| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teresita Bellido, Lilian I Plotki. Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability. Bone. vol 49. issue 1. 2011-09-28. PMID:20727997. |
hemichannel opening leads to activation of the kinases src and extracellular signal-regulated kinases (erks), followed by phosphorylation of the erk cytoplasmic target p90(rsk) kinase and its substrates bad and c/ebpβ, resulting in inhibition of apoptosis. |
2011-09-28 |
2023-08-12 |
mouse |
| Jang Choon Lee, Kwang Seok Ahn, Soo-Jin Jeong, Ji Hoon Jung, Tae-Rin Kwon, Yun-Hee Rhee, Sun-Hee Kim, Si-Young Kim, Hwi-Joong Yoon, Shudong Zhu, Chang-Yan Chen, Sung-Hoon Ki. Signal transducer and activator of transcription 3 pathway mediates genipin-induced apoptosis in U266 multiple myeloma cells. Journal of cellular biochemistry. vol 112. issue 6. 2011-08-25. PMID:21344490. |
our data suggest that through regulation of src and shp-1, genipin antagonizes stat3 for the induction of apoptosis in myeloma cells. |
2011-08-25 |
2023-08-12 |
Not clear |
| Fahad Haroon, Katrin Drögemüller, Ulrike Händel, Anna Brunn, Dirk Reinhold, Gopala Nishanth, Werner Mueller, Christian Trautwein, Matthias Ernst, Martina Deckert, Dirk Schlüte. Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. Journal of immunology (Baltimore, Md. : 1950). vol 186. issue 11. 2011-08-11. PMID:21515788. |
an analysis of mice deficient in either astrocytic gp130- src homology region 2 domain-containing phosphatase 2/ras/erk or gp130-stat1/3 signaling revealed that prevention of astrocyte apoptosis, restriction of demyelination, and t cell infiltration were dependent on the astrocytic gp130-src homology region 2 domain-containing phosphatase 2/ras/erk, but not on the gp130-stat1/3 pathway, further demonstrating that gp130-dependent astrocyte activation is crucial to ameliorate eae. |
2011-08-11 |
2023-08-12 |
mouse |
| Scott Kopet. Targeting SRC and epidermal growth factor receptor in colorectal cancer: rationale and progress into the clinic. Gastrointestinal cancer research : GCR. vol 1. issue 4 Suppl 2. 2011-07-14. PMID:19360146. |
src is a non-receptor protein tyrosine kinase that affects proliferation, angiogenesis, differentiation, migration, invasion, and regulation of apoptosis in colorectal cancer cells. |
2011-07-14 |
2023-08-12 |
Not clear |
| Radha Munagala, Farrukh Aqil, Ramesh C Gupt. Promising molecular targeted therapies in breast cancer. Indian journal of pharmacology. vol 43. issue 3. 2011-07-14. PMID:21713084. |
several other targeted agents currently under evaluation in preclinical and clinical trials include inhibitors of epidermal growth factor receptor (egfr), dual egfr and her2 inhibitors, vegf/vegfr inhibitors, and agents that interfere with crucial signaling pathways such as pi3k/akt/mtor and ras/mek/erk; agents against other tyrosine kinases such as src, insulin-like growth factor (igf)/igf-receptor (igfr); agents that promote apoptosis such as poly adp ribose polymerase inhibitors; agents that target invasion and metastasis such as matrix metalloproteinases inhibitors and others. |
2011-07-14 |
2023-08-12 |
human |
| Katsunari Kina, Hiromi Masuda, Hitoshi Nakayama, Yasuko Nagatsuka, Takuji Nabetani, Yoshio Hirabayashi, Yasue Takahashi, Kazunori Shimada, Hiroyuki Daida, Hideoki Ogawa, Kenji Takamori, Kazuhisa Iwabuch. The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 186. issue 9. 2011-07-05. PMID:21451106. |
dim21-induced apoptosis was inhibited by specific inhibitors of cysteine-containing aspartate-specific proteases (caspases)-8, -9, and -3 but not by the src family kinase inhibitor pp1, pip(3) kinase inhibitor ly294002, nadph oxidase inhibitor diphenyleneiodonium, superoxide dismutase, or catalase. |
2011-07-05 |
2023-08-12 |
human |
| S N Arun, I Kaddour-Djebbar, B A Shapiro, W B Bolla. Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes. Oncogene. vol 30. issue 13. 2011-06-06. PMID:21132013. |
indeed, a mutant that cannot be phosphorylated by src kinases exacerbated uvb-elicited apoptosis. |
2011-06-06 |
2023-08-12 |
mouse |
| Yuji Sakuma, Jun Tsunezumi, Yoshiyasu Nakamura, Mitsuyo Yoshihara, Shoichi Matsukuma, Shiro Koizume, Yohei Miyag. ABT-263, a Bcl-2 inhibitor, enhances the susceptibility of lung adenocarcinoma cells treated with Src inhibitors to anoikis. Oncology reports. vol 25. issue 3. 2011-05-09. PMID:21206976. |
several suspension lung adenocarcinoma cell lines, which express phosphorylated src, undergo apoptosis, or anoikis, in the presence of src kinase inhibitors. |
2011-05-09 |
2023-08-12 |
Not clear |
| Emmanuelle David, Pierre Guihard, Bénédicte Brounais, Anne Riet, Céline Charrier, Séverine Battaglia, François Gouin, Stéphanie Ponsolle, Ronan Le Bot, Carl D Richards, Dominique Heymann, Françoise Rédini, Frédéric Blanchar. Direct anti-cancer effect of oncostatin M on chondrosarcoma. International journal of cancer. vol 128. issue 8. 2011-04-18. PMID:21344373. |
adenoviral gene transfer of osm (adosm) in the swarm rat chondrosarcoma (src) model indicated that local intra-tumoral osm over-expression reduces chondrosarcoma development not only with reduced tumor proliferation and enhanced apoptosis but also with enhanced rankl expression, osteoclast formation and reduced bone volumes. |
2011-04-18 |
2023-08-12 |
rat |
| Yan ZHU, Shu-wu XIE, Jian-feng ZHANG, Ting-ting ZHANG, Jie-yun ZHOU, Yang CAO, Lin CA. Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells. Acta pharmacologica Sinica. vol 31. issue 12. 2011-04-15. PMID:21102482. |
involvement of bcl-2, src, and erα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells. |
2011-04-15 |
2023-08-12 |
human |
| Seobo Sim, Jae-Ran Yu, Young Ah Lee, Myeong Heon Shi. Involvement of Src family tyrosine kinase in apoptosis of human neutrophils induced by protozoan parasite Entamoeba histolytica. The Korean journal of parasitology. vol 48. issue 4. 2011-04-14. PMID:21234229. |
involvement of src family tyrosine kinase in apoptosis of human neutrophils induced by protozoan parasite entamoeba histolytica. |
2011-04-14 |
2023-08-12 |
human |
| Seobo Sim, Jae-Ran Yu, Young Ah Lee, Myeong Heon Shi. Involvement of Src family tyrosine kinase in apoptosis of human neutrophils induced by protozoan parasite Entamoeba histolytica. The Korean journal of parasitology. vol 48. issue 4. 2011-04-14. PMID:21234229. |
these results suggest that src tyrosine kinases may participate in the signaling event for ros-dependent activation of mapks during neutrophil apoptosis induced by e. histolytica. |
2011-04-14 |
2023-08-12 |
human |
| Asish K Ghosh, Charla Secreto, Justin Boysen, Traci Sassoon, Tait D Shanafelt, Debabrata Mukhopadhyay, Neil E Ka. The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy. Blood. vol 117. issue 6. 2011-04-04. PMID:21135257. |
when axl and src kinases were targeted by a src/abl kinase inhibitor, bosutinib (ski-606), or a specific-inhibitor of axl (r428), robust induction of cll b-cell apoptosis was observed in both a dose- and time-dependent manner. |
2011-04-04 |
2023-08-12 |
Not clear |
| Yun Dai, Shuang Chen, Rena Shah, Xin-Yan Pei, Li Wang, Jorge A Almenara, Lora B Kramer, Paul Dent, Steven Gran. Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo. Blood. vol 117. issue 6. 2011-04-04. PMID:21148814. |
disruption of src function potentiates chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo. |
2011-04-04 |
2023-08-12 |
human |
| Yun Dai, Shuang Chen, Rena Shah, Xin-Yan Pei, Li Wang, Jorge A Almenara, Lora B Kramer, Paul Dent, Steven Gran. Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo. Blood. vol 117. issue 6. 2011-04-04. PMID:21148814. |
loss-of-function src mutants (k297r, k296r/y528f) or shrna knock-down of src prevented the erk1/2 activation induced by chk1 inhibitors and increased apoptosis. |
2011-04-04 |
2023-08-12 |
human |
| Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang X. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20881478. |
sorafenib induces apoptosis in hl60 cells by inhibiting src kinase-mediated stat3 phosphorylation. |
2011-03-04 |
2023-08-12 |
human |
| Wei Zhao, Tao Zhang, Bingqian Qu, Xingxin Wu, Xu Zhu, Fanyu Meng, Yanhong Gu, Yongqian Shu, Yan Shen, Yang Sun, Qiang X. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20881478. |
taken together, our study indicates that sorafenib blocks src kinase-mediated stat3 phosphorylation and decreases the expression of apoptosis regulatory proteins mcl-1 and bcl-2, which are associated with increased apoptosis in hl60 cells. |
2011-03-04 |
2023-08-12 |
human |
| Juliette Martin, Pamela Romanque, Olivier Maurhofer, Karin Schmitter, Caroline Hora, Gisèle Ferrand, Jean-François Dufou. Ablation of the tumor suppressor histidine triad nucleotide binding protein 1 is protective against hepatic ischemia/reperfusion injury. Hepatology (Baltimore, Md.). vol 53. issue 1. 2011-03-02. PMID:21140474. |
the serum aminotransferase levels, histological lesions, apoptosis, reactive oxygen species, and expression of b cell lymphoma 2-associated x protein (bax), heme oxygenase 1 (ho-1), interleukin-6 (il-6), il-10, tumor necrosis factor-a, src, nuclear factor kappa b (p65/rela), and c-jun were quantified. |
2011-03-02 |
2023-08-12 |
mouse |
| M W Harr, P F Caimi, K S McColl, F Zhong, S N Patel, P M Barr, C W Distelhors. Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia. Cell death and differentiation. vol 17. issue 9. 2011-01-13. PMID:20300113. |
moreover, stable expression of shrnas that selectively targeted lck or treatment with the src inhibitor dasatinib (bms-354825) enhanced apoptosis induction by dexamethasone. |
2011-01-13 |
2023-08-12 |
Not clear |
| G Delso. [Molecular abnormalities in lymphomas]. Bulletin du cancer. vol 97. issue 11. 2010-12-22. PMID:21084243. |
alk tyrosine kinase activates downstream pathways (stat3/5b, src kinases, plcγ, pi3 kinase) implicated in lymphomagenesis, proliferation and protection against apoptosis. |
2010-12-22 |
2023-08-12 |
Not clear |