| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick Laprise, Eve-Marie Poirier, Anne Vézina, Nathalie Rivard, Pierre H Vacho. Merosin-integrin promotion of skeletal myofiber cell survival: Differentiation state-distinct involvement of p60Fyn tyrosine kinase and p38alpha stress-activated MAP kinase. Journal of cellular physiology. vol 191. issue 1. 2002-04-15. PMID:11920683. |
herein, we report that: 1) of four members of the src family of tyrosine kinases studied (p60src, p53/56lyn, p59yes, or p60fyn), the expression and activity of p60fyn are found in myotubes exclusively; 2) a severe decrease of p60fyn activity correlates with myotube apoptosis/anoikis induced by pharmocological compounds (herbimycin a or pp2) which inhibit tyrosine kinases of the src family, by merosin deficiency and by beta1 integrin inhibition; 3) myoblast survival depends on fak and the mek/erk pathway, in contrast to myotubes; 4) the pi3-k pathway is not involved in either myoblast or myotube survival; and 5) p38alpha sapk stimulation and activity (but not that of p38beta) are required in the progression of myotube apoptosis/anoikis induced by p60fyn inhibition, merosin deficiency or beta1 integrin-inhibition; however, p38 is not involved in myoblast apoptosis. |
2002-04-15 |
2023-08-12 |
Not clear |
| V Boudny, S Nakan. Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2. British journal of cancer. vol 86. issue 3. 2002-04-05. PMID:11875716. |
src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of bcl-2. |
2002-04-05 |
2023-08-12 |
human |
| V Boudny, S Nakan. Src tyrosine kinase augments taxotere-induced apoptosis through enhanced expression and phosphorylation of Bcl-2. British journal of cancer. vol 86. issue 3. 2002-04-05. PMID:11875716. |
treatment of hag/src3-1 cells with herbimycin a significantly reduced the expression and phosphorylation of bcl-2, and abrogated taxotere-induced apoptosis, suggesting a potential role for src protein tyrosine kinase in the taxotere-induced apoptotic events. |
2002-04-05 |
2023-08-12 |
human |
| Leiming Li, Masaya Okura, Akira Imamot. Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion. Molecular and cellular biology. vol 22. issue 4. 2002-03-01. PMID:11809811. |
it is therefore likely that the primary cause of cell rounding and detachment induced by fa-csk involves dysfunction of fas rather than caspase-mediated apoptosis that may result from possible loss of survival signals mediated by src family kinases. |
2002-03-01 |
2023-08-12 |
Not clear |
| Kathryn Mercer, Antonio Chiloeches, Martin Hüser, Michelle Kiernan, Richard Marais, Catrin Pritchar. ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821947. |
to investigate the specific role of a-raf in this process we generated a-raf deficient mouse embryonic fibroblasts (mefs) and embryonic stem (es) cells by gene targeting and characterized their ability to undergo proliferation, differentiation, apoptosis, erk activation, and transformation by oncogenic ras and src. |
2002-02-14 |
2023-08-12 |
mouse |
| J Ohanian, V Ohania. Sphingolipids in mammalian cell signalling. Cellular and molecular life sciences : CMLS. vol 58. issue 14. 2002-01-31. PMID:11814056. |
many signalling molecules, for example src family tyrosine kinases and glycosylinositolphosphate-anchored proteins, are associated with rafts, and disruption of these domains affects cellular responses such as apoptosis. |
2002-01-31 |
2023-08-12 |
Not clear |
| K Lamberth, M H Claesso. Ligation of major histocompatibility complex class I antigens (MHC-I) prevents apoptosis induced by Fas or SAPK/JNK activation in T-lymphoma cells. Tissue antigens. vol 58. issue 3. 2002-01-25. PMID:11703825. |
studies on three different jurkat cell mutants deficient for src p56(lck), zap-70 kinase, or tcr/cd3 gamma-chain showed that the cells undergo apoptosis after fas ligation. |
2002-01-25 |
2023-08-12 |
Not clear |
| K Lamberth, M H Claesso. Ligation of major histocompatibility complex class I antigens (MHC-I) prevents apoptosis induced by Fas or SAPK/JNK activation in T-lymphoma cells. Tissue antigens. vol 58. issue 3. 2002-01-25. PMID:11703825. |
anisomycin exposure induced apoptosis in the src p56(lck)-deficient cell line but not in the two other mutant cell lines. |
2002-01-25 |
2023-08-12 |
Not clear |
| K Lamberth, M H Claesso. Ligation of major histocompatibility complex class I antigens (MHC-I) prevents apoptosis induced by Fas or SAPK/JNK activation in T-lymphoma cells. Tissue antigens. vol 58. issue 3. 2002-01-25. PMID:11703825. |
simultaneous cross-linking of mhc-i and fas ligation inhibited apoptosis in the zap-70 kinase and the tcr/cd3 gamma-chain mutants, but did not protect the src p56(lck)-deficient cells. |
2002-01-25 |
2023-08-12 |
Not clear |
| K Lamberth, M H Claesso. Ligation of major histocompatibility complex class I antigens (MHC-I) prevents apoptosis induced by Fas or SAPK/JNK activation in T-lymphoma cells. Tissue antigens. vol 58. issue 3. 2002-01-25. PMID:11703825. |
similarly, mhc-i ligation did not protect anisomycin-treated src p56(lck)-deficient cells against apoptosis. |
2002-01-25 |
2023-08-12 |
Not clear |
| K Lamberth, M H Claesso. Ligation of major histocompatibility complex class I antigens (MHC-I) prevents apoptosis induced by Fas or SAPK/JNK activation in T-lymphoma cells. Tissue antigens. vol 58. issue 3. 2002-01-25. PMID:11703825. |
these data suggest that mhc-i-induced inhibition of apoptosis depends on intact src p56(lck) activity, but not on major secondary messenger molecules associated with tcr signaling. |
2002-01-25 |
2023-08-12 |
Not clear |
| Y R Chen, R Kori, B John, T H Ta. Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis. Biochemical and biophysical research communications. vol 288. issue 4. 2001-12-18. PMID:11689006. |
we found that actin-binding and src homology 3 (sh3)-domain-containing proteins cortactin, hematopoietic-specific protein 1 (hs1), and hematopoietic progenitor kinase 1-interacting protein of 55 kda (hip-55, also called sh3p7 and abp1) were degraded in a caspase-dependent manner during apoptosis. |
2001-12-18 |
2023-08-12 |
Not clear |
| A V Grishin, O Azhipa, I Semenov, S J Core. Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 18. 2001-10-04. PMID:11517336. |
interaction between growth arrest-dna damage protein 34 and src kinase lyn negatively regulates genotoxic apoptosis. |
2001-10-04 |
2023-08-12 |
Not clear |
| M Chiariello, M J Marinissen, J S Gutkin. Regulation of c-myc expression by PDGF through Rho GTPases. Nature cell biology. vol 3. issue 6. 2001-09-20. PMID:11389443. |
src family protein-tyrosine kinases have a central role in several biological functions, including cell adhesion and spreading, chemotaxis, cell cycle progression, differentiation and apoptosis. |
2001-09-20 |
2023-08-12 |
Not clear |
| H H Sedlace. Mechanisms of action of flavopiridol. Critical reviews in oncology/hematology. vol 38. issue 2. 2001-09-13. PMID:11311660. |
however, no in situ data from flavopiridol treated cells have been published yet that prove that by inhibition of egfr, pp60 src, pkc and/or erk-1 (in addition to inhibition of cdk's) flavopiridol is able to induce apoptosis. |
2001-09-13 |
2023-08-12 |
Not clear |
| F Luciano, J E Ricci, P Auberge. Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation. Oncogene. vol 20. issue 36. 2001-09-13. PMID:11526478. |
cleavage of fyn and lyn in their n-terminal unique regions during induction of apoptosis: a new mechanism for src kinase regulation. |
2001-09-13 |
2023-08-12 |
human |
| F Luciano, J E Ricci, P Auberge. Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation. Oncogene. vol 20. issue 36. 2001-09-13. PMID:11526478. |
in the present study, we have undertaken experiments to test whether src kinase cleavage and relocation is a general mechanism during induction of apoptosis. |
2001-09-13 |
2023-08-12 |
human |
| F Luciano, J E Ricci, P Auberge. Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation. Oncogene. vol 20. issue 36. 2001-09-13. PMID:11526478. |
thus, cleavage of fyn and lyn during induction of apoptosis represents a new mechanism for the regulation of src kinases that may have important functional and physiological consequences. |
2001-09-13 |
2023-08-12 |
human |
| A P Belsches-Jablonski, J S Biscardi, D R Peavy, D A Tice, D A Romney, S J Parson. Src family kinases and HER2 interactions in human breast cancer cell growth and survival. Oncogene. vol 20. issue 12. 2001-05-10. PMID:11313890. |
pp1, a src family kinase inhibitor, reduced or ablated hrg-dependent and independent soft agar growth or anchorage dependent growth, and triggered apoptosis in all cell lines tested. |
2001-05-10 |
2023-08-12 |
human |
| L Xing, A M Venegas, A Chen, L Garrett-Beal, B F Boyce, H E Varmus, P L Schwartzber. Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes & development. vol 15. issue 2. 2001-03-15. PMID:11157779. |
we demonstrate that expression of a truncated src molecule, src251, lacking the kinase domain, induces osteopetrosis in wild-type and src(+/-) mice and worsens osteopetrosis in src(-/-) mice by a novel mechanism, increased osteoclast apoptosis. |
2001-03-15 |
2023-08-12 |
mouse |