| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Yan, Stephen F Vatner, Dorothy E Vatne. Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockade. American journal of physiology. Heart and circulatory physiology. vol 307. issue 10. 2015-01-15. PMID:25193472. |
transgenic (tg) mice, where β-ar signaling is chronically enhanced by overexpression of cardiac β₂-ars, is a surrogate for this mechanism, since these mice develop cardiomyopathy as reflected by reduced left ventricular (lv) function, increased fibrosis, apoptosis, and myocyte hypertrophy. |
2015-01-15 |
2023-08-13 |
mouse |
| Shiyu Liu, Lan Jiang, Haijian Li, Haigang Shi, Hailang Luo, Yongjie Zhang, Chunyan Yu, Yan Ji. Mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis. The Journal of investigative dermatology. vol 134. issue 10. 2015-01-13. PMID:24714203. |
mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis. |
2015-01-13 |
2023-08-13 |
human |
| Wenjuan Wang, Siying Li, Hui Wang, Bin Li, Lei Shao, Yimu Lai, Gary Horvath, Qian Wang, Masayuki Yamamoto, Joseph S Janicki, Xing Li Wang, Dongqi Tang, Taixing Cu. Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins. Journal of molecular and cellular cardiology. vol 72. 2015-01-13. PMID:24747945. |
we found that the cardiomyocyte-specific activation of nrf2 suppressed myocardial oxidative stress as well as cardiac apoptosis, fibrosis, hypertrophy, and dysfunction in a setting of sustained pressure overload induced by transverse aortic arch constriction (tac) in mice. |
2015-01-13 |
2023-08-13 |
mouse |
| Eva S Liu, Alena Zalutskaya, Byongsoo Timothy Chae, Eric D Zhu, Francesca Gori, Marie B Dema. Phosphate interacts with PTHrP to regulate endochondral bone formation. Endocrinology. vol 155. issue 10. 2015-01-05. PMID:25057796. |
hypophosphatemia impairs hypertrophic chondrocyte apoptosis leading to rachitic expansion of the growth plate; however, the effect of phosphate restriction on chondrocyte differentiation during endochondral bone formation has not been examined. |
2015-01-05 |
2023-08-13 |
mouse |
| Eva S Liu, Alena Zalutskaya, Byongsoo Timothy Chae, Eric D Zhu, Francesca Gori, Marie B Dema. Phosphate interacts with PTHrP to regulate endochondral bone formation. Endocrinology. vol 155. issue 10. 2015-01-05. PMID:25057796. |
in vivo studies in postnatal mice demonstrated that pthrp haploinsufficiency also prevents the impaired hypertrophic chondrocyte apoptosis observed with phosphate restriction. |
2015-01-05 |
2023-08-13 |
mouse |
| Eva S Liu, Alena Zalutskaya, Byongsoo Timothy Chae, Eric D Zhu, Francesca Gori, Marie B Dema. Phosphate interacts with PTHrP to regulate endochondral bone formation. Endocrinology. vol 155. issue 10. 2015-01-05. PMID:25057796. |
thus, these data demonstrate that phosphate restriction attenuates chondrocyte differentiation as well as impairing hypertrophic chondrocyte apoptosis and implicate a functional role for the pth/pthrp signaling pathway in the abnormalities in chondrocyte differentiation and hypertrophic chondrocyte apoptosis observed under phosphate restricted conditions. |
2015-01-05 |
2023-08-13 |
mouse |
| Anna Bielicka, Beata Zielnik-Jurkiewicz, Edyta Podsiadły, Joanna Rogulska, Urszula Demko. Chlamydia pneumoniae and typical bacteria occurrence in adenoid in children qualified for adenoidectomy. International journal of pediatric otorhinolaryngology. vol 78. issue 5. 2014-12-22. PMID:24636749. |
the ability to occur in a persistent form and to inhibit apoptosis in host cells are the features of chlamydia pneumoniae which may be associated with adenoid hypertrophy. |
2014-12-22 |
2023-08-12 |
Not clear |
| Chelsea S Bahney, Diane P Hu, Aaron J Taylor, Federico Ferro, Hayley M Britz, Benedikt Hallgrimsson, Brian Johnstone, Theodore Miclau, Ralph S Marcuci. Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 29. issue 5. 2014-12-09. PMID:24259230. |
further, in contrast to the dogmatic view that hypertrophic chondrocytes undergo apoptosis before bone formation, our data suggest cartilage can transform into bone by activating the pluripotent transcription factor oct4a. |
2014-12-09 |
2023-08-12 |
human |
| James T Tsoporis, Shehla Izhar, Jean-Francois Desjardins, Howard Leong-Poi, Thomas G Parke. Conditional cardiac overexpression of S100A6 attenuates myocyte hypertrophy and apoptosis following myocardial infarction. Current pharmaceutical design. vol 20. issue 12. 2014-12-08. PMID:23844739. |
conditional cardiac overexpression of s100a6 attenuates myocyte hypertrophy and apoptosis following myocardial infarction. |
2014-12-08 |
2023-08-12 |
mouse |
| James T Tsoporis, Shehla Izhar, Jean-Francois Desjardins, Howard Leong-Poi, Thomas G Parke. Conditional cardiac overexpression of S100A6 attenuates myocyte hypertrophy and apoptosis following myocardial infarction. Current pharmaceutical design. vol 20. issue 12. 2014-12-08. PMID:23844739. |
hemodynamic studies, echocardiography and postmortem examination indicated that s100a6-αmhc-tta mice on dox 35 days post-mi mounted a hypertrophic response (20-22.5 % increase) accompanied by a program of fetal gene re-expression, fibrosis and myocardial apoptosis. |
2014-12-08 |
2023-08-12 |
mouse |
| James T Tsoporis, Shehla Izhar, Jean-Francois Desjardins, Howard Leong-Poi, Thomas G Parke. Conditional cardiac overexpression of S100A6 attenuates myocyte hypertrophy and apoptosis following myocardial infarction. Current pharmaceutical design. vol 20. issue 12. 2014-12-08. PMID:23844739. |
whereas the s100a6-α-mhc-tta mice off dox showed an attenuated myocyte hypertrophic response, less fibrosis and apoptosis which was beneficial to preservation of cardiac function. |
2014-12-08 |
2023-08-12 |
mouse |
| Kuan-Chou Chen, Chiu-Lan Hsieh, Chiung-Chi Peng, Robert Y Pen. Exercise rescued chronic kidney disease by attenuating cardiac hypertrophy through the cardiotrophin-1 -> LIFR/gp 130 -> JAK/STAT3 pathway. European journal of preventive cardiology. vol 21. issue 4. 2014-11-24. PMID:23064267. |
chronic kidney disease (ckd) is usually associated with cardiac apoptosis and/or cardiac hypertrophy. |
2014-11-24 |
2023-08-12 |
Not clear |
| Yonggang Wang, Xiao Miao, Yucheng Liu, Fengsheng Li, Quan Liu, Jian Sun, Lu Ca. Dysregulation of histone acetyltransferases and deacetylases in cardiovascular diseases. Oxidative medicine and cellular longevity. vol 2014. 2014-11-24. PMID:24693336. |
new evidence has revealed that histone acetylation regulators blunt cardiovascular and related disease states in certain cellular processes including myocyte hypertrophy, apoptosis, fibrosis, oxidative stress, and inflammation. |
2014-11-24 |
2023-08-13 |
Not clear |
| Shenhong Gu, Wei Zhang, Ji Chen, Ruilian Ma, Xiang Xiao, Xiaotang Ma, Zhen Yao, Yanfang Che. EPC-derived microvesicles protect cardiomyocytes from Ang II-induced hypertrophy and apoptosis. PloS one. vol 9. issue 1. 2014-11-18. PMID:24392165. |
epc-derived microvesicles protect cardiomyocytes from ang ii-induced hypertrophy and apoptosis. |
2014-11-18 |
2023-08-12 |
Not clear |
| Shenhong Gu, Wei Zhang, Ji Chen, Ruilian Ma, Xiang Xiao, Xiaotang Ma, Zhen Yao, Yanfang Che. EPC-derived microvesicles protect cardiomyocytes from Ang II-induced hypertrophy and apoptosis. PloS one. vol 9. issue 1. 2014-11-18. PMID:24392165. |
in this study, we evaluated whether epc-mvs protect cardiomyocytes (cms) against angiotensin ii (ang ii)-induced hypertrophy and apoptosis. |
2014-11-18 |
2023-08-12 |
Not clear |
| Shenhong Gu, Wei Zhang, Ji Chen, Ruilian Ma, Xiang Xiao, Xiaotang Ma, Zhen Yao, Yanfang Che. EPC-derived microvesicles protect cardiomyocytes from Ang II-induced hypertrophy and apoptosis. PloS one. vol 9. issue 1. 2014-11-18. PMID:24392165. |
our data indicate that epc-mvs protect cms from hypertrophy and apoptosis through activating the pi3k/akt/enos pathway via the rnas carried by epc-mvs. |
2014-11-18 |
2023-08-12 |
Not clear |
| Ivonne Loeffler, Gunter Wol. Transforming growth factor-β and the progression of renal disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 29 Suppl 1. 2014-11-04. PMID:24030832. |
different types of renal cells undergo different pathophysiological changes induced by tgf-β, leading to apoptosis, hypertrophy and abnormalities of podocyte foot processes, which ultimately result in renal dysfunction. |
2014-11-04 |
2023-08-12 |
Not clear |
| Rodrigo Troncoso, Cristián Ibarra, Jose Miguel Vicencio, Enrique Jaimovich, Sergio Lavander. New insights into IGF-1 signaling in the heart. Trends in endocrinology and metabolism: TEM. vol 25. issue 3. 2014-10-29. PMID:24380833. |
insulin-like growth factor 1 (igf-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. |
2014-10-29 |
2023-08-12 |
Not clear |
| E V Tchetina, F Mwale, A R Pool. Changes in gene expression associated with matrix turnover, chondrocyte proliferation and hypertrophy in the bovine growth plate. Acta naturae. vol 6. issue 3. 2014-10-28. PMID:25349717. |
with the onset of hypertrophy expression of proteinases and their inhibitors, extracellular matrix molecules, as well as activity associated with vascularization and apoptosis were significantly upregulated. |
2014-10-28 |
2023-08-13 |
cattle |
| Chih-Yang Huang, Wei-Wen Kuo, Chia-Hua Kuo, Fuu-Jen Tsai, Peng-Yu Liu, Dennis Jine-Yuan Hsie. Protective effect of Danggui (Radix Angelicae Sinensis) on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells. BMC complementary and alternative medicine. vol 14. 2014-10-23. PMID:25256260. |
angiotensin ii (ang ii) has been shown to play important roles in mediating cardiovascular diseases, and may cause cardiac hypertrophy and apoptosis. |
2014-10-23 |
2023-08-13 |
Not clear |