| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alessandro Natoni, Marion MacFarlane, Satoshi Inoue, Renata Walewska, Aneela Majid, Deborah Knee, David R Stover, Martin J S Dyer, Gerald M Cohe. TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2. British journal of haematology. vol 139. issue 4. 2008-04-16. PMID:17922877. |
tumour necrosis factor (tnf)-related apoptosis-inducing ligand (trail), a member of the tnf family, which is being developed as an anti-tumour agent due to its selective toxicity to tumour cells, induces apoptosis by binding to two membrane-bound receptors, trail-r1 and trail-r2. |
2008-04-16 |
2023-08-12 |
Not clear |
| Young-Ok Son, Sung-Ho Kook, Ki-Choon Choi, Yong-Suk Jang, Yong-Sung Choi, Young-Mi Jeon, Jong-Ghee Kim, Hyeon-Shik Hwang, Jeong-Chae Le. Quercetin accelerates TNF-alpha-induced apoptosis of MC3T3-E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways. European journal of pharmacology. vol 579. issue 1-3. 2008-04-15. PMID:17988664. |
however, our previous findings revealed that quercetin did not inhibit but facilitate the tumor necrosis factor (tnf)-alpha-mediated apoptosis of mc3t3-e1 osteoblastic cells. |
2008-04-15 |
2023-08-12 |
Not clear |
| Toshiro Kita, Midori Ogawa, Hiroaki Sato, Kentaro Kasai, Toshiko Tanaka, Noriyuki Tanak. Role of p38 mitogen-activated protein kinase pathway on heart failure in the infant rat after burn injury. International journal of experimental pathology. vol 89. issue 1. 2008-04-10. PMID:18005133. |
we examined the hypothesis that post-burn activation of the p38 mitogen-activated protein kinase (mapk) pathway is one aspect of the signalling cascade culminating in post-burn secretion of tumour necrosis factor (tnf)-alpha which contributes to post-burn myocardial apoptosis. |
2008-04-10 |
2023-08-12 |
rat |
| Giacomina Brunetti, Angela Oranger, Giorgio Mori, Roberto Tamma, Adriana Di Benedetto, Paolo Pignataro, Felice R Grassi, Alberta Zallone, Maria Grano, Silvia Colucc. TRAIL is involved in human osteoclast apoptosis. Annals of the New York Academy of Sciences. vol 1116. 2008-03-31. PMID:17584981. |
trail, a member of the tnf superfamily, induces apoptosis in neoplastic and normal cells. |
2008-03-31 |
2023-08-12 |
human |
| Sabine Gröbner, Irena Adkins, Sebastian Schulz, Kathleen Richter, Stefan Borgmann, Sebastian Wesselborg, Klaus Ruckdeschel, Olivier Micheau, Ingo B Autenriet. Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells. Apoptosis : an international journal on programmed cell death. vol 12. issue 10. 2008-03-27. PMID:17624595. |
yopp-dependent caspase-8 activation was, however, not mediated by tumor necrosis factor (tnf) receptor family members since the expression of both cd95/fas/apo-1 and trail-r2 on dc was low, and dc were resistant to apoptosis induced by agonistic anti-cd95 antibodies or tnf-related apoptosis-inducing ligand (trail). |
2008-03-27 |
2023-08-12 |
mouse |
| Dongmei Lu, Usha Sivaprasad, Jie Huang, Eswar Shankar, Shavonda Morrow, Alakananda Bas. Protein kinase C-epsilon protects MCF-7 cells from TNF-mediated cell death by inhibiting Bax translocation. Apoptosis : an international journal on programmed cell death. vol 12. issue 10. 2008-03-27. PMID:17668322. |
we have previously shown that protein kinase cepsilon (pkcepsilon) acts as an antiapoptotic protein and protects breast cancer mcf-7 cells from tumor necrosis factor-alpha (tnf)-mediated apoptosis. |
2008-03-27 |
2023-08-12 |
Not clear |
| Z Y Xu, B J Sun, M X Chang, P Ni. Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella. Veterinary immunology and immunopathology. vol 121. issue 1-2. 2008-03-27. PMID:17868904. |
tnf receptor associated factor 1 (traf1) plays an important role in regulating the tnf signaling and protecting cells from apoptosis. |
2008-03-27 |
2023-08-12 |
rabbit |
| T Abdollahi, N M Robertson, A Abdollahi, G Litwac. Inhibition of TRAIL-induced apoptosis by IL-8 is mediated by the p38-MAPK pathway in OVCAR3 cells. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215677. |
trail (tnf-related apoptosis inducing ligand) is a member of the tnf superfamily of cell death inducing ligands. |
2008-03-25 |
2023-08-12 |
Not clear |
| Yi-Rong Wang, Ren-Yi Liu, Liang-Chun Wang, Hai-Feng Mao, Jia-Qin Che. Effect of Huwentoxin-I on the Fas and TNF apoptosis pathway in the hippocampus of rat with global cerebral ischemia. Toxicon : official journal of the International Society on Toxinology. vol 50. issue 8. 2008-03-25. PMID:17900647. |
effect of huwentoxin-i on the fas and tnf apoptosis pathway in the hippocampus of rat with global cerebral ischemia. |
2008-03-25 |
2023-08-12 |
rat |
| Frank Schneider, Julia Neugebauer, Janine Griese, Nicola Liefold, Helmut Kutz, Cinthia Briseño, Arnd Kiese. The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity. PLoS biology. vol 6. issue 1. 2008-03-24. PMID:18198944. |
the tumor necrosis factor (tnf)-receptor 1-associated death domain protein (tradd) mediates induction of apoptosis as well as activation of nf-kappab by cellular tnf-receptor 1 (tnfr1). |
2008-03-24 |
2023-08-12 |
human |
| R Ihnatko, M Kube. TNF signaling: early events and phosphorylation. General physiology and biophysics. vol 26. issue 3. 2008-02-19. PMID:18063842. |
tumor necrosis factor-alpha (tnf) is a major mediator of apoptosis as well as immunity and inflammation. |
2008-02-19 |
2023-08-12 |
human |
| R Ihnatko, M Kube. TNF signaling: early events and phosphorylation. General physiology and biophysics. vol 26. issue 3. 2008-02-19. PMID:18063842. |
other cellular substrates as tradd adaptor protein, traf protein family and rip kinases are reviewed in relation to tnf receptor-mediated apoptosis or survival pathways and regulation of their actions by phosphorylation. |
2008-02-19 |
2023-08-12 |
human |
| L R Motadi, N L Misso, Z Dlamini, K D Bhool. Molecular genetics and mechanisms of apoptosis in carcinomas of the lung and pleura: therapeutic targets. International immunopharmacology. vol 7. issue 14. 2008-02-15. PMID:18039530. |
of the several molecular targets, those receiving attention are p53 gene replacement, bcl-2 downregulation, apoptosis by induced by tnf, the fas/cd95 receptor system and trail, and inhibition of nf-kappab. |
2008-02-15 |
2023-08-12 |
Not clear |
| A M Chromik, A Daigeler, C Hilgert, D Bulut, A Geisler, V Liu, J M Otte, W Uhl, U Mittelkötte. Synergistic effects in apoptosis induction by taurolidine and TRAIL in HCT-15 colon carcinoma cells. Journal of investigative surgery : the official journal of the Academy of Surgical Research. vol 20. issue 6. 2008-02-15. PMID:18097875. |
induction of apoptosis in tumor cells by trail (tumor necrosis factor [tnf]-related apoptosis-inducing ligand) is a promising therapeutic principle in oncology, although toxicity and resistance against trail are limiting factors. |
2008-02-15 |
2023-08-12 |
human |
| Hideki Ohtsubo, Toshihiro Ichiki, Ikuyo Imayama, Hiroki Ono, Kae Fukuyama, Yasuko Hashiguchi, Junichi Sadoshima, Kenji Sunagaw. Involvement of Mst1 in tumor necrosis factor-alpha-induced apoptosis of endothelial cells. Biochemical and biophysical research communications. vol 367. issue 2. 2008-02-15. PMID:18182160. |
we examined whether mst1 is involved in the tumor necrosis factor (tnf)-alpha-induced apoptosis of ecs. |
2008-02-15 |
2023-08-12 |
Not clear |
| Jürgen Eberle, Lothar F Fecker, Amir M Hossini, Bahtier M Kurbanov, Henry Fechne. Apoptosis pathways and oncolytic adenoviral vectors: promising targets and tools to overcome therapy resistance of malignant melanoma. Experimental dermatology. vol 17. issue 1. 2008-02-14. PMID:18095940. |
genes and strategies suitable for efficient induction of apoptosis in melanoma cells were identified, which are based on proapoptotic bcl-2 proteins (bcl-x(s), bcl-x(ak), bik/nbk and bax) as well as on tumor necrosis factor (tnf)-related death ligands (cd95l/fas ligand and tnf-related apoptosis-inducing ligand, trail). |
2008-02-14 |
2023-08-12 |
Not clear |
| Yasuaki Murata, Ulf Nannmark, Björn Rydevik, Kazuhisa Takahashi, Kjell Olmarke. The role of tumor necrosis factor-alpha in apoptosis of dorsal root ganglion cells induced by herniated nucleus pulposus in rats. Spine. vol 33. issue 2. 2008-02-14. PMID:18197099. |
the mechanisms of apoptosis underlying a characteristic tissue reaction at the surface of the dorsal root ganglion (drg) exposed to nucleus pulposus were studied in rats with special reference to the role of tumor necrosis factor-alpha (tnf). |
2008-02-14 |
2023-08-12 |
rat |
| Henning Walczak, Tobias L Haa. Biochemical analysis of the native TRAIL death-inducing signaling complex. Methods in molecular biology (Clifton, N.J.). vol 414. 2008-02-11. PMID:18175822. |
the extrinsic apoptosis pathway is activated when certain members of the tumor necrosis factor (tnf) receptor superfamily (tnfrsf) are oligomerized by their cognate ligands that are members of the tnf superfamily (tnfsf). |
2008-02-11 |
2023-08-12 |
Not clear |
| Manuela Flórido, Rui Appelber. Characterization of the deregulated immune activation occurring at late stages of mycobacterial infection in TNF-deficient mice. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 11. 2008-02-05. PMID:18025216. |
in the absence of tnf, mice infected with mycobacterium avium suffer a peculiar disintegration of the granulomas, with extensive apoptosis and necrosis of their cells, occurring during the course of the infection and leading to the death of the animals within a few days of its onset. |
2008-02-05 |
2023-08-12 |
mouse |
| Zeguo Zhao, Linda C Burkly, Sean Campbell, Noa Schwartz, Alberto Molano, Arpita Choudhury, Robert A Eisenberg, Jennifer S Michaelson, Chaim Putterma. TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 11. 2008-02-05. PMID:18025243. |
tnf-like weak inducer of apoptosis (tweak), a member of the tnf superfamily, is a prominent inducer of proinflammatory cytokines in vitro and in vivo. |
2008-02-05 |
2023-08-12 |
mouse |