMID:10855699. |
these results indicate that apoptosis is a mechanism by which hypertrophic chondrocytes are eliminated from cartilage prior to calcification, but that other mechanisms are also likely to be involved. |
2000-10-12 |
2023-08-12 |
rat |
| E C Dempsey, A C Newton, D Mochly-Rosen, A P Fields, M E Reyland, P A Insel, R O Messin. Protein kinase C isozymes and the regulation of diverse cell responses. American journal of physiology. Lung cellular and molecular physiology. vol 279. issue 3. 2000-09-21. PMID:10956616. |
individual protein kinase c (pkc) isozymes have been implicated in many cellular responses important in lung health and disease, including permeability, contraction, migration, hypertrophy, proliferation, apoptosis, and secretion. |
2000-09-21 |
2023-08-12 |
mouse |
| N Kyprianou, C M Bennin. Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis. Cancer research. vol 60. issue 16. 2000-09-14. PMID:10969806. |
recent evidence from our laboratory has demonstrated that alpha1-adrenoceptor antagonists doxazosin and terazosin induced apoptosis in prostate epithelial and smooth muscle cells in patients with benign prostatic hypertrophy (bph; j. |
2000-09-14 |
2023-08-12 |
mouse |
| B Ding, R L Price, E C Goldsmith, T K Borg, X Yan, P S Douglas, E O Weinberg, J Bartunek, T Thielen, V V Didenko, B H Lorel. Left ventricular hypertrophy in ascending aortic stenosis mice: anoikis and the progression to early failure. Circulation. vol 101. issue 24. 2000-07-13. PMID:10859293. |
to determine potential mechanisms of the transition from hypertrophy to very early failure, we examined apoptosis in a model of ascending aortic stenosis (as) in male fvb/n mice. |
2000-07-13 |
2023-08-12 |
mouse |
| P Delafontaine, M Brin. The growth hormone and insulin-like growth factor 1 axis in heart failure. Annales d'endocrinologie. vol 61. issue 1. 2000-06-27. PMID:10790588. |
beneficial effects of growth hormone and igf-1 include vasodilatation, stimulation of cardiac hypertrophy, increase in calcium sensitivity of cardiac myofilaments and prevention of apoptosis. |
2000-06-27 |
2023-08-12 |
rat |
| B S Tea, S Der Sarkissian, R M Touyz, P Hamet, D deBloi. Proapoptotic and growth-inhibitory role of angiotensin II type 2 receptor in vascular smooth muscle cells of spontaneously hypertensive rats in vivo. Hypertension (Dallas, Tex. : 1979). vol 35. issue 5. 2000-06-21. PMID:10818066. |
we reported that transient induction of smooth muscle cell (smc) apoptosis precedes dna synthesis inhibition and aortic hypertrophy regression in spontaneously hypertensive rats treated with the at(1) antagonist losartan or the converting-enzyme inhibitor enalapril. |
2000-06-21 |
2023-08-12 |
rat |
| C Stefanelli, I Stanic', M Zini, F Bonavita, F Flamigni, L Zambonin, L Landi, C Pignatti, C Guarnieri, C M Caldarer. Polyamines directly induce release of cytochrome c from heart mitochondria. The Biochemical journal. vol 347 Pt 3. 2000-06-15. PMID:10769194. |
these data indicate a novel mechanism of cytochrome c release from the mitochondrion, and suggest that prolonged and sustained elevation of polyamines, characteristic of some pathologies such as heart hypertrophy, could be involved in the development of apoptosis. |
2000-06-15 |
2023-08-12 |
rat |
| Y J Kang, Z X Zhou, H Wu, G W Wang, J T Saari, J B Klei. Metallothionein inhibits myocardial apoptosis in copper-deficient mice: role of atrial natriuretic peptide. Laboratory investigation; a journal of technical methods and pathology. vol 80. issue 5. 2000-06-08. PMID:10830785. |
corresponding to the progression of heart hypertrophy, myocardial apoptosis and atrial natriuretic peptide (anp) production in the left ventricle were detected in non-transgenic copper-deficient mice; these effects were significantly suppressed in transgenic copper-deficient mice. |
2000-06-08 |
2023-08-12 |
mouse |
| Y J Kang, Z X Zhou, H Wu, G W Wang, J T Saari, J B Klei. Metallothionein inhibits myocardial apoptosis in copper-deficient mice: role of atrial natriuretic peptide. Laboratory investigation; a journal of technical methods and pathology. vol 80. issue 5. 2000-06-08. PMID:10830785. |
the results suggest that mt inhibits the transition from heart hypertrophy to failure by suppressing apoptosis through inhibition of both cardiac anp production and its apoptotic effect. |
2000-06-08 |
2023-08-12 |
mouse |
| D Zhang, V Gaussin, G E Taffet, N S Belaguli, M Yamada, R J Schwartz, L H Michael, P A Overbeek, M D Schneide. TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Nature medicine. vol 6. issue 5. 2000-05-25. PMID:10802712. |
an activating mutation of tak1 expressed in myocardium of transgenic mice was sufficient to produce p38 mitogen-activated protein kinase phosphorylation in vivo, cardiac hypertrophy, interstitial fibrosis, severe myocardial dysfunction, 'fetal' gene induction, apoptosis and early lethality. |
2000-05-25 |
2023-08-12 |
mouse |
| S J Shankland, G Wol. Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis. American journal of physiology. Renal physiology. vol 278. issue 4. 2000-05-02. PMID:10751212. |
cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis. |
2000-05-02 |
2023-08-12 |
Not clear |
| S J Shankland, G Wol. Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis. American journal of physiology. Renal physiology. vol 278. issue 4. 2000-05-02. PMID:10751212. |
the response to glomerular and tubulointerstitial cell injury in most forms of renal disease includes changes in cell number (proliferation and apoptosis) and cell size (hypertrophy). |
2000-05-02 |
2023-08-12 |
Not clear |
| S J Shankland, G Wol. Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis. American journal of physiology. Renal physiology. vol 278. issue 4. 2000-05-02. PMID:10751212. |
equally exciting is the expanding body of literature showing novel biological roles for cell cycle proteins in the regulation of cell hypertrophy and apoptosis. |
2000-05-02 |
2023-08-12 |
Not clear |
| D E Vatner, K Asai, M Iwase, Y Ishikawa, R P Shannon, C J Homcy, S F Vatne. Beta-adrenergic receptor-G protein-adenylyl cyclase signal transduction in the failing heart. The American journal of cardiology. vol 83. issue 12A. 2000-04-19. PMID:10750593. |
the result is a dilated heart with a large amount of fibrosis and myocyte hypertrophy, degeneration atrophy, and apoptosis. |
2000-04-19 |
2023-08-12 |
mouse |
| Y Akasaka, Y Ishikawa, I Ono, K Fujita, T Masuda, N Asuwa, K Inuzuka, H Kiguchi, T Ishi. Enhanced expression of caspase-3 in hypertrophic scars and keloid: induction of caspase-3 and apoptosis in keloid fibroblasts in vitro. Laboratory investigation; a journal of technical methods and pathology. vol 80. issue 3. 2000-04-12. PMID:10744070. |
enhanced expression of caspase-3 in hypertrophic scars and keloid: induction of caspase-3 and apoptosis in keloid fibroblasts in vitro. |
2000-04-12 |
2023-08-12 |
Not clear |
| Y Akasaka, Y Ishikawa, I Ono, K Fujita, T Masuda, N Asuwa, K Inuzuka, H Kiguchi, T Ishi. Enhanced expression of caspase-3 in hypertrophic scars and keloid: induction of caspase-3 and apoptosis in keloid fibroblasts in vitro. Laboratory investigation; a journal of technical methods and pathology. vol 80. issue 3. 2000-04-12. PMID:10744070. |
considering the role of caspase-3 as a key effector molecule in the execution of apoptotic stimuli, our results suggested that enhanced expression of caspase-3 in hypertrophic scars and keloid induces apoptosis of fibroblasts, which may play a role in the process of pathological scarring. |
2000-04-12 |
2023-08-12 |
Not clear |
| H Y Stevens, J Reeve, B S Nobl. Bcl-2, tissue transglutaminase and p53 protein expression in the apoptotic cascade in ribs of premature infants. Journal of anatomy. vol 196 ( Pt 2). 2000-04-11. PMID:10739014. |
tissue transglutaminase (ttg) expression was associated with apoptosis of osteocytes and hypertrophic chondrocytes. |
2000-04-11 |
2023-08-12 |
human |
| P Anvers. Plasticity of the pathologic heart. Italian heart journal : official journal of the Italian Federation of Cardiology. vol 1. issue 2. 2000-04-05. PMID:10730607. |
myocyte necrosis and apoptosis, and myocyte hypertrophy and proliferation are major elements of the plasticity of the heart. |
2000-04-05 |
2023-08-12 |
Not clear |
| L J De Windt, H W Lim, T Taigen, D Wencker, G Condorelli, G W Dorn, R N Kitsis, J D Molkenti. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure. Circulation research. vol 86. issue 3. 2000-03-16. PMID:10679475. |
calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: an apoptosis-independent model of dilated heart failure. |
2000-03-16 |
2023-08-12 |
mouse |