| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Venkaiah Betapudi, Meenal Shukla, Ravi Alluri, Sergei Merkulov, Keith R McCra. Novel role for p56/Lck in regulation of endothelial cell survival and angiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 10. 2017-09-08. PMID:27402674. |
previous studies have demonstrated that cleaved high-molecular-weight kininogen (hka) induces endothelial apoptosis and inhibits angiogenesis and have suggested that this occurs through inhibition of src family kinases. |
2017-09-08 |
2023-08-13 |
human |
| Weier Qi, Qian Li, Chong Wee Liew, Christian Rask-Madsen, Samuel M Lockhart, Lars Melholt Rasmussen, Yu Xia, Xuanchun Wang, Mogher Khamaisi, Kevin Croce, George L Kin. SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes. Diabetologia. vol 60. issue 3. 2017-08-28. PMID:27933336. |
elevation of src homology 2-containing protein tyrosine phosphatase 1 (shp-1) induces apoptosis in the microvasculature. |
2017-08-28 |
2023-08-13 |
Not clear |
| Bijesh Puthusseri, Amarnath Marudamuthu, Nivedita Tiwari, Jian Fu, Steven Idell, Sreerama Shett. Regulation of p53-mediated changes in the uPA-fibrinolytic system and in lung injury by loss of surfactant protein C expression in alveolar epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 6. 2017-07-31. PMID:28385810. |
furthermore, caveolin-1 expression and phosphorylation were increased in aecs, indicating an intricate link between caveolin-1 and src kinase-mediated cell signaling and aec apoptosis due to loss of sp-c expression through p53 and upa system-mediated cross-talk. |
2017-07-31 |
2023-08-13 |
mouse |
| Wei-Ting Kuo, Tsung-Chun Lee, Linda Chia-Hui Y. Eritoran Suppresses Colon Cancer by Altering a Functional Balance in Toll-like Receptors That Bind Lipopolysaccharide. Cancer research. vol 76. issue 16. 2017-07-21. PMID:27328732. |
blocking pkcζ activation by a src kinase inhibitor and a pkcζ-pseudosubstrate prevented eritoran-induced apoptosis. |
2017-07-21 |
2023-08-13 |
mouse |
| Ah-Rong Nam, Ji-Won Kim, Ji Eun Park, Ju-Hee Bang, Mei Hua Jin, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Ban. Src as a Therapeutic Target in Biliary Tract Cancer. Molecular cancer therapeutics. vol 15. issue 7. 2017-06-29. PMID:27196758. |
bosutinib abrogated phosphorylation of src and its downstream molecules, and significantly increased g1 cell-cycle arrest and apoptosis. |
2017-06-29 |
2023-08-13 |
human |
| Li-Fu Li, Yuh-Lih Chang, Ning-Hung Chen, Chien-Ying Wang, Gwo-Jyh Chang, Meng-Chih Lin, Chih-Hao Chang, Chung-Chi Huang, Jen-Hua Chuang, Yi-Pin Yang, Shih-Hwa Chiou, Yung-Yang Li. Inhibition of Src and forkhead box O1 signaling by induced pluripotent stem-cell therapy attenuates hyperoxia-augmented ventilator-induced diaphragm dysfunction. Translational research : the journal of laboratory and clinical medicine. vol 173. 2017-06-26. PMID:27055225. |
mv during hyperoxia aggravated vidd, as demonstrated by the increases in src activation, foxo1 dephosphorylation, malondialdehyde, caspase-3, atrogin-1 and muscle ring finger-1 production, microtubule-associated protein light chain 3-ii, disorganized myofibrils, disrupted mitochondria, autophagy, and myonuclear apoptosis; however, mv with hyperoxia reduced mitochondrial cytochrome c, diaphragm muscle fiber size, and contractility (p < 0.05). |
2017-06-26 |
2023-08-13 |
mouse |
| Bernardo Nuche-Berenguer, Irene Ramos-Álvarez, R T Jense. Src kinases play a novel dual role in acute pancreatitis affecting severity but no role in stimulated enzyme secretion. American journal of physiology. Gastrointestinal and liver physiology. vol 310. issue 11. 2017-06-08. PMID:27033118. |
in pancreatic acinar cells, the src family of kinases (sfk) is involved in the activation of several signaling cascades that are implicated in mediating cellular processes (growth, cytoskeletal changes, apoptosis). |
2017-06-08 |
2023-08-13 |
rat |
| Mariko Morii, Sho Kubota, Takuya Honda, Ryuzaburo Yuki, Takao Morinaga, Takahisa Kuga, Takeshi Tomonaga, Noritaka Yamaguchi, Naoto Yamaguch. Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530. The Journal of biological chemistry. vol 292. issue 5. 2017-06-01. PMID:27998981. |
src acts as an effector for ku70-dependent suppression of apoptosis through phosphorylation of ku70 at tyr-530. |
2017-06-01 |
2023-08-13 |
Not clear |
| Mariko Morii, Sho Kubota, Takuya Honda, Ryuzaburo Yuki, Takao Morinaga, Takahisa Kuga, Takeshi Tomonaga, Noritaka Yamaguchi, Naoto Yamaguch. Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530. The Journal of biological chemistry. vol 292. issue 5. 2017-06-01. PMID:27998981. |
despite the significance of src in suppression of apoptosis, its mechanism remains poorly understood. |
2017-06-01 |
2023-08-13 |
Not clear |
| Mariko Morii, Sho Kubota, Takuya Honda, Ryuzaburo Yuki, Takao Morinaga, Takahisa Kuga, Takeshi Tomonaga, Noritaka Yamaguchi, Naoto Yamaguch. Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530. The Journal of biological chemistry. vol 292. issue 5. 2017-06-01. PMID:27998981. |
here we show that src acts as an effector for ku70-dependent suppression of apoptosis. |
2017-06-01 |
2023-08-13 |
Not clear |
| Mariko Morii, Sho Kubota, Takuya Honda, Ryuzaburo Yuki, Takao Morinaga, Takahisa Kuga, Takeshi Tomonaga, Noritaka Yamaguchi, Naoto Yamaguch. Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530. The Journal of biological chemistry. vol 292. issue 5. 2017-06-01. PMID:27998981. |
inhibition of endogenous src activity promotes uv-induced apoptosis, which is impaired by ku70 knockdown. |
2017-06-01 |
2023-08-13 |
Not clear |
| Mariko Morii, Sho Kubota, Takuya Honda, Ryuzaburo Yuki, Takao Morinaga, Takahisa Kuga, Takeshi Tomonaga, Noritaka Yamaguchi, Naoto Yamaguch. Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530. The Journal of biological chemistry. vol 292. issue 5. 2017-06-01. PMID:27998981. |
src phosphorylates ku70 at tyr-530, being close to the possible acetylation sites involved in promotion of apoptosis. |
2017-06-01 |
2023-08-13 |
Not clear |
| Leif D Nelin, Hilary A White, Yi Jin, Jennifer K Trittmann, Bernadette Chen, Yusen Li. The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 310. issue 9. 2017-05-30. PMID:26919896. |
the src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells. |
2017-05-30 |
2023-08-13 |
human |
| Leif D Nelin, Hilary A White, Yi Jin, Jennifer K Trittmann, Bernadette Chen, Yusen Li. The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 310. issue 9. 2017-05-30. PMID:26919896. |
together, our data demonstrate that, in hpmvec, yes activation blunts the erk cascade in response to cytomix, resulting in greater apoptosis, while cytomix-induced src activation induces the phosphatidylinositol 3-kinase pathway, which leads to activation of akt and erk and attenuation of apoptosis. |
2017-05-30 |
2023-08-13 |
human |
| Ryoji Eguchi, Yumiko Fujita, Chiharu Tabata, Hiroyasu Ogawa, Ichiro Wakabayashi, Takashi Nakano, Yoshihiro Fujimor. Inhibition of Src family kinases overcomes anoikis resistance induced by spheroid formation and facilitates cisplatin-induced apoptosis in human mesothelioma cells. Oncology reports. vol 34. issue 5. 2017-04-27. PMID:26323315. |
inhibition of src family kinases overcomes anoikis resistance induced by spheroid formation and facilitates cisplatin-induced apoptosis in human mesothelioma cells. |
2017-04-27 |
2023-08-13 |
human |
| Zhilin Qi, Shimei Qi, Lin Gui, Lei She. β-arrestin2 regulates TRAIL-induced HepG2 cell apoptosis via the Src-extracellular signal-regulated signaling pathway. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27177228. |
furthermore, downregulating β‑arrestin2 expression attenuated the trail‑induced activation of src and erk survival signaling and enhanced trail‑induced apoptosis. |
2017-04-06 |
2023-08-13 |
Not clear |
| Zhilin Qi, Shimei Qi, Lin Gui, Lei She. β-arrestin2 regulates TRAIL-induced HepG2 cell apoptosis via the Src-extracellular signal-regulated signaling pathway. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27177228. |
pp2, a pharmacological inhibitor of src, reduced activation of the src‑erk signaling pathway and enhanced trail‑induced hepg2 cell apoptosis. |
2017-04-06 |
2023-08-13 |
Not clear |
| Zhilin Qi, Shimei Qi, Lin Gui, Lei She. β-arrestin2 regulates TRAIL-induced HepG2 cell apoptosis via the Src-extracellular signal-regulated signaling pathway. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27177228. |
to the best of our knowledge, these findings are the first to demonstrate that β‑arrestin2 mediates trail‑induced apoptosis by combing with drs and src, and regulates the activation of src‑erk signaling in hepg2 cells. |
2017-04-06 |
2023-08-13 |
Not clear |
| Zhilin Qi, Shimei Qi, Lin Gui, Lei She. β-arrestin2 regulates TRAIL-induced HepG2 cell apoptosis via the Src-extracellular signal-regulated signaling pathway. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27177228. |
it is hypothesized that the formation of a signaling complex comprising dr, β‑arrestin2 and src is required for the action of trail on hepg2 cell apoptosis, which provides a novel insight into analyzing the effects of β‑arrestin2 on protecting cells from trail‑induced apoptosis. |
2017-04-06 |
2023-08-13 |
Not clear |
| Guang-Zong Zhao, Long-Qiang Zhang, Yao Liu, Jun Fang, Hua-Zhuang Li, Ke-Hai Gao, Yun-Zhen Che. Effects of platelet-derived growth factor on chondrocyte proliferation, migration and apoptosis via regulation of GIT1 expression. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27220359. |
furthermore, the results indicated that pdgf promoted chondrocyte proliferation and migration, however, the effect on cell apoptosis induction was suppressed after adding the src inhibitor, pp2. |
2017-04-06 |
2023-08-13 |
Not clear |