| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyoung H Kim, Shannon M Grande, John G Monroe, Susan R Ros. Mouse mammary tumor virus suppresses apoptosis of mammary epithelial cells through ITAM-mediated signaling. Journal of virology. vol 86. issue 24. 2013-01-28. PMID:23015704. |
we also found that src kinase was activated in the mmtv-expressing cells and that mmtv-induced apoptosis resistance was completely restored by the src inhibitor pp2. |
2013-01-28 |
2023-08-12 |
mouse |
| Hyoung H Kim, Shannon M Grande, John G Monroe, Susan R Ros. Mouse mammary tumor virus suppresses apoptosis of mammary epithelial cells through ITAM-mediated signaling. Journal of virology. vol 86. issue 24. 2013-01-28. PMID:23015704. |
our results show that mmtv suppresses apoptosis through itam-mediated src tyrosine kinase signaling. |
2013-01-28 |
2023-08-12 |
mouse |
| Martina Cozzi, Francesca Giorgi, Eleonora Marcelli, Francesca Pentimalli, Iris Maria Forte, Silvia Schenone, Vittorio D'Urso, Giulia De Falco, Maurizio Botta, Antonio Giordano, Paola Indovin. Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition. Cell cycle (Georgetown, Tex.). vol 11. issue 5. 2013-01-04. PMID:22333592. |
we found that new pyrazolo[3,4-d]pyrimidine src inhibitors exerted a significant cytotoxic effect and induced apoptosis on two bl cell lines, as determined by mts assays, cytofluorimetric analyses and caspase 3 assay. |
2013-01-04 |
2023-08-12 |
Not clear |
| Martina Cozzi, Francesca Giorgi, Eleonora Marcelli, Francesca Pentimalli, Iris Maria Forte, Silvia Schenone, Vittorio D'Urso, Giulia De Falco, Maurizio Botta, Antonio Giordano, Paola Indovin. Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition. Cell cycle (Georgetown, Tex.). vol 11. issue 5. 2013-01-04. PMID:22333592. |
by using a small-molecule inhibitor of wee1, a crucial cdk1 negative regulator, we were able to shift the balance toward apoptosis rather than growth arrest and enhance the efficacy of the src inhibitors, suggesting a possible use of these selective drugs in combination for a safe and efficient treatment of bl. |
2013-01-04 |
2023-08-12 |
Not clear |
| Shigeru Kihira, Junpei Yoshida, Yukari Kawada, Yuriko Hitomi, Tomohisa Asada, Rie Hisatomi, Akina Ohta, Tetsushi Iwasaki, A K M Mahbub Hasan, Yasuo Fukami, Ken-Ichi Sat. Membrane microdomain-associated uroplakin IIIa contributes to Src-dependent mechanisms of anti-apoptotic proliferation in human bladder carcinoma cells. Biology open. vol 1. issue 10. 2012-12-06. PMID:23213380. |
results obtained so far revealed: 1) upiiia undergoes partial proteolysis in serum-starved cells; 2) a specific antibody to the extracellular domain of upiiia inhibits the proteolysis of upiiia and the activation of src, and promotes apoptosis in serum-starved cells; and 3) knockdown of upiiia by short interfering rna also promotes apoptosis in serum-starved cells. |
2012-12-06 |
2023-08-12 |
human |
| Gautam Bandyopadhyay, Paul E Bankey, Carol L Miller-Grazian. Trauma patients' elevated tumor necrosis related apoptosis inducing ligand (TRAIL) contributes to increased T cell apoptosis. Clinical immunology (Orlando, Fla.). vol 145. issue 1. 2012-11-27. PMID:22926077. |
augmentation of t cell trail-induced apoptosis was secondary to cd47 triggered activation of the src homology-containing phosphatase-1 (shp-1) and was partially blocked by a shp-1 inhibitor. |
2012-11-27 |
2023-08-12 |
Not clear |
| Youness Limami, Aline Pinon, David Yannick Leger, Emilie Pinault, Christiane Delage, Jean-Louis Beneytout, Alain Simon, Bertrand Liagr. The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells. Biochimie. vol 94. issue 8. 2012-11-26. PMID:22521508. |
upon activation, p2y(2) activated src which in turn phosphorylated p38 leading to cox-2 overexpression which induced resistance to apoptosis in both ht-29 and du145 cells. |
2012-11-26 |
2023-08-12 |
Not clear |
| Yu-Chin Lin, Meng-Hsuan Wu, Tzu-Tang Wei, Shu-Hui Chuang, Kuen-Feng Chen, Ann-Lii Cheng, Ching-Chow Che. Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells. Neoplasia (New York, N.Y.). vol 14. issue 6. 2012-11-13. PMID:22787428. |
growth inhibition and apoptosis were correlated with its inhibition on akt, erk, and bcl-2, irrespective of src inhibition. |
2012-11-13 |
2023-08-12 |
Not clear |
| B Casar, Y He, M Iconomou, J D Hooper, J P Quigley, E I Deryugin. Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. Oncogene. vol 31. issue 35. 2012-11-05. PMID:22179830. |
the in vivo cleavage of cdcp1 triggers a survival program involving recruitment of src and pkcδ, src-mediated phosphorylation of cell-surface-retained 70-kda cdcp1, activation of akt and suppression of parp1-induced apoptosis. |
2012-11-05 |
2023-08-12 |
mouse |
| Evan Ingle. Functions of the Lyn tyrosine kinase in health and disease. Cell communication and signaling : CCS. vol 10. issue 1. 2012-10-02. PMID:22805580. |
src family kinases such as lyn are important signaling intermediaries, relaying and modulating different inputs to regulate various outputs, such as proliferation, differentiation, apoptosis, migration and metabolism. |
2012-10-02 |
2023-08-12 |
mouse |
| A K M Mahbub Hasan, Takashi Ijiri, Ken-Ichi Sat. Involvement of Src in the Adaptation of Cancer Cells under Microenvironmental Stresses. Journal of signal transduction. vol 2012. 2012-09-19. PMID:22988500. |
in this paper, we focus on the roles played by src and other ptks in cancer cell-specific behavior, that is, evasion of apoptosis or cell death under stressful extracellular and/or intracellular microenvironments (i.e., hypoxia, anoikis, hypoglycemia, and serum deprivation). |
2012-09-19 |
2023-08-12 |
Not clear |
| Ryoji Eguchi, Shuji Kubo, Hiromi Takeda, Toshiro Ohta, Chiharu Tabata, Hiroyasu Ogawa, Takashi Nakano, Yoshihiro Fujimor. Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells. Carcinogenesis. vol 33. issue 5. 2012-08-10. PMID:22354875. |
deficiency of fyn protein is prerequisite for apoptosis induced by src family kinase inhibitors in human mesothelioma cells. |
2012-08-10 |
2023-08-12 |
human |
| Ryoji Eguchi, Shuji Kubo, Hiromi Takeda, Toshiro Ohta, Chiharu Tabata, Hiroyasu Ogawa, Takashi Nakano, Yoshihiro Fujimor. Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells. Carcinogenesis. vol 33. issue 5. 2012-08-10. PMID:22354875. |
src family kinases (sfks) have a pivotal role in cell adhesion, proliferation, survival and apoptosis. |
2012-08-10 |
2023-08-12 |
human |
| J A P Spijkers-Hagelstein, P Schneider, E Hulleman, J de Boer, O Williams, R Pieters, R W Sta. Elevated S100A8/S100A9 expression causes glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia. Leukemia. vol 26. issue 6. 2012-08-07. PMID:22282267. |
in addition, the src kinase inhibitor pp2 markedly sensitized mll-rearranged all cells otherwise resistant to prednisolone, via downregulation of s100a8 and s100a9, which allowed prednisolone-induced ca(2+) fluxes to reach the mitochondria and trigger apoptosis. |
2012-08-07 |
2023-08-12 |
Not clear |
| María P Gil, Teresa Modol, Agustín España, María J López-Zabalz. Inhibition of FAK prevents blister formation in the neonatal mouse model of pemphigus vulgaris. Experimental dermatology. vol 21. issue 4. 2012-07-16. PMID:22320676. |
we have previously demonstrated that her (human epidermal growth factor receptor related) isoforms, src (rous sarcoma) and mammalian target of rapamycin (mtor), three molecules implicated in signalling processes, take part in suprabasal acantholysis and apoptosis induced by pv-igg in a mouse model. |
2012-07-16 |
2023-08-12 |
mouse |
| Pratibha Gaur, Priya Ranjan, Shipra Sharma, Jenish R Patel, J Bradford Bowzard, Shah K Rahman, Rashmi Kumari, Shivaprakash Gangappa, Jacqueline M Katz, Nancy J Cox, Renu B Lal, Suryaprakash Sambhara, Sunil K La. Influenza A virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22396546. |
na/c6 interaction leads to increased tyrosyl phosphorylation of src, fak, akt, gsk3β, and bcl-2, which affects cell survival, proliferation, migration, differentiation, and apoptosis. |
2012-07-02 |
2023-08-12 |
human |
| Pratibha Gaur, Priya Ranjan, Shipra Sharma, Jenish R Patel, J Bradford Bowzard, Shah K Rahman, Rashmi Kumari, Shivaprakash Gangappa, Jacqueline M Katz, Nancy J Cox, Renu B Lal, Suryaprakash Sambhara, Sunil K La. Influenza A virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein. The Journal of biological chemistry. vol 287. issue 18. 2012-07-02. PMID:22396546. |
sirna-mediated suppression of c6 resulted in a down-regulation of activated src, fak, and akt, increased apoptosis, and reduced expression of viral proteins and viral titers in influenza virus-infected human lung adenocarcinoma epithelial and normal human bronchial epithelial cells. |
2012-07-02 |
2023-08-12 |
human |
| Ilaria Marech, Angelo Vacca, Girolamo Ranieri, Antonio Gnoni, Franco Dammacc. Novel strategies in the treatment of castration-resistant prostate cancer (Review). International journal of oncology. vol 40. issue 5. 2012-06-29. PMID:22322981. |
additional therapeutic targets have been analyzed in prostate cancer, including apoptosis, angiogenic receptors, vitamin d and src pathways. |
2012-06-29 |
2023-08-12 |
Not clear |
| Sunyoung Ahn, Hyun Jeong Kim, Sung-Gil Chi, Heonyong Par. XIAP reverses various functional activities of FRNK in endothelial cells. Biochemical and biophysical research communications. vol 419. issue 2. 2012-05-07. PMID:22366087. |
we recently found that fak is recruited into focal adhesion (fa) sites through interactions with xiap (x-chromosome linked inhibitor of apoptosis protein) and activated by src kinase in response to shear stress. |
2012-05-07 |
2023-08-12 |
Not clear |
| P Indovina, F Giorgi, V Rizzo, B Khadang, S Schenone, D Di Marzo, I M Forte, V Tomei, E Mattioli, V D'Urso, B Grilli, M Botta, A Giordano, F Pentimall. New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization. Oncogene. vol 31. issue 7. 2012-05-04. PMID:21785466. |
new pyrazolo[3,4-d]pyrimidine src inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization. |
2012-05-04 |
2023-08-12 |
Not clear |