| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E S Shin, Q Huang, Z Gurel, T L Palenski, I Zaitoun, C M Sorenson, N Sheiban. STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions. Cell death & disease. vol 5. 2014-09-02. PMID:24407239. |
although the increased rate of apoptosis in pericytes (pcs) has been linked to increased oxidative stress and activation of protein kinase c-δ (pkc-δ) and shp-1 (src homology region 2 domain-containing phosphatase-1) tyrosine phosphatase during diabetes, the detailed mechanisms require further elucidation. |
2014-09-02 |
2023-08-12 |
mouse |
| Sushil Kumar Pathak, Raquel Tavares, Nele de Klerk, Anna-Lena Spetz, Ann-Beth Jonsso. Helicobacter pylori protein JHP0290 binds to multiple cell types and induces macrophage apoptosis via tumor necrosis factor (TNF)-dependent and independent pathways. PloS one. vol 8. issue 11. 2014-08-20. PMID:24223737. |
intracellular signaling involving src family of tyrosine kinases (sfks) and erk mapk were required for rjhp0290-induced tnf release and apoptosis in macrophages. |
2014-08-20 |
2023-08-12 |
human |
| V A Rudrapatna, E Bangi, R L Caga. A Jnk-Rho-Actin remodeling positive feedback network directs Src-driven invasion. Oncogene. vol 33. issue 21. 2014-07-24. PMID:23831567. |
we found that arps were required for many oncogenic effects of src including mmp1 expression and initiation of apoptosis. |
2014-07-24 |
2023-08-12 |
drosophila_melanogaster |
| Meirav Avital-Shacham, Rakefet Sharf, Tamar Kleinberge. NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein through PP2A-dependent and -independent mechanisms and contribute to induction of cell death. Journal of virology. vol 88. issue 11. 2014-07-02. PMID:24672025. |
the adenovirus e4orf4 protein induces nonclassical apoptosis in mammalian cells through at least two complementing pathways regulated by the interactions of e4orf4 with protein phosphatase 2a (pp2a) and src kinases. |
2014-07-02 |
2023-08-12 |
Not clear |
| Melissa Heffler, Vita M Golubovskaya, Kelli M Bullard Dunn, William Canc. Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy. Cancer biology & therapy. vol 14. issue 8. 2014-05-22. PMID:23792569. |
finally, tumors treated with y15 expressed less y397 phosphorylation, src phosphorylation and had greater apoptosis than controls. |
2014-05-22 |
2023-08-12 |
Not clear |
| Hui Mao, Gen Kano, Sherry A Hudson, Mary Brummet, Nives Zimmermann, Zhou Zhu, Bruce S Bochne. Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen. PloS one. vol 8. issue 6. 2014-04-24. PMID:23840825. |
mechanisms of siglec-f-induced eosinophil apoptosis: a role for caspases but not for shp-1, src kinases, nadph oxidase or reactive oxygen. |
2014-04-24 |
2023-08-12 |
mouse |
| Francesca Zonta, Mario Angelo Pagano, Livio Trentin, Elena Tibaldi, Federica Frezzato, Cristina Gattazzo, Veronica Martini, Valentina Trimarco, Marco Mazzorana, Luciana Bordin, Gianpietro Semenzato, Anna Maria Brunat. Lyn-mediated procaspase 8 dimerization blocks apoptotic signaling in B-cell chronic lymphocytic leukemia. Blood. vol 123. issue 6. 2014-04-04. PMID:24352878. |
lyn, a member of the group of tyrosine kinases named the src family kinases (sfks), is overexpressed, associated with an aberrant multiprotein complex and constitutively active in b-cell chronic lymphocytic leukemia (b-cll) cells, resulting in a high level of tyrosine phosphorylation and contributing to their resistance to apoptosis. |
2014-04-04 |
2023-08-12 |
Not clear |
| Roberto Ciarcia, Sara Damiano, Serena Montagnaro, Ugo Pagnini, Antonio Ruocco, Giuseppe Caparrotti, Danila d'Angelo, Silvia Boffo, Fátima Morales, Flavio Rizzolio, Salvatore Florio, Antonio Giordan. Combined effects of PI3K and SRC kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in CML-PBL cells. Cell cycle (Georgetown, Tex.). vol 12. issue 17. 2014-03-20. PMID:23966159. |
combined effects of pi3k and src kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in cml-pbl cells. |
2014-03-20 |
2023-08-12 |
Not clear |
| Roberto Ciarcia, Sara Damiano, Serena Montagnaro, Ugo Pagnini, Antonio Ruocco, Giuseppe Caparrotti, Danila d'Angelo, Silvia Boffo, Fátima Morales, Flavio Rizzolio, Salvatore Florio, Antonio Giordan. Combined effects of PI3K and SRC kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in CML-PBL cells. Cell cycle (Georgetown, Tex.). vol 12. issue 17. 2014-03-20. PMID:23966159. |
in this study, we verified the effect of imatinib mesylate (im), alone or in association with ly294002 (ly) (a specific pi3k protein tyrosine kinase inhibitor) or 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]-pyrimidine (pp1) (a src tyrosine kinase inhibitor), on viability, intracellular calcium mobilization, apoptosis, and autophagy, in order to verify possible mechanisms of interaction. |
2014-03-20 |
2023-08-12 |
Not clear |
| Sheng-Hung Liu, Chao-Hsiung Lin, Fong-Ping Liang, Pei-Fen Chen, Cheng-Deng Kuo, Mohd Mujahid Alam, Barnali Maiti, Shih-Kai Hung, Chin-Wen Chi, Chung-Ming Sun, Shu-Ling F. Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy. Biochemical pharmacology. vol 87. issue 2. 2014-03-18. PMID:24161787. |
in cancer cells, the induction of hsp90 cleavage by andrographolide and its structural derivatives correlated well with decreased src levels, the suppression of transformation, and the induction of apoptosis. |
2014-03-18 |
2023-08-12 |
human |
| Sheng-Hung Liu, Chao-Hsiung Lin, Fong-Ping Liang, Pei-Fen Chen, Cheng-Deng Kuo, Mohd Mujahid Alam, Barnali Maiti, Shih-Kai Hung, Chin-Wen Chi, Chung-Ming Sun, Shu-Ling F. Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy. Biochemical pharmacology. vol 87. issue 2. 2014-03-18. PMID:24161787. |
moreover, the andrographolide-induced hsp90 cleavage, src degradation, inhibition of transformation, and induction of apoptosis were abolished by a ros inhibitor, n-acetyl-cysteine. |
2014-03-18 |
2023-08-12 |
human |
| Lara H El Touny, Anthony Vieira, Arnulfo Mendoza, Chand Khanna, Mark J Hoenerhoff, Jeffrey E Gree. Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells. The Journal of clinical investigation. vol 124. issue 1. 2014-03-03. PMID:24316974. |
combination treatment of cells undergoing the dormant-to-proliferative switch with the src inhibitor (azd0530) and mek1/2 inhibitor (azd6244) induced apoptosis in a large fraction of the dormant cells and delayed metastatic outgrowth, neither of which was observed with either inhibitor alone. |
2014-03-03 |
2023-08-12 |
Not clear |
| Aung Naing, Roger Cohen, Grace K Dy, David S Hong, Lyn Dyster, David G Hangauer, Rudolf Kwan, Gerald Fetterly, Razelle Kurzrock, Alex A Adje. A phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket- directed SRC inhibitor, in patients with advanced malignancies. Investigational new drugs. vol 31. issue 4. 2014-02-11. PMID:23361621. |
src kinase is central to tumor cell proliferation, apoptosis, and metastasis. |
2014-02-11 |
2023-08-12 |
Not clear |
| Julianna Novák, Éva Kriston-Pál, Ágnes Czibula, Magdolna Deák, László Kovács, Éva Monostori, Roberta Fajka-Boj. GM1 controlled lateral segregation of tyrosine kinase Lck predispose T-cells to cell-derived galectin-1-induced apoptosis. Molecular immunology. vol 57. issue 2. 2014-02-11. PMID:24231767. |
one prominent immunoregulatory function of galectin-1 (gal-1), a β-galactoside binding mammalian lectin, is induction of apoptosis in activated t-cells by a process depending on the activity of src family tyrosine kinase, lck. |
2014-02-11 |
2023-08-12 |
Not clear |
| Sangkil Nam, Wei Wen, Anne Schroeder, Andreas Herrmann, Hua Yu, Xinlai Cheng, Karl-Heinz Merz, Gerhard Eisenbrand, Hongzhi Li, Yate-Ching Yuan, Richard Jov. Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells. Molecular oncology. vol 7. issue 3. 2013-12-23. PMID:23206899. |
dual inhibition of janus and src family kinases by novel indirubin derivative blocks constitutively-activated stat3 signaling associated with apoptosis of human pancreatic cancer cells. |
2013-12-23 |
2023-08-12 |
human |
| Annabelle Ballesta, Jonathan Lopez, Nikolay Popgeorgiev, Philippe Gonzalo, Marie Doumic, Germain Gille. Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization. PLoS computational biology. vol 9. issue 4. 2013-12-19. PMID:23592961. |
data-driven modeling of src control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization. |
2013-12-19 |
2023-08-12 |
mouse |
| Annabelle Ballesta, Jonathan Lopez, Nikolay Popgeorgiev, Philippe Gonzalo, Marie Doumic, Germain Gille. Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization. PLoS computational biology. vol 9. issue 4. 2013-12-19. PMID:23592961. |
we previously described that src activation in nih-3t3 mouse fibroblasts promoted cell resistance to apoptosis. |
2013-12-19 |
2023-08-12 |
mouse |
| Annabelle Ballesta, Jonathan Lopez, Nikolay Popgeorgiev, Philippe Gonzalo, Marie Doumic, Germain Gille. Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization. PLoS computational biology. vol 9. issue 4. 2013-12-19. PMID:23592961. |
it showed that src inhibitors could circumvent resistance to apoptosis in src-transformed cells but gave no specific advantage to parental cells. |
2013-12-19 |
2023-08-12 |
mouse |
| Elizabeth M H Kim, Kelly Mueller, Elaina Gartner, Julie Boerne. Dasatinib is synergistic with cetuximab and cisplatin in triple-negative breast cancer cells. The Journal of surgical research. vol 185. issue 1. 2013-12-17. PMID:23899511. |
we hypothesize that dasatinib, an src family tyrosine kinase inhibitor, may help overcome egfr resistance to cetuximab, and in combination with cisplatin may enhance growth inhibition and apoptosis and reduce metastatic potential. |
2013-12-17 |
2023-08-12 |
Not clear |
| Dongkyu Kim, Jueun Hong, Hyung-Ho Moon, Hye Yeong Nam, Hyejung Mok, Ji Hoon Jeong, Sung Wan Kim, Donghoon Choi, Sun Hwa Ki. Anti-apoptotic cardioprotective effects of SHP-1 gene silencing against ischemia-reperfusion injury: use of deoxycholic acid-modified low molecular weight polyethyleneimine as a cardiac siRNA-carrier. Journal of controlled release : official journal of the Controlled Release Society. vol 168. issue 2. 2013-12-12. PMID:23500061. |
herein, we report ischemic-reperfused myocardial infarction (mi) repair with sirna against src homology region 2 domain-containing tyrosine phosphatase-1 (shp-1), which is known as a key factor involved in regulating the progress of apoptosis in many cell types. |
2013-12-12 |
2023-08-12 |
rat |