| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jilong Yang, Wei Zhan. WWOX tumor suppressor gene. Histology and histopathology. vol 23. issue 7. 2008-05-29. PMID:18437686. |
the nature of the various proteins that the wwox protein can interact with, such as c-jun, tnf, p53, p73, ap-2 gamma, and e2f-1, suggests that wwox plays a central role in tumor suppression through transcriptional repression and apoptosis, with its apoptotic function the more prominent of the two. |
2008-05-29 |
2023-08-12 |
mouse |
| Ana Belen Sanz, Pilar Justo, Maria Dolores Sanchez-Niño, Luis Miguel Blanco-Colio, Jeffrey A Winkles, Matthias Kreztler, Aniela Jakubowski, Julia Blanco, Jesús Egido, Marta Ruiz-Ortega, Alberto Orti. The cytokine TWEAK modulates renal tubulointerstitial inflammation. Journal of the American Society of Nephrology : JASN. vol 19. issue 4. 2008-05-28. PMID:18235096. |
tnf-like weak inducer of apoptosis (tweak) is a member of the tnf superfamily of cytokines. |
2008-05-28 |
2023-08-12 |
mouse |
| M E Gasparian, L V Domnina, O Yu Ivanova, D S Izyumov, A Yu Lomakin, E N Popova, A V Yagolovich, O Yu Pletjushkina, D A Dolgikh, B V Chernya. Cytoskeleton inhibitors combined with TRAIL induce apoptosis in HeLa carcinoma cells overexpressing antiapoptotic protein Bcl-2. Biochemistry. Biokhimiia. vol 73. issue 3. 2008-05-27. PMID:18393775. |
trail (apo2l), a cytokine from the family of tumor necrosis factors (tnf), causes apoptosis in various types of tumor cells but is not toxic for normal cells. |
2008-05-27 |
2023-08-12 |
Not clear |
| Shi Jin, Ramesh M Ray, Leonard R Johnso. TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species. American journal of physiology. Gastrointestinal and liver physiology. vol 294. issue 4. 2008-05-22. PMID:18218673. |
previously we have shown that both rac1 and c-jun nh(2)-terminal kinase (jnk1/2) are key proapoptotic molecules in tumor necrosis factor (tnf)-alpha/cycloheximide (chx)-induced apoptosis in intestinal epithelial cells, whereas the role of reactive oxygen species (ros) in apoptosis is unclear. |
2008-05-22 |
2023-08-12 |
Not clear |
| Yoshiaki Takahashi, Reiko Tanaka, Naoki Yamamoto, Yuetsu Tanak. Enhancement of OX40-induced apoptosis by TNF coactivation in OX40-expressing T cell lines in vitro leading to decreased targets for HIV type 1 production. AIDS research and human retroviruses. vol 24. issue 3. 2008-05-20. PMID:18327975. |
enhancement of ox40-induced apoptosis by tnf coactivation in ox40-expressing t cell lines in vitro leading to decreased targets for hiv type 1 production. |
2008-05-20 |
2023-08-12 |
Not clear |
| Philip Diessenbacher, Mike Hupe, Martin R Sprick, Andreas Kerstan, Peter Geserick, Tobias L Haas, Tina Wachter, Manfred Neumann, Henning Walczak, John Silke, Martin Leverku. NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2. The Journal of investigative dermatology. vol 128. issue 5. 2008-05-19. PMID:17989734. |
nf-kappab inhibition reveals differential mechanisms of tnf versus trail-induced apoptosis upstream or at the level of caspase-8 activation independent of ciap2. |
2008-05-19 |
2023-08-12 |
human |
| Philip Diessenbacher, Mike Hupe, Martin R Sprick, Andreas Kerstan, Peter Geserick, Tobias L Haas, Tina Wachter, Manfred Neumann, Henning Walczak, John Silke, Martin Leverku. NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2. The Journal of investigative dermatology. vol 128. issue 5. 2008-05-19. PMID:17989734. |
although tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) and tnf both activate nf-kappab in human keratinocytes, only trail potently induces apoptosis. |
2008-05-19 |
2023-08-12 |
human |
| Philip Diessenbacher, Mike Hupe, Martin R Sprick, Andreas Kerstan, Peter Geserick, Tobias L Haas, Tina Wachter, Manfred Neumann, Henning Walczak, John Silke, Martin Leverku. NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2. The Journal of investigative dermatology. vol 128. issue 5. 2008-05-19. PMID:17989734. |
interestingly, the inhibitor of apoptosis protein (iap) family member ciap2, but not ciap1, x-linked inhibitor of apoptosis, tnf receptor-associated factor (traf)-1, or traf2, was downregulated in sensitive but not in resistant hacat keratinocytes. |
2008-05-19 |
2023-08-12 |
human |
| Philip Diessenbacher, Mike Hupe, Martin R Sprick, Andreas Kerstan, Peter Geserick, Tobias L Haas, Tina Wachter, Manfred Neumann, Henning Walczak, John Silke, Martin Leverku. NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2. The Journal of investigative dermatology. vol 128. issue 5. 2008-05-19. PMID:17989734. |
in conclusion, we demonstrate that inhibition of nf-kappab dramatically sensitizes human keratinocytes to tnf- but not to trail-induced apoptosis and that this sensitization for tnf was largely independent of ciap2. |
2008-05-19 |
2023-08-12 |
human |
| Philip Diessenbacher, Mike Hupe, Martin R Sprick, Andreas Kerstan, Peter Geserick, Tobias L Haas, Tina Wachter, Manfred Neumann, Henning Walczak, John Silke, Martin Leverku. NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2. The Journal of investigative dermatology. vol 128. issue 5. 2008-05-19. PMID:17989734. |
our data thus clearly exclude the candidates proposed to date to confer tnf apoptosis resistance and suggest the function of an unanticipated effector of nf-kappab critical for the survival of hacat keratinocytes upstream or at the level of caspase-8 activation. |
2008-05-19 |
2023-08-12 |
human |
| Atsuyasu Sato, Yuma Hoshino, Tomijiro Hara, Shigeo Muro, Hajime Nakamura, Michiaki Mishima, Junji Yodo. Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice. The Journal of pharmacology and experimental therapeutics. vol 325. issue 2. 2008-05-19. PMID:18256171. |
oxidative stress and apoptosis were enhanced, and the expression of cytokines macrophage inflammatory protein-2 and tumor necrosis factor (tnf)-alpha was increased 15.3- and 2.4-fold, respectively. |
2008-05-19 |
2023-08-12 |
mouse |
| Hirotsugu Ogura, Yoshinori Tsukumo, Hikaru Sugimoto, Masayuki Igarashi, Kazuo Nagai, Takao Kataok. Ectodomain shedding of TNF receptor 1 induced by protein synthesis inhibitors regulates TNF-alpha-mediated activation of NF-kappaB and caspase-8. Experimental cell research. vol 314. issue 6. 2008-05-14. PMID:18289527. |
it has been established that the protein synthesis inhibitor cycloheximide (chx) sensitizes many types of cells to tumor necrosis factor (tnf)-alpha-induced apoptosis, mainly due to its ability to block de novo synthesis of cellular flice-inhibitory protein (c-flip). |
2008-05-14 |
2023-08-12 |
human |
| Derek L Stirewalt, Andrew J Mhyre, Mario Marcondes, Era Pogosova-Agadjanyan, Nissa Abbasi, Jerald P Radich, H Joachim Dee. Tumour necrosis factor-induced gene expression in human marrow stroma: clues to the pathophysiology of MDS? British journal of haematology. vol 140. issue 4. 2008-05-08. PMID:18162123. |
overall, the results suggested that tnf induced a complex set of pro-inflammatory and pro-apoptotic signals in stroma cells that promote apoptosis in malignant myeloid clones. |
2008-05-08 |
2023-08-12 |
human |
| Xiaoping Zhang, Wenhua Li, Aria F Olum. Low-dose 12-O-tetradecanoylphorbol-13-acetate enhances tumor necrosis factor related apoptosis-inducing ligand induced apoptosis in prostate cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 13. issue 23. 2008-05-07. PMID:18056199. |
previously, we have shown that c-fos/activator protein-1 (ap-1) promotes tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail)-induced apoptosis by repressing the antiapoptotic molecule c-flip(l). |
2008-05-07 |
2023-08-12 |
Not clear |
| Feng Feng, Lijun Wang, Nathaniel Albanese, Andrew Holmes, Pu Xi. Tumor necrosis factor-like weak inducer of apoptosis attenuates the action of insulin in hepatocytes. Endocrinology. vol 149. issue 4. 2008-05-06. PMID:18174283. |
tnf-like weak inducer of apoptosis (tweak), a relatively new member of the tnf superfamily, is an important immune/inflammatory regulator that has different functional properties from that of other members of this superfamily. |
2008-05-06 |
2023-08-12 |
human |
| Georges Herbein, Kashif Aziz Kha. Is HIV infection a TNF receptor signalling-driven disease? Trends in immunology. vol 29. issue 2. 2008-05-06. PMID:18178131. |
hiv proteins have been shown to target tnf receptor signalling, leading both to apoptosis of uninfected bystander t cells and to sustained viral replication in infected t cells and macrophages. |
2008-05-06 |
2023-08-12 |
Not clear |
| Yasunari Takada, Gautam Sethi, Bokyung Sung, Bharat B Aggarwa. Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells. Molecular pharmacology. vol 73. issue 5. 2008-05-06. PMID:18287248. |
overall, our results clearly suggest that flavopiridol interferes with the tnf cell-signaling pathway, leading to suppression of antiapoptotic mechanisms and enhancement of apoptosis. |
2008-05-06 |
2023-08-12 |
human |
| T Drewa, Z Wolski, B Misterek, R Debski, J Styczynsk. The influence of alpha1-antagonist on the expression pattern of TNF receptor family in primary culture of prostate epithelial cells from BPH patients. Prostate cancer and prostatic diseases. vol 11. issue 1. 2008-05-01. PMID:17533395. |
tnf receptor self-assembly process should be checked as a potential mechanism leading to apoptosis after doxazosin treatment. |
2008-05-01 |
2023-08-12 |
Not clear |
| John G Albeck, John M Burke, Bree B Aldridge, Mingsheng Zhang, Douglas A Lauffenburger, Peter K Sorge. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Molecular cell. vol 30. issue 1. 2008-05-01. PMID:18406323. |
apoptosis in response to trail or tnf requires the activation of initiator caspases, which then activate the effector caspases that dismantle cells and cause death. |
2008-05-01 |
2023-08-12 |
Not clear |
| G Mori, G Brunetti, S Colucci, F Ciccolella, M Coricciati, P Pignataro, A Oranger, A Ballini, D Farronato, F Mastrangelo, S Tetè, F R Grassi, M Gran. Alteration of activity and survival of osteoblasts obtained from human periodontitis patients: role of TRAIL. Journal of biological regulators and homeostatic agents. vol 21. issue 3-4. 2008-04-24. PMID:18261262. |
trail, a member of the tnf superfamily, induces apoptosis by interacting with its death receptors, (dr4, dr5). |
2008-04-24 |
2023-08-12 |
human |