| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vita M Golubovskaya, Christopher Virnig, William G Canc. TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Molecular carcinogenesis. vol 47. issue 3. 2008-03-17. PMID:17849451. |
we have shown previously that the dominant-negative fak, c-terminal fak-cd, caused detachment and apoptosis in human breast cancer cells, and that overexpression of an activated form of src tyrosine kinase or epidermal growth factor receptor, egfr, suppressed fak-cd induced apoptotic effects in breast cancer cells. |
2008-03-17 |
2023-08-12 |
human |
| Vita M Golubovskaya, Christopher Virnig, William G Canc. TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Molecular carcinogenesis. vol 47. issue 3. 2008-03-17. PMID:17849451. |
the tae226 drug caused a dose-dependent increase of detachment and apoptosis in both bt474 and mcf-7-vector and src cells and in bt474-egfr and bt474-pcdna3 cells. |
2008-03-17 |
2023-08-12 |
human |
| Chiung-Ho Liao, Shengmin Sang, Chi-Tang Ho, Jen-Kun Li. Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. Journal of cellular biochemistry. vol 96. issue 1. 2008-02-01. PMID:16052481. |
garcinol modulates tyrosine phosphorylation of fak and subsequently induces apoptosis through down-regulation of src, erk, and akt survival signaling in human colon cancer cells. |
2008-02-01 |
2023-08-12 |
human |
| Silvia Schenone, Fabrizio Manetti, Maurizio Bott. Synthetic SRC-kinase domain inhibitors and their structural requirements. Anti-cancer agents in medicinal chemistry. vol 7. issue 6. 2008-01-03. PMID:18045061. |
in particular, src and src-family are non-receptor tyrosine kinases that regulate cell growth, differentiation, migration, adhesion and apoptosis. |
2008-01-03 |
2023-08-12 |
human |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells. Cellular signalling. vol 19. issue 12. 2007-12-20. PMID:17825525. |
in addition, inhibition of integrin beta3 activity (with rgds), src activity (with pp2), or egfr kinase activity (with ag1478), increased basal apoptosis and prevented protection conferred by either dfmo or egf. |
2007-12-20 |
2023-08-12 |
Not clear |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells. Cellular signalling. vol 19. issue 12. 2007-12-20. PMID:17825525. |
fibronectin activated the egfr, src, erks and protected cells from apoptosis. |
2007-12-20 |
2023-08-12 |
Not clear |
| Ivan Ischenko, Markus Guba, Maksim Yezhelyev, Armine Papyan, Gerald Schmid, Tim Green, Michael Fennell, Karl-Walter Jauch, Christiane J Brun. Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer. Angiogenesis. vol 10. issue 3. 2007-11-30. PMID:17486419. |
inhibition of src kinase promoted huvec apoptosis in a dose-dependent manner. |
2007-11-30 |
2023-08-12 |
mouse |
| Daniel Nowak, Simone Boehrer, Simone Hochmuth, Bettina Trepohl, Wencke Hofmann, Dieter Hoelzer, Wolf-Karsten Hofmann, Paris S Mitrou, Martin Ruthardt, Kai Uwe Cho. Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells. Anti-cancer drugs. vol 18. issue 9. 2007-11-30. PMID:17704648. |
src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells. |
2007-11-30 |
2023-08-12 |
Not clear |
| Daniel Nowak, Simone Boehrer, Simone Hochmuth, Bettina Trepohl, Wencke Hofmann, Dieter Hoelzer, Wolf-Karsten Hofmann, Paris S Mitrou, Martin Ruthardt, Kai Uwe Cho. Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells. Anti-cancer drugs. vol 18. issue 9. 2007-11-30. PMID:17704648. |
src kinases are involved in multiple cellular contexts such as proliferation, adhesion, tumor invasiveness, angiogenesis, cell cycle control and apoptosis. |
2007-11-30 |
2023-08-12 |
Not clear |
| Ralf Schmidmaier, Sonja Mandl-Weber, Leander Gaul, Philipp Baumann, Irmgard Bumeder, Christian Straka, Bertold Emmeric. Inhibition of lymphocyte function associated antigen 1 by LFA878 induces apoptosis in multiple myeloma cells and is associated with downregulation of the focal adhesion kinase/phosphatidylinositol 3 kinase/Akt pathway. International journal of oncology. vol 31. issue 4. 2007-11-08. PMID:17786331. |
additionally, sequential inhibition of the pathway by simultaneous application of src family kinase or pi3-k inhibitors significantly increases lfa878 induced apoptosis. |
2007-11-08 |
2023-08-12 |
Not clear |
| Yang Lu, Xinqun Li, Ke Liang, Rodney Luwor, Zahid H Siddik, Gordon B Mills, John Mendelsohn, Zhen Fa. Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab. Cancer research. vol 67. issue 17. 2007-10-30. PMID:17804738. |
most importantly, inhibition of src kinase activity with pp2 reversed the resistance of difi5 cells to cetuximab-induced apoptosis without affecting the levels of egfr in the cells. |
2007-10-30 |
2023-08-12 |
Not clear |
| Rafal Fudala, Agnieszka Krupa, Michael A Matthay, Timothy C Allen, Anna K Kurdowsk. Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 2. 2007-09-26. PMID:17513455. |
finally, we established that igg receptor, fcgammariia, mediates antiapoptotic activity of anti-il-8:il-8 complexes and that the key components of the fcgammariia signaling pathway, src, syk, pi3 kinase, and erk, may be involved in regulation of neutrophil apoptosis by the complexes. |
2007-09-26 |
2023-08-12 |
human |
| Dieter Häussinger, Freimut Schlies. Glutamine metabolism and signaling in the liver. Frontiers in bioscience : a journal and virtual library. vol 12. 2007-08-23. PMID:17127305. |
recent progress concerns the understanding of glutamine-induced hepatocyte swelling and the downstream activation of integrins, src, and map-kinases in the regulation of autophagic proteolysis, canalicular bile acid excretion, glycogen and fatty acid synthesis, insulin signaling, and protection from apoptosis. |
2007-08-23 |
2023-08-12 |
human |
| Cheryl H Baker, Jose G Trevino, Justin M Summy, Fahao Zhang, Alexis Caron, Mark Nesbit, Gary E Gallick, Isaiah J Fidle. Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice. International journal of oncology. vol 29. issue 1. 2007-08-03. PMID:16773192. |
administration of gn963 inhibited pdgfr phosphorylation in both tumor and tumor-associated endothelial cells, decreased src and akt kinase activity in tumor cells, decreased microvessel density, and decreased tumor cell proliferation, while increasing apoptosis of tumor and tumor-associated endothelial cells. |
2007-08-03 |
2023-08-12 |
mouse |
| Irene Mamali, Marianthi N Tatari, Ilina Micheva, Maria Lampropoulou, Vassilis J Marmara. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17177294. |
apoptosis in medfly hemocytes is regulated during pupariation through fak, src, erk, pi-3k p85a, and akt survival signaling. |
2007-07-24 |
2023-08-12 |
Not clear |
| Irene Mamali, Marianthi N Tatari, Ilina Micheva, Maria Lampropoulou, Vassilis J Marmara. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17177294. |
in particular, we show using western blot, elisa and flow cytometry analysis, that fak expression silencing in transfected by fak double-stranded rna (dsrna) hemocytes, enhances twofold hemocyte apoptosis, by signaling through src, mek/erk, and pi-3k/akt signaling pathways. |
2007-07-24 |
2023-08-12 |
Not clear |
| Irene Mamali, Marianthi N Tatari, Ilina Micheva, Maria Lampropoulou, Vassilis J Marmara. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17177294. |
the novel aspect of this report is based on the fact that hemocytes attempt to suppress apoptosis, by increasing the expression/phosphorylation of fak and, hence its downstream targets signaling molecules src, erk, pi-3k p85a, and akt. |
2007-07-24 |
2023-08-12 |
Not clear |
| Yael Gus, Rotem Karni, Alexander Levitzk. Subunit S5a of the 26S proteasome is regulated by antiapoptotic signals. The FEBS journal. vol 274. issue 11. 2007-07-20. PMID:17459097. |
we found that s5a rescued saos-2 cells from apoptosis induced by src inhibitor 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (pp1). |
2007-07-20 |
2023-08-12 |
Not clear |
| Xiaoyang Ling, Marina Konopleva, Zhihong Zeng, Vivian Ruvolo, L Clifton Stephens, Wendy Schober, Teresa McQueen, Martin Dietrich, Timothy L Madden, Michael Andreef. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Cancer research. vol 67. issue 9. 2007-06-18. PMID:17483332. |
in vitro, after treatment of 4t1 cells with 500 nmol/l cddo-me for 2 h, we found (a) inactivation of stat3, (b) inactivation of src and akt, (c) 4-fold reduction of c-myc mrna levels, (d) accumulation of cells in g(2)-m cell cycle phase, (e) abrogation of invasive growth of 4t1 cells, and (f) lack of apoptosis induction. |
2007-06-18 |
2023-08-12 |
mouse |
| Alessia Di Florio, Gabriele Capurso, Massimo Milione, Francesco Panzuto, Raffaele Geremia, Gianfranco Delle Fave, Claudio Sett. Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells. Endocrine-related cancer. vol 14. issue 1. 2007-06-04. PMID:17395980. |
accordingly, the actin cytoskeleton was profoundly altered after inhibition of src kinases, whereas even prolonged incubation with pp2 exerted no effect on cell cycle progression and/or apoptosis of pet cells. |
2007-06-04 |
2023-08-12 |
human |