| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I Ischenko, P Camaj, H Seeliger, A Kleespies, M Guba, E N De Toni, B Schwarz, C Graeb, M E Eichhorn, K-W Jauch, C J Brun. Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling. Oncogene. vol 27. issue 57. 2009-01-22. PMID:18794807. |
furthermore, when small-interfering rna approach to silence src gene expression was applied, the degree of 5-fu-induced apoptosis was increased in all cell lines independently of the chemoresistance status. |
2009-01-22 |
2023-08-12 |
human |
| Serena Di Cosimo, José Baselg. Targeted therapies in breast cancer: where are we now? European journal of cancer (Oxford, England : 1990). vol 44. issue 18. 2009-01-22. PMID:19013786. |
in addition, there are classes of therapies under evaluation including novel anti-her2 therapies, agents against other tyrosine kinases including src and insulin-like growth factor receptor agents interfering with critically important signalling pathways such as the pi3k/akt/mtor inhibitors and agents that promote apoptosis such as parp inhibitors and others. |
2009-01-22 |
2023-08-12 |
human |
| François-Xavier Mahon, Sandrine Hayette, Valérie Lagarde, Francis Belloc, Béatrice Turcq, Franck Nicolini, Coralie Belanger, Paul W Manley, Cédric Leroy, Gabriel Etienne, Serge Roche, Jean-Max Pasque. Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression. Cancer research. vol 68. issue 23. 2009-01-16. PMID:19047160. |
in contrast, dasatinib, a dual bcr-abl and src kinase inhibitor, inhibited the phosphorylation of both bcr-abl and lyn, and induced apoptosis of the bcr-abl cell line overexpressing p53/56 lyn. |
2009-01-16 |
2023-08-12 |
Not clear |
| T Pene-Dumitrescu, L F Peterson, N J Donato, T E Smithgal. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259. Oncogene. vol 27. issue 56. 2009-01-06. PMID:18794796. |
global inhibition of myeloid src family kinase (sfk) activity with the broad-spectrum pyrrolo-pyrimidine inhibitor, a-419259, blocks proliferation and induces apoptosis in cml cell lines, suggesting that transformation by bcr-abl requires sfk activity. |
2009-01-06 |
2023-08-12 |
Not clear |
| Ching-Ming Chien, Sheng-Huei Yang, Kuei-Li Lin, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Li. Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells. Chemico-biological interactions. vol 176. issue 1. 2008-11-24. PMID:18638462. |
taken together, these results indicate that iqdma causes significant induction of apoptosis in hl-60 cells via down-regulation of src, il-6, and stat5 signaling and modulation of bcl-2 family, cyclin d1 and vegf proteins. |
2008-11-24 |
2023-08-12 |
human |
| S Messaoudi, J F Peyrat, J D Brion, M Alam. Recent advances in Hsp90 inhibitors as antitumor agents. Anti-cancer agents in medicinal chemistry. vol 8. issue 7. 2008-11-03. PMID:18855578. |
consequently, many client proteins are targeted for degradation via the ubiquitin-proteasome pathway including receptor and non receptor kinases (erb-b2, epidermal growth factor receptor, and src family kinases), serine/threonine kinases (c-raf-1 and cdk4), steroid hormone receptors (androgen and estrogen), and apoptosis regulators such as mutant p53. |
2008-11-03 |
2023-08-12 |
Not clear |
| Marcia I Dawson, Zebin Xia, Tao Jiang, Mao Ye, Joseph A Fontana, Lulu Farhana, Bhaumik Patel, Li Ping Xue, Mohammad Bhuiyan, Roberto Pellicciari, Antonio Macchiarulo, Roberto Nuti, Xiao-Kun Zhang, Young-Hoon Han, Lutz Tautz, Peter D Hobbs, Ling Jong, Nahid Waleh, Wan-Ru Chao, Gen-Sheng Feng, Yuhong Pang, Ying S. Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity. Journal of medicinal chemistry. vol 51. issue 18. 2008-10-09. PMID:18759424. |
adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of src homology 2 domain-containing protein tyrosine phosphatase-2 activity. |
2008-10-09 |
2023-08-12 |
human |
| Toshimitsu Yamaoka, Fang Yan, Hanwei Cao, Stuart S Hobbs, Rebecca S Dise, Wei Tong, D Brent Pol. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 33. 2008-09-16. PMID:18701712. |
activation of egfr, erbb2, akt, src, and apoptosis were determined in vivo and in vitro. |
2008-09-16 |
2023-08-12 |
mouse |
| Hirohito Yamaguchi, Nicholas T Woods, Jay F Dorsey, Yoshinori Takahashi, Nicole R Gjertsen, Timothy Yeatman, Jie Wu, Hong-Gang Wan. SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis. The Journal of biological chemistry. vol 283. issue 27. 2008-08-19. PMID:18474606. |
together, these results suggest that phosphorylation of bif-1 impairs its binding to bax and represses apoptosis, providing another mechanism by which src oncogenic signaling can prevent cell death. |
2008-08-19 |
2023-08-12 |
Not clear |
| Mohammad N Uddin, Darijana Horvat, Shannon S Glaser, Brett M Mitchell, Jules B Puschet. Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function. The Journal of biological chemistry. vol 283. issue 26. 2008-08-18. PMID:18434301. |
mbg significantly increased the phosphorylation of jnk, p38, and src and increased the expression of caspase 9 and 3/7 indicating the activation of apoptosis. |
2008-08-18 |
2023-08-12 |
human |
| Mohammad N Uddin, Darijana Horvat, Shannon S Glaser, Brett M Mitchell, Jules B Puschet. Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function. The Journal of biological chemistry. vol 283. issue 26. 2008-08-18. PMID:18434301. |
in conclusion, the mbg-induced impairment of ctb function occurs via activation of jnk, p38, and src leading to increased apoptosis and il-6 secretion. |
2008-08-18 |
2023-08-12 |
human |
| Ying Shi, Chen-Hui Wang, Xing-Guo Gon. Apoptosis-inducing effects of two anthraquinones from Hedyotis diffusa WILLD. Biological & pharmaceutical bulletin. vol 31. issue 6. 2008-06-30. PMID:18520033. |
compared with compound 2, compound 1 is more active as an antagonist of src kinase, which might account for its higher potency to induce growth arrest and apoptosis. |
2008-06-30 |
2023-08-12 |
Not clear |
| John Doukas, Sankaranarayana Mahesh, Naoyasu Umeda, Shu Kachi, Hideo Akiyama, Katsutoshi Yokoi, Jon Cao, Zoe Chen, Luis Dellamary, Betty Tam, Adrienne Racanelli-Layton, John Hood, Michael Martin, Glenn Noronha, Richard Soll, Peter A Campochiar. Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. Journal of cellular physiology. vol 216. issue 1. 2008-06-04. PMID:18330892. |
tg100572, which inhibits src kinases and selected receptor tyrosine kinases, induced apoptosis of proliferating endothelial cells in vitro. |
2008-06-04 |
2023-08-12 |
mouse |
| F Shafiei, F Rahnama, L Pawella, M D Mitchell, P D Gluckman, P E Lobi. DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells. Oncogene. vol 27. issue 18. 2008-05-19. PMID:17998942. |
autocrine hgh stimulation of dnmt3a and dnmt3b expression was mediated by jak2 and src kinases, and treatment of mammary carcinoma cells with the dnmt inhibitor, 5'-aza-2'-deoxycytidine (aza), abrogated autocrine hgh-stimulated cellular proliferation, apoptosis and anchorage-independent growth. |
2008-05-19 |
2023-08-12 |
human |
| P D Koeberle, M Bäh. The upregulation of GLAST-1 is an indirect antiapoptotic mechanism of GDNF and neurturin in the adult CNS. Cell death and differentiation. vol 15. issue 3. 2008-04-30. PMID:18064044. |
however, gdnf also required src and mitogen-activated protein kinase activity to prevent rgc apoptosis. |
2008-04-30 |
2023-08-12 |
Not clear |
| Wenbin Xiao, Hong Hong, Yuko Kawakami, Clifford A Lowell, Toshiaki Kawakam. Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5. The Journal of clinical investigation. vol 118. issue 3. 2008-04-22. PMID:18246197. |
here we have shown that, similar to mice deficient in the lipid phosphatase ship, loss of 2 src family kinases, lyn and hck, profoundly affects hsc differentiation, producing hematopoietic progenitors with increased proliferation, reduced apoptosis, growth factor-independent survival, and skewed differentiation toward m2 macrophages. |
2008-04-22 |
2023-08-12 |
mouse |
| F Zhang, C Li, R Wang, D Han, Q-G Zhang, C Zhou, H-M Yu, G-Y Zhan. Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion. Neuroscience. vol 150. issue 4. 2008-04-08. PMID:18022328. |
activation of gaba receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of nr2a by src after cerebral ischemia and reperfusion. |
2008-04-08 |
2023-08-12 |
rat |
| Xinmin Zheng, Ross J Resnick, David Shallowa. Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. International journal of cancer. vol 122. issue 9. 2008-03-18. PMID:18183590. |
apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by ptp alpha and src rnai. |
2008-03-18 |
2023-08-12 |
human |
| Xinmin Zheng, Ross J Resnick, David Shallowa. Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi. International journal of cancer. vol 122. issue 9. 2008-03-18. PMID:18183590. |
src and ptp alpha rnai induced apoptosis in estrogen receptor (er)-negative breast cancer and colon cancer cells, but not in immortalized noncancerous breast cells, er-positive breast cancer cells or other cancer cell types tested. |
2008-03-18 |
2023-08-12 |
human |
| Vita M Golubovskaya, Christopher Virnig, William G Canc. TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR. Molecular carcinogenesis. vol 47. issue 3. 2008-03-17. PMID:17849451. |
tae226-induced apoptosis in breast cancer cells with overexpressed src or egfr. |
2008-03-17 |
2023-08-12 |
human |