| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Palchetti, Donatella Starace, Paola De Cesaris, Antonio Filippini, Elio Ziparo, Anna Ricciol. Transfected poly(I:C) activates different dsRNA receptors, leading to apoptosis or immunoadjuvant response in androgen-independent prostate cancer cells. The Journal of biological chemistry. vol 290. issue 9. 2015-05-11. PMID:25568326. |
by using genetic inhibition of different poly(i:c) receptors, we demonstrate the crucial role of tlr3 and src in in-poly(i:c)-induced apoptosis. |
2015-05-11 |
2023-08-13 |
Not clear |
| Pierre Vanden Borre, Viswanath Gunda, David G McFadden, Peter M Sadow, Shohreh Varmeh, Maria Bernasconi, Sareh Parang. Combined BRAF(V600E)- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer. Oncotarget. vol 5. issue 12. 2015-04-24. PMID:24994118. |
inhibition of either oncogenic braf or src has marked anti-tumor effects in mouse models of thyroid cancer, however, neither drug induces notable apoptosis. |
2015-04-24 |
2023-08-13 |
mouse |
| K Mizrahi, S Ash, T Peled, I Yaniv, J Stein, N Askenas. Negative selection by apoptosis enriches progenitors in naïve and expanded human umbilical cord blood grafts. Bone marrow transplantation. vol 49. issue 7. 2015-04-17. PMID:24777188. |
the sensitivity of progenitors to apoptosis was also unaffected by fas cross-linking following tnf-induced upregulation of the receptor, increasing cfu frequency without impairing scid repopulating cell (src) activity. |
2015-04-17 |
2023-08-13 |
human |
| Teresa Mòdol, Natalia Brice, Marina Ruiz de Galarreta, Antonia García Garzón, María J Iraburu, Juan J Martínez-Irujo, María J López-Zabalz. Fibronectin peptides as potential regulators of hepatic fibrosis through apoptosis of hepatic stellate cells. Journal of cellular physiology. vol 230. issue 3. 2015-02-10. PMID:24976518. |
by the use of specific inhibitors we demonstrated the involvement of src, jnk, and p38 in apoptosis induced by fibronectin peptides on hsc. |
2015-02-10 |
2023-08-13 |
human |
| Ling Xu, Xiujuan Qu, Heming Li, Ce Li, Jing Liu, Huachuan Zheng, Yunpeng Li. Src/caveolin-1-regulated EGFR activation antagonizes TRAIL-induced apoptosis in gastric cancer cells. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24840271. |
a src inhibitor prevented these interactions and the activation of caveolin-1 and egfr, and thus enhanced trail-induced apoptosis. |
2015-01-14 |
2023-08-13 |
Not clear |
| Ling Xu, Xiujuan Qu, Heming Li, Ce Li, Jing Liu, Huachuan Zheng, Yunpeng Li. Src/caveolin-1-regulated EGFR activation antagonizes TRAIL-induced apoptosis in gastric cancer cells. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24840271. |
these data suggest that src activates egfr through the interaction of both src-egfr and src-caveolin-1, and then antagonizes trail-induced apoptosis in gastric cancer cells. |
2015-01-14 |
2023-08-13 |
Not clear |
| Marta Woźniak, Katarzyna Hotowy, Elżbieta Czapińska, Kamila Duś-Szachniewicz, Izabela Szczuka, Elżbieta Gamian, Andrzej Gamian, Grzegorz Terlecki, Piotr Ziółkowsk. Early induction of stress-associated Src activator/Homo sapiens chromosome 9 open reading frame 10 protein following photodynamic therapy. Photodiagnosis and photodynamic therapy. vol 11. issue 1. 2014-12-29. PMID:24280438. |
the oxidative stress-associated src activator/homo sapiens chromosome 9 open reading frame 10 protein (ossa/c9orf10) protects cancer cells from oxidative stress-induced apoptosis by src family kinases activation. |
2014-12-29 |
2023-08-12 |
Not clear |
| Yan Song, Yao-Dong Dong, Wei-Liang Bai, Xiu-Lan M. Silencing of Src by siRNA inhibits laryngeal carcinoma growth through the Src/PI-3 K/Akt pathway in vitro and in vivo. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 9. 2014-12-29. PMID:24903382. |
this study has demonstrated that src participates in the regulation of apoptosis through the src/pi-3 k/akt signaling pathway in the hep-2 cell line. |
2014-12-29 |
2023-08-13 |
Not clear |
| Yu-Qing Duan, Ying Ma, Xue-Jiao Wang, Yuan-Yuan Jin, Run-Ling Wang, Wei-Li Dong, Wei-Ren Xu, De-Xin Kong, Shu-Qing Wan. Design potential selective inhibitors for treating cancer by targeting the Src homology 2 (SH2) domain-containing phosphatase 2 (Shp2) with core hopping approach. Protein and peptide letters. vol 21. issue 6. 2014-12-17. PMID:24364859. |
due to the vital role in many cell regulatory processes, such as cell cycle control, survival and apoptosis, as well as growth and neurotransmitter signaling, src homology 2 (sh2) domain-containing phosphatase 2(shp2) has attracted considerable attention for developing drugs to treat cancers. |
2014-12-17 |
2023-08-12 |
Not clear |
| Song Hui Jia, Jean Parodo, Emmanuel Charbonney, Jennifer L Y Tsang, Sang Yang Jia, Ori D Rotstein, Andras Kapus, John C Marshal. Activated neutrophils induce epithelial cell apoptosis through oxidant-dependent tyrosine dephosphorylation of caspase-8. The American journal of pathology. vol 184. issue 4. 2014-12-05. PMID:24589337. |
cells transfected with a mutant caspase-8 in which tyrosine residues at tyr397 or tyr465 are replaced by nonphosphorylatable phenylalanine underwent accelerated apoptosis, whereas either mutation of these residues to phosphomimetic glutamic acid or transfection with the src kinases lyn or c-src inhibited hydrogen peroxide-induced apoptosis. |
2014-12-05 |
2023-08-12 |
Not clear |
| Li-Fu Li, Yung-Yang Liu, Kuo-Chin Kao, Chen-Te Wu, Chih-Hao Chang, Chen-Yiu Hung, Cheng-Ta Yan. Mechanical ventilation augments bleomycin-induced epithelial-mesenchymal transition through the Src pathway. Laboratory investigation; a journal of technical methods and pathology. vol 94. issue 9. 2014-10-27. PMID:24955896. |
mechanical stretch-augmented emt and epithelial apoptosis were attenuated in src-deficient mice and pharmacological inhibition of src activity by pp2 (p<0.05). |
2014-10-27 |
2023-08-13 |
mouse |
| Yuan Lin, Fei Wang, Guo-Lin Zhan. Natural products and their derivatives regulating the janus kinase/signal transducer and activator of transcription pathway. Journal of Asian natural products research. vol 16. issue 7. 2014-10-15. PMID:25076196. |
the proteins of jak/stat pathway or interferon response element (such as jak, stat, src, socs, 2'5'-oas, and isre) might be as drug targets for the study of physiological processes and treatment of related diseases, including cell proliferation, differentiation, apoptosis and immune processes, inflammation, cancer, arthritis, asthma, diabetes, and other diseases. |
2014-10-15 |
2023-08-13 |
human |
| Shao-Peng Zhou, Wei-Tao Liao, Lu-Kun Yang, Liao Su. Effects of sevoflurane pretreatment on renal Src and FAK expression in diabetic rats after renal ischemia/reperfusion injury. Molecular and cellular biochemistry. vol 384. issue 1-2. 2014-09-30. PMID:24002704. |
the aim of this study was to determine if sevoflurane pretreatment could help preserve renal function in rats with diabetes mellitus (dm) by altering non-receptor tyrosine kinases steroid receptor coactivator (src) and focal adhesion kinase (fak) expression (src and fak are mediators of cellular apoptosis and necrosis). |
2014-09-30 |
2023-08-12 |
rat |
| Wenchang Guo, Ruiwu Liu, Gaurav Bhardwaj, Ai-Hong Ma, Chun Changou, Joy C Yang, Yuanpei Li, Caihong Feng, Yan Luo, Anisha Mazloom, Eduardo Sanchez, Yan Wang, Wenzhe Huang, Randen Patterson, Christopher P Evans, Kit S Lam, Hsing-Jien Kun. CTA095, a novel Etk and Src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to Src inhibitors. PloS one. vol 8. issue 8. 2014-09-23. PMID:23967135. |
cta095, a novel etk and src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to src inhibitors. |
2014-09-23 |
2023-08-12 |
human |
| Wenchang Guo, Ruiwu Liu, Gaurav Bhardwaj, Ai-Hong Ma, Chun Changou, Joy C Yang, Yuanpei Li, Caihong Feng, Yan Luo, Anisha Mazloom, Eduardo Sanchez, Yan Wang, Wenzhe Huang, Randen Patterson, Christopher P Evans, Kit S Lam, Hsing-Jien Kun. CTA095, a novel Etk and Src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to Src inhibitors. PloS one. vol 8. issue 8. 2014-09-23. PMID:23967135. |
it induces apoptosis in src inhibitor resistant prostate cancer cells, likely through a mechanism of down regulation of myc and bcl2. |
2014-09-23 |
2023-08-12 |
human |
| Toshikage Nagao, Tetsuya Kurosu, Yoshihiro Umezawa, Ayako Nogami, Gaku Oshikawa, Shuji Tohda, Masahide Yamamoto, Osamu Miur. Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera. PloS one. vol 9. issue 1. 2014-09-16. PMID:24404189. |
proliferation of pvtl-1 was inhibited and apoptosis was induced by the pan-jak inhibitor jak inhibitor-1 (jaki-1) or dasatinib, which inhibits the src family kinases as well as bcr/abl. |
2014-09-16 |
2023-08-12 |
Not clear |
| Tilman Polonio-Vallon, Joanna Kirkpatrick, Jeroen Krijgsveld, Thomas G Hofman. Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization. Cell cycle (Georgetown, Tex.). vol 13. issue 1. 2014-09-04. PMID:24196445. |
accordingly, we find that hyperactive src decreases chemotherapeutic drug-induced p53 ser46 phosphorylation and apoptosis activation. |
2014-09-04 |
2023-08-12 |
Not clear |
| Virginie Vlaeminck-Guillem, Germain Gillet, Ruth Rimok. SRC: marker or actor in prostate cancer aggressiveness. Frontiers in oncology. vol 4. 2014-09-03. PMID:25184116. |
indeed, src is at the cross-roads of several pathways [including androgen receptor (ar), tgfbeta, bcl-2, akt/pten or mapk, and erk …], and is now known to influence some of the cellular and tissular events that accompany tumor progression: cell proliferation, cell motility, invasion, epithelial-to-mesenchymal transition, resistance to apoptosis, angiogenesis, neuroendocrine differentiation, and metastatic spread. |
2014-09-03 |
2023-08-13 |
Not clear |
| Y Fu, G Yang, F Zhu, C Peng, W Li, H Li, H-G Kim, A M Bode, Z Dong, Z Don. Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation. Cell death & disease. vol 5. 2014-09-02. PMID:24407236. |
mouse embryonic fibroblasts that are deficient in src showed a clear resistance to 5-fu, and knocking down src protein expression in colon cancer cells also decreased 5-fu-induced apoptosis. |
2014-09-02 |
2023-08-12 |
mouse |
| Y Fu, G Yang, F Zhu, C Peng, W Li, H Li, H-G Kim, A M Bode, Z Dong, Z Don. Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation. Cell death & disease. vol 5. 2014-09-02. PMID:24407236. |
when using 5-fu and antioxidants together, src activation was blocked, resulting in decreased 5-fu-induced apoptosis. |
2014-09-02 |
2023-08-12 |
mouse |