| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H C Hsu, L D Shultz, X Su, J Shi, P A Yang, M J Relyea, H G Zhang, J D Mount. Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice. Journal of immunology (Baltimore, Md. : 1950). vol 166. issue 2. 2001-03-08. PMID:11145649. |
mutation of the hematopoietic cell phosphatase (hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in src homology protein tyrosine phosphatase (shp)-1-deficient "motheaten" mutant mice. |
2001-03-08 |
2023-08-12 |
mouse |
| J Rak, J L Yu, G Klement, R S Kerbe. Oncogenes and angiogenesis: signaling three-dimensional tumor growth. The journal of investigative dermatology. Symposium proceedings. vol 5. issue 1. 2001-03-08. PMID:11147671. |
activated oncogenes (e.g., ras, src, her-2) induce co-expression of angiogenic properties concomitantly with several highly selectable traits (increased mitogenesis, resistance to apoptosis), a circumstance that may accelerate selection of the angiogenic phenotype at the cell population level. |
2001-03-08 |
2023-08-12 |
Not clear |
| J J Smith, E K Evans, M Murakami, M B Moyer, M A Moseley, G Vande Woude, S Kornblut. Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. The Journal of cell biology. vol 151. issue 7. 2001-02-08. PMID:11134069. |
moreover, we demonstrated that removal of crk src homology (sh)2 or sh3 interactors from the extracts prevented apoptosis. |
2001-02-08 |
2023-08-12 |
xenopus_laevis |
| J N Lavoie, C Champagne, M C Gingras, A Rober. Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases. The Journal of cell biology. vol 150. issue 5. 2000-10-10. PMID:10973994. |
adenovirus e4 open reading frame 4-induced apoptosis involves dysregulation of src family kinases. |
2000-10-10 |
2023-08-12 |
Not clear |
| J N Lavoie, C Champagne, M C Gingras, A Rober. Adenovirus E4 open reading frame 4-induced apoptosis involves dysregulation of Src family kinases. The Journal of cell biology. vol 150. issue 5. 2000-10-10. PMID:10973994. |
taken together, these observations indicate that expression of adenovirus 2 e4orf4 can initiate caspase-independent extranuclear manifestations of apoptosis through a modulation of src family kinases and that these are involved in signaling e4orf4-dependent apoptosis. |
2000-10-10 |
2023-08-12 |
Not clear |
| M R Burnham, P J Bruce-Staskal, M T Harte, C L Weidow, A Ma, S A Weed, A H Bouto. Regulation of c-SRC activity and function by the adapter protein CAS. Molecular and cellular biology. vol 20. issue 16. 2000-08-28. PMID:10913170. |
src family kinases play essential roles in a variety of cellular functions, including proliferation, survival, differentiation, and apoptosis. |
2000-08-28 |
2023-08-12 |
Not clear |
| R Karni, A Levitzk. pp60(cSrc) is a caspase-3 substrate and Is essential for the transformed phenotype of A431 cells. Molecular cell biology research communications : MCBRC. vol 3. issue 2. 2000-08-15. PMID:10775506. |
(ii) the src kinase inhibitor pp1 sensitizes a431 cells to cddp-induced apoptosis. |
2000-08-15 |
2023-08-12 |
Not clear |
| M Raghunath, R Patti, P Bannerman, C M Lee, S Baker, L N Sutton, P C Phillips, C Damodar Redd. A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. Brain research. Molecular brain research. vol 77. issue 2. 2000-08-11. PMID:10837911. |
apoptosis associated tyrosine kinase (aatyk), a novel protein recently isolated from differentiating 32d mouse myeloid cells, contains a putative tyrosine kinase domain and several binding motifs for src homology 2 (sh-2) and src homology 3 (sh-3) domain containing proteins. |
2000-08-11 |
2023-08-12 |
mouse |
| J Hanusch, A Schwieger, C Sers, R Schäfer, G Baue. Oncogenic transformation increases the sensitivity for apoptosis induction by inhibitors of macromolecular synthesis. International journal of oncology. vol 17. issue 1. 2000-07-24. PMID:10853023. |
transformation of rat fibroblasts by a constitutively expressed src oncogene or an inducible ras oncogene increases the sensitivity for apoptosis induction by inhibitors of macromolecular synthesis, indicating that their endogenous survival factor pool has been decreased. |
2000-07-24 |
2023-08-12 |
rat |
| J Dixelius, H Larsson, T Sasaki, K Holmqvist, L Lu, A Engström, R Timpl, M Welsh, L Claesson-Wels. Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis. Blood. vol 95. issue 11. 2000-06-29. PMID:10828022. |
induction of apoptosis was dependent on the heparin-binding ability of endostatin and the expression of shb with a functional src homology 2 (sh2)-domain. |
2000-06-29 |
2023-08-12 |
mouse |
| D Liu, G Martino, M Thangaraju, M Sharma, F Halwani, S H Shen, Y C Patel, C B Srikan. Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis. The Journal of biological chemistry. vol 275. issue 13. 2000-05-04. PMID:10734062. |
we have shown that somatostatin (sst), acting via the src homology 2 bearing tyrosine phosphatase shp-1, exerts cytotoxic action in mcf-7 cells, and triggers cell acidification and apoptosis. |
2000-05-04 |
2023-08-12 |
Not clear |
| W Wang, R N Wine, R E Chapi. Rat testicular Src: normal distribution and involvement in ethylene glycol monomethyl ether-induced apoptosis. Toxicology and applied pharmacology. vol 163. issue 2. 2000-04-07. PMID:10698670. |
rat testicular src: normal distribution and involvement in ethylene glycol monomethyl ether-induced apoptosis. |
2000-04-07 |
2023-08-12 |
rat |
| B P Eliceiri, R Paul, P L Schwartzberg, J D Hood, J Leng, D A Cheres. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Molecular cell. vol 4. issue 6. 2000-01-31. PMID:10635317. |
src kinase activity was found to protect endothelial cells from apoptosis during vascular endothelial growth factor (vegf)-, but not basic fibroblast growth factor (bfgf)-, mediated angiogenesis in chick embryos and mice. |
2000-01-31 |
2023-08-12 |
mouse |
| A Maruo, I Oishi, K Sada, M Nomi, T Kurosaki, Y Minami, H Yamamur. Protein tyrosine kinase Lyn mediates apoptosis induced by topoisomerase II inhibitors in DT40 cells. International immunology. vol 11. issue 9. 1999-12-07. PMID:10464158. |
ectopic expression of fyn, another src family member, in dt40/lyn(-) cells restores largely the susceptibility of the cells against topo ii inhibitor-induced apoptosis. |
1999-12-07 |
2023-08-12 |
chicken |
| J Zhang, A K Somani, S Watt, G B Mills, K A Siminovitc. The Src-homology domain 2-bearing protein tyrosine phosphatase-1 inhibits antigen receptor-induced apoptosis of activated peripheral T cells. Journal of immunology (Baltimore, Md. : 1950). vol 162. issue 11. 1999-06-16. PMID:10352248. |
in view of the role for the src homology domain 2-bearing protein tyrosine phosphatase-1 (shp-1) in modulating tcr signaling, we investigated the influence of shp-1 on tcr-mediated apoptosis by assaying the sensitivity of peripheral t cells from shp-1-deficient viable motheaten (mev) mice to cell death following tcr restimulation. |
1999-06-16 |
2023-08-12 |
mouse |
| A M Brunati, A Donella-Deana, P James, M Quadroni, A Contri, O Marin, L A Pinn. Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. The Journal of biological chemistry. vol 274. issue 11. 1999-04-13. PMID:10066823. |
the hematopoietic lineage cell-specific protein hs1 was shown to undergo a process of sequential phosphorylation both in vitro and in vivo, which is synergistically mediated by syk and src family protein-tyrosine kinases and essential for b cell antigen receptor-mediated apoptosis. |
1999-04-13 |
2023-08-12 |
Not clear |
| A Vassilev, Z Ozer, C Navara, S Mahajan, F M Ucku. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. The Journal of biological chemistry. vol 274. issue 3. 1999-02-11. PMID:9880544. |
the src homology 2, pleckstrin homology (ph), and kinase domains of btk are all individually important and apparently indispensable, but not sufficient, for its function as a negative regulator of fas-mediated apoptosis. |
1999-02-11 |
2023-08-12 |
human |
| A Vassilev, Z Ozer, C Navara, S Mahajan, F M Ucku. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex. The Journal of biological chemistry. vol 274. issue 3. 1999-02-11. PMID:9880544. |
introduction of an src homology 2 domain, a ph domain, or a kinase domain mutant human btk gene into btk-deficient cells did not restore the resistance to fas-mediated apoptosis. |
1999-02-11 |
2023-08-12 |
human |
| I Timokhina, H Kissel, G Stella, P Besme. Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation. The EMBO journal. vol 17. issue 21. 1999-01-11. PMID:9799234. |
we have investigated the role of phosphatidylinositol 3'-kinase (pi 3-kinase) and src kinases in kit-mediated cell proliferation and suppression of apoptosis induced both by factor deprivation and irradiation in bone marrow-derived mast cells (bmmc). |
1999-01-11 |
2023-08-12 |
Not clear |
| G W Krystal, C S DeBerry, D Linnekin, J Lit. Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1. Cancer research. vol 58. issue 20. 1998-11-06. PMID:9788619. |
these data demonstrate that, in the h526 sclc cell line, lck and, possibly, yes are downstream of kit in a signal transduction pathway; the inhibition by pp1 of scf-mediated proliferation and inhibition of apoptosis suggests that src family kinases are intermediates in the signaling pathways that regulate these processes. |
1998-11-06 |
2023-08-12 |
Not clear |