| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahesha H Gangadhariah, James M Luther, Victor Garcia, Paisit Paueksakon, Ming-Zhi Zhang, Simon W Hayward, Harold D Love, John R Falck, Vijaya L Manthati, John D Imig, Michal L Schwartzman, Roy Zent, Jorge H Capdevila, Ambra Pozz. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. Journal of the American Society of Nephrology : JASN. vol 26. issue 3. 2015-04-28. PMID:25071086. |
in the kidney, 20-hydroxyeicosatetraenoic acid (20-hete) is a primary cytochrome p450 4 (cyp4)-derived eicosanoid that enhances vasoconstriction of renal vessels and induces hypertension, renal tubular cell hypertrophy, and podocyte apoptosis. |
2015-04-28 |
2023-08-13 |
mouse |
| C-Y Huang, W-W Kuo, Y-L Yeh, T-J Ho, J-Y Lin, D-Y Lin, C-H Chu, F-J Tsai, C-H Tsai, C-Y Huan. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. Cell death and differentiation. vol 21. issue 8. 2015-04-19. PMID:24786827. |
hypertension-induced cardiac hypertrophy and apoptosis are major characteristics of early-stage heart failure. |
2015-04-19 |
2023-08-13 |
Not clear |
| C-Y Huang, W-W Kuo, Y-L Yeh, T-J Ho, J-Y Lin, D-Y Lin, C-H Chu, F-J Tsai, C-H Tsai, C-Y Huan. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. Cell death and differentiation. vol 21. issue 8. 2015-04-19. PMID:24786827. |
ang ii activates jnk to degrade sirt1, resulting in hsf1 acetylation, which induces igf-iir expression and eventually results in cardiac hypertrophy and apoptosis. |
2015-04-19 |
2023-08-13 |
Not clear |
| Laurel A Grisanti, Ashley A Repas, Jennifer A Talarico, Jessica I Gold, Rhonda L Carter, Walter J Koch, Douglas G Tille. Temporal and gefitinib-sensitive regulation of cardiac cytokine expression via chronic β-adrenergic receptor stimulation. American journal of physiology. Heart and circulatory physiology. vol 308. issue 4. 2015-04-13. PMID:25485901. |
cardiac contractility decreased following 2 wk of iso treatment, while cardiac hypertrophy, fibrosis, and apoptosis were enhanced at both timepoints. |
2015-04-13 |
2023-08-13 |
mouse |
| Laurel A Grisanti, Ashley A Repas, Jennifer A Talarico, Jessica I Gold, Rhonda L Carter, Walter J Koch, Douglas G Tille. Temporal and gefitinib-sensitive regulation of cardiac cytokine expression via chronic β-adrenergic receptor stimulation. American journal of physiology. Heart and circulatory physiology. vol 308. issue 4. 2015-04-13. PMID:25485901. |
inclusion of gef preserved contractility, blocked iso-induced apoptosis, and prevented hypertrophy at the 2-wk timepoint, but caused fibrosis on its own. |
2015-04-13 |
2023-08-13 |
mouse |
| David I Brown, Kathy K Griendlin. Regulation of signal transduction by reactive oxygen species in the cardiovascular system. Circulation research. vol 116. issue 3. 2015-04-13. PMID:25634975. |
in particular, we consider how ros modulate signaling pathways related to phenotypic modulation, migration and adhesion, contractility, proliferation and hypertrophy, angiogenesis, endoplasmic reticulum stress, apoptosis, and senescence. |
2015-04-13 |
2023-08-13 |
Not clear |
| Shizuka Uchida, Stefanie Dimmele. Long noncoding RNAs in cardiovascular diseases. Circulation research. vol 116. issue 4. 2015-04-09. PMID:25677520. |
several lncrnas are regulated during acute myocardial infarction (eg, novlnc6) and heart failure (eg, mhrt), whereas others control hypertrophy, mitochondrial function and apoptosis of cardiomyocytes. |
2015-04-09 |
2023-08-13 |
mouse |
| Jian-Yu Chen, Lei Zhang, Hong Zhang, Li Su, Lu-Ping Qi. Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts. Phytotherapy research : PTR. vol 28. issue 10. 2015-03-31. PMID:24706573. |
triggering of p38 mapk and jnk signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts. |
2015-03-31 |
2023-08-13 |
Not clear |
| Jian-Yu Chen, Lei Zhang, Hong Zhang, Li Su, Lu-Ping Qi. Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts. Phytotherapy research : PTR. vol 28. issue 10. 2015-03-31. PMID:24706573. |
in the present study, the mechanism of oleanolic acid (oa)-induced apoptosis in hypertrophic scar fibroblasts (hsfs) was investigated for the first time. |
2015-03-31 |
2023-08-13 |
Not clear |
| Xavier Lieben Louis, Sijo Joseph Thandapilly, Wilhelmina Kalt, Melinda Vinqvist-Tymchuk, Basma Milad Aloud, Pema Raj, Liping Yu, Hoa Le, Thomas Netticada. Blueberry polyphenols prevent cardiomyocyte death by preventing calpain activation and oxidative stress. Food & function. vol 5. issue 8. 2015-03-30. PMID:24910858. |
cardiomyocyte hypertrophy, cell death, oxidative stress, apoptosis and cardiomyocyte contractile function as well as the activities of calpain, superoxide dismutase (sod) and catalase (cat) were measured in cardiomyocytes treated with and without ne and blueberry fraction (bf). |
2015-03-30 |
2023-08-13 |
rat |
| Paolo De Vit. Atrial natriuretic peptide: an old hormone or a new cytokine? Peptides. vol 58. 2015-03-30. PMID:24973596. |
the hormone shows protective effects during: (i) ventricular hypertrophy and myocardial injury; (ii) atherosclerosis and hypertension by the induction of antiproliferative effects; (iii) oxidative stress counteracting the dangerous effects of ros; (iv) growth of tumors cells by the induction of apoptosis or necrosis. |
2015-03-30 |
2023-08-13 |
Not clear |
| Celestino Sardu, Raffaele Marfella, Gaetano Santulli, Giuseppe Paoliss. Functional role of miRNA in cardiac resynchronization therapy. Pharmacogenomics. vol 15. issue 8. 2015-03-30. PMID:25084208. |
heart failure (hf) disease progression is related to numerous adaptive processes including cardiac fibrosis, hypertrophy and apoptosis by activation of the 'fetal' gene program and downregulation of mrna signatures, suggesting the importance of molecular mechanisms that suppress mrna steady-state levels. |
2015-03-30 |
2023-08-13 |
Not clear |
| Xiaohui Zhang, Zhaohui Feng, Chunhua Li, Yuping Zhen. Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress. Neural regeneration research. vol 7. issue 1. 2015-03-25. PMID:25806055. |
following 24 hours of culture, compensatory hypertrophy was observed and cellular apoptosis increased. |
2015-03-25 |
2023-08-13 |
Not clear |
| Yoon Sin O. Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids. Anatomy & cell biology. vol 48. issue 1. 2015-03-25. PMID:25806118. |
beta-cell mass is increased by neogenesis, proliferation and cell hypertrophy, and is decreased by beta-cell death primarily through apoptosis. |
2015-03-25 |
2023-08-13 |
Not clear |
| Jun Ren, Piero Anvers. The insulin-like growth factor I system: physiological and pathophysiological implication in cardiovascular diseases associated with metabolic syndrome. Biochemical pharmacology. vol 93. issue 4. 2015-03-20. PMID:25541285. |
igf-1 signaling may regulate contractility, metabolism, hypertrophy, apoptosis, autophagy, stem cell regeneration and senescence in the heart to maintain cardiac homeostasis. |
2015-03-20 |
2023-08-13 |
Not clear |
| Gerhild Eule. Good and bad sides of TGFβ-signaling in myocardial infarction. Frontiers in physiology. vol 6. 2015-03-19. PMID:25788886. |
in this review, an overview on the functional role of tgfβ signaling in the process of cardiac remodeling is given, as it can influence apoptosis, fibrosis and hypertrophy thereby predominantly aggravating ischemia/reperfusion injury. |
2015-03-19 |
2023-08-13 |
Not clear |
| Eva Márquez, Marta Riera, Julio Pascual, María José Sole. Renin-angiotensin system within the diabetic podocyte. American journal of physiology. Renal physiology. vol 308. issue 1. 2015-03-11. PMID:25339703. |
furthermore, angiotensin ii promotes podocyte injury indirectly by inducing cellular hypertrophy, increased apoptosis, and changes in the anionic charge of the glomerular basement membrane, among other effects. |
2015-03-11 |
2023-08-13 |
Not clear |
| Min Zhang, Marco Hagenmueller, Johannes H Riffel, Michael M Kreusser, Elmar Bernhold, Jingjing Fan, Hugo A Katus, Johannes Backs, Stefan E Hard. Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy. Hypertension (Dallas, Tex. : 1979). vol 65. issue 2. 2015-03-05. PMID:25489064. |
these mice displayed a normal cardiac phenotype without cardiac hypertrophy, fibrosis, apoptosis, or left ventricular dysfunction. |
2015-03-05 |
2023-08-13 |
mouse |
| Ming-Hui Li, Yao-Jun Zhang, Yi-Hui Yu, Shao-Hua Yang, Javaid Iqbal, Qiong-Yu Mi, Bing Li, Zhi-Mei Wang, Wen-Xing Mao, Hong-Guang Xie, Shao-Liang Che. Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy. European journal of pharmacology. vol 728. 2015-03-02. PMID:24508518. |
in the current study, we observed that transverse aortic contraction (tac) surgery induced a marked increase in heart size, the ratio of heart weight to body weight, cardiomyocyte apoptosis, myocardial fibrosis, and hypertrophic marker brain natriuretic peptide, all of which were effectively suppressed by berberine administration. |
2015-03-02 |
2023-08-12 |
rat |
| Ming-Hui Li, Yao-Jun Zhang, Yi-Hui Yu, Shao-Hua Yang, Javaid Iqbal, Qiong-Yu Mi, Bing Li, Zhi-Mei Wang, Wen-Xing Mao, Hong-Guang Xie, Shao-Liang Che. Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy. European journal of pharmacology. vol 728. 2015-03-02. PMID:24508518. |
in addition, berberine enhanced autophagy in hypertrophic hearts, which was accompanied by a decrease in heart size, cardiac apoptosis, and the attenuation of cardiac dysfunction. |
2015-03-02 |
2023-08-12 |
rat |