| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brittelle E Kessler, Katie M Mishall, Meghan D Kellett, Erin G Clark, Umarani Pugazhenthi, Nikita Pozdeyev, Jihye Kim, Aik Choon Tan, Rebecca E Schwepp. Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis. Oncogene. vol 38. issue 14. 2019-04-29. PMID:30531837. |
we further demonstrate that upfront combined inhibition of fak and src synergistically inhibits growth and invasion, and induces apoptosis in a panel of braf- and ras-mutant thyroid cancer cell lines. |
2019-04-29 |
2023-08-13 |
Not clear |
| Z C Song, L Ding, Z Y Ren, X S Sun, Q Yang, L Wang, M J Feng, C L Liu, J T Wan. [Effects of Src on cervical cancer cells proliferation and apoptosis through ERK signal transduction pathway]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. vol 38. issue 9. 2019-04-04. PMID:28910941. |
[effects of src on cervical cancer cells proliferation and apoptosis through erk signal transduction pathway]. |
2019-04-04 |
2023-08-13 |
Not clear |
| Xiangyang Yu, Lili Jia, Kuoqi Yin, Jingshu Lv, Wenli Yu, Hongyin D. Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation. Neuroscience. vol 391. 2019-02-27. PMID:30213765. |
inhibition of src and nr2a with pp2 and nvp-aam077 respectively not only down-regulated the levels of p-src and p-nr2a, but also ameliorated hippocampal neurons apoptosis and long-term cognitive impairment after hir. |
2019-02-27 |
2023-08-13 |
mouse |
| Cinzia Giagulli, Pasqualina D'Ursi, Wangxiao He, Simone Zorzan, Francesca Caccuri, Kristen Varney, Alessandro Orro, Stefania Marsico, Benoît Otjacques, Carlo Laudanna, Luciano Milanesi, Riccardo Dolcetti, Simona Fiorentini, Wuyuan Lu, Arnaldo Carus. A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17. Scientific reports. vol 7. issue 1. 2019-02-04. PMID:28747658. |
here, we show that a single arginine (r) to glycine (g) mutation at position 76 in the refp17 backbone (p17r76g), as in the s75x variant, is per se sufficient to confer a b-cell clonogenic potential to the viral protein and modulate, through activation of the pten/pi3k/akt signaling pathway, different molecules involved in apoptosis inhibition (casp-9, casp-7, dff-45, npm, ywhaz, src, pax2, mapk8), cell cycle promotion and cancer progression (cdk1, cdk2, cdk8, chek1, chek2, gsk-3 beta, npm, pak1, pp2c-alpha). |
2019-02-04 |
2023-08-13 |
Not clear |
| Jing-Fei Teng, Kai Wang, Zhuo-Min Jia, Yan-Jie Guo, Ya-Wei Guan, Zhi-Hui Li, Xing A. Lentivirus-Mediated Silencing of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 Inhibits Release of Inflammatory Cytokines and Apoptosis in Renal Tubular Epithelial Cells Via Inhibition of the TLR4/NF-kB Pathway in Renal Ischemia-Reperfusion Injury. Kidney & blood pressure research. vol 43. issue 4. 2018-11-19. PMID:29991025. |
lentivirus-mediated silencing of src homology 2 domain-containing protein tyrosine phosphatase 2 inhibits release of inflammatory cytokines and apoptosis in renal tubular epithelial cells via inhibition of the tlr4/nf-kb pathway in renal ischemia-reperfusion injury. |
2018-11-19 |
2023-08-13 |
rat |
| Jing-Fei Teng, Kai Wang, Zhuo-Min Jia, Yan-Jie Guo, Ya-Wei Guan, Zhi-Hui Li, Xing A. Lentivirus-Mediated Silencing of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2 Inhibits Release of Inflammatory Cytokines and Apoptosis in Renal Tubular Epithelial Cells Via Inhibition of the TLR4/NF-kB Pathway in Renal Ischemia-Reperfusion Injury. Kidney & blood pressure research. vol 43. issue 4. 2018-11-19. PMID:29991025. |
the current study aims to explore the effects of src homology 2 domain-containing protein tyrosine phosphatase 2 (shp-2) on the release of inflammatory cytokines and the apoptosis of renal tubular epithelial cells by regulating the tlr4/nf-κb signaling pathway in rats with renal ischemia-reperfusion (i/r) injury. |
2018-11-19 |
2023-08-13 |
rat |
| Chunlan Tang, Hu Luo, Dan Luo, Heping Yang, Xiangdong Zho. Src homology phosphotyrosyl phosphatase 2 mediates cisplatin-related drug resistance by inhibiting apoptosis and activating the Ras/PI3K/Akt1/survivin pathway in lung cancer cells. Oncology reports. vol 39. issue 2. 2018-09-05. PMID:29207183. |
src homology phosphotyrosyl phosphatase 2 mediates cisplatin-related drug resistance by inhibiting apoptosis and activating the ras/pi3k/akt1/survivin pathway in lung cancer cells. |
2018-09-05 |
2023-08-13 |
Not clear |
| Wei-Qiang Jia, Zhao-Tao Wang, Ming-Ming Zou, Jian-Hao Lin, Ye-Hai Li, Liang Zhang, Ru-Xiang X. Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 47. issue 5. 2018-08-17. PMID:29961065. |
thus, this study aimed to investigate the effects of vb on glioblastoma cell proliferation, apoptosis, migration, and invasion as well as the mechanism involving signal transducer and activator of transcription 3 (stat3) and src homology 2 domain-containing protein tyrosine phosphatase 1 (shp-1). |
2018-08-17 |
2023-08-13 |
Not clear |
| Marisa A Fuse, Stephani Klingeman Plati, Sarah S Burns, Christine T Dinh, Olena Bracho, Denise Yan, Rahul Mittal, Rulong Shen, Julia N Soulakova, Alicja J Copik, Xue Zhong Liu, Fred F Telischi, Long-Sheng Chang, Maria Clara Franco, Cristina Fernandez-Vall. Combination Therapy with c-Met and Src Inhibitors Induces Caspase-Dependent Apoptosis of Merlin-Deficient Schwann Cells and Suppresses Growth of Schwannoma Cells. Molecular cancer therapeutics. vol 16. issue 11. 2018-07-23. PMID:28775147. |
combination therapy with c-met and src inhibitors induces caspase-dependent apoptosis of merlin-deficient schwann cells and suppresses growth of schwannoma cells. |
2018-07-23 |
2023-08-13 |
Not clear |
| Lu Zhang, Zhilong Ren, Qian Yang, Guohua Din. Csk regulates angiotensin II-induced podocyte apoptosis. Apoptosis : an international journal on programmed cell death. vol 21. issue 7. 2018-02-05. PMID:27225249. |
c-terminal src kinase (csk) is a cytoplasmic kinase that interacts with scaffolding proteins involved in cell growth, adhesion, and polarization, and the role of csk in regulating cellular apoptosis has gradually attracted attention. |
2018-02-05 |
2023-08-13 |
mouse |
| Zhicong Liao, Xiaojun Wang, Hongwei Liang, Ao Yu, Uzair Ur Rehman, Qian Fan, Yue Hu, Chen Wang, Zhen Zhou, Tao Wan. miR-1 suppresses the proliferation and promotes the apoptosis of esophageal carcinoma cells by targeting Src. Cancer medicine. vol 6. issue 12. 2018-01-29. PMID:29034995. |
mir-1 suppresses the proliferation and promotes the apoptosis of esophageal carcinoma cells by targeting src. |
2018-01-29 |
2023-08-13 |
Not clear |
| Zhicong Liao, Xiaojun Wang, Hongwei Liang, Ao Yu, Uzair Ur Rehman, Qian Fan, Yue Hu, Chen Wang, Zhen Zhou, Tao Wan. miR-1 suppresses the proliferation and promotes the apoptosis of esophageal carcinoma cells by targeting Src. Cancer medicine. vol 6. issue 12. 2018-01-29. PMID:29034995. |
nonreceptor tyrosine kinase c-src, also known as src, is a potent oncogene involved in a series of biological processes including cell growth, differentiation, and apoptosis; however, its expression pattern and function in esophageal cancer is poorly addressed. |
2018-01-29 |
2023-08-13 |
Not clear |
| Zhicong Liao, Xiaojun Wang, Hongwei Liang, Ao Yu, Uzair Ur Rehman, Qian Fan, Yue Hu, Chen Wang, Zhen Zhou, Tao Wan. miR-1 suppresses the proliferation and promotes the apoptosis of esophageal carcinoma cells by targeting Src. Cancer medicine. vol 6. issue 12. 2018-01-29. PMID:29034995. |
moreover, we manipulated knockdown and overexpression experiment on te-1 and te-10 cells to demonstrate mir-1 suppressed proliferation and promoted apoptosis in esophageal cancer cells by inhibiting src. |
2018-01-29 |
2023-08-13 |
Not clear |
| Li Gao, Xiao-Dong Wang, Yang-Yang Niu, Dan-Dan Duan, Xue Yang, Jian Hao, Cui-Hong Zhu, Dan Chen, Ke-Xin Wang, Xue-Mei Qin, Xiong-Zhi W. Molecular targets of Chinese herbs: a clinical study of hepatoma based on network pharmacology. Scientific reports. vol 6. 2018-01-16. PMID:27143508. |
network pharmacology analysis revealed that the 8 herbs regulated multiple hcc relative genes, among which the genes affected proliferation (kras, akt2, mapk), metastasis (src, mmp), angiogenesis (ptgs2) and apoptosis (casp3) etc. |
2018-01-16 |
2023-08-13 |
Not clear |
| Dongkyu Kim, Sook Hee Ku, Hyosuk Kim, Ji Hoon Jeong, Minhyung Lee, Ick Chan Kwon, Donghoon Choi, Sun Hwa Ki. Simultaneous regulation of apoptotic gene silencing and angiogenic gene expression for myocardial infarction therapy: Single-carrier delivery of SHP-1 siRNA and VEGF-expressing pDNA. Journal of controlled release : official journal of the Controlled Release Society. vol 243. 2017-12-27. PMID:27765623. |
herein, we simultaneously loaded both sirna (src homology region 2 domain-containing tyrosine phosphatase-1 sirna, sishp-1) for anti-apoptosis and pdna (hypoxia-inducible vascular endothelial growth factor expression vector, phi-vegf) for angiogenesis in a single polymeric nanocarrier and used to synergistically attenuate ischemia-reperfusion (ir)-induced myocardial infarction, which is mainly caused by dysregulating of cardiac apoptosis and angiogenesis. |
2017-12-27 |
2023-08-13 |
human |
| Nicole Tegtmeyer, Matthias Neddermann, Carmen Isabell Asche, Steffen Backer. Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA. Molecular microbiology. vol 105. issue 3. 2017-11-16. PMID:28508421. |
here we review the signal transmission by translocated caga on multiple receptor kinases (c-met and egfr) and non-receptor kinases (src, abl, csk, apkc, par1, pi3k, akt, fak, gsk-3, jak, pak1, pak2 and map kinases), manipulating a selection of fundamental processes in the human gastric epithelium such as cell adhesion, polarity, proliferation, motility, receptor endocytosis, cytoskeletal rearrangements, apoptosis, inflammation and cell cycle progression. |
2017-11-16 |
2023-08-13 |
human |
| Baoman Li, Shuang Qi, Guangfeng Sun, Li Yang, Jidong Han, Yue Zhu, Maosheng Xi. Leptin suppresses adenosine triphosphate-induced impairment of spinal cord astrocytes. Journal of neuroscience research. vol 94. issue 10. 2017-11-03. PMID:27316329. |
in this study, we found that 1) prolonged leptin treatment suppressed the atp-stimulated release of aa and pge2 from cultured spinal cord astrocytes; 2) leptin elevated the expression of caveolin-1 (cav-1) via the jak2/stat3 signaling pathway; 3) cav-1 blocked the interaction between src and egfr, thereby inhibiting the phosphorylation of egfr and cpla2 and attenuating the release of aa or pge2; 4) pretreatment with leptin decreased ;he level of apoptosis and the release of interleukin-6 from cocultured neurons and astrocytes; and 5) leptin improved the recovery of locomotion in mice after sci. |
2017-11-03 |
2023-08-13 |
mouse |
| Lin Liu, PeiYu Huang, ZhiHui Wang, Nan Chen, Con Tang, Zhong Lin, PeiJian Pen. Inhibition of eEF-2 kinase sensitizes human nasopharyngeal carcinoma cells to lapatinib-induced apoptosis through the Src and Erk pathways. BMC cancer. vol 16. issue 1. 2017-09-26. PMID:27756261. |
inhibition of eef-2 kinase sensitizes human nasopharyngeal carcinoma cells to lapatinib-induced apoptosis through the src and erk pathways. |
2017-09-26 |
2023-08-13 |
human |
| Tianshu Guo, Ling Xu, Xiaofang Che, Simeng Zhang, Ce Li, Jin Wang, Jing Gong, Rui Ma, Yibo Fan, Kezuo Hou, Huiming Zhou, Xuejun Hu, Yunpeng Liu, Xiujuan Q. Formation of the IGF1R/CAV1/SRC tri-complex antagonizes TRAIL-induced apoptosis in gastric cancer cells. Cell biology international. vol 41. issue 7. 2017-09-21. PMID:28403518. |
knockdown of igf1r or cav1 or inhibition of src activity reduced the formation of this tri-complex and enhanced trail-induced apoptosis. |
2017-09-21 |
2023-08-13 |
Not clear |
| Esther P Jane, Daniel R Premkumar, Philip A Sutera, Jonathon M Cavaleri, Ian F Pollac. Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl-xL silenced glioma cell lines. Molecular carcinogenesis. vol 56. issue 4. 2017-09-12. PMID:27805285. |
although limited apoptosis induction was observed with a series of inhibitors for receptor tyrosine kinases, pkc inhibitors, src family members, jak/stat, histone deacetylase, the pi3k/akt/mtor pathway, map kinase, cdk, heat shock proteins, proteasomal processing, and various conventional chemotherapeutic agents, we observed a dramatic potentiation of apoptosis in bcl-xl silenced cells with the survivin inhibitor, ym155. |
2017-09-12 |
2023-08-13 |
Not clear |