| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Lu, Bo Sun, Rong Huo, Yu-Chun Wang, Di Yang, Yue Xing, Xiao-Lin Xiao, Xin Xie, De-Li Don. Bone morphogenetic protein-2 antagonizes bone morphogenetic protein-4 induced cardiomyocyte hypertrophy and apoptosis. Journal of cellular physiology. vol 229. issue 10. 2014-09-05. PMID:24648278. |
in conclusion, bmp2 antagonizes bmp4-induced cardiomyocyte hypertrophy and apoptosis. |
2014-09-05 |
2023-08-12 |
mouse |
| Amarylis Claudine Bonito Azeredo Wanschel, Viviane Menezes Caceres, Ana Iochabel Soares Moretti, Alexandre Bruni-Cardoso, Hernandes Faustino de Carvalho, Heraldo Possolo de Souza, Francisco Rafael Martins Laurindo, Regina Célia Spadari, Marta Helena Kriege. Cardioprotective mechanism of S-nitroso-N-acetylcysteine via S-nitrosated betadrenoceptor-2 in the LDLr-/- mice. Nitric oxide : biology and chemistry. vol 36. 2014-09-04. PMID:24333561. |
the findings show that o₂⁻ and h₂o₂ production and also cell apoptosis were increased during left ventricular hypertrophy (lvh). |
2014-09-04 |
2023-08-12 |
mouse |
| Lv Yaundong, Wang Dongyan, Hao Lijun, Xiao Zhib. Effects of downregulation of S100A8 protein expression on cell cycle and apoptosis of fibroblasts derived from hypertrophic scars. Aesthetic surgery journal. vol 34. issue 1. 2014-09-02. PMID:24334497. |
effects of downregulation of s100a8 protein expression on cell cycle and apoptosis of fibroblasts derived from hypertrophic scars. |
2014-09-02 |
2023-08-12 |
Not clear |
| Lv Yaundong, Wang Dongyan, Hao Lijun, Xiao Zhib. Effects of downregulation of S100A8 protein expression on cell cycle and apoptosis of fibroblasts derived from hypertrophic scars. Aesthetic surgery journal. vol 34. issue 1. 2014-09-02. PMID:24334497. |
uncontrolled growth and lack of apoptosis in fibroblasts derived from a hypertrophic scar play an important role in pathology. |
2014-09-02 |
2023-08-12 |
Not clear |
| Domenico M Taglieri, Keven R Johnson, Brian T Burmeister, Michelle M Monasky, Matthew J Spindler, Jaime DeSantiago, Kathrin Banach, Bruce R Conklin, Graeme K Carnegi. The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy. Journal of molecular and cellular cardiology. vol 66. 2014-08-18. PMID:24161911. |
akap-lbc-Δpkd mice display attenuated compensatory cardiac hypertrophy, increased collagen deposition and apoptosis, compared to wild-type (wt) control littermates. |
2014-08-18 |
2023-08-12 |
mouse |
| Guofang Zeng, Fang Zhong, Jin Li, Shaojun Luo, Peihua Zhan. Resveratrol-mediated reduction of collagen by inhibiting proliferation and producing apoptosis in human hypertrophic scar fibroblasts. Bioscience, biotechnology, and biochemistry. vol 77. issue 12. 2014-08-18. PMID:24317052. |
resveratrol-mediated reduction of collagen by inhibiting proliferation and producing apoptosis in human hypertrophic scar fibroblasts. |
2014-08-18 |
2023-08-12 |
human |
| Matthew S Alexander, Juan Carlos Casar, Norio Motohashi, Natássia M Vieira, Iris Eisenberg, Jamie L Marshall, Molly J Gasperini, Angela Lek, Jennifer A Myers, Elicia A Estrella, Peter B Kang, Frederic Shapiro, Fedik Rahimov, Genri Kawahara, Jeffrey J Widrick, Louis M Kunke. MicroRNA-486-dependent modulation of DOCK3/PTEN/AKT signaling pathways improves muscular dystrophy-associated symptoms. The Journal of clinical investigation. vol 124. issue 6. 2014-08-18. PMID:24789910. |
dock3 overexpression in human myotubes modulated pten/akt signaling, which regulates muscle hypertrophy and growth, and induced apoptosis. |
2014-08-18 |
2023-08-13 |
mouse |
| Satoshi Okumura, Takayuki Fujita, Wenqian Cai, Meihua Jin, Iyuki Namekata, Yasumasa Mototani, Huiling Jin, Yoshiki Ohnuki, Yayoi Tsuneoka, Reiko Kurotani, Kenji Suita, Yuko Kawakami, Shogo Hamaguchi, Takaya Abe, Hiroshi Kiyonari, Takashi Tsunematsu, Yunzhe Bai, Sayaka Suzuki, Yuko Hidaka, Masanari Umemura, Yasuhiro Ichikawa, Utako Yokoyama, Motohiko Sato, Fumio Ishikawa, Hiroko Izumi-Nakaseko, Satomi Adachi-Akahane, Hikaru Tanaka, Yoshihiro Ishikaw. Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. The Journal of clinical investigation. vol 124. issue 6. 2014-08-18. PMID:24892712. |
compared with wt mice, aortic banding induced a similar degree of cardiac hypertrophy in epac1 ko; however, lack of epac1 prevented subsequent cardiac dysfunction as a result of decreased cardiac myocyte apoptosis and fibrosis. |
2014-08-18 |
2023-08-13 |
mouse |
| Clifford R Elcombe, Richard C Peffer, Douglas C Wolf, Jason Bailey, Remi Bars, David Bell, Russell C Cattley, Stephen S Ferguson, David Geter, Amber Goetz, Jay I Goodman, Susan Hester, Abigail Jacobs, Curtis J Omiecinski, Rita Schoeny, Wen Xie, Brian G Lak. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Critical reviews in toxicology. vol 44. issue 1. 2014-08-14. PMID:24180433. |
associative events in the moa include altered epigenetic changes, induction of hepatic cyp2b enzymes, liver hypertrophy and decreased apoptosis; with inhibition of gap junctional intercellular communication being an associative event or modulating factor. |
2014-08-14 |
2023-08-12 |
human |
| Fuzhong Qin, Deborah A Siwik, David R Pimentel, Robert J Morgan, Andreia Biolo, Vivian H Tu, Y James Kang, Richard A Cohen, Wilson S Colucc. Cytosolic H2O2 mediates hypertrophy, apoptosis, and decreased SERCA activity in mice with chronic hemodynamic overload. American journal of physiology. Heart and circulatory physiology. vol 306. issue 10. 2014-08-13. PMID:24633550. |
cytosolic h2o2 mediates hypertrophy, apoptosis, and decreased serca activity in mice with chronic hemodynamic overload. |
2014-08-13 |
2023-08-12 |
mouse |
| Fuzhong Qin, Deborah A Siwik, David R Pimentel, Robert J Morgan, Andreia Biolo, Vivian H Tu, Y James Kang, Richard A Cohen, Wilson S Colucc. Cytosolic H2O2 mediates hypertrophy, apoptosis, and decreased SERCA activity in mice with chronic hemodynamic overload. American journal of physiology. Heart and circulatory physiology. vol 306. issue 10. 2014-08-13. PMID:24633550. |
pcat overexpression ameliorated myocardial hypertrophy and apoptosis, decreased pathological remodeling, and prevented the progression to heart failure. |
2014-08-13 |
2023-08-12 |
mouse |
| Fuzhong Qin, Deborah A Siwik, David R Pimentel, Robert J Morgan, Andreia Biolo, Vivian H Tu, Y James Kang, Richard A Cohen, Wilson S Colucc. Cytosolic H2O2 mediates hypertrophy, apoptosis, and decreased SERCA activity in mice with chronic hemodynamic overload. American journal of physiology. Heart and circulatory physiology. vol 306. issue 10. 2014-08-13. PMID:24633550. |
in pressure overload-induced heart failure cardiac myocyte cytosolic ros play a pivotal role in mediating key pathophysiologic events including hypertrophy, apoptosis, and decreased serca activity. |
2014-08-13 |
2023-08-12 |
mouse |
| Hsiao-Chuan Chang, Yung-Wei Chiu, Yueh-Min Lin, Ray-Jade Chen, James A Lin, Fuu-Jen Tsai, Chang-Hai Tsai, Yu-Chun Kuo, Jer-Yuh Liu, Chih-Yang Huan. Herbal supplement attenuation of cardiac fibrosis in rats with CCl₄-induced liver cirrhosis. The Chinese journal of physiology. vol 57. issue 1. 2014-07-31. PMID:24621337. |
previously we found carbon tetrachloride (ccl₄) induced cirrhosis associated cardiac hypertrophy and apoptosis. |
2014-07-31 |
2023-08-12 |
rat |
| Vijayalakshmi Venkatesan, Soundarya L Madhira, Venkata M Malakapalli, Maniprabha Chalasani, Sarfaraz N Shaik, Vasudevan Seshadri, Venkaiah Kodavalla, Ramesh R Bhonde, Giridharan Nappanveetti. Obesity, insulin resistance, and metabolic syndrome: a study in WNIN/Ob rats from a pancreatic perspective. BioMed research international. vol 2013. 2014-07-29. PMID:24455710. |
these include hypertrophy, macrophage infiltration (cd11b/tnfα/il6), apoptosis, β-cell vacuolation, hyperinsulinemia (hi), and stress markers (rl-77/hsp104/tbars) all of which correlated well with indices for obesity (2-3 fold), ir (1.5-3 fold), and hi (2-3 fold). |
2014-07-29 |
2023-08-12 |
rat |
| Li Li, Chuanyu Wei, Il-Kwon Kim, Yvonne Janssen-Heininger, Sudhiranjan Gupt. Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice. Hypertension (Dallas, Tex. : 1979). vol 63. issue 6. 2014-07-25. PMID:24614212. |
we conclude that nf-κb regulates bone morphogenetic protein receptor 2-inhibitor of differentiation-notch-3 axis genes and the subsequent endothelial cell apoptosis and endothelial-to-mesenchymal transition events in the lungs, providing new mechanistic information about mct-induced pah and right ventricular hypertrophy. |
2014-07-25 |
2023-08-12 |
mouse |
| Anna Caretti, Paola Bianciardi, Marina Marini, Provvidenza M Abruzzo, Alessandra Bolotta, Carlo Terruzzi, Franco Lucchina, Michele Samaj. Supplementation of creatine and ribose prevents apoptosis and right ventricle hypertrophy in hypoxic hearts. Current pharmaceutical design. vol 19. issue 39. 2014-07-22. PMID:23590158. |
supplementation of creatine and ribose prevents apoptosis and right ventricle hypertrophy in hypoxic hearts. |
2014-07-22 |
2023-08-12 |
Not clear |
| Belén Picatoste, Elisa Ramírez, Alicia Caro-Vadillo, Cristian Iborra, Sara Ares-Carrasco, Jesús Egido, José Tuñón, Oscar Lorenz. Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms. PloS one. vol 8. issue 10. 2014-06-25. PMID:24302978. |
sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-ii diabetes. |
2014-06-25 |
2023-08-12 |
Not clear |
| Lin Yan, Shumin Gao, David Ho, Misun Park, Hui Ge, Chunbo Wang, Yimin Tian, Lo Lai, Mariana S De Lorenzo, Dorothy E Vatner, Stephen F Vatne. Calorie restriction can reverse, as well as prevent, aging cardiomyopathy. Age (Dordrecht, Netherlands). vol 35. issue 6. 2014-06-19. PMID:23334601. |
aging cardiomyopathy in 2-year-old mice was characterized by reduced left ventricular (lv) function, cardiac hypertrophy, and increased cardiac apoptosis and fibrosis. |
2014-06-19 |
2023-08-12 |
mouse |
| Prakash K Gupta, Donald J DiPette, Scott C Supowi. Protective effect of resveratrol against pressure overload-induced heart failure. Food science & nutrition. vol 2. issue 3. 2014-06-17. PMID:24936291. |
likewise, the tac protocol increased markers of oxidative stress, cardiac hypertrophy, inflammation, fibrosis, hypoxia, and apoptosis. |
2014-06-17 |
2023-08-13 |
mouse |
| Huan Wang, Xin Xu, John Fassett, Dongmin Kwak, Xiaoyu Liu, Xinli Hu, Therasa J Falls, John C Bell, Hongliang Li, Peter Bitterman, Robert J Bache, Yingjie Che. Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure. Circulation. vol 129. issue 13. 2014-06-10. PMID:24463368. |
congestive heart failure is associated with cardiomyocyte hypertrophy, inflammation, and apoptosis, but the role of pkr in left ventricular hypertrophy and the development of congestive heart failure has not been examined. |
2014-06-10 |
2023-08-12 |
Not clear |