| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brant M Wagener, Nicole A Marjon, Eric R Prossnit. Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction. PloS one. vol 11. issue 1. 2016-08-11. PMID:26788723. |
unlike wild type arrestin, arr2-p91g/p121e did not inhibit fpr-mediated apoptosis, suggesting that src binding to arrestin-2 prevents apoptotic signaling. |
2016-08-11 |
2023-08-13 |
Not clear |
| Brant M Wagener, Nicole A Marjon, Eric R Prossnit. Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction. PloS one. vol 11. issue 1. 2016-08-11. PMID:26788723. |
however, in cells expressing this mutant, fpr-mediated apoptosis was still blocked by inhibition of src kinase activity, suggesting that activation of src independent of arrestin-2 binding is involved in fpr-mediated apoptosis. |
2016-08-11 |
2023-08-13 |
Not clear |
| Brant M Wagener, Nicole A Marjon, Eric R Prossnit. Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction. PloS one. vol 11. issue 1. 2016-08-11. PMID:26788723. |
on the contrary, inhibition of src kinase activity mediated the accumulation of activated fpr-wild type arrestin-2 in recycling endosomes without initiating fpr-mediated apoptosis. |
2016-08-11 |
2023-08-13 |
Not clear |
| Jiliang Yan, Chunyan Ma, Jian Cheng, Zhengguo Li, Chao Li. HAX-1 inhibits apoptosis in prostate cancer through the suppression of caspase-9 activation. Oncology reports. vol 34. issue 5. 2016-08-08. PMID:26323553. |
hs1 associated protein x-1 (hax-1), a substrate of src family tyrosine kinases, plays a critical role in cell apoptosis. |
2016-08-08 |
2023-08-13 |
Not clear |
| Qiong Zhang, Xueying Song, Peng Su, Ranran Li, Chang Liu, Meng Gou, Hao Wang, Xin Liu, Qingwei L. A novel homolog of protein tyrosine kinase Fyn identified in Lampetra japonica with roles in the immune response. Gene. vol 579. issue 2. 2016-05-31. PMID:26743129. |
the non-receptor protein tyrosine kinase (nrptk) fyn, a member of the avian sarcoma virus transforming gene (src) kinase family, plays a very significant role in cell growth, survival, apoptosis, tumor formation and immune response. |
2016-05-31 |
2023-08-13 |
Not clear |
| Shi-mei Qi, Jun Lv, Yu Meng, Zhi-lin Qi, Lie-feng Lin. [Effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis by inhibiting AKT, ERK and upstream signal SRC activity]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 16. 2016-03-10. PMID:26790305. |
[effect of sodium aescinate in inducing human breast cancer mcf-7 cells apoptosis by inhibiting akt, erk and upstream signal src activity]. |
2016-03-10 |
2023-08-13 |
human |
| Shi-mei Qi, Jun Lv, Yu Meng, Zhi-lin Qi, Lie-feng Lin. [Effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis by inhibiting AKT, ERK and upstream signal SRC activity]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 16. 2016-03-10. PMID:26790305. |
the findings indicated that sodium aescinate can block signals transiting to downstream molecules akt, erk, inhibit the proliferation of breast cancer cell mcf-7 cell apoptosis and induced cell apoptosis by suppressing the activation of src. |
2016-03-10 |
2023-08-13 |
human |
| Aaron Goldman, Biswanath Majumder, Andrew Dhawan, Sudharshan Ravi, David Goldman, Mohammad Kohandel, Pradip K Majumder, Shiladitya Sengupt. Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition. Nature communications. vol 6. 2016-02-01. PMID:25669750. |
this state is associated with a clustering of cd44 and cd24 in membrane lipid rafts, leading to the activation of src family kinase (sfk)/hemopoietic cell kinase (hck) and suppression of apoptosis. |
2016-02-01 |
2023-08-13 |
mouse |
| Nan Wang, Hongwei Liang, Yong Zhou, Chen Wang, Suyang Zhang, Yi Pan, Yanbo Wang, Xin Yan, Junfeng Zhang, Chen-Yu Zhang, Ke Zen, Donghai Li, Xi Che. miR-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting SRC. PloS one. vol 9. issue 8. 2015-11-09. PMID:25140799. |
mir-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting src. |
2015-11-09 |
2023-08-13 |
Not clear |
| Nan Wang, Hongwei Liang, Yong Zhou, Chen Wang, Suyang Zhang, Yi Pan, Yanbo Wang, Xin Yan, Junfeng Zhang, Chen-Yu Zhang, Ke Zen, Donghai Li, Xi Che. miR-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting SRC. PloS one. vol 9. issue 8. 2015-11-09. PMID:25140799. |
finally, we demonstrated that the repression of src by mir-203 suppressed the proliferation and migration and promoted the apoptosis of lung cancer cells. |
2015-11-09 |
2023-08-13 |
Not clear |
| Sergio Wehinger, Rina Ortiz, María Inés Díaz, Adam Aguirre, Manuel Valenzuela, Paola Llanos, Christopher Mc Master, Lisette Leyton, Andrew F G Ques. Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells. Biochimica et biophysica acta. vol 1852. issue 5. 2015-10-01. PMID:25572853. |
thus, caveolin-1 expression promotes palmitate-induced ros-dependent apoptosis in min6 cells in a manner requiring src family kinase mediated tyrosine-14 phosphorylation. |
2015-10-01 |
2023-08-13 |
Not clear |
| Vera Sun, Wen B Zhou, Mehdi Nosrati, Shahana Majid, Suresh Thummala, David de Semir, Vladimir Bezrookove, Sebastien de Feraudy, Liane Chun, Dirk Schadendorf, Robert Debs, Mohammed Kashani-Sabet, Altaf A Da. Antitumor activity of miR-1280 in melanoma by regulation of Src. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 1. 2015-09-30. PMID:25195599. |
mir-1280-mediated suppression of src led to substantial decreases in melanoma cell proliferation, cell cycle progression, invasion, as well as induced melanoma cell apoptosis. |
2015-09-30 |
2023-08-13 |
human |
| Hongxia Hu, Naoharu Takano, Lisha Xiang, Daniele M Gilkes, Weibo Luo, Gregg L Semenz. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. vol 5. issue 19. 2015-08-07. PMID:25326682. |
binding of glutamate to its receptors activated src family kinases and downstream pathways, which stimulated cancer cell proliferation, apoptosis resistance, migration and invasion in different cancer cell lines. |
2015-08-07 |
2023-08-13 |
human |
| Chun-Hui Zhang, Ming-Wu Zheng, Ya-Ping Li, Xing-Dong Lin, Mei Huang, Lei Zhong, Guo-Bo Li, Rong-Jie Zhang, Wan-Ting Lin, Yan Jiao, Xiao-Ai Wu, Jiao Yang, Rong Xiang, Li-Juan Chen, Ying-Lan Zhao, Wei Cheng, Yu-Quan Wei, Sheng-Yong Yan. Design, Synthesis, and Structure-Activity Relationship Studies of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Derivatives as a New Class of Src Inhibitors with Potent Activities in Models of Triple Negative Breast Cancer. Journal of medicinal chemistry. vol 58. issue 9. 2015-08-06. PMID:25835317. |
western blot and immunohistochemical assays revealed that compound 1j significantly inhibited src and mapk signaling and markedly induced apoptosis in tumor tissues. |
2015-08-06 |
2023-08-13 |
mouse |
| Xingxin Wu, Fenli Shao, Yuanyuan Yang, Liyun Gu, Wei Zheng, Xuefeng Wu, Yanhong Gu, Yongqian Shu, Yang Sun, Qiang X. Epigallocatechin-3-gallate sensitizes IFN-γ-stimulated CD4+ T cells to apoptosis via alternative activation of STAT1. International immunopharmacology. vol 23. issue 2. 2015-08-03. PMID:25261409. |
the increases in stat1 activation and apoptosis induced by egcg in ifn-γ-activated cd4(+) t cells were almost completely abolished by a selective src family kinase inhibitor, su6656. |
2015-08-03 |
2023-08-13 |
mouse |
| Xingxin Wu, Fenli Shao, Yuanyuan Yang, Liyun Gu, Wei Zheng, Xuefeng Wu, Yanhong Gu, Yongqian Shu, Yang Sun, Qiang X. Epigallocatechin-3-gallate sensitizes IFN-γ-stimulated CD4+ T cells to apoptosis via alternative activation of STAT1. International immunopharmacology. vol 23. issue 2. 2015-08-03. PMID:25261409. |
in conclusion, the present study reports an alternative activation of stat1 via src by egcg in ifn-γ-activated cd4(+) t cells, which promotes the apoptosis of ifn-γ-activated cd4(+) t cells and contributes to the improvement of t cell-mediated colitis. |
2015-08-03 |
2023-08-13 |
mouse |
| Roland Reinehr, Annika Sommerfeld, Dieter Häussinge. The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver. Biomolecular concepts. vol 4. issue 2. 2015-07-27. PMID:25436571. |
the src family kinases yes, fyn, and c-src play a pivotal role in regulating diverse liver functions such as bile flow, proteolysis, apoptosis, and proliferation and are regulated by anisoosmotic cell volume changes, death receptor ligands, and bile acids. |
2015-07-27 |
2023-08-13 |
Not clear |
| Jinlin Hou, Anguo Cui, Peiying Song, Hui Hua, Ting Luo, Yangfu Jian. Reactive oxygen species-mediated activation of the Src-epidermal growth factor receptor-Akt signaling cascade prevents bortezomib-induced apoptosis in hepatocellular carcinoma cells. Molecular medicine reports. vol 11. issue 1. 2015-06-24. PMID:25338626. |
the combination of bortezomib and saracatinib, a src inhibitor, synergistically induced hepatoma cell apoptosis. |
2015-06-24 |
2023-08-13 |
Not clear |
| Paul Den. HDACIs and the inhibition of invasive potential. Cancer biology & therapy. vol 14. issue 9. 2015-05-12. PMID:23974427. |
inhibition of src, erk, or stat3 can all suppress tumor cell migration and reduce the threshold at which tumor cells undergo apoptosis. |
2015-05-12 |
2023-08-12 |
Not clear |
| Gagan Deep, Rahul Kumar, Anil K Jain, Chapla Agarwal, Rajesh Agarwa. Silibinin inhibits fibronectin induced motility, invasiveness and survival in human prostate carcinoma PC3 cells via targeting integrin signaling. Mutation research. vol 768. 2015-05-11. PMID:25285031. |
molecular analyses revealed that silibinin treatment modulated the fibronectin-induced expression of integrins (α5, αv, β1 and β3), actin-remodeling (fak, src, gtpases, arp2 and cortactin), apoptosis (cparp and cleaved caspase 3), emt (e-cadherin and β-catenin), and cell survival (survivin and akt) related signaling molecules in pc3 cells. |
2015-05-11 |
2023-08-13 |
mouse |