| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen W Fesi. Promoting apoptosis as a strategy for cancer drug discovery. Nature reviews. Cancer. vol 5. issue 11. 2006-01-11. PMID:16239906. |
apoptosis targets that are currently being explored for cancer drug discovery include the tumour-necrosis factor (tnf)-related apoptosis-inducing ligand (trail) receptors, the bcl2 family of anti-apoptotic proteins, inhibitor of apoptosis (iap) proteins and mdm2. |
2006-01-11 |
2023-08-12 |
Not clear |
| Claudia van de Sand, Sebastian Horstmann, Anja Schmidt, Angelika Sturm, Stefanie Bolte, Andreas Krueger, Marc Lütgehetmann, Jörg-Matthias Pollok, Claude Libert, Volker T Heussle. The liver stage of Plasmodium berghei inhibits host cell apoptosis. Molecular microbiology. vol 58. issue 3. 2006-01-05. PMID:16238623. |
to prove the physiological relevance of these results, mice were infected with high numbers of p. berghei sporozoites and treated with tumour necrosis factor (tnf)-alpha/d-galactosamine to induce massive liver apoptosis. |
2006-01-05 |
2023-08-12 |
mouse |
| Thomas J Sayers, William J Murph. Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. Cancer immunology, immunotherapy : CII. vol 55. issue 1. 2005-12-28. PMID:15864587. |
one major way to promote apoptosis involves signaling through members of the tumor necrosis factor (tnf) superfamily. |
2005-12-28 |
2023-08-12 |
human |
| Thomas J Sayers, William J Murph. Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. Cancer immunology, immunotherapy : CII. vol 55. issue 1. 2005-12-28. PMID:15864587. |
on binding to their appropriate receptors, some tnf family members can promote caspase activation and apoptosis. |
2005-12-28 |
2023-08-12 |
human |
| Thomas J Sayers, William J Murph. Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. Cancer immunology, immunotherapy : CII. vol 55. issue 1. 2005-12-28. PMID:15864587. |
early studies on tnf indicated that a limited number of tumor cell lines could be induced to undergo apoptosis on exposure to tnf. |
2005-12-28 |
2023-08-12 |
human |
| Thomas J Sayers, William J Murph. Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. Cancer immunology, immunotherapy : CII. vol 55. issue 1. 2005-12-28. PMID:15864587. |
another member of the tnf family fas ligand (fasl) is also known to induce apoptosis in a variety of tumor cells. |
2005-12-28 |
2023-08-12 |
human |
| Thomas J Sayers, William J Murph. Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. Cancer immunology, immunotherapy : CII. vol 55. issue 1. 2005-12-28. PMID:15864587. |
although tnf and fasl can efficiently induce apoptosis in a limited number of tumor cells, administration of either of these agents is associated with extreme toxicity. |
2005-12-28 |
2023-08-12 |
human |
| Thomas J Sayers, William J Murph. Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy. Cancer immunology, immunotherapy : CII. vol 55. issue 1. 2005-12-28. PMID:15864587. |
however, within the last 8 years another member of the tnf family, tnf-related apoptosis-inducing ligand (apo2l/trail) has been characterized, which induces apoptosis of a wider range of cancer cells than either tnf or fasl. |
2005-12-28 |
2023-08-12 |
human |
| Yosuke Osawa, Yusuf A Hannun, Richard L Proia, David A Brenne. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology (Baltimore, Md.). vol 42. issue 6. 2005-12-22. PMID:16317686. |
tumor necrosis factor (tnf) receptor- and fas-mediated apoptosis are major death processes of hepatocytes in liver disease. |
2005-12-22 |
2023-08-12 |
mouse |
| Shishir Shishodia, Angelica M Gutierrez, Reuben Lotan, Bharat B Aggarwa. N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products. Cancer research. vol 65. issue 20. 2005-12-19. PMID:16230421. |
we found that 4-hpr potentiated the apoptosis induced by tumor necrosis factor (tnf) and chemotherapeutic agents, suppressed tnf-induced invasion, and inhibited rankl-induced osteoclastogenesis, all of which are known to require nf-kappab activation. |
2005-12-19 |
2023-08-12 |
Not clear |
| Shishir Shishodia, Angelica M Gutierrez, Reuben Lotan, Bharat B Aggarwa. N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products. Cancer research. vol 65. issue 20. 2005-12-19. PMID:16230421. |
this correlated with potentiation of apoptosis induced by tnf and chemotherapeutic agents. |
2005-12-19 |
2023-08-12 |
Not clear |
| Aniela Jakubowski, Christine Ambrose, Michael Parr, John M Lincecum, Monica Z Wang, Timothy S Zheng, Beth Browning, Jennifer S Michaelson, Manfred Baetscher, Manfred Baestcher, Bruce Wang, D Montgomery Bissell, Linda C Burkl. TWEAK induces liver progenitor cell proliferation. The Journal of clinical investigation. vol 115. issue 9. 2005-12-14. PMID:16110324. |
herein we present evidence that a tnf family member called tweak (tnf-like weak inducer of apoptosis) stimulates oval cell proliferation in mouse liver through its receptor fn14. |
2005-12-14 |
2023-08-12 |
mouse |
| Kan Kondo, Seiji Yamasaki, Tomoharu Sugie, Naoki Teratani, Takatsugu Kan, Masayuki Imamura, Yutaka Shimad. Cisplatin-dependent upregulation of death receptors 4 and 5 augments induction of apoptosis by TNF-related apoptosis-inducing ligand against esophageal squamous cell carcinoma. International journal of cancer. vol 118. issue 1. 2005-12-13. PMID:16003725. |
tnf-related apoptosis-inducing ligand (trail) is a member of the tnf superfamily known to induce apoptosis in a variety of cancers. |
2005-12-13 |
2023-08-12 |
mouse |
| Gillian Hughes, Michael P Murphy, Elizabeth C Ledgerwoo. Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants. The Biochemical journal. vol 389. issue Pt 1. 2005-12-12. PMID:15727562. |
furthermore, there was an increased cleavage of the proapoptotic bcl-2 family member bid and an increased release of cytochrome c from mitochondria, in cells treated with tnf in the presence of mitovit e. we considered several mechanisms by which mitovit e might accelerate tnf-induced apoptosis including mitochondrial integrity (atp/adp levels and permeability transition), alterations in calcium homoeostasis and transcription factor activation. |
2005-12-12 |
2023-08-12 |
Not clear |
| Gillian Hughes, Michael P Murphy, Elizabeth C Ledgerwoo. Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants. The Biochemical journal. vol 389. issue Pt 1. 2005-12-12. PMID:15727562. |
tnf caused maximal nuclear translocation of nf-kappab within 15 min, compared with 1 h in cells pretreated with mitovit e. thus the accumulation of an antioxidant within the mitochondrial matrix enhances tnf-induced apoptosis by decreasing or delaying the expression of the protective antiapoptotic proteins. |
2005-12-12 |
2023-08-12 |
Not clear |
| Gillian Hughes, Michael P Murphy, Elizabeth C Ledgerwoo. Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants. The Biochemical journal. vol 389. issue Pt 1. 2005-12-12. PMID:15727562. |
these results demonstrate that mitochondrial ros production is a physiologically relevant component of the tnf signal-transduction pathway during apoptosis, and reveal a novel functional role for mitochondrial ros as a temporal regulator of nf-kappab activation and nf-kappab-dependent antiapoptotic signalling. |
2005-12-12 |
2023-08-12 |
Not clear |
| Y Huang, N Erdmann, H Peng, Y Zhao, Jialin Zhen. The role of TNF related apoptosis-inducing ligand in neurodegenerative diseases. Cellular & molecular immunology. vol 2. issue 2. 2005-12-12. PMID:16191417. |
tnf-related apoptosis-inducing ligand (trail), a member of the tnf family, has been shown to be involved in apoptosis during many diseases. |
2005-12-12 |
2023-08-12 |
Not clear |
| Rei Shibata, Kaori Sato, David R Pimentel, Yukihiro Takemura, Shinji Kihara, Koji Ohashi, Tohru Funahashi, Noriyuki Ouchi, Kenneth Wals. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nature medicine. vol 11. issue 10. 2005-12-07. PMID:16155579. |
ischemia-reperfusion in adiponectin-deficient (apn-ko) mice resulted in increased myocardial infarct size, myocardial apoptosis and tumor necrosis factor (tnf)-alpha expression compared with wild-type mice. |
2005-12-07 |
2023-08-12 |
mouse |
| Jindan Zhang, Ning Liu, Jingchun Zhang, Shilian Liu, Yanxin Liu, Dexian Zhen. PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. Journal of cellular biochemistry. vol 96. issue 3. 2005-12-06. PMID:16114000. |
tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) induces apoptosis in a number of tumorogenic or transformed cells, yet is relatively non-toxic to most normal cells, therefore, it is a promising agent for cancer therapy. |
2005-12-06 |
2023-08-12 |
human |
| b' U Lademann, T Kallunki, M J\\xc3\\xa4\\xc3\\xa4ttel\\xc3\\xa. A20 zinc finger protein inhibits TNF-induced apoptosis and stress response early in the signaling cascades and independently of binding to TRAF2 or 14-3-3 proteins. Cell death and differentiation. vol 8. issue 3. 2005-12-01. PMID:11319609.' |
a20 zinc finger protein is a negative regulator of tumor necrosis factor (tnf)-induced signaling pathways leading to apoptosis, stress response and inflammation. |
2005-12-01 |
2023-08-12 |
Not clear |