| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae-Ho Lee, Byoung Kuk Jang, Mi Kyung Ki. Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway. International journal of molecular sciences. vol 22. issue 19. 2021-11-01. PMID:34638852. |
the src pathway is associated with apoptosis in cancer. |
2021-11-01 |
2023-08-13 |
human |
| Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae-Ho Lee, Byoung Kuk Jang, Mi Kyung Ki. Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway. International journal of molecular sciences. vol 22. issue 19. 2021-11-01. PMID:34638852. |
in this study, we found that kahweol induces apoptosis by inhibiting phosphorylation of src, and also inhibiting p-mtor and p-stat3. |
2021-11-01 |
2023-08-13 |
human |
| Teng Wang, Chun-Yi Lyu, Yue-Hua Jiang, Xue-Yan Dong, Yan Wang, Zong-Hong Li, Jin-Xin Wang, Rui-Rong X. A drug-biomarker interaction model to predict the key targets of Scutellaria barbata D. Don in adverse-risk acute myeloid leukaemia. Molecular diversity. vol 25. issue 4. 2021-10-28. PMID:32676746. |
the results suggest that luteolin and quercetin are the main active components of sbd against adverse-risk aml, and affected drug resistance, apoptosis, immune regulation and angiogenesis through the core targets akt1, mapk1, il6, egfr, src, vegfa and tp53. |
2021-10-28 |
2023-08-13 |
Not clear |
| Nak Yoon Sung, Deok Jeong, Youn Young Shim, Zubair Ahmed Ratan, Young-Jin Jang, Martin J T Reaney, Sarah Lee, Byoung-Hee Lee, Jong-Hoon Kim, Young-Su Yi, Jae Youl Ch. The Anti-Cancer Effect of Linusorb B3 from Flaxseed Oil through the Promotion of Apoptosis, Inhibition of Actin Polymerization, and Suppression of Src Activity in Glioblastoma Cells. Molecules (Basel, Switzerland). vol 25. issue 24. 2021-09-08. PMID:33322712. |
the anti-cancer effect of linusorb b3 from flaxseed oil through the promotion of apoptosis, inhibition of actin polymerization, and suppression of src activity in glioblastoma cells. |
2021-09-08 |
2023-08-13 |
Not clear |
| Ling-Yen Chiu, I-Lun Hsin, Jen-Ning Tsai, Chih-Jung Chen, Chu-Chyn Ou, Wen-Jun Wu, Gwo-Tarng Sheu, Jiunn-Liang K. Combination treatment of Src inhibitor Saracatinib with GMI, a Ganoderma microsporum immunomodulatory protein, induce synthetic lethality via autophagy and apoptosis in lung cancer cells. Journal of cellular physiology. vol 236. issue 2. 2021-09-07. PMID:32686156. |
combination treatment of src inhibitor saracatinib with gmi, a ganoderma microsporum immunomodulatory protein, induce synthetic lethality via autophagy and apoptosis in lung cancer cells. |
2021-09-07 |
2023-08-13 |
Not clear |
| Junbiao Wang, Romilde Iannarelli, Stefania Pucciarelli, Emiliano Laudadio, Roberta Galeazzi, Mara Giangrossi, Maurizio Falconi, Lishan Cui, Aleix Marti Navia, Michela Buccioni, Gabriella Marucci, Daniele Tomassoni, Laura Serini, Stefania Sut, Filippo Maggi, Stefano Dall'Acqua, Cristina Marchini, Augusto Amic. Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice. Pharmacological research. vol 161. 2021-09-01. PMID:32822867. |
acetylshikonin anticancer effect depends on its ability to act as a potent inhibitor of dihydrofolate reductase (dhfr), to down-regulate key mediators governing cancer growth and progression, such as her2, src and stat3, and to induce apoptosis by caspase-3 activation. |
2021-09-01 |
2023-08-13 |
mouse |
| Nehal Gupta, Sanjay K Srivastav. Atovaquone Suppresses the Growth of Metastatic Triple-Negative Breast Tumors in Lungs and Brain by Inhibiting Integrin/FAK Signaling Axis. Pharmaceuticals (Basel, Switzerland). vol 14. issue 6. 2021-07-14. PMID:34071408. |
we showed that atovaquone induced apoptosis and reduced the survival of several aggressive metastatic tnbc cell lines including metastatic patient-derived cells by reducing the expression of integrin α6, integrin β4, fak, src, and vimentin. |
2021-07-14 |
2023-08-13 |
mouse |
| Zejia Yang, Jipei Liao, Kevin J Cullen, Hancai Da. Inhibition of IKKβ/NF-κB signaling pathway to improve Dasatinib efficacy in suppression of cisplatin-resistant head and neck squamous cell carcinoma. Cell death discovery. vol 6. 2021-06-28. PMID:32435511. |
furthermore, we found that simultaneous inhibition of src and ikkβ through a dasatinib and cmpda combination synergistically inhibited nf-κb activation and ets-1expression, suppressed cell proliferation, and induced apoptosis. |
2021-06-28 |
2023-08-13 |
Not clear |
| Li Zhang, Lu Wang, Han Xiao, Hui Gan, Hui Chen, Shuyue Zheng, Dan Jian, Xuan Zhai, Ning Jiang, Zhao Jing, Ping Lian. Tyrosine kinase Fyn promotes apoptosis after intracerebral hemorrhage in rats by activating Drp1 signaling. Journal of molecular medicine (Berlin, Germany). vol 99. issue 3. 2021-06-09. PMID:33409551. |
tyrosine kinase fyn is a member of the src kinase family, which is involved in neuroinflammation, apoptosis, and oxidative stress. |
2021-06-09 |
2023-08-13 |
human |
| Xiaoming Lin, Guangfei Wang, Ping Liu, Lei Han, Tong Wang, Kaili Chen, Yonglin Ga. Gallic acid suppresses colon cancer proliferation by inhibiting SRC and EGFR phosphorylation. Experimental and therapeutic medicine. vol 21. issue 6. 2021-05-13. PMID:33968169. |
the aim of the present study was to investigate the effects of gallic acid (ga) on the proliferation and apoptosis of colon cancer cells and to further clarify the mechanism of ga function associated with src and egfr phosphorylation. |
2021-05-13 |
2023-08-13 |
Not clear |
| Wenjuan Li, Hengxiao Ni, Shaofeng Wu, Shang Han, Chang'an Chen, Li Li, Yunzhan Li, Fu Gui, Jiahuai Han, Xianming Den. Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis. FEBS letters. vol 594. issue 14. 2021-05-07. PMID:32412649. |
herein, we found that pp2, a known src inhibitor, inhibits tnf-α-induced necroptosis without initiating apoptosis. |
2021-05-07 |
2023-08-13 |
Not clear |
| Fei Zhuang, Han Bao, Qian Shi, Jing Li, Zong-Lai Jiang, Yingxiao Wang, Ying-Xin Q. Endothelial microparticles induced by cyclic stretch activate Src and modulate cell apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 10. 2021-04-23. PMID:32856783. |
endothelial microparticles induced by cyclic stretch activate src and modulate cell apoptosis. |
2021-04-23 |
2023-08-13 |
Not clear |
| Fei Zhuang, Han Bao, Qian Shi, Jing Li, Zong-Lai Jiang, Yingxiao Wang, Ying-Xin Q. Endothelial microparticles induced by cyclic stretch activate Src and modulate cell apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 10. 2021-04-23. PMID:32856783. |
ec apoptosis, which was significantly decreased by 5% cs-derived emps, showed obvious increase after pretreatment with src inhibitor in target ecs. |
2021-04-23 |
2023-08-13 |
Not clear |
| Fei Zhuang, Han Bao, Qian Shi, Jing Li, Zong-Lai Jiang, Yingxiao Wang, Ying-Xin Q. Endothelial microparticles induced by cyclic stretch activate Src and modulate cell apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 10. 2021-04-23. PMID:32856783. |
our present research suggests that mechanical stretch changes the components of emps, which in turn modulates ec apoptosis by src activation. |
2021-04-23 |
2023-08-13 |
Not clear |
| Xuetao Li, Zhennan Tao, Hao Wang, Zhitong Deng, Youxin Zhou, Ziwei D. Dual inhibition of Src and PLK1 regulate stemness and induce apoptosis through Notch1-SOX2 signaling in EGFRvIII positive glioma stem cells (GSCs). Experimental cell research. vol 396. issue 1. 2021-03-10. PMID:32896567. |
dual inhibition of src and plk1 regulate stemness and induce apoptosis through notch1-sox2 signaling in egfrviii positive glioma stem cells (gscs). |
2021-03-10 |
2023-08-13 |
mouse |
| Xueming Cao, Na Zhu, Yuwei Zhang, Yan Chen, Jing Zhang, Jiang Li, Peiyuan Hao, Chuanyu Gao, Li L. Y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via SHP-1-dependent STAT3 inactivation. Journal of cellular physiology. vol 235. issue 11. 2021-03-08. PMID:31967332. |
in vitro, h/r treatment upregulated the yb1 expression in h9c2 cells, whereas yb1 knockdown inhibited h/r-induced cardiomyocyte apoptosis and induced h9c2 cell proliferation via src homology region 2 domain-containing phosphatase 1 (shp-1)-mediated activation of signal transducer and activator of transcription 3 (stat3). |
2021-03-08 |
2023-08-13 |
Not clear |
| Jae Hun Jeong, Eun Bee Choi, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Gyeongah Park, Eun Ae Jeong, Hyun Joo Shin, Jaewoong Lee, Kyung Eun Kim, Gu Seob Ro. The Role of SHIP1 on Apoptosis and Autophagy in the Adipose Tissue of Obese Mice. International journal of molecular sciences. vol 21. issue 19. 2021-02-23. PMID:33007882. |
src homology domain-containing inositol 5'-phosphatase 1 (ship1) is a key factor of apoptosis and inflammation. |
2021-02-23 |
2023-08-13 |
mouse |
| Jiong Yue, Chao Liang, Kefu Wu, Zhi Hou, Lukang Wang, Chunqing Zhang, Shiyong Liu, Hui Yan. Upregulated SHP-2 expression in the epileptogenic zone of temporal lobe epilepsy and various effects of SHP099 treatment on a pilocarpine model. Brain pathology (Zurich, Switzerland). vol 30. issue 2. 2021-01-13. PMID:31398269. |
shp-2 (src homology 2-containing protein tyrosine phosphatase 2) is a widely expressed cytosolic tyrosine phosphatase protein that participates in the regulation of inflammation, angiogenesis, gliosis, neurogenesis and apoptosis, suggesting a potential role of shp-2 in tle. |
2021-01-13 |
2023-08-13 |
mouse |
| Hugo Talbot, Sofiane Saada, Elodie Barthout, Paul-François Gallet, Nathalie Gachard, Julie Abraham, Arnaud Jaccard, Danielle Troutaud, Fabrice Lalloué, Thomas Naves, Anne-Laure Fauchais, Marie-Odile Jaubertea. BDNF belongs to the nurse-like cell secretome and supports survival of B chronic lymphocytic leukemia cells. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32724091. |
previously, we demonstrated that brain-derived neurotrophic factor (bdnf) protects b-cll cells from spontaneous apoptosis by activating the oncogenic complex ntsr2-trkb (neurotensin receptor 2-tropomyosin-related kinase receptor b), only overexpressed in b-cll cells, inducing anti-apoptotic protein bcl-2 (b-cell lymphoma 2) expression and src kinase survival signaling pathways. |
2020-12-11 |
2023-08-13 |
Not clear |
| Dadong Shen, Wenxia Chen, Jinlin Zhu, Guofeng Wu, Runpu Shen, Meiyang Xi, Haopeng Su. Therapeutic potential of targeting SHP2 in human developmental disorders and cancers. European journal of medicinal chemistry. vol 190. 2020-12-04. PMID:32061959. |
src homology 2 (sh2)-containing protein tyrosine phosphatase 2 (shp2), encoded by ptpn11, regulates cell proliferation, differentiation, apoptosis and survival via releasing intramolecular autoinhibition and modulating various signaling pathways, such as mitogen-activated protein kinase (mapk) pathway. |
2020-12-04 |
2023-08-13 |
human |