| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Schesser, A K Spiik, J M Dukuzumuremyi, M F Neurath, S Pettersson, H Wolf-Wat. The yopJ locus is required for Yersinia-mediated inhibition of NF-kappaB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity. Molecular microbiology. vol 28. issue 6. 1998-10-20. PMID:9680199. |
interestingly, the yopj protein contains a region that resembles a src homology domain 2 (sh2), and we show that a wild-type version of this motif is required for yopj activity in suppressing cytokine expression and inducing apoptosis. |
1998-10-20 |
2023-08-12 |
Not clear |
| A Sobko, A Peretz, B Attal. Constitutive activation of delayed-rectifier potassium channels by a src family tyrosine kinase in Schwann cells. The EMBO journal. vol 17. issue 16. 1998-10-07. PMID:9707431. |
in the nervous system, src family tyrosine kinases are thought to be involved in cell growth, migration, differentiation, apoptosis, as well as in myelination and synaptic plasticity. |
1998-10-07 |
2023-08-12 |
mouse |
| G Chen, J Shu, D W Stace. Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide. Oncogene. vol 15. issue 14. 1997-11-13. PMID:9349497. |
treatment with vp16 induced significantly increased apoptosis in nih3t3 cells transformed by oncogenic src, ras or raf, compared with the normal 3t3 cells. |
1997-11-13 |
2023-08-12 |
Not clear |
| G McGill, A Shimamura, R C Bates, R E Savage, D E Fishe. Loss of matrix adhesion triggers rapid transformation-selective apoptosis in fibroblasts. The Journal of cell biology. vol 138. issue 4. 1997-09-15. PMID:9265655. |
transformation with activated src rather than ras rendered fibroblasts selectively resistant to adhesion-dependent apoptosis, an effect likely related to src's role in integrin signaling, while simultaneously sensitizing the cells to radiation-induced apoptosis. |
1997-09-15 |
2023-08-12 |
Not clear |
| D M Farschon, C Couture, T Mustelin, D D Newmeye. Temporal phases in apoptosis defined by the actions of Src homology 2 domains, ceramide, Bcl-2, interleukin-1beta converting enzyme family proteases, and a dense membrane fraction. The Journal of cell biology. vol 137. issue 5. 1997-06-30. PMID:9166411. |
temporal phases in apoptosis defined by the actions of src homology 2 domains, ceramide, bcl-2, interleukin-1beta converting enzyme family proteases, and a dense membrane fraction. |
1997-06-30 |
2023-08-12 |
xenopus_laevis |
| D M Farschon, C Couture, T Mustelin, D D Newmeye. Temporal phases in apoptosis defined by the actions of Src homology 2 domains, ceramide, Bcl-2, interleukin-1beta converting enzyme family proteases, and a dense membrane fraction. The Journal of cell biology. vol 137. issue 5. 1997-06-30. PMID:9166411. |
we used this system to investigate the potential involvement in apoptosis of proteins containing src homology 2 (sh2) domains, which are known to interact with specific tyrosine-phosphorylated ligands. |
1997-06-30 |
2023-08-12 |
xenopus_laevis |
| D M Farschon, C Couture, T Mustelin, D D Newmeye. Temporal phases in apoptosis defined by the actions of Src homology 2 domains, ceramide, Bcl-2, interleukin-1beta converting enzyme family proteases, and a dense membrane fraction. The Journal of cell biology. vol 137. issue 5. 1997-06-30. PMID:9166411. |
sh2 domains from a number of signaling proteins, including lck, src, and abl, inhibited apoptosis when present at concentrations of 10-100 nm. |
1997-06-30 |
2023-08-12 |
xenopus_laevis |
| D M Farschon, C Couture, T Mustelin, D D Newmeye. Temporal phases in apoptosis defined by the actions of Src homology 2 domains, ceramide, Bcl-2, interleukin-1beta converting enzyme family proteases, and a dense membrane fraction. The Journal of cell biology. vol 137. issue 5. 1997-06-30. PMID:9166411. |
a synthetic peptide ligand for src family sh2 domains also inhibited apoptosis in a phosphotyrosine-dependent manner. |
1997-06-30 |
2023-08-12 |
xenopus_laevis |
| L Liu, J E Damen, M R Hughes, I Babic, F R Jirik, G Krysta. The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis. The Journal of biological chemistry. vol 272. issue 14. 1997-05-08. PMID:9083021. |
the src homology 2 (sh2) domain of sh2-containing inositol phosphatase (ship) is essential for tyrosine phosphorylation of ship, its association with shc, and its induction of apoptosis. |
1997-05-08 |
2023-08-12 |
Not clear |
| S G Kennedy, A J Wagner, S D Conzen, J Jordán, A Bellacosa, P N Tsichlis, N Ha. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes & development. vol 11. issue 6. 1997-05-02. PMID:9087425. |
we studied five downstream effectors of growth factor receptors--ras, raf, src, phosphoinositide 3-kinase (pi 3-kinase), and akt (pkb)--for their abilities to block apoptosis. |
1997-05-02 |
2023-08-12 |
Not clear |
| T Karlsson, M Wels. Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb. Oncogene. vol 13. issue 5. 1996-11-05. PMID:8806685. |
apoptosis of nih3t3 cells overexpressing the src homology 2 domain protein shb. |
1996-11-05 |
2023-08-12 |
Not clear |
| J Corbeil, M Tremblay, D D Richma. HIV-induced apoptosis requires the CD4 receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck. The Journal of experimental medicine. vol 183. issue 1. 1996-02-22. PMID:8551242. |
the roles of the cd4 receptor and the src kinase p56lck were examined in the process of hiv-induced apoptosis of cd4+ t lymphocytes. |
1996-02-22 |
2023-08-12 |
Not clear |
| A Basu, J S Clin. Oncogenic transformation alters cisplatin-induced apoptosis in rat embryo fibroblasts. International journal of cancer. vol 63. issue 4. 1995-12-28. PMID:7591272. |
over-expression of myc, but not ras, src or mos, induced apoptosis in r6 cells. |
1995-12-28 |
2023-08-12 |
mouse |
| M Takata, Y Homma, T Kurosak. Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis. The Journal of experimental medicine. vol 182. issue 4. 1995-11-20. PMID:7561693. |
src homology 2 domains of plc-gamma 2 were essential for both its activation and sigm-induced apoptosis. |
1995-11-20 |
2023-08-12 |
Not clear |
| B Schraven, M E Pete. APO-1(CD95)-mediated apoptosis in Jurkat cells does not involve src kinases or CD45. FEBS letters. vol 368. issue 3. 1995-09-08. PMID:7543423. |
apo-1(cd95)-mediated apoptosis in jurkat cells does not involve src kinases or cd45. |
1995-09-08 |
2023-08-12 |
Not clear |
| B Schraven, M E Pete. APO-1(CD95)-mediated apoptosis in Jurkat cells does not involve src kinases or CD45. FEBS letters. vol 368. issue 3. 1995-09-08. PMID:7543423. |
furthermore, herbimycin a did not inhibit but rather augmented apoptosis at concentrations which effectively degraded the src related kinases lck and fyn. |
1995-09-08 |
2023-08-12 |
Not clear |
| K G Waddick, H P Chae, L Tuel-Ahlgren, L J Jarvis, I Dibirdik, D E Myers, F M Ucku. Engagement of the CD19 receptor on human B-lineage leukemia cells activates LCK tyrosine kinase and facilitates radiation-induced apoptosis. Radiation research. vol 136. issue 3. 1994-02-10. PMID:7506428. |
this common biochemical signaling pathway involves the rapid activation of the src family tyrosine kinase lck (p56lck), which is physically associated with the cd19 receptor, and enhanced tyrosine phosphorylation of multiple substrates leading to stimulation of phosphoinositide turnover, and activation of protein kinase c. importantly, engagement of the cd19 receptor promoted radiation-induced apoptosis in radiation-resistant b-lineage all cells in a cell type-specific fashion. |
1994-02-10 |
2023-08-12 |
human |