| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa Yu, Satbir Thakur, Rebecca Yy Leong-Quong, Keiko Suzuki, Andy Pang, Jeffrey D Bjorge, Karl Riabowol, Donald J Fujit. Src regulates the activity of the ING1 tumor suppressor. PloS one. vol 8. issue 4. 2013-10-22. PMID:23585863. |
functionally, src antagonizes the ability of ing1 to induce apoptosis, most likely through relocalization of ing1 and down regulation of ing1 levels. |
2013-10-22 |
2023-08-12 |
Not clear |
| Edward X She, Zhonglin Ha. A novel piperazine derivative potently induces caspase-dependent apoptosis of cancer cells via inhibition of multiple cancer signaling pathways. American journal of translational research. vol 5. issue 6. 2013-10-04. PMID:24093059. |
our studies suggest that this piperazine derivative effectively (gi50 = 0.06-0.16 μm) inhibits cancer cell proliferation and induces caspase-dependent apoptosis via inhibiting multiple cancer signaling pathways including the pi3k/akt, the src family kinases and the bcr-abl pathways. |
2013-10-04 |
2023-08-12 |
Not clear |
| Carol Chen-Scarabelli, Louis Saravolatz Ii, Roy McCaukey, Gabriele Scarabelli, Justin Di Rezze, Bibhu Mohanty, Sean Barry, David Latchman, Vassilis Georgiadis, James McCormick, Louis Saravolatz, Richard Knight, Giuseppe Faggian, Jagat Narula, Anastasis Stephanou, Tiziano M Scarabell. The cardioprotective effects of urocortin are mediated via activation of the Src tyrosine kinase-STAT3 pathway. JAK-STAT. vol 2. issue 3. 2013-09-26. PMID:24069562. |
src kinase was also shown to reduce apoptosis in different cancer cell lines, enhancing phosphorylation and dna binding affinity of signal transducer and activator of transcription (stat)3. |
2013-09-26 |
2023-08-12 |
Not clear |
| Misaki Ono, Takako Higuchi, Mikako Takeshima, Chen Chen, Shuji Nakan. Differential anti-tumor activities of curcumin against Ras- and Src-activated human adenocarcinoma cells. Biochemical and biophysical research communications. vol 436. issue 2. 2013-09-20. PMID:23726918. |
these data indicate that curcumin-induced growth inhibition would be mediated mainly by g2/m arrest in ras-driven cells but by apoptosis induction in src-driven cells, providing a mechanistic rationale for the potential use of curcumin in the treatment of human cancers with activated src or ras. |
2013-09-20 |
2023-08-12 |
human |
| Zengguang Wang, Jikui Sun, Xue Li, Shuyuan Yang, Shuyuan Yue, Jianning Zhang, Xuejun Yang, Tao Zhu, Rongcai Jiang, Weidong Yan. Downregulation of Src enhances the cytotoxic effect of temozolomide through AKT in glioma. Oncology reports. vol 29. issue 4. 2013-09-12. PMID:23338526. |
src silencing suppressed tumor proliferation and induced apoptosis in glioma. |
2013-09-12 |
2023-08-12 |
Not clear |
| Zengguang Wang, Jikui Sun, Xue Li, Shuyuan Yang, Shuyuan Yue, Jianning Zhang, Xuejun Yang, Tao Zhu, Rongcai Jiang, Weidong Yan. Downregulation of Src enhances the cytotoxic effect of temozolomide through AKT in glioma. Oncology reports. vol 29. issue 4. 2013-09-12. PMID:23338526. |
thus, the present study demonstrated that src plays a biologically significant role in tumor proliferation and apoptosis and enhances the cytotoxic effect of temozolomide through akt supression in glioma. |
2013-09-12 |
2023-08-12 |
Not clear |
| Yun-Ki Kim, Jun-Ho Ahn, Michael Le. Src Family Kinase Inhibitor PP2 Induces LC3 Conversion in a Manner That is Uncoupled from Autophagy and Increases Apoptosis in Multidrug-Resistant Cells. Biomolecules & therapeutics. vol 20. issue 4. 2013-09-06. PMID:24009826. |
src family kinase inhibitor pp2 induces lc3 conversion in a manner that is uncoupled from autophagy and increases apoptosis in multidrug-resistant cells. |
2013-09-06 |
2023-08-12 |
Not clear |
| Yanan Guo, Jinyan Du, David J Kwiatkowsk. Molecular dissection of AKT activation in lung cancer cell lines. Molecular cancer research : MCR. vol 11. issue 3. 2013-09-03. PMID:23319332. |
despite the activation of notch, akt activation and cell survival were not affected by notch inhibitors dapt or compound e. in contrast, src inhibitors pp2 and dasatinib both significantly decreased pakt(ser473) levels and reduced cell survival by inducing apoptosis. |
2013-09-03 |
2023-08-12 |
human |
| Yanan Guo, Jinyan Du, David J Kwiatkowsk. Molecular dissection of AKT activation in lung cancer cell lines. Molecular cancer research : MCR. vol 11. issue 3. 2013-09-03. PMID:23319332. |
furthermore, a combination of src and mtor inhibition synergistically blocked activation of akt and induced apoptosis. |
2013-09-03 |
2023-08-12 |
human |
| José G Treviño, Smitha Pillai, Sateesh Kunigal, Sandeep Singh, William J Fulp, Barbara A Centeno, Srikumar P Chellappa. Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Neoplasia (New York, N.Y.). vol 14. issue 12. 2013-07-10. PMID:23308043. |
nicotine could also confer resistance to apoptosis induced by gemcitabine in pancreatic cancer cells in vitro and depletion of src or id1 rendered the cells sensitive to gemcitabine. |
2013-07-10 |
2023-08-12 |
mouse |
| Yong Guo, Qingqing Shan, Yuping Gong, Juan Lin, Xi Yang, Ruiqing Zho. Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway. Cancer biology & therapy. vol 13. issue 13. 2013-07-03. PMID:22895079. |
to investigate the anticancer activity of oridonin, we examined its role in constitutively activated akt/mtor, raf/mek/erk, stat5 and src pathway, mrna level of bcr/abl gene, cell viability and apoptosis in ph+ all sup-b15 cells. |
2013-07-03 |
2023-08-12 |
Not clear |
| Yong Guo, Qingqing Shan, Yuping Gong, Juan Lin, Xi Yang, Ruiqing Zho. Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway. Cancer biology & therapy. vol 13. issue 13. 2013-07-03. PMID:22895079. |
our results showed that oridonin inhibiting activations of lyn (one of src family kinases) and abl and their downstream akt/mtor, raf/mek/erk and stat5 pathways, downregulated bcl-2 but upregulated bax protein and then induced apoptosis in ph+ all cells. |
2013-07-03 |
2023-08-12 |
Not clear |
| J Lopez, C Hesling, J Prudent, N Popgeorgiev, R Gadet, I Mikaelian, R Rimokh, G Gillet, P Gonzal. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell death and differentiation. vol 19. issue 9. 2013-06-19. PMID:22388352. |
src tyrosine kinase inhibits apoptosis through the erk1/2- dependent degradation of the death accelerator bik. |
2013-06-19 |
2023-08-12 |
mouse |
| J Lopez, C Hesling, J Prudent, N Popgeorgiev, R Gadet, I Mikaelian, R Rimokh, G Gillet, P Gonzal. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell death and differentiation. vol 19. issue 9. 2013-06-19. PMID:22388352. |
in addition to its effects on cell proliferation and motility, src is often considered as an inhibitor of apoptosis, although this remains controversial. |
2013-06-19 |
2023-08-12 |
mouse |
| J Lopez, C Hesling, J Prudent, N Popgeorgiev, R Gadet, I Mikaelian, R Rimokh, G Gillet, P Gonzal. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell death and differentiation. vol 19. issue 9. 2013-06-19. PMID:22388352. |
thus, whether the ability of src to generate malignancies relies on an intrinsic aptitude to inhibit apoptosis or requires preexistent resistance to apoptosis remains somewhat elusive. |
2013-06-19 |
2023-08-12 |
mouse |
| J Lopez, C Hesling, J Prudent, N Popgeorgiev, R Gadet, I Mikaelian, R Rimokh, G Gillet, P Gonzal. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell death and differentiation. vol 19. issue 9. 2013-06-19. PMID:22388352. |
here, using mouse fibroblasts transformed with v-src as a model, we show that the observed src-dependent resistance to cell death relies on src ability to inhibit the mitochondrial pathway of apoptosis by specifically increasing the degradation rate of the bh3-only protein bik. |
2013-06-19 |
2023-08-12 |
mouse |
| Himanshu Vashistha, Pravin C Singhal, Ashwani Malhotra, Mohammad Husain, Peter Mathieson, Moin A Saleem, Cyril Kuriakose, Surya Seshan, Anna Wilk, Luis Delvalle, Francesca Peruzzi, Marco Giorgio, Pier Giuseppe Pelicci, Oliver Smithies, Hyung-Suk Kim, Masao Kakoki, Krzysztof Reiss, Leonard G Megg. Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. American journal of physiology. Renal physiology. vol 303. issue 12. 2013-04-02. PMID:23019230. |
src homology 2 domain transforming protein 1 (p66) controls mitochondrial metabolism and cellular responses to oxidative stress, aging, and apoptosis. |
2013-04-02 |
2023-08-12 |
mouse |
| Landon J Inge, Aaron J Fowler, Kimberly M Paquette, Amanda L Richer, Nhan Tran, Ross M Bremne. Dasatinib, a small molecule inhibitor of the Src kinase, reduces the growth and activates apoptosis in pre-neoplastic Barrett's esophagus cell lines: evidence for a noninvasive treatment of high-grade dysplasia. The Journal of thoracic and cardiovascular surgery. vol 145. issue 2. 2013-03-14. PMID:23142123. |
dasatinib, a small molecule inhibitor of the src kinase, reduces the growth and activates apoptosis in pre-neoplastic barrett's esophagus cell lines: evidence for a noninvasive treatment of high-grade dysplasia. |
2013-03-14 |
2023-08-12 |
Not clear |
| Cai-Ping Du, Ran Tan, Xiao-Yu Ho. Fyn kinases play a critical role in neuronal apoptosis induced by oxygen and glucose deprivation or amyloid-β peptide treatment. CNS neuroscience & therapeutics. vol 18. issue 9. 2013-02-12. PMID:22709448. |
in this study, we investigated whether src and fyn kinases, two major members of srcptks in the brain, have distinct roles in the oxygen and glucose deprivation (ogd) and amyloid-β peptide (aβ)-induced neuronal apoptosis. |
2013-02-12 |
2023-08-12 |
Not clear |
| Muralidharan Anbalagan, Alaa Ali, Ryan K Jones, Carolyn G Marsden, Mei Sheng, Latonya Carrier, Yahao Bu, David Hangauer, Brian G Rowa. Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts. Molecular cancer therapeutics. vol 11. issue 9. 2013-02-07. PMID:22784709. |
kx-01 inhibited activity of src and downstream mediator fak in tumors that was coincident with reduced proliferation and angiogenesis and increased apoptosis. |
2013-02-07 |
2023-08-12 |
mouse |