| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Li. Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon : official journal of the International Society on Toxinology. vol 56. issue 4. 2010-12-13. PMID:20493203. |
taiwan cobra cardiotoxin iii inhibits src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma ca9-22 cells. |
2010-12-13 |
2023-08-12 |
Not clear |
| Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Li. Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon : official journal of the International Society on Toxinology. vol 56. issue 4. 2010-12-13. PMID:20493203. |
taken together, these results indicate that ctx iii induces apoptosis and s-phase arrest in ca9-22 cells via concomitant inactivation of the src, egfr, stat3, stat5, pi3 k(p110), and akt signaling pathways. |
2010-12-13 |
2023-08-12 |
Not clear |
| Nagathihalli S Nagaraj, J Joshua Smith, Frank Revetta, M Kay Washington, Nipun B Merchan. Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis. Molecular cancer therapeutics. vol 9. issue 8. 2010-11-26. PMID:20682659. |
src kinase inhibition with dasatinib markedly inhibits cell proliferation, migration, invasion, cell cycle progression and anchorage-independent growth, and stimulates apoptosis. |
2010-11-26 |
2023-08-12 |
Not clear |
| B L Slomiany, A Slomian. Constitutive nitric oxide synthase-mediated caspase-3 S-nitrosylation in ghrelin protection against Porphyromonas gingivalis-induced salivary gland acinar cell apoptosis. Inflammopharmacology. vol 18. issue 3. 2010-10-29. PMID:20155328. |
the loss in countering effect of ghrelin on the lps-induced changes in apoptosis and caspase-3 activity was attained with src kinase inhibitor, pp2, as well as akt inhibitor, sh-5, and cnos inhibitor, l-name, but not the inos inhibitor, 1400w. |
2010-10-29 |
2023-08-12 |
Not clear |
| Chao Shang, Yan Guo, Shuang Fu, Weineng Fu, Kailai Su. SH3GL2 gene participates in MEK-ERK signal pathway partly by regulating EGFR in the laryngeal carcinoma cell line Hep2. Medical science monitor : international medical journal of experimental and clinical research. vol 16. issue 6. 2010-09-28. PMID:20512084. |
the human src homology 3 (sh3) domain grb2-like 2 (sh3gl2) gene, a novel tumor suppressor gene in laryngeal squamous cell carcinoma (lscc), induces apoptosis of tumor cells by regulating intra-cellular signal transduction networks. |
2010-09-28 |
2023-08-12 |
human |
| Hsiu-Chuan Chou, Yi-Wen Chen, Tian-Ren Lee, Fen-Shiun Wu, Hsin-Tsu Chan, Ping-Chiang Lyu, John F Timms, Hong-Lin Cha. Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment. Free radical biology & medicine. vol 49. issue 1. 2010-09-22. PMID:20385227. |
immunofluorescence studies, fluorescence-activated cell sorting, and cell-based assays were used to demonstrate oxidative stress-induced modification of cell adhesion structures and the cytoskeleton, induced de-adhesion, and increased apoptosis, which were reversed by treatment with the src kinase inhibitor pp1. |
2010-09-22 |
2023-08-12 |
rat |
| Jyoti Nautiyal, Yingjie Yu, Amro Aboukameel, Shailender S Kanwar, Jayanta K Das, Jianhua Du, Bhaumik B Patel, Fazlul H Sarkar, Arun K Rishi, Ramzi M Mohammad, Adhip P N Majumda. ErbB-inhibitory protein: a modified ectodomain of epidermal growth factor receptor synergizes with dasatinib to inhibit growth of breast cancer cells. Molecular cancer therapeutics. vol 9. issue 6. 2010-09-16. PMID:20515951. |
in egfr-overexpressing mda-mb-468 cells, the combination, but not monotherapy, markedly stimulated apoptosis mediated by caspase-9 and caspase-8 and attenuated activation of egfr and src as well as tyrosine kinase activity. |
2010-09-16 |
2023-08-12 |
mouse |
| Bronislaw L Slomiany, Amalia Slomian. Ghrelin protection against lipopolysaccharide-induced gastric mucosal cell apoptosis involves constitutive nitric oxide synthase-mediated caspase-3 S-nitrosylation. Mediators of inflammation. vol 2010. 2010-06-21. PMID:20369000. |
the loss in countering effect of ghrelin on the lps-induced changes in apoptosis and caspase-3 activity was attained with src kinase inhibitor, pp2, as well as akt inhibitor, sh-5, and cnos inhibitor, l-name. |
2010-06-21 |
2023-08-12 |
Not clear |
| F Fei, S Stoddart, M Müschen, Y-m Kim, J Groffen, N Heisterkam. Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia. Leukemia. vol 24. issue 4. 2010-05-20. PMID:20111071. |
dasatinib eradicated bcr/abl all cells, caused significant apoptosis and eliminated tyrosine phosphorylation on bcr/abl, src, crkl and stat-5. |
2010-05-20 |
2023-08-12 |
mouse |
| Hua-chuan Zheng, Yu-shuang Zheng, Pu Xia, Xiao-yan Xu, Ya-nan Xing, Hiroyuki Takahashi, Yi-fu Guan, Yasuo Takan. The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes. Histology and histopathology. vol 25. issue 4. 2010-05-13. PMID:20183797. |
lower levels of proliferation and apoptosis, as well as alterations in tumor suppressor genes, mucin production and er stress protein played important roles in the pathogenesis of poorly-differentiated and src carcinomas. |
2010-05-13 |
2023-08-12 |
Not clear |
| Hong-Lin Chan, Hsiu-Chuan Chou, MaCarmen Duran, Jana Gruenewald, Michael D Waterfield, Anne Ridley, John F Timm. Major role of epidermal growth factor receptor and Src kinases in promoting oxidative stress-dependent loss of adhesion and apoptosis in epithelial cells. The Journal of biological chemistry. vol 285. issue 7. 2010-05-11. PMID:19996095. |
major role of epidermal growth factor receptor and src kinases in promoting oxidative stress-dependent loss of adhesion and apoptosis in epithelial cells. |
2010-05-11 |
2023-08-12 |
human |
| Soumya Jaganathan, Peibin Yue, James Turkso. Enhanced sensitivity of pancreatic cancer cells to concurrent inhibition of aberrant signal transducer and activator of transcription 3 and epidermal growth factor receptor or Src. The Journal of pharmacology and experimental therapeutics. vol 333. issue 2. 2010-05-10. PMID:20100905. |
by contrast, the concurrent inhibition of stat3 and egfr or src induced greater viability loss and apoptosis and decreased the migration/invasion of pancreatic cancer cells in vitro. |
2010-05-10 |
2023-08-12 |
human |
| Chun-Yen Chen, Chin-Yang Chang, Hung-Jen Liu, Ming-Huei Liao, Chi-I Chang, Jue-Liang Hsu, Wen-Ling Shi. Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathways. Veterinary research. vol 41. issue 2. 2010-04-30. PMID:19846041. |
src and c-jun n-terminal kinase (jnk) inhibitor, but not extracellular signal-regulated kinase (erk) or p38 inhibitor, alleviated befv-mediated cytopathic effect and apoptosis. |
2010-04-30 |
2023-08-12 |
cattle |
| Mythilypriya Rajendran, Paul Thomes, Li Zhang, Suresh Veeramani, Ming-Fong Li. p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis. Cancer metastasis reviews. vol 29. issue 1. 2010-04-27. PMID:20111892. |
p66shc, a 66 kda proto-oncogene src homologous-collagen homologue (shc) adaptor protein, is classically known in mediating receptor tyrosine kinase signaling and recently identified as a sensor to oxidative stress-induced apoptosis and as a longevity protein in mammals. |
2010-04-27 |
2023-08-12 |
mouse |
| Takeshi Yoshida, Isamu Okamoto, Wataru Okamoto, Erina Hatashita, Yuki Yamada, Kiyoko Kuwata, Kazuto Nishio, Masahiro Fukuoka, Pasi A Jänne, Kazuhiko Nakagaw. Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification. Cancer science. vol 101. issue 1. 2010-03-30. PMID:19804422. |
src inhibitors blocked akt and erk signaling pathways, resulting in both suppression of cell growth and induction of apoptosis, in hcc827 gr cells as effectively as did the combination of gefitinib and pha-665752. |
2010-03-30 |
2023-08-12 |
Not clear |
| Shinobu Kitazume, Rie Imamaki, Kazuko Ogawa, Yusuke Komi, Satoshi Futakawa, Soichi Kojima, Yasuhiro Hashimoto, Jamey D Marth, James C Paulson, Naoyuki Taniguch. Alpha2,6-sialic acid on platelet endothelial cell adhesion molecule (PECAM) regulates its homophilic interactions and downstream antiapoptotic signaling. The Journal of biological chemistry. vol 285. issue 9. 2010-03-26. PMID:20048157. |
we also found that the absence of alpha2,6-sialic acid down-regulated the tyrosine phosphorylation of pecam and recruitment of src homology 2 domain-containing protein-tyrosine phosphatase 2 and rendered the cells more prone to mitochondrion-dependent apoptosis, as evaluated using pecam- deficient endothelial cells. |
2010-03-26 |
2023-08-12 |
Not clear |
| Elizabeth A Beierle, Xiaojie Ma, Angelica Trujillo, Elena V Kurenova, William G Cance, Vita M Golubovskay. Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Molecular carcinogenesis. vol 49. issue 3. 2010-03-25. PMID:19885861. |
inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. |
2010-03-25 |
2023-08-12 |
human |
| Elizabeth A Beierle, Xiaojie Ma, Angelica Trujillo, Elena V Kurenova, William G Cance, Vita M Golubovskay. Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines. Molecular carcinogenesis. vol 49. issue 3. 2010-03-25. PMID:19885861. |
the results of the current study suggest that both fak and src play a role in protecting neuroblastoma cells from apoptosis, and that dual inhibition of these kinases may be important when designing therapeutic interventions for this tumor. |
2010-03-25 |
2023-08-12 |
human |
| Robyn J Macfarlane, Kim N Ch. Novel targeted therapies for prostate cancer. The Urologic clinics of North America. vol 37. issue 1. 2010-03-16. PMID:20152524. |
agents targeting androgen receptor activation and local steroidogenesis, angiogenesis, apoptosis, chaperone proteins, the insulinlike growth factor pathway, rank ligand, endothelin receptors, and src family kinases are entering, or have recently completed, accrual to phase iii trials for patients with crpc. |
2010-03-16 |
2023-08-12 |
Not clear |
| Alfonso Sánchez-Muñoz, Elisabeth Pérez-Ruiz, Begoña Jiménez, Nuria Ribelles, Antonia Márquez, Isabel García-Ríos, Emilio Alba Conej. Targeted therapy of metastatic breast cancer. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. vol 11. issue 10. 2010-01-26. PMID:19828406. |
in addition, there are other therapy classes under evaluation, including novel antiegfr or antiher2 therapies; agents fighting other tyrosine kinases, including the src and the insulinlike growth factor receptor; agents interfering critically relevant pathways, such as pi3k/akt/mtor inhibitors; and agents promoting apoptosis, such as parp inhibitors (for particular breast cancer subtypes, such as basal-like, or breast cancer with brca mutations) and others. |
2010-01-26 |
2023-08-12 |
human |