| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Packham, J M Lahti, B E Fee, J M Gawn, E Coustan-Smith, D Campana, I Douglas, V J Kidd, S Ghosh, J L Clevelan. Fas activates NF-kappaB and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-alpha. Cell death and differentiation. vol 4. issue 2. 2006-03-02. PMID:16465219. |
the p55 tumor necrosis factor (tnf) receptor and the fas (cd95/apo-1) receptor share an intracellular domain necessary to induce apoptosis, suggesting they utilize common signaling pathways. |
2006-03-02 |
2023-08-12 |
human |
| G Packham, J M Lahti, B E Fee, J M Gawn, E Coustan-Smith, D Campana, I Douglas, V J Kidd, S Ghosh, J L Clevelan. Fas activates NF-kappaB and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-alpha. Cell death and differentiation. vol 4. issue 2. 2006-03-02. PMID:16465219. |
thus, the fas and tnf receptors utilize distinct signal transduction pathways in t-cells to induce nf-kappab and apoptosis. |
2006-03-02 |
2023-08-12 |
human |
| D M Vanags, P Larsson, S Feltenmark, P J Jakobsson, S Orrenius, H E Claesson, M Aguilar-Santelise. Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells. Cell death and differentiation. vol 4. issue 6. 2006-03-02. PMID:16465269. |
u937 human myeloid leukemia cells are induced to apoptosis by tumour necrosis factor (tnf) plus cycloheximide (chx). |
2006-03-02 |
2023-08-12 |
human |
| Lutz Thon, Heike Möhlig, Sabine Mathieu, Arne Lange, Elena Bulanova, Supandi Winoto-Morbach, Stefan Schütze, Silvia Bulfone-Paus, Dieter Ada. Ceramide mediates caspase-independent programmed cell death. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 14. 2006-02-27. PMID:16319138. |
under conditions where apoptosis is either not initiated or actively inhibited, tnf induces caspase-independent pcd in l929 fibrosarcoma cells, nih3t3 fibroblasts, human leukemic jurkat t cells, and lung fibroblasts by increasing intracellular ceramide levels prior to the onset of cell death. |
2006-02-27 |
2023-08-12 |
human |
| Vincenza Sofo, Francesca Maria Salmeri, Paolo Di Bella, Edoardo Sessa, Giangaetano D'Aleo, Giuseppe Trimarchi, Placido Bramant. Short communication: impairment of membrane markers on peripheral blood mononuclear cells and imbalance of cytokine secretion in the pathogenesis of multiple sclerosis active phases. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 25. issue 11. 2006-02-23. PMID:16318579. |
the aim of this research is to study on pbmcs and in the serum of stable and active ms subjects (1) the behavior of the cd40/cd40l system and the consequent balance of th1 and th2 cytokines and (2) the apoptosis marker system cd95/cd95l and tumor necrosis factor (tnf)- binding receptors, tnfri and tnfrii. |
2006-02-23 |
2023-08-12 |
human |
| Qingde Zhou, Salomon Ama. Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting. Infection and immunity. vol 74. issue 2. 2006-02-22. PMID:16428770. |
the expression of proteins involved in gene transcription (e.g., monocyte enhancer factor 2d [mef2d], signal transducer and activator of transcription 1 [stat1], stat3, stat6, and il enhancer binding factors [ilf3]), of protein kinases (e.g., mitogen-activated protein kinase 3 [mapk3], map3k8, double-stranded rna-activated protein kinase [prkr], and map2k4), and of proteins involved in immune responses (e.g., tnf super family member 6 [tnfsf6] and interferon-induced protein with tetratricopeptide repeat 4 [ifit4]), apoptosis (e.g., genes associated with retinoid interferon-induced mortality 19 [grim19]), and other fundamental cellular processes (e.g., clathrin heavy-chain polypeptide, culreticulin, and ras-associated protein rab27a) was found to be modulated differentially by p. gingivalis, lps, and fima. |
2006-02-22 |
2023-08-12 |
human |
| Sharmila Shankar, Thiyam R Singh, Tamer E Fandy, Thitidaj Luetrakul, Douglas D Ross, Rakesh K Srivastav. Interactive effects of histone deacetylase inhibitors and TRAIL on apoptosis in human leukemia cells: involvement of both death receptor and mitochondrial pathways. International journal of molecular medicine. vol 16. issue 6. 2006-02-21. PMID:16273296. |
in the present study, we aimed to elucidate the mechanism responsible for the interactive effects of histone deacetylase (hdac) inhibitors [suberoylanilide hydroxamic acid (saha), ms-275, m-carboxycinnamic acid bishydroxamide (cbha), and trichostatin-a (tsa)] and tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) on apoptosis in leukemia cells. |
2006-02-21 |
2023-08-12 |
human |
| Masanori Ii, Hiroyuki Yamamoto, Yasushi Adachi, Yumiko Maruyama, Yasuhisa Shinomur. Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis. Experimental biology and medicine (Maywood, N.J.). vol 231. issue 1. 2006-02-16. PMID:16380641. |
tumor necrosis factor (tnf)-alpha precursor is cleaved to release soluble tnf-alpha to increase apoptosis. |
2006-02-16 |
2023-08-12 |
human |
| C Van Poznak, S S Cross, M Saggese, C Hudis, K S Panageas, L Norton, R E Coleman, I Hole. Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor kappaB ligand (RANKL) in human breast tumours. Journal of clinical pathology. vol 59. issue 1. 2006-02-16. PMID:16394281. |
expression of osteoprotegerin (opg), tnf related apoptosis inducing ligand (trail), and receptor activator of nuclear factor kappab ligand (rankl) in human breast tumours. |
2006-02-16 |
2023-08-12 |
human |
| Jianping Liu, Qian Guo, Buxin Chen, Yao Yu, Hong Lu, Yu-Yang L. Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90. FEBS letters. vol 580. issue 1. 2006-02-14. PMID:16364318. |
here we found that apoptosis of ovarian cancer cells ov-90 triggered by tnf was cathepsin b-depended. |
2006-02-14 |
2023-08-12 |
Not clear |
| Xia Wang, Wei Ju, Jordan Renouard, James Aden, Steven A Belinsky, Yong Li. 17-allylamino-17-demethoxygeldanamycin synergistically potentiates tumor necrosis factor-induced lung cancer cell death by blocking the nuclear factor-kappaB pathway. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16424045. |
the other components of the tnf receptor i signaling cascade were not altered, whereas tnf-induced c-jun nh(2)-terminal kinase activation and apoptosis were potentiated. |
2006-02-14 |
2023-08-12 |
Not clear |
| Kai Uwe Chow, Daniel Nowak, Soo-Zin Kim, Bernd Schneider, Martina Komor, Simone Boehrer, Paris S Mitrou, Dieter Hoelzer, Eckhart Weidmann, Wolf-Karsten Hofman. In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling. Pharmacological research. vol 53. issue 1. 2006-02-09. PMID:16213748. |
among these 30 genes we found a high proportion of genes associated with apoptotic cell death, cell proliferation and cell cycle signalling including complement lysis inhibitor (clusterin/clu), beta-catenin interacting protein (icat), peroxisome proliferator activated receptor alpha (pparalpha), tnf alpha converting enzyme (adam17/tace), homeo box a3 (hox1), inositol polyphosphatase 5-phosphatase type iv (ppi5piv) and inhibitor of p53 induced apoptosis alpha (ipia-alpha/nm23-h6). |
2006-02-09 |
2023-08-12 |
Not clear |
| Hui-Chen Hsu, Yalei Wu, John D Mount. Tumor necrosis factor ligand-receptor superfamily and arthritis. Current directions in autoimmunity. vol 9. 2006-02-09. PMID:16394654. |
the current studies of apoptosis in rheumatoid arthritis (ra) suggest that the tnf ligand-receptor superfamily (tnfrsf) molecules, downstream pathways (activation of proapoptosis or anti-apoptosis pathway), cell types (lymphocytes and synovial fibroblast), and the mechanism that triggers apoptosis (tolerance induction-related, downmodulation of inflammation-related, or dna damage-related) all exhibit a capability to determine the induction or prevention of ra. |
2006-02-09 |
2023-08-12 |
mouse |
| Hiroo Hasegawa, Yasuaki Yamada, Kanki Komiyama, Masahiko Hayashi, Masami Ishibashi, Tatsushi Yoshida, Toshiyuki Sakai, Takashi Koyano, Toh-Seok Kam, Ken Murata, Kazuyuki Sugahara, Kazuto Tsuruda, Norihiko Akamatsu, Kunihiro Tsukasaki, Masato Masuda, Nobuyuki Takasu, Shimeru Kamihir. Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells. Blood. vol 107. issue 2. 2006-02-07. PMID:16195335. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) induces apoptosis in many transformed cells but not in normal cells and, hence, has emerged as a novel anticancer agent. |
2006-02-07 |
2023-08-12 |
Not clear |
| Sita Aggarwal, Haruyo Ichikawa, Yasunari Takada, Santosh K Sandur, Shishir Shishodia, Bharat B Aggarwa. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Molecular pharmacology. vol 69. issue 1. 2006-02-07. PMID:16219905. |
such tnf-induced nf-kappab-regulated gene products involved in cellular proliferation [cyclooxygenase-2 (cox-2), cyclin d1, and c-myc], antiapoptosis [inhibitor of apoptosis protein (iap)1, iap2, x-chromosome-linked iap, bcl-2, bcl-x(l), bfl-1/a1, tnf receptor-associated factor 1, and cellular fas-associated death domain protein-like interleukin-1beta-converting enzyme inhibitory protein-like inhibitory protein], and metastasis (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1) were also down-regulated by curcumin. |
2006-02-07 |
2023-08-12 |
Not clear |
| Naoki Makino, Toyoki Maeda, Masahiro Sugano, Shinji Satoh, Reiko Watanabe, Nobuyuki Ab. High serum TNF-alpha level in Type 2 diabetic patients with microangiopathy is associated with eNOS down-regulation and apoptosis in endothelial cells. Journal of diabetes and its complications. vol 19. issue 6. 2006-02-03. PMID:16260352. |
a high dose of tumor necrosis factor (tnf)-alpha induces endothelial dysfunction and enhances apoptosis in vitro. |
2006-02-03 |
2023-08-12 |
human |
| Anna Nilsson, Angelo de Milito, Frida Mowafi, Gösta Winberg, Olle Björk, Elisabeth Z Wolpert, Francesca Chiod. Expression of CD27-CD70 on early B cell progenitors in the bone marrow: implication for diagnosis and therapy of childhood ALL. Experimental hematology. vol 33. issue 12. 2006-02-03. PMID:16338493. |
cd27, a member of the tnf receptor family, plays an important role in lymphoid proliferation, differentiation and apoptosis. |
2006-02-03 |
2023-08-12 |
Not clear |
| José C Fernandez-Checa, Anna Colell, Montserrat Mari, Carmen García-Rui. Ceramide, tumor necrosis factor and alcohol-induced liver disease. Alcoholism, clinical and experimental research. vol 29. issue 11 Suppl. 2006-01-26. PMID:16344602. |
one of the key processes mediating the progression of ald involved the overproduction of tumor necrosis factor (tnf) and the susceptibility of hepatocytes to tnf-induced apoptosis by alcohol intake. |
2006-01-26 |
2023-08-12 |
Not clear |
| Mohamad A Abd el-Aziz, Hosny A Hassan, Mahmoud H Mohamed, Abdel-Raheim M A Meki, Sary K H Abdel-Ghaffar, Mahmoud R Hussei. The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model. International journal of experimental pathology. vol 86. issue 6. 2006-01-13. PMID:16309544. |
the animals were killed, and their serum and tissues were evaluated for (a) markers of tumorigenicity [serum levels of total sialic acid (tsa) and lipid-bound sialic acid (lsa)], (b) markers of endocrine derangement (serum prolactin, estradiol and progesterone levels), (c) apoptotic changes [serum tumour necrosis factor (tnf)-alpha, tissue caspase-3 activity, percentage of dna fragmentation and ultrastructural features of apoptosis] and (d) markers of oxidative stress (tissue levels of lipid peroxides and nitric oxide). |
2006-01-13 |
2023-08-12 |
rat |
| Gang-Ming Zou, Wen-Yang H. LIGHT regulates CD86 expression on dendritic cells through NF-kappaB, but not JNK/AP-1 signal transduction pathway. Journal of cellular physiology. vol 205. issue 3. 2006-01-11. PMID:15895390. |
light is a type ii transmembrane protein belonging to the tnf family that was originally identified as a weak inducer of apoptosis. |
2006-01-11 |
2023-08-12 |
Not clear |