| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Sekut, K Connoll. AntiTNF-alpha agents in the treatment of inflammation. Expert opinion on investigational drugs. vol 7. issue 11. 2005-07-19. PMID:15991932. |
tumour necrosis factor/cachecin (tnf-alpha) and lymphotoxin (ltalpha / tnf-alpha), 2 members of the tnf family of cytokines, have numerous biological functions, such as induction of apoptosis, cytotoxicity, inflammation, immunoregulation, proliferation and antiviral responses. |
2005-07-19 |
2023-08-12 |
Not clear |
| Sunghee Kim, Anastasia Fotiadu, Vassiliki Kotoul. Increased expression of soluble decoy receptor 3 in acutely inflamed intestinal epithelia. Clinical immunology (Orlando, Fla.). vol 115. issue 3. 2005-07-14. PMID:15893696. |
decoy receptor 3 (dcr3), a soluble receptor in the tumor necrosis factor (tnf) receptor family, is known to inhibit apoptosis mediated by pro-apoptotic tnf family cytokines such as fas ligand (fasl), tl1a, and light. |
2005-07-14 |
2023-08-12 |
human |
| Tomohiro Banno, Alix Gazel, Miroslav Blumenber. Pathway-specific profiling identifies the NF-kappa B-dependent tumor necrosis factor alpha-regulated genes in epidermal keratinocytes. The Journal of biological chemistry. vol 280. issue 19. 2005-07-12. PMID:15722350. |
immune response, cell cycle, and apoptosis) through several signal transduction pathways that convey the tnf alpha signals to the nucleus. |
2005-07-12 |
2023-08-12 |
human |
| Wei Zhang, Shusen Zheng, Peter Storz, Wang Mi. Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. The Journal of biological chemistry. vol 280. issue 19. 2005-07-12. PMID:15755722. |
consistently, h2o2, but not tnf, induced phosphorylation of pkd and translocation of pkd from endothelial cell membrane to cytoplasm where it associates with the jnk upstream activator, apoptosis signal-regulating kinase 1 (ask1). |
2005-07-12 |
2023-08-12 |
Not clear |
| M N Lub-de Hooge, E G E de Vries, S de Jong, M Bij. Soluble TRAIL concentrations are raised in patients with systemic lupus erythematosus. Annals of the rheumatic diseases. vol 64. issue 6. 2005-07-11. PMID:15564310. |
apoptosis is induced by binding of death receptor ligands, members of the tumour necrosis factor (tnf) superfamily, to their cognate receptors. |
2005-07-11 |
2023-08-12 |
Not clear |
| M N Lub-de Hooge, E G E de Vries, S de Jong, M Bij. Soluble TRAIL concentrations are raised in patients with systemic lupus erythematosus. Annals of the rheumatic diseases. vol 64. issue 6. 2005-07-11. PMID:15564310. |
tnf related apoptosis inducing ligand (trail), another ligand of the tnf superfamily, induces apoptosis in sensitive cells. |
2005-07-11 |
2023-08-12 |
Not clear |
| Ioana Potrovita, Wen Zhang, Linda Burkly, Kyungmin Hahm, John Lincecum, Monica Z Wang, Martin H Maurer, Moritz Rossner, Armin Schneider, Markus Schwaninge. Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 38. 2005-07-07. PMID:15385607. |
tumor necrosis factor-like weak inducer of apoptosis (tweak) is a member of the tumor necrosis factor (tnf) family of cytokines. |
2005-07-07 |
2023-08-12 |
Not clear |
| George Lotocki, Ofelia F Alonso, W Dalton Dietrich, Robert W Kean. Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 49. 2005-07-07. PMID:15590916. |
the tumor necrosis factor (tnf) ligand-receptor system plays an essential role in apoptosis that contributes to secondary damage after traumatic brain injury (tbi). |
2005-07-07 |
2023-08-12 |
rat |
| George Lotocki, Ofelia F Alonso, W Dalton Dietrich, Robert W Kean. Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 49. 2005-07-07. PMID:15590916. |
in the normal rat cortex, a portion of tnfr1 was present in lipid raft microdomains, where it associated with the adaptor proteins tradd (tnf receptor-associated death domain), tnf receptor-associated factor-2 (traf-2), the ser/thr kinase rip (receptor-interacting protein), traf1, and ciap-1 (cellular inhibitor of apoptosis protein-1), forming a survival signaling complex. |
2005-07-07 |
2023-08-12 |
rat |
| Kathrin Maria Bernt, Shaoheng Ni, Anh-Thu Tieu, André Liebe. Assessment of a combined, adenovirus-mediated oncolytic and immunostimulatory tumor therapy. Cancer research. vol 65. issue 10. 2005-07-07. PMID:15899826. |
in this study, we identified murine breast cancer cell lines that support dna replication of e1-deleted adenovirus vectors and which can be killed by an oncolytic adenovirus expressing adenovirus e1a and tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) in a replication-dependent manner (ad.ir-e1a/trail). |
2005-07-07 |
2023-08-12 |
mouse |
| Ramon Arens, Paul A Baars, Margot Jak, Kiki Tesselaar, Martin van der Valk, Marinus H J van Oers, René A W van Lie. Cutting edge: CD95 maintains effector T cell homeostasis in chronic immune activation. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 10. 2005-07-05. PMID:15879081. |
here we show that triggering of the costimulatory tnf receptor family member cd27 sensitized t cells for cd95-induced apoptosis. |
2005-07-05 |
2023-08-12 |
mouse |
| Sun-Mi Park, Sunshin Kim, Jin-Suk Choi, Dae-Young Hur, Wang-Jae Lee, Myung-Shik Lee, Jongseon Choe, Tae H Le. TGF-beta inhibits Fas-mediated apoptosis of a follicular dendritic cell line by down-regulating the expression of Fas and caspase-8: counteracting role of TGF-beta on TNF sensitization of Fas-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 10. 2005-07-05. PMID:15879113. |
tgf-beta inhibits fas-mediated apoptosis of a follicular dendritic cell line by down-regulating the expression of fas and caspase-8: counteracting role of tgf-beta on tnf sensitization of fas-mediated apoptosis. |
2005-07-05 |
2023-08-12 |
mouse |
| Sun-Mi Park, Sunshin Kim, Jin-Suk Choi, Dae-Young Hur, Wang-Jae Lee, Myung-Shik Lee, Jongseon Choe, Tae H Le. TGF-beta inhibits Fas-mediated apoptosis of a follicular dendritic cell line by down-regulating the expression of Fas and caspase-8: counteracting role of TGF-beta on TNF sensitization of Fas-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 10. 2005-07-05. PMID:15879113. |
we have previously shown that tnf promotes fas-mediated apoptosis of hk cells, an established fdc-like cell line, by up-regulating fas expression. |
2005-07-05 |
2023-08-12 |
mouse |
| Sun-Mi Park, Sunshin Kim, Jin-Suk Choi, Dae-Young Hur, Wang-Jae Lee, Myung-Shik Lee, Jongseon Choe, Tae H Le. TGF-beta inhibits Fas-mediated apoptosis of a follicular dendritic cell line by down-regulating the expression of Fas and caspase-8: counteracting role of TGF-beta on TNF sensitization of Fas-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 174. issue 10. 2005-07-05. PMID:15879113. |
the inhibitory effect of tgf-beta can be observed when hk cells were simultaneously treated with tnf and tgf-beta, indicating that tgf-beta counteracts the effect of tnf in sensitizing cells to fas-mediated apoptosis. |
2005-07-05 |
2023-08-12 |
mouse |
| Tiejun Mai, Xin Wang, Zhiwen Zhang, Dianqi Xin, Yanqun Na, Yinglu Gu. Androgen receptor coregulator ARA267-alpha interacts with death receptor-6 revealed by the yeast two-hybrid. Science in China. Series C, Life sciences. vol 47. issue 5. 2005-06-28. PMID:15623156. |
dr6 is the member of tnf receptor family and has a death domain in its intracellular cytoplasmic portion (dr6cp) to mediate the cell apoptosis. |
2005-06-28 |
2023-08-12 |
Not clear |
| Yun Liu, Zhiguo Liu, Hua Gao, You Zhou, Elliot J Androphy, Jason J Che. Opposing effects of bovine papillomavirus type 1 E6 and E7 genes on Fas-mediated apoptosis. Oncogene. vol 24. issue 24. 2005-06-28. PMID:15782122. |
tumor necrosis factor alpha (tnf) and related cytokines are employed by host defenses to eliminate virally infected cells through induction of apoptosis. |
2005-06-28 |
2023-08-12 |
human |
| Glen C Ulett, Elisabeth E Adderso. Nitric oxide is a key determinant of group B streptococcus-induced murine macrophage apoptosis. The Journal of infectious diseases. vol 191. issue 10. 2005-06-28. PMID:15838805. |
tumor necrosis factor (tnf)-alpha , interleukin (il)-1, and inducible nitric oxide synthase (inos) gene expression coincided with apoptosis. |
2005-06-28 |
2023-08-12 |
mouse |
| Boris Zhivotovsky, Sten Orreniu. Caspase-2 function in response to DNA damage. Biochemical and biophysical research communications. vol 331. issue 3. 2005-06-27. PMID:15865942. |
caspase-2 appears to be necessary for the onset of apoptosis triggered by several insults, including dna damage, administration of tnf, and different pathogens and viruses. |
2005-06-27 |
2023-08-12 |
Not clear |
| Tarek A Taha, Kazuyuki Kitatani, Jacek Bielawski, Wonhwa Cho, Yusuf A Hannun, Lina M Obei. Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. The Journal of biological chemistry. vol 280. issue 17. 2005-06-21. PMID:15710602. |
therefore, these studies show that sk1 down-regulation by tnf is dependent on the "lysosomal pathway" of apoptosis and specifically on cathepsin b, which functions as an sk1 protease in cells. |
2005-06-21 |
2023-08-12 |
Not clear |
| Clare C Davies, Danai Bem, Lawrence S Young, Aristides G Eliopoulo. NF-kappaB overrides the apoptotic program of TNF receptor 1 but not CD40 in carcinoma cells. Cellular signalling. vol 17. issue 6. 2005-06-20. PMID:15722197. |
in this report we show that cd40 ligand, another member of the tnf superfamily, also triggers the activation of these signalling pathways but, importantly, utilises only the pi3 kinase cascade for anti-apoptotic responses, inasmuch as suppression of pi3 kinase but not nf-kappab sensitises carcinoma cells to cd40l-induced apoptosis. |
2005-06-20 |
2023-08-12 |
Not clear |