| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paola Signorelli, Riccardo Ghidon. Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. The Journal of nutritional biochemistry. vol 16. issue 8. 2005-09-22. PMID:16043028. |
part of these events is mediated by mitogen-activated protein kinases (mapks) and tyrosine kinases (e.g., src) and leads to the modulation of survival and apoptotic factors [e.g., bcl2 family members, inhibitors of apoptosis (iaps), ceramide] as well as enzymes involved in carcinogenesis [cyclooxygenases (coxs), nitric oxide synthase (nos), phase i and ii enzymes]. |
2005-09-22 |
2023-08-12 |
Not clear |
| Yuko Yonezawa, Yoji Nagashima, Hiromi Sato, Nantiga Virgona, Keiko Fukumoto, Sumiko Shirai, Hiromi Hagiwara, Taiichiro Seki, Toyohiko Ariga, Hironobu Senba, Kazuyuki Suzuki, Ryuji Asano, Kiyokazu Hagiwara, Tomohiro Yan. Contribution of the Src family of kinases to the appearance of malignant phenotypes in renal cancer cells. Molecular carcinogenesis. vol 43. issue 4. 2005-09-09. PMID:15864803. |
these results suggested that src contributed to the appearance of malignant phenotypes in renal cancer cells, particularly due to the resistance against apoptosis by bcl-xl and angiogenesis stimulated by src-stat3-vegf signaling. |
2005-09-09 |
2023-08-12 |
human |
| Roland Reinehr, Stephan Becker, Andrea Eberle, Susanne Grether-Beck, Dieter Häussinge. Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. The Journal of biological chemistry. vol 280. issue 29. 2005-09-09. PMID:15917250. |
involvement of nadph oxidase isoforms and src family kinases in cd95-dependent hepatocyte apoptosis. |
2005-09-09 |
2023-08-12 |
rat |
| Xue Qing Wang, Shan Ping Y. Novel regulation of Na, K-ATPase by Src tyrosine kinases in cortical neurons. Journal of neurochemistry. vol 93. issue 6. 2005-08-02. PMID:15935067. |
these data suggest that the na+, k+-atpase activity in central neurons is regulated by specific src tyrosine kinases via a protein-protein mechanism and may play a role in apoptosis. |
2005-08-02 |
2023-08-12 |
Not clear |
| Anton Vichalkovski, Kurt Baltensperger, Daniel Thomann, Hartmut Porzi. Two different pathways link G-protein-coupled receptors with tyrosine kinases for the modulation of growth and survival in human hematopoietic progenitor cells. Cellular signalling. vol 17. issue 4. 2005-07-15. PMID:15601623. |
by contrast, in erythroid cells, inhibitors of src family and c-abl tyrosine kinases (tyrphostin ag 82, pp2, imatinib) enhanced protein kinase c (pkc)-dependent cell growth and antagonized thrombin-promoted apoptosis by specifically stimulating pkcbeta activity. |
2005-07-15 |
2023-08-12 |
human |
| Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola, Saïd M Sebt. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. vol 24. issue 20. 2005-05-31. PMID:15735720. |
cuc q inhibits selectively the activation of stat3 and induces apoptosis without inhibition of jak2, src, akt, erk, or jnk activation. |
2005-05-31 |
2023-08-12 |
mouse |
| Paul A Bromann, Hasan Korkaya, Craig P Webb, Jeremy Miller, Tammy L Calvin, Sara A Courtneidg. Platelet-derived growth factor stimulates Src-dependent mRNA stabilization of specific early genes in fibroblasts. The Journal of biological chemistry. vol 280. issue 11. 2005-04-25. PMID:15637050. |
the src family of protein-tyrosine kinases (sfks) participates in a variety of signal transduction pathways, including promotion of cell growth, prevention of apoptosis, and regulation of cell interactions and motility. |
2005-04-25 |
2023-08-12 |
Not clear |
| G Dupéré-Minier, C Hamelin, P Desharnais, J Bernie. Apoptotic volume decrease, pH acidification and chloride channel activation during apoptosis requires CD45 expression in HPB-ALL T cells. Apoptosis : an international journal on programmed cell death. vol 9. issue 5. 2005-04-12. PMID:15314282. |
our hypothesis is that the absence of cd45 disturbs protein function regulated by a proto-oncogene of the src family playing a significant role in nuclear apoptosis. |
2005-04-12 |
2023-08-12 |
Not clear |
| Tadashi Narita, Tadahiro Nishimura, Kazuyuki Yoshizaki, Tadayoshi Taniyam. CIN85 associates with TNF receptor 1 via Src and modulates TNF-alpha-induced apoptosis. Experimental cell research. vol 304. issue 1. 2005-04-04. PMID:15707590. |
cin85 associates with tnf receptor 1 via src and modulates tnf-alpha-induced apoptosis. |
2005-04-04 |
2023-08-12 |
human |
| Tadashi Narita, Tadahiro Nishimura, Kazuyuki Yoshizaki, Tadayoshi Taniyam. CIN85 associates with TNF receptor 1 via Src and modulates TNF-alpha-induced apoptosis. Experimental cell research. vol 304. issue 1. 2005-04-04. PMID:15707590. |
taken together, these results indicate that cin85 associates with tnfr1 via src and modulates tnf-alpha-induced apoptosis. |
2005-04-04 |
2023-08-12 |
human |
| Brantley R Herrin, Alison L Groeger, Louis B Justemen. The adaptor protein HSH2 attenuates apoptosis in response to ligation of the B cell antigen receptor complex on the B lymphoma cell line, WEHI-231. The Journal of biological chemistry. vol 280. issue 5. 2005-03-22. PMID:15569688. |
expression of the adaptor protein hematopoietic src homology 2 (hsh2) was found to significantly decrease bcr-mediated apoptosis in the murine wehi-231 cell line. |
2005-03-22 |
2023-08-12 |
Not clear |
| Bronislaw L Slomiany, Amalia Slomian. Role of epidermal growth factor receptor transactivation in PPAR gamma-dependent suppression of Helicobacter pylori interference with gastric mucin synthesis. Inflammopharmacology. vol 12. issue 2. 2005-02-17. PMID:15265318. |
moreover, the inhibitory effect of ciglitazone on the lps-induced reduction in mucin synthesis and upregulation in apoptosis, caspase-3 activity and no generation was countered by pp2, a selective inhibitor of tyrosine kinase src responsible for ligand-independent egfr transactivation. |
2005-02-17 |
2023-08-12 |
Not clear |
| Jaime Melendez, Christopher Turner, Hava Avraham, Susan F Steinberg, Erik Schaefer, Mark A Sussma. Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. The Journal of biological chemistry. vol 279. issue 51. 2005-02-04. PMID:15322113. |
cardiomyocyte apoptosis triggered by raftk/pyk2 via src kinase is antagonized by paxillin. |
2005-02-04 |
2023-08-12 |
rat |
| Jaime Melendez, Christopher Turner, Hava Avraham, Susan F Steinberg, Erik Schaefer, Mark A Sussma. Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. The Journal of biological chemistry. vol 279. issue 51. 2005-02-04. PMID:15322113. |
multiple apoptotic signaling cascades are recruited by raftk as demonstrated by prevention of apoptosis using caspase-3 inhibitor iv (caspase-3 specific inhibitor), pp2 (src-specific kinase inhibitor), or csk (cellular negative regulator for src), as well as dominant negative constructs for p38beta or mkp-1. |
2005-02-04 |
2023-08-12 |
rat |
| Wenlin Deng, Helen Poppleton, Satoshi Yasuda, Natalia Makarova, Yoriko Shinozuka, De-An Wang, Leonard R Johnson, Tarun B Patel, Gabor Tigy. Optimal lysophosphatidic acid-induced DNA synthesis and cell migration but not survival require intact autophosphorylation sites of the epidermal growth factor receptor. The Journal of biological chemistry. vol 279. issue 46. 2005-01-21. PMID:15364923. |
lpa equally protected b82l cells, or transfectants expressing egfr, the kinase dead egfr(k721a), egfr(y5f) receptor mutant, which lacks five autophosphorylation sites, or egfr(y845f), which lacks the src phosphorylation site from tumor necrosis factor-alpha-induced apoptosis. |
2005-01-21 |
2023-08-12 |
Not clear |
| Bronislaw L Slomiany, Amalia Slomian. Src kinase-dependent epidermal growth factor receptor transactivation in PPARgamma ligand-induced suppression of Porphyromonas gingivalis interference with salivary mucin synthesis. IUBMB life. vol 56. issue 3. 2005-01-11. PMID:15185749. |
moreover, the inhibitory effect of ciglitazone on the lps-induced reduction in mucin synthesis and upregulation in apoptosis, caspase-3 activity, and no generation was blunted by a selective inhibitor of tyrosine kinase src, pp2, responsible for ligand-independent egfr transactivation. |
2005-01-11 |
2023-08-12 |
human |
| Martin P Playford, Michael D Schalle. The interplay between Src and integrins in normal and tumor biology. Oncogene. vol 23. issue 48. 2004-12-28. PMID:15489911. |
we will identify the key players in the integrin-mediated signaling pathways involved in cell motility and apoptosis, such as fak, paxillin and p130(cas), and discuss how src signaling affects the formation of focal adhesions and the extracellular matrix. |
2004-12-28 |
2023-08-12 |
human |
| Roland Reinehr, Stephan Becker, Matthias Wettstein, Dieter Häussinge. Involvement of the Src family kinase yes in bile salt-induced apoptosis. Gastroenterology. vol 127. issue 5. 2004-12-03. PMID:15521021. |
involvement of the src family kinase yes in bile salt-induced apoptosis. |
2004-12-03 |
2023-08-12 |
Not clear |
| Gareth J Griffiths, Mei Yee Koh, Valerie G Brunton, Christopher Cawthorne, Natalie A Reeves, Martin Greaves, Michael J Tilby, D Graham Pearson, Christopher J Ottley, Paul Workman, Margaret C Frame, Caroline Div. Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis. The Journal of biological chemistry. vol 279. issue 44. 2004-11-30. PMID:15326164. |
the data suggest that longer term suppression of src kinase activity may be required to lower bcl-x(l) levels and sensitize colon cancer cells to oxaliplatin-induced apoptosis. |
2004-11-30 |
2023-08-12 |
human |
| Megan S Lim, Kojo S J Elenitoba-Johnso. Ubiquitin ligases in malignant lymphoma. Leukemia & lymphoma. vol 45. issue 7. 2004-11-01. PMID:15359630. |
identification and characterization of their substrates indicate that they regulate the turnover of key cell cycle proteins (p27kip1, p21cip1, p57kip2, cyclin e), tumor suppressor proteins (p53, rb), signaling kinases (src, zap70, pi-3 kinase), apoptosis regulators (bcl-2, bax, bik) and transcription factors (myc, nf-kappab, e1f1), all of which have been implicated in the pathogenesis of malignant lymphoma. |
2004-11-01 |
2023-08-12 |
Not clear |