| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David H Adams, Simon C Affor. Effector mechanisms of nonsuppurative destructive cholangitis in graft-versus-host disease and allograft rejection. Seminars in liver disease. vol 25. issue 3. 2005-11-29. PMID:16143944. |
the mechanisms of cholangiocyte killing are complex but involve activation of apoptosis by the granzyme/perforin pathway and by activation of death receptors belonging to the tumor necrosis factor (tnf) receptor superfamily, most notably fas. |
2005-11-29 |
2023-08-12 |
Not clear |
| David H Adams, Simon C Affor. Effector mechanisms of nonsuppurative destructive cholangitis in graft-versus-host disease and allograft rejection. Seminars in liver disease. vol 25. issue 3. 2005-11-29. PMID:16143944. |
fas-dependent apoptosis is carefully regulated by cooperative interactions with other tnf receptors, particularly cd40, that act to amplify autocrine and paracrine expression of fas ligand and fas-mediated killing. |
2005-11-29 |
2023-08-12 |
Not clear |
| Matthias Kresse, Markus Latta, Gerald Künstle, Hans-Martin Riehle, Nico van Rooijen, Hannes Hentze, Gisa Tiegs, Markus Biburger, Rudolf Lucas, Albrecht Wende. Kupffer cell-expressed membrane-bound TNF mediates melphalan hepatotoxicity via activation of both TNF receptors. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 6. 2005-11-29. PMID:16148157. |
neutralization of tnf prevented melphalan-induced apoptosis and liver cells derived from mice genetically deficient in either tnfr 1 or 2, but not from lpr mice lacking a functional cd95 receptor, were completely resistant. |
2005-11-29 |
2023-08-12 |
mouse |
| Matthias Kresse, Markus Latta, Gerald Künstle, Hans-Martin Riehle, Nico van Rooijen, Hannes Hentze, Gisa Tiegs, Markus Biburger, Rudolf Lucas, Albrecht Wende. Kupffer cell-expressed membrane-bound TNF mediates melphalan hepatotoxicity via activation of both TNF receptors. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 6. 2005-11-29. PMID:16148157. |
in conclusion, this study shows that melphalan elicits membrane tnf on kupffer cells due to inhibition of tnf processing and thereby initiates apoptosis of hepatocytes via obligatory activation of both tnfrs. |
2005-11-29 |
2023-08-12 |
mouse |
| Mi-Ae Lyu, Michael G Rosenblu. The immunocytokine scFv23/TNF sensitizes HER-2/neu-overexpressing SKBR-3 cells to tumor necrosis factor (TNF) via up-regulation of TNF receptor-1. Molecular cancer therapeutics. vol 4. issue 8. 2005-11-14. PMID:16093436. |
these results indicate that the immunocytokine scfv23/tnf sensitizes tnf-resistant her-2/neu-overexpressing skbr-3-lp cells to tnf-induced apoptosis via the overexpression of tnf receptor-1 and suggest that the overexpression of tnf receptor-1 plays a crucial role in tnf sensitivity in her-2/neu-overexpressing cancer cells. |
2005-11-14 |
2023-08-12 |
Not clear |
| Silke Lüschen, Markus Falk, Gudrun Scherer, Sandra Ussat, Maren Paulsen, Sabine Adam-Klage. The Fas-associated death domain protein/caspase-8/c-FLIP signaling pathway is involved in TNF-induced activation of ERK. Experimental cell research. vol 310. issue 1. 2005-11-14. PMID:16129431. |
the cytokine tnf activates multiple signaling pathways leading to cellular responses ranging from proliferation and survival to apoptosis. |
2005-11-14 |
2023-08-12 |
human |
| Andreas Wicovsky, Daniela Siegmund, Harald Wajan. Interferons induce proteolytic degradation of TRAILR4. Biochemical and biophysical research communications. vol 337. issue 1. 2005-11-14. PMID:16185657. |
ifngamma and its transcriptional target tumor necrosis factor (tnf)-related apoptosis inducing ligand (trail) are two major effector molecules of activated ctls and nk cells. |
2005-11-14 |
2023-08-12 |
Not clear |
| J Frederick Harrington, Arthur A Messier, April Levine, Joanna Szmydynger-Chodobska, Adam Chodobsk. Shedding of tumor necrosis factor type 1 receptor after experimental spinal cord injury. Journal of neurotrauma. vol 22. issue 8. 2005-11-10. PMID:16083358. |
in a number of stress conditions, the biological effects of tumor necrosis factor-alpha (tnf-alpha), such as the induction of neuronal apoptosis, are presumably attenuated by the soluble fragments of tnf receptors (stnfrs). |
2005-11-10 |
2023-08-12 |
rat |
| Jose M Mellado-Gil, Manuel Aguilar-Diosdad. Assay for high glucose-mediated islet cell sensitization to apoptosis induced by streptozotocin and cytokines. Biological procedures online. vol 7. 2005-11-10. PMID:16281079. |
in this study we develop an experimental design to sensitize pancreatic islet cells by high glucose to streptozotocin (stz) and proinflammatory cytokines [interleukin (il)-1beta, tumor necrosis factor (tnf)-alpha and interferon (ifn)-gamma]-induced apoptosis. |
2005-11-10 |
2023-08-12 |
Not clear |
| E Jirillo, D Caccavo, T Magrone, E Piccigallo, L Amati, A Lembo, C Kalis, M Gumenscheime. The role of the liver in the response to LPS: experimental and clinical findings. Journal of endotoxin research. vol 8. issue 5. 2005-11-08. PMID:12537690. |
in experimental shock models, tumor necrosis factor (tnf)-alpha induces hepatocyte apoptosis and lethal effects are due to secreted tnf-alpha and not to cell-associated tnf-alpha. |
2005-11-08 |
2023-08-12 |
mouse |
| Stephen J Renaud, Lynne-Marie Postovit, Shannyn K Macdonald-Goodfellow, Gail T McDonald, Jason D Caldwell, Charles H Graha. Activated macrophages inhibit human cytotrophoblast invasiveness in vitro. Biology of reproduction. vol 73. issue 2. 2005-11-08. PMID:15800179. |
moreover, addition of up to 10 ng/ml of tnf did not increase the rate of apoptosis in htr-8/svneo cells. |
2005-11-08 |
2023-08-12 |
human |
| Georg H Waetzig, Philip Rosenstiel, Alexander Arlt, Andreas Till, Karen Bräutigam, Heiner Schäfer, Stefan Rose-John, Dirk Seegert, Stefan Schreibe. Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 1. 2005-11-07. PMID:15514103. |
soluble tumor necrosis factor (tnf) receptor-1 induces apoptosis via reverse tnf signaling and autocrine transforming growth factor-beta1. |
2005-11-07 |
2023-08-12 |
Not clear |
| Ewa Jaruga-Killeen, Walter Rayfor. TNF receptor 1 is involved in the induction of apoptosis by the cyclin dependent kinase inhibitor p27Kip1 in the prostate cancer cell line PC-3. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 1. 2005-11-07. PMID:15545300. |
tnf receptor 1 is involved in the induction of apoptosis by the cyclin dependent kinase inhibitor p27kip1 in the prostate cancer cell line pc-3. |
2005-11-07 |
2023-08-12 |
mouse |
| Maryse Remacle-Bonnet, Françoise Garrouste, Gilbert Baillat, Frédéric Andre, Jacques Marvaldi, Gilbert Pommie. Membrane rafts segregate pro- from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. The American journal of pathology. vol 167. issue 3. 2005-11-07. PMID:16127155. |
thus, we propose that segregation of igf-ir in and out of lipid rafts may dynamically regulate the pro- and anti-apoptotic effects of igf-i on apoptosis induced by tnf superfamily members. |
2005-11-07 |
2023-08-12 |
human |
| Rudolf Lucas, Matthias Kresse, Markus Latta, Albrecht Wende. Tumor necrosis factor: how to make a killer molecule tumor-specific? Current cancer drug targets. vol 5. issue 6. 2005-11-07. PMID:16178815. |
the hemorrhagic necrosis of the tumors induced by tnf seems to be predominantly mediated by an induction of apoptosis as well as by an anti-angiogenic effect in the endothelial cells of the microvasculature supplying the tumor. |
2005-11-07 |
2023-08-12 |
Not clear |
| Heui-Young Ryu, Jessica K Emberley, Jennifer J Schlezinger, Lenka L Allan, Songqing Na, David H Sher. Environmental chemical-induced bone marrow B cell apoptosis: death receptor-independent activation of a caspase-3 to caspase-8 pathway. Molecular pharmacology. vol 68. issue 4. 2005-11-02. PMID:16014577. |
cells from mice defective in tumor necrosis factor (tnf)-alpha, tnf-beta, lymphotoxin-beta, or tnfr1, tnfr2, fas, or death receptor 6 were as susceptible to apoptosis signaling as wild-type cells. |
2005-11-02 |
2023-08-12 |
mouse |
| Hun Sik Kim, Sunshin Kim, Myung-Shik Le. IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation. Biochemical and biophysical research communications. vol 336. issue 3. 2005-11-01. PMID:16154537. |
here, we found that: (i) xiap level was inversely correlated with tumor necrosis factor (tnf)-alpha-induced apoptosis in min6n8 insulinoma cells; (ii) adenoviral xiap overexpression abrogated the tnf-alpha-induced apoptosis through inhibition of caspase activity; (iii) downregulation of xiap by antisense oligonucleotide or smac peptide sensitized min6n8 cells to tnf-alpha-induced apoptosis; (iv) xiap expression was induced by tnf-alpha through a nuclear factor-kappab (nf-kappab)-dependent pathway, and interferon (ifn)-gamma prevented such an induction in a manner independent of nf-kappab, which presents a potential mechanism underlying cytotoxic ifn-gamma/tnf-alpha synergism. |
2005-11-01 |
2023-08-12 |
Not clear |
| Z Wu, I Nagano, T Boonmars, Y Takahash. Tumor necrosis factor receptor-mediated apoptosis in Trichinella spiralis-infected muscle cells. Parasitology. vol 131. issue Pt 3. 2005-10-28. PMID:16178359. |
the analysed factors included tnf-alpha, tnfr-1, tnf receptor-associated death-domain (tradd), caspase 3, caspase 8, tnf receptor associated factor-2 (traf2) and receptor interactive protein (rip), all of which are involved in the tnf-alpha/tnfr-1 signalling pathway-mediated apoptosis. |
2005-10-28 |
2023-08-12 |
Not clear |
| Giuseppe Nunnari, Yan Xu, Edward A Acheampong, Jianhua Fang, Rene Daniel, Chune Zhang, Hui Zhang, Muhammad Mukhtar, Roger J Pomerant. Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection. Journal of neurovirology. vol 11. issue 4. 2005-10-25. PMID:16162475. |
human apoptosis genomic microarray analyses of il-7-treated human neurons showed up-regulated expression of proapoptotic genes: protein kinases, caspase-10, fast kinase, tumor necrosis factor (tnf) receptor, and bcl2-antagonist of cell death. |
2005-10-25 |
2023-08-12 |
human |
| J F Kucharczak, M J Simmons, C S Duckett, C Gélina. Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. Cell death and differentiation. vol 12. issue 9. 2005-10-24. PMID:16094403. |
moreover, while bfl-1 suppresses apoptosis induced by staurosporine or cytokine withdrawal, it is proapoptotic in response to tumor necrosis factor (tnf) receptor activation in fl5.12 pro-b cells. |
2005-10-24 |
2023-08-12 |
Not clear |