| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Indovina, F Giorgi, V Rizzo, B Khadang, S Schenone, D Di Marzo, I M Forte, V Tomei, E Mattioli, V D'Urso, B Grilli, M Botta, A Giordano, F Pentimall. New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization. Oncogene. vol 31. issue 7. 2012-05-04. PMID:21785466. |
we also showed that src inhibitor-induced apoptosis occurred concomitantly with an increase in the nuclear stability of the cyclin-dependent kinase inhibitor p27. |
2012-05-04 |
2023-08-12 |
Not clear |
| P Indovina, F Giorgi, V Rizzo, B Khadang, S Schenone, D Di Marzo, I M Forte, V Tomei, E Mattioli, V D'Urso, B Grilli, M Botta, A Giordano, F Pentimall. New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization. Oncogene. vol 31. issue 7. 2012-05-04. PMID:21785466. |
to determine whether p27 stabilization has a direct role in apoptosis induced by src inhibition, we stably silenced the cdkn1b gene, encoding p27, in msto-211h and ren mesothelioma cells by transduction with lentiviral vectors expressing short hairpin rnas against the cdkn1b transcript. |
2012-05-04 |
2023-08-12 |
Not clear |
| P Indovina, F Giorgi, V Rizzo, B Khadang, S Schenone, D Di Marzo, I M Forte, V Tomei, E Mattioli, V D'Urso, B Grilli, M Botta, A Giordano, F Pentimall. New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization. Oncogene. vol 31. issue 7. 2012-05-04. PMID:21785466. |
strikingly, p27 silencing was able to suppress the apoptosis induced by these src inhibitors in both mm cell lines, suggesting that p27 has a crucial proapoptotic role in mm cells treated with src inhibitors. |
2012-05-04 |
2023-08-12 |
Not clear |
| P Indovina, F Giorgi, V Rizzo, B Khadang, S Schenone, D Di Marzo, I M Forte, V Tomei, E Mattioli, V D'Urso, B Grilli, M Botta, A Giordano, F Pentimall. New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization. Oncogene. vol 31. issue 7. 2012-05-04. PMID:21785466. |
our findings reveal a new mechanism, dependent on p27 nuclear stabilization, by which src inhibition can induce apoptosis in mm cells and provide a new rationale for the use of src inhibitors in mm therapy. |
2012-05-04 |
2023-08-12 |
Not clear |
| Michela Garofalo, Giulia Romano, Gianpiero Di Leva, Gerard Nuovo, Young-Jun Jeon, Apollinaire Ngankeu, Jin Sun, Francesca Lovat, Hansjuerg Alder, Gerolama Condorelli, Jeffrey A Engelman, Mayumi Ono, Jin Kyung Rho, Luciano Cascione, Stefano Volinia, Kenneth P Nephew, Carlo M Croc. EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nature medicine. vol 18. issue 1. 2012-03-14. PMID:22157681. |
we showed that these mirnas have important roles in gefitinib-induced apoptosis and epithelial-mesenchymal transition of nsclc cells in vitro and in vivo by inhibiting the expression of the genes encoding bcl2-like 11 (bim), apoptotic peptidase activating factor 1 (apaf-1), protein kinase c ɛ (pkc-ɛ) and sarcoma viral oncogene homolog (src). |
2012-03-14 |
2023-08-12 |
Not clear |
| Haiou Liu, Jiejie Xu, Lei Zhou, Xiaojing Yun, Lin Chen, Shanshan Wang, Linlin Sun, Yumei Wen, Jianxin G. Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway. Cancer research. vol 71. issue 24. 2012-03-06. PMID:21994334. |
proliferation induced by stable lhbs expression was associated with increased g(1)-s cell-cycle progression and apoptosis resistance mediated by src kinase activation, as established in hepatocellular carcinoma clinical specimens. |
2012-03-06 |
2023-08-12 |
mouse |
| Christina Leah B Kline, Rosalyn B Irb. The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU. Apoptosis : an international journal on programmed cell death. vol 16. issue 12. 2012-02-15. PMID:21910008. |
the pro-apoptotic protein prostate apoptosis response protein-4 (par-4) can be activated in colon cancer cells by treatment with src inhibitor and 5-fu. |
2012-02-15 |
2023-08-12 |
Not clear |
| Christina Leah B Kline, Rosalyn B Irb. The pro-apoptotic protein Prostate Apoptosis Response Protein-4 (Par-4) can be activated in colon cancer cells by treatment with Src inhibitor and 5-FU. Apoptosis : an international journal on programmed cell death. vol 16. issue 12. 2012-02-15. PMID:21910008. |
the activation of the pro-apoptotic protein par-4 as reported in this study is a novel mechanism by which apoptosis occurs with a src kinase inhibitor and 5-fu. |
2012-02-15 |
2023-08-12 |
Not clear |
| Sharanjot Saini, Sumit Arora, Shahana Majid, Varahram Shahryari, Yi Chen, Guoren Deng, Soichiro Yamamura, Koji Ueno, Rajvir Dahiy. Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer. Cancer prevention research (Philadelphia, Pa.). vol 4. issue 10. 2012-02-02. PMID:21836020. |
this leads to downregulation of mir-203 target genes akt2 and src that culminates in decreased proliferation and increased apoptosis of bladder cancer cells. |
2012-02-02 |
2023-08-12 |
Not clear |
| Jun Liu, Xinnv Xu, Xuequan Feng, Biao Zhang, Jinhuan Wan. Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251. Journal of experimental & clinical cancer research : CR. vol 30. 2012-01-17. PMID:21906308. |
in the current study, we found that in glioma cells u251, ad-bfgf-sirna impedes the activation of erk1/2 and jak2, but not src, decreases il-6 secretion, reduces stat3 phosphorylation, decreases the levels of downstream molecules cyclind1 and bcl-xl, and ultimately results in the collapse of mitochondrial membrane potentials as well as the induction of mitochondrial-related apoptosis. |
2012-01-17 |
2023-08-12 |
human |
| Madeleine Rådinger, Daniel Smrž, Dean D Metcalfe, Alasdair M Gilfilla. Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 11. 2012-01-13. PMID:22039301. |
the decrease in stem cell factor (scf)-mediated survival in the gsk3β knockdown humcs was reflected by enhancement of scf withdrawal-induced apoptosis, as determined by annexin v staining and caspase cleavage, and this was associated with a pronounced reduction in scf-mediated phosphorylation of src homology 2 domain-containing phosphatase 2 and erk1/2 and reduced expression of the antiapoptotic proteins bcl-xl and bcl-2. |
2012-01-13 |
2023-08-12 |
human |
| Patrick J M Murphy, Hannah R Franklin, Nathan W Furukaw. Biochemical reconstitution of steroid receptor•Hsp90 protein complexes and reactivation of ligand binding. Journal of visualized experiments : JoVE. issue 55. 2011-12-22. PMID:21968922. |
src, raf, akt kinase) involved in cell cycling, tumorigenesis, apoptosis, and multiple eukaryotic signaling pathways (1,2). |
2011-12-22 |
2023-08-12 |
Not clear |
| Jinlong Jian, Qing Yang, Xi Huan. Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival. The Journal of biological chemistry. vol 286. issue 41. 2011-12-12. PMID:21859709. |
interestingly, only src inhibitor pp2 greatly sensitized the cells to ga-mediated apoptosis. |
2011-12-12 |
2023-08-12 |
Not clear |
| Hsing-Jien Kun. Targeting tyrosine kinases and autophagy in prostate cancer. Hormones & cancer. vol 2. issue 1. 2011-11-29. PMID:21350583. |
while effective in inducing growth arrest and inhibiting metastasis of castration-resistant tumors, src inhibitors rarely induce a significant level of apoptosis. |
2011-11-29 |
2023-08-12 |
Not clear |
| Zhi-Yu Chen, Lei Cai, Jin Zhu, Min Chen, Jian Chen, Zhi-Hua Li, Xiang-De Liu, Shu-Guang Wang, Ping Bie, Peng Jiang, Jia-Hong Dong, Xiao-Wu L. Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer. Carcinogenesis. vol 32. issue 10. 2011-11-29. PMID:21642356. |
the src family kinase fyn, heterogenous nuclear ribonucleoprotein (hnrnp) a2b1 and sam68 are thought to be associated with the metastasis of tumors, but their roles in the regulation of apoptosis remain unclear. |
2011-11-29 |
2023-08-12 |
human |
| Zhaoju Wu, Pei-Ching Chang, Joy C Yang, Cheng-Ying Chu, Ling-Yu Wang, Nien-Tsu Chen, Ai-Hong Ma, Sonal J Desai, Su Hao Lo, Christopher P Evans, Kit S Lam, Hsing-Jien Kun. Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors. Genes & cancer. vol 1. issue 1. 2011-11-10. PMID:20811583. |
previously, the authors reported that src inhibitors such as saracatinib and pp2 caused g1 growth arrest and diminished invasiveness in prostate cancer cells but rarely apoptosis. |
2011-11-10 |
2023-08-12 |
mouse |
| Zhaoju Wu, Pei-Ching Chang, Joy C Yang, Cheng-Ying Chu, Ling-Yu Wang, Nien-Tsu Chen, Ai-Hong Ma, Sonal J Desai, Su Hao Lo, Christopher P Evans, Kit S Lam, Hsing-Jien Kun. Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors. Genes & cancer. vol 1. issue 1. 2011-11-10. PMID:20811583. |
here, they have shown that src family kinase (sfk) inhibitors can induce a high level of autophagy, which protects treated cells from undergoing apoptosis. |
2011-11-10 |
2023-08-12 |
mouse |
| Suryakant K Niture, Abhinav K Jain, Phillip M Shelton, Anil K Jaiswa. Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression. The Journal of biological chemistry. vol 286. issue 33. 2011-10-19. PMID:21690096. |
the overexpression of src kinases in hepa-1 cells led to decreased nrf2, increased apoptosis, and decreased cell survival. |
2011-10-19 |
2023-08-12 |
mouse |
| Suryakant K Niture, Abhinav K Jain, Phillip M Shelton, Anil K Jaiswa. Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression. The Journal of biological chemistry. vol 286. issue 33. 2011-10-19. PMID:21690096. |
mouse embryonic fibroblasts deficient in src kinases showed nuclear accumulation of nrf2, induction of nrf2 and downstream gene expression, reduced apoptosis, and increased cell survival. |
2011-10-19 |
2023-08-12 |
mouse |
| Jing Zhao, Yoji Kyotani, Satoyasu Itoh, Hitoshi Nakayama, Minoru Isosaki, Masanori Yoshizum. Big mitogen-activated protein kinase 1 protects cultured rat aortic smooth muscle cells from oxidative damage. Journal of pharmacological sciences. vol 116. issue 2. 2011-10-14. PMID:21597237. |
cell apoptosis was evaluated by using the tdt-mediated dutp nick end labeling (tunel) method, and bmk1 and src activities were determined by western blotting. |
2011-10-14 |
2023-08-12 |
rat |