| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen-Ying Zhang, Xiu-Hua Liu, Yong-Jun Ye, Sheng Sun, Fei Rong, Xiao-Sun Guo, Wei-Cheng H. [C/EBP homologous protein-mediated endoplasmic reticulum stress-related apoptosis pathway is involved in abdominal aortic constriction-induced myocardium hypertrophy in rats.]. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 2. 2015-05-16. PMID:19377828. |
prolonged ers triggered myocyte apoptosis, as both the mrna and protein level of chop in model group increased by 22.2% (p<0.01) and 76.0% (p<0.01) respectively compared with control on 7 d after hypertrophy (14 d after surgery), and meanwhile, the protein expression of pro-apoptotic bax increased by 41.1% (p<0.01) and anti-apoptotic bcl-2 protein expression decreased by 25.5% (p<0.01). |
2015-05-16 |
2023-08-12 |
rat |
| Zhen-Ying Zhang, Xiu-Hua Liu, Yong-Jun Ye, Sheng Sun, Fei Rong, Xiao-Sun Guo, Wei-Cheng H. [C/EBP homologous protein-mediated endoplasmic reticulum stress-related apoptosis pathway is involved in abdominal aortic constriction-induced myocardium hypertrophy in rats.]. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 2. 2015-05-16. PMID:19377828. |
these results suggest that abdominal aortic constriction induces a significant up-regulation in er molecular chaperones at early stage of post-surgery, indicating that ers response is activated in the rat heart; while prolonged ers could lead to myocyte apoptosis, and chop-mediated ers-associated apoptosis may contribute to myocardial hypertrophy. |
2015-05-16 |
2023-08-12 |
rat |
| Zhen-Ying Zhang, Xiu-Hua Liu, Yong-Jun Ye, Sheng Sun, Fei Rong, Xiao-Sun Guo, Wei-Cheng H. [C/EBP homologous protein-mediated endoplasmic reticulum stress-related apoptosis pathway is involved in abdominal aortic constriction-induced myocardium hypertrophy in rats.]. Sheng li xue bao : [Acta physiologica Sinica]. vol 61. issue 2. 2015-05-16. PMID:19377828. |
we speculate that cell apoptosis may take part in the regulation of myocardial hypertrophy and heart failure, and determine the progression of decompensated hypertrophy. |
2015-05-16 |
2023-08-12 |
rat |
| Wei-Cheng Gao, Hu-Jun Wang, Xing Qiao, Juan Ma, Jin Du, Shao-Lin M. [Effect of uighur medicine abnormal savda munzip on human hypertrophic scar fibroblasts in vitro]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery. vol 29. issue 6. 2015-05-16. PMID:24624878. |
to evaluate in vitro effect of abnormal savda munziq (asmq) on the proliferation and apoptosis of human hypertrophic scar fibroblasts (hsfs). |
2015-05-16 |
2023-08-12 |
human |
| Mohamed Nemir, Mélanie Metrich, Isabelle Plaisance, Mario Lepore, Steeve Cruchet, Corinne Berthonneche, Alexandre Sarre, Freddy Radtke, Thierry Pedrazzin. The Notch pathway controls fibrotic and regenerative repair in the adult heart. European heart journal. vol 35. issue 32. 2015-05-12. PMID:23166366. |
notch inhibition leads to increased cardiomyocyte apoptosis, and exacerbates the development of cardiac hypertrophy and fibrosis. |
2015-05-12 |
2023-08-12 |
Not clear |
| Jun Zhang, Rodney L Rous. Histopathology and pathogenesis of caerulein-, duct ligation-, and arginine-induced acute pancreatitis in Sprague-Dawley rats and C57BL6 mice. Histology and histopathology. vol 29. issue 9. 2015-05-12. PMID:24585404. |
nine morphologically detectable processes were used in the lexicon; acinar cell hypertrophy; acinar cell autophagy; acinar cell apoptosis; acinar cell necrosis; vascular injury; interstitial edema, inflammation and hemorrhage; fat necrosis; ductal changes; acinar cell atrophy. |
2015-05-12 |
2023-08-12 |
mouse |
| Yixuan Shi, Chao-Sheng Lo, Ranjit Padda, Shaaban Abdo, Isabelle Chenier, Janos G Filep, Julie R Ingelfinger, Shao-Ling Zhang, John S D Cha. Angiotensin-(1-7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice. Clinical science (London, England : 1979). vol 128. issue 10. 2015-05-09. PMID:25495544. |
ang-(1-7) administration prevented shtn and attenuated kidney injury (reduced urinary albumin/creatinine ratio, glomerular hyperfiltration, renal hypertrophy and fibrosis, and tubular apoptosis) without affecting blood glucose levels in akita mice. |
2015-05-09 |
2023-08-13 |
mouse |
| Mahesha H Gangadhariah, James M Luther, Victor Garcia, Paisit Paueksakon, Ming-Zhi Zhang, Simon W Hayward, Harold D Love, John R Falck, Vijaya L Manthati, John D Imig, Michal L Schwartzman, Roy Zent, Jorge H Capdevila, Ambra Pozz. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. Journal of the American Society of Nephrology : JASN. vol 26. issue 3. 2015-04-28. PMID:25071086. |
in the kidney, 20-hydroxyeicosatetraenoic acid (20-hete) is a primary cytochrome p450 4 (cyp4)-derived eicosanoid that enhances vasoconstriction of renal vessels and induces hypertension, renal tubular cell hypertrophy, and podocyte apoptosis. |
2015-04-28 |
2023-08-13 |
mouse |
| C-Y Huang, W-W Kuo, Y-L Yeh, T-J Ho, J-Y Lin, D-Y Lin, C-H Chu, F-J Tsai, C-H Tsai, C-Y Huan. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. Cell death and differentiation. vol 21. issue 8. 2015-04-19. PMID:24786827. |
hypertension-induced cardiac hypertrophy and apoptosis are major characteristics of early-stage heart failure. |
2015-04-19 |
2023-08-13 |
Not clear |
| C-Y Huang, W-W Kuo, Y-L Yeh, T-J Ho, J-Y Lin, D-Y Lin, C-H Chu, F-J Tsai, C-H Tsai, C-Y Huan. ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation. Cell death and differentiation. vol 21. issue 8. 2015-04-19. PMID:24786827. |
ang ii activates jnk to degrade sirt1, resulting in hsf1 acetylation, which induces igf-iir expression and eventually results in cardiac hypertrophy and apoptosis. |
2015-04-19 |
2023-08-13 |
Not clear |
| Laurel A Grisanti, Ashley A Repas, Jennifer A Talarico, Jessica I Gold, Rhonda L Carter, Walter J Koch, Douglas G Tille. Temporal and gefitinib-sensitive regulation of cardiac cytokine expression via chronic β-adrenergic receptor stimulation. American journal of physiology. Heart and circulatory physiology. vol 308. issue 4. 2015-04-13. PMID:25485901. |
cardiac contractility decreased following 2 wk of iso treatment, while cardiac hypertrophy, fibrosis, and apoptosis were enhanced at both timepoints. |
2015-04-13 |
2023-08-13 |
mouse |
| Laurel A Grisanti, Ashley A Repas, Jennifer A Talarico, Jessica I Gold, Rhonda L Carter, Walter J Koch, Douglas G Tille. Temporal and gefitinib-sensitive regulation of cardiac cytokine expression via chronic β-adrenergic receptor stimulation. American journal of physiology. Heart and circulatory physiology. vol 308. issue 4. 2015-04-13. PMID:25485901. |
inclusion of gef preserved contractility, blocked iso-induced apoptosis, and prevented hypertrophy at the 2-wk timepoint, but caused fibrosis on its own. |
2015-04-13 |
2023-08-13 |
mouse |
| David I Brown, Kathy K Griendlin. Regulation of signal transduction by reactive oxygen species in the cardiovascular system. Circulation research. vol 116. issue 3. 2015-04-13. PMID:25634975. |
in particular, we consider how ros modulate signaling pathways related to phenotypic modulation, migration and adhesion, contractility, proliferation and hypertrophy, angiogenesis, endoplasmic reticulum stress, apoptosis, and senescence. |
2015-04-13 |
2023-08-13 |
Not clear |
| Shizuka Uchida, Stefanie Dimmele. Long noncoding RNAs in cardiovascular diseases. Circulation research. vol 116. issue 4. 2015-04-09. PMID:25677520. |
several lncrnas are regulated during acute myocardial infarction (eg, novlnc6) and heart failure (eg, mhrt), whereas others control hypertrophy, mitochondrial function and apoptosis of cardiomyocytes. |
2015-04-09 |
2023-08-13 |
mouse |
| Jian-Yu Chen, Lei Zhang, Hong Zhang, Li Su, Lu-Ping Qi. Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts. Phytotherapy research : PTR. vol 28. issue 10. 2015-03-31. PMID:24706573. |
triggering of p38 mapk and jnk signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts. |
2015-03-31 |
2023-08-13 |
Not clear |
| Jian-Yu Chen, Lei Zhang, Hong Zhang, Li Su, Lu-Ping Qi. Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts. Phytotherapy research : PTR. vol 28. issue 10. 2015-03-31. PMID:24706573. |
in the present study, the mechanism of oleanolic acid (oa)-induced apoptosis in hypertrophic scar fibroblasts (hsfs) was investigated for the first time. |
2015-03-31 |
2023-08-13 |
Not clear |
| Xavier Lieben Louis, Sijo Joseph Thandapilly, Wilhelmina Kalt, Melinda Vinqvist-Tymchuk, Basma Milad Aloud, Pema Raj, Liping Yu, Hoa Le, Thomas Netticada. Blueberry polyphenols prevent cardiomyocyte death by preventing calpain activation and oxidative stress. Food & function. vol 5. issue 8. 2015-03-30. PMID:24910858. |
cardiomyocyte hypertrophy, cell death, oxidative stress, apoptosis and cardiomyocyte contractile function as well as the activities of calpain, superoxide dismutase (sod) and catalase (cat) were measured in cardiomyocytes treated with and without ne and blueberry fraction (bf). |
2015-03-30 |
2023-08-13 |
rat |
| Paolo De Vit. Atrial natriuretic peptide: an old hormone or a new cytokine? Peptides. vol 58. 2015-03-30. PMID:24973596. |
the hormone shows protective effects during: (i) ventricular hypertrophy and myocardial injury; (ii) atherosclerosis and hypertension by the induction of antiproliferative effects; (iii) oxidative stress counteracting the dangerous effects of ros; (iv) growth of tumors cells by the induction of apoptosis or necrosis. |
2015-03-30 |
2023-08-13 |
Not clear |
| Celestino Sardu, Raffaele Marfella, Gaetano Santulli, Giuseppe Paoliss. Functional role of miRNA in cardiac resynchronization therapy. Pharmacogenomics. vol 15. issue 8. 2015-03-30. PMID:25084208. |
heart failure (hf) disease progression is related to numerous adaptive processes including cardiac fibrosis, hypertrophy and apoptosis by activation of the 'fetal' gene program and downregulation of mrna signatures, suggesting the importance of molecular mechanisms that suppress mrna steady-state levels. |
2015-03-30 |
2023-08-13 |
Not clear |
| Xiaohui Zhang, Zhaohui Feng, Chunhua Li, Yuping Zhen. Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress. Neural regeneration research. vol 7. issue 1. 2015-03-25. PMID:25806055. |
following 24 hours of culture, compensatory hypertrophy was observed and cellular apoptosis increased. |
2015-03-25 |
2023-08-13 |
Not clear |