| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Wada, K Hata, K Yamaguchi, K Shiozaki, K Koseki, S Moriya, T Miyag. A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells. Oncogene. vol 26. issue 17. 2007-05-31. PMID:17334392. |
ras activation by neu3 was abrogated by pp2 (src inhibitor) or ag1478 (epidermal growth factor receptor (egfr) inhibitor), and neu3 actually enhanced egf-stimulated tyrosine-phosphorylation of egfr, suggesting that the upstream targets might be tyrosine kinases including src and egfr, and the subsequent stimulation of ras cascade leads to the inhibition of cell apoptosis. |
2007-05-31 |
2023-08-12 |
human |
| Claudie Hooper, Jennifer M Pococ. Chromogranin A activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia. Neuroscience letters. vol 413. issue 3. 2007-04-24. PMID:17267111. |
in primary rat microglia, cga-mediated inducible nitric oxide (inos) expression, nitric oxide (no) production, mitochondrial depolarisation and apoptosis were inhibited by pp2 (src kinase inhibitor). |
2007-04-24 |
2023-08-12 |
rat |
| Audrey C Shor, Elizabeth A Keschman, Francis Y Lee, Carlos Muro-Cacho, G Douglas Letson, Jonathan C Trent, W Jack Pledger, Richard Jov. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. Cancer research. vol 67. issue 6. 2007-04-19. PMID:17363602. |
dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on src kinase for survival. |
2007-04-19 |
2023-08-12 |
human |
| Audrey C Shor, Elizabeth A Keschman, Francis Y Lee, Carlos Muro-Cacho, G Douglas Letson, Jonathan C Trent, W Jack Pledger, Richard Jov. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. Cancer research. vol 67. issue 6. 2007-04-19. PMID:17363602. |
inhibition of src protein expression by small interfering rna also induced apoptosis, indicating that these bone sarcoma cell lines are dependent on src activity for survival. |
2007-04-19 |
2023-08-12 |
human |
| Bharat B Aggarwal, Gautam Sethi, Kwang Seok Ahn, Santosh K Sandur, Manoj K Pandey, Ajaikumar B Kunnumakkara, Bokyung Sung, Haruyo Ichikaw. Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution. Annals of the New York Academy of Sciences. vol 1091. 2007-03-28. PMID:17341611. |
its role in cancer is indicated by numerous avenues of evidence, including the following: stat3 is constitutively active in tumor cells; stat3 is activated by growth factors (e.g., egf, tgf-alpha, il-6, hepatocyte growth factor) and oncogenic kinases (e.g., src); stat3 regulates the expression of genes that mediate proliferation (e.g., c-myc and cyclin d1), suppress apoptosis (e.g., bcl-x(l) and survivin), or promote angiogenesis (e.g, vegf); stat3 activation has been linked with chemoresistance and radioresistance; and chemopreventive agents have been shown to suppress stat3 activation. |
2007-03-28 |
2023-08-12 |
Not clear |
| J Guillermet-Guibert, N Saint-Laurent, L Davenne, P Rochaix, O Cuvillier, M D Culler, L Pradayrol, L Buscail, C Susini, C Bousque. Novel synergistic mechanism for sst2 somatostatin and TNFalpha receptors to induce apoptosis: crosstalk between NF-kappaB and JNK pathways. Cell death and differentiation. vol 14. issue 2. 2007-03-16. PMID:16645635. |
somatostatin receptor subtype 2 expression induced an executioner caspase-mediated apoptosis through a tyrosine phosphatase shp-1 (src homology domain phosphatase-1)-dependent stimulation of nuclear factor kappa b (nf-kappab) activity and subsequent inhibition of the mitogen-activated protein kinase jnk. |
2007-03-16 |
2023-08-12 |
Not clear |
| Lin Ping-Yuan, Liu Hung-Jen, Lai Meng-Jiun, Yu Feng-Ling, Hsu Hsue-Yin, Lee Jeng-Woei, Shih Wen-Lin. Avian reovirus activates a novel proapoptotic signal by linking Src to p53. Apoptosis : an international journal on programmed cell death. vol 11. issue 12. 2007-03-13. PMID:17051326. |
uv-inactivated virus failed to activate src, p53 or induce apoptosis. |
2007-03-13 |
2023-08-12 |
Not clear |
| Lin Ping-Yuan, Liu Hung-Jen, Lai Meng-Jiun, Yu Feng-Ling, Hsu Hsue-Yin, Lee Jeng-Woei, Shih Wen-Lin. Avian reovirus activates a novel proapoptotic signal by linking Src to p53. Apoptosis : an international journal on programmed cell death. vol 11. issue 12. 2007-03-13. PMID:17051326. |
inhibition of src by over-expression of c-terminal src kinase (csk) or treatment with src family tyrosine kinase inhibitor su-6656 diminished the arv s1133-induced p53 expression, activation, and apoptosis. |
2007-03-13 |
2023-08-12 |
Not clear |
| Marius Vantler, Michael Huntgeburth, Evren Caglayan, Henrik Ten Freyhaus, Petra Schnabel, Stephan Rosenkran. PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases. FEBS letters. vol 580. issue 30. 2007-01-30. PMID:17141222. |
this novel function of src in antiapoptotic signaling introduces src kinases as an interesting therapeutic target in apoptosis related diseases. |
2007-01-30 |
2023-08-12 |
Not clear |
| Aikaterini Anagnostopoulou, Adina Vultur, Rozanne Arulanandam, Jun Cao, James Turkson, Richard Jove, Joon S Kim, Matthew Glenn, Andrew D Hamilton, Leda Rapti. Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells. Cancer letters. vol 242. issue 1. 2006-12-08. PMID:16377083. |
the results demonstrate that stat3 downregulation in vsrc transformed nih3t3 cells or in breast cancer lines harboring activated src induces apoptosis, which is evident at all densities but is more pronounced at post-confluence. |
2006-12-08 |
2023-08-12 |
Not clear |
| Patrick Laplante, Marc-André Raymond, Andrée Labelle, Jun-Ichi Abe, Renato V Iozzo, Marie-Josée Héber. Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. The Journal of biological chemistry. vol 281. issue 41. 2006-11-27. PMID:16882656. |
these results suggest that extracellular matrix fragments produced by apoptotic ec initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/sfk (src and fyn)/phosphatidylinositol 3-kinase (pi3k)-dependent pathway. |
2006-11-27 |
2023-08-12 |
Not clear |
| Malcolm A Meyn, Matthew B Wilson, Fadi A Abdi, Nathalie Fahey, Anthony P Schiavone, Jiong Wu, James M Hochrein, John R Engen, Thomas E Smithgal. Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity. The Journal of biological chemistry. vol 281. issue 41. 2006-11-27. PMID:16912036. |
hck, lyn, and fyn) induces growth arrest and apoptosis in bcr-abl-transformed cells, suggesting that cell transformation by bcr-abl involves src family kinases (wilson, m. b., schreiner, s. j., choi, h. j., kamens, j., and smithgall, t. e. (2002) oncogene 21, 8075-8088). |
2006-11-27 |
2023-08-12 |
Not clear |
| Shibichakravarthy Kannan, Aaron Audet, Jessica Knittel, Saman Mullegama, George F Gao, Min W. Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells. European journal of immunology. vol 36. issue 7. 2006-09-11. PMID:16791881. |
lyn is an important b cell signaling kinase of the src tyrosine kinase family with a broad range of functions from cytoskeletal changes to induction of apoptosis. |
2006-09-11 |
2023-08-12 |
rat |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16669788. |
integrin beta3-mediated src activation regulates apoptosis in iec-6 cells via akt and stat3. |
2006-08-25 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16669788. |
arg-gly-asp-ser inhibited beta3, src and akt phosphorylation and sensitized polyamine-depleted cells to tumour necrosis factor alpha/cycloheximide-mediated apoptosis. |
2006-08-25 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Integrin beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3. The Biochemical journal. vol 397. issue 3. 2006-08-25. PMID:16669788. |
fibronectin activated src and subsequently protected cells from apoptosis. |
2006-08-25 |
2023-08-12 |
Not clear |
| Amy L Howes, Shigeki Miyamoto, John W Adams, Elizabeth A Woodcock, Joan Heller Brow. Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy. Journal of molecular and cellular cardiology. vol 40. issue 5. 2006-08-14. PMID:16466740. |
egfr activation appears to be required for galphaq-mediated protection since inhibition of src or egfr rendered cells susceptible to 2dog-induced apoptosis. |
2006-08-14 |
2023-08-12 |
rat |
| Sara Cabodi, Agata Tinnirello, Paola Di Stefano, Brigitte Bisarò, Elena Ambrosino, Isabella Castellano, Anna Sapino, Riccardo Arisio, Federica Cavallo, Guido Forni, Marina Glukhova, Lorenzo Silengo, Fiorella Altruda, Emilia Turco, Guido Tarone, Paola Defilipp. p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. Cancer research. vol 66. issue 9. 2006-07-05. PMID:16651418. |
these phenotypes are associated with activation of src kinase, extracellular signal-regulated kinase 1/2, mitogen-activated protein kinase, and akt pathways, leading to an increased rate of proliferation and a decreased apoptosis. |
2006-07-05 |
2023-08-12 |
mouse |
| Thomas Geeraerts, Kumaran Deiva, Ilana M'sika, Hassan Salim, Christiane Héry, Marc Tardie. Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16481105. |
sdf1alpha-induced apoptosis was completely abolished by the inhibition of src phosphorylation by pp2. |
2006-06-30 |
2023-08-12 |
human |
| Thomas Geeraerts, Kumaran Deiva, Ilana M'sika, Hassan Salim, Christiane Héry, Marc Tardie. Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16481105. |
by contrast, gp120(iiib)-induced apoptosis was not affected by the inhibition of src phosphorylation. |
2006-06-30 |
2023-08-12 |
human |