| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenfeng Hao, Jing Qian, Jishi Yan. Shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of Src and FAK. Oncology letters. vol 9. issue 2. 2020-10-01. PMID:25621031. |
shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of src and fak. |
2020-10-01 |
2023-08-13 |
Not clear |
| Quanchi Chen, Zifei Zhou, Liancheng Shan, Hui Zeng, Yingqi Hua, Zhengdong Ca. The importance of Src signaling in sarcoma. Oncology letters. vol 10. issue 1. 2020-10-01. PMID:26170970. |
previous studies have suggested that src has essential functions in cell proliferation, apoptosis, invasion, metastasis and the tumor microenvironment. |
2020-10-01 |
2023-08-13 |
Not clear |
| Quanchi Chen, Zifei Zhou, Liancheng Shan, Hui Zeng, Yingqi Hua, Zhengdong Ca. The importance of Src signaling in sarcoma. Oncology letters. vol 10. issue 1. 2020-10-01. PMID:26170970. |
src has been found to enhance proliferation, reduce apoptosis and promote metastasis in certain subtypes of sarcoma, including osteosarcoma, chondrosarcoma and ewing's sarcoma. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yang Fu, Ge Yang, Peipei Xue, Luwei Guo, Yuhan Yin, Zhiqiang Ye, Sanfei Peng, Yanru Qin, Qiuhong Duan, Feng Zh. Dasatinib reduces 5-Fu-triggered apoptosis in colon carcinoma by directly modulating Src-dependent caspase-9 phosphorylation. Cell death discovery. vol 4. 2020-10-01. PMID:29844931. |
dasatinib dramatically decreased 5-fu triggered apoptosis in colon carcinoma via suppression of src activation. |
2020-10-01 |
2023-08-13 |
Not clear |
| Han-Lin Chou, Yi-Hsiung Lin, Wangta Liu, Chang-Yi Wu, Ruei-Nian Li, Hurng-Wern Huang, Chi-Hsien Chou, Shean-Jaw Chiou, Chien-Chih Chi. Combination Therapy of Chloroquine and C₂-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells. Cancers. vol 11. issue 3. 2020-10-01. PMID:30884764. |
alterations of related signaling factors, including src and sirt1 inhibition and activation of the autophagic regulators lamp2 and lc3-i/ii, contributed to the autophagy-dependent apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Na Song, Xiujuan Qu, Shizhou Liu, Simeng Zhang, Jing Liu, Jinglei Qu, Huachuan Zheng, Yunpeng Liu, Xiaofang Ch. Dual inhibition of MET and SRC kinase activity as a combined targeting strategy for colon cancer. Experimental and therapeutic medicine. vol 14. issue 2. 2020-09-30. PMID:28810597. |
considering that both the activation of met and src was required in ligand-dependent and -independent met activation, the antitumor effect of concurrent inhibition of met and src was examined, and it was demonstrated that combination treatment exerted increased viability inhibition and apoptosis enhancement in mutant and wild type ras colon cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Debo Kong, Feng Chen, N I Sim. Inhibition of focal adhesion kinase induces apoptosis in bladder cancer cells via Src and the phosphatidylinositol 3-kinase/Akt pathway. Experimental and therapeutic medicine. vol 10. issue 5. 2020-09-29. PMID:26640543. |
inhibition of focal adhesion kinase induces apoptosis in bladder cancer cells via src and the phosphatidylinositol 3-kinase/akt pathway. |
2020-09-29 |
2023-08-13 |
Not clear |
| Eun-Ok Kim, Shi-Eun Kang, Minji Choi, Ki-Jong Rhee, Miyong Yu. CCR4‑NOT transcription complex subunit 2 regulates TRAIL sensitivity in non‑small‑cell lung cancer cells via the STAT3 pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894259. |
under this condition, src homology region 2 domain containing phosphatase‑1 (shp1) was significantly upregulated and subsequently increased apoptosis. |
2020-09-11 |
2023-08-13 |
Not clear |
| Yu-Long Lan, Yu-Jie Zou, Jia-Cheng Lou, Jin-Shan Xing, Xun Wang, Shuang Zou, Bin-Bin Ma, Yan Ding, Bo Zhan. The sodium pump α1 subunit regulates bufalin sensitivity of human glioblastoma cells through the p53 signaling pathway. Cell biology and toxicology. vol 35. issue 6. 2020-09-01. PMID:30739221. |
mechanistic studies confirmed the important roles of src and p53 signaling in mediating bufalin-induced apoptosis. |
2020-09-01 |
2023-08-13 |
human |
| Andreas Herrmann, Toshikage Nagao, Chunyan Zhang, Christoph Lahtz, Yi-Jia Li, Chanyu Yue, Ronja Mülfarth, Hua Y. An effective cell-penetrating antibody delivery platform. JCI insight. vol 4. issue 14. 2020-08-21. PMID:31341104. |
both local and systemic administrations of low doses of modified antibodies effectively inhibited intracellular targets, such as transcription factors myc, interferon regulatory factor 4, and tyrosine-protein kinase src, and expression of their downstream genes in tumors, resulting in tumor cell apoptosis and tumor growth inhibition. |
2020-08-21 |
2023-08-13 |
Not clear |
| Xiang Xiao, Yue Yang, Baiping Mao, C Yan Cheng, Ya N. Emerging role for SRC family kinases in junction dynamics during spermatogenesis. Reproduction (Cambridge, England). vol 157. issue 3. 2020-08-19. PMID:30608903. |
src family kinases (sfks) are known regulators of multiple cellular events, including cell movement, differentiation, proliferation, survival and apoptosis. |
2020-08-19 |
2023-08-13 |
Not clear |
| Tong Zhang, Xiaofang Zhao, Rihan Hai, Ruilan Li, Wenguang Zhang, Jiaxin Zhan. p66Shc is associated with hydrogen peroxide-induced oxidative stress in preimplantation sheep embryos. Molecular reproduction and development. vol 86. issue 3. 2020-04-20. PMID:30636355. |
p66shc is a 66-kda protein of the shca (src homologous-collagen homolog) adaptor protein family, which is involved in signaling pathways involved in oxidative stress regulation, apoptosis induction, and aging. |
2020-04-20 |
2023-08-13 |
Not clear |
| Yun Zhang, Wei Huo, Yan Wen, Hai L. Silencing Nogo-B receptor inhibits penile corpus cavernosum vascular smooth muscle cell apoptosis of rats with diabetic erectile dysfunction by down-regulating ICAM-1. PloS one. vol 14. issue 8. 2020-03-23. PMID:31442237. |
reverse transcription quantitative polymerase chain reaction assay and western blot analysis were carried out for the assessment of ngbr, factors correlated to icam-1, including steroid receptor coactivator (src) and proline-rich tyrosine kinase2 (pyk2), and factors associated with apoptosis, including b-cell lymphoma-2 (bcl-2), bcl-2 associated protein x (bax), caspase 3 and cleaved-caspase 3. |
2020-03-23 |
2023-08-13 |
rat |
| Tamires Cunha Almeida, Camila Chaves Coelho Guerra, Bárbara Letícia Gonçalves De Assis, Rodrigo Dian de Oliveira Aguiar Soares, Camila Carriao Machado Garcia, Angélica Alves Lima, Glenda Nicioli da Silv. Antiproliferative and toxicogenomic effects of resveratrol in bladder cancer cells with different TP53 status. Environmental and molecular mutagenesis. vol 60. issue 8. 2019-12-12. PMID:31095781. |
cell proliferation, clonogenic survival, morphological changes, cell cycle progression, apoptosis rates, genotoxicity, global methylation, immunocytochemistry for p53 and pcna and relative expression profiles of the akt, mtor, rassf1a, hoxb3, src, plk1, and dnmt1 were evaluated. |
2019-12-12 |
2023-08-13 |
Not clear |
| Tamires Cunha Almeida, Camila Chaves Coelho Guerra, Bárbara Letícia Gonçalves De Assis, Rodrigo Dian de Oliveira Aguiar Soares, Camila Carriao Machado Garcia, Angélica Alves Lima, Glenda Nicioli da Silv. Antiproliferative and toxicogenomic effects of resveratrol in bladder cancer cells with different TP53 status. Environmental and molecular mutagenesis. vol 60. issue 8. 2019-12-12. PMID:31095781. |
increased rates of apoptosis were found in the tp53 wild type cells and this was accompanied by akt, mtor, and src downregulation. |
2019-12-12 |
2023-08-13 |
Not clear |
| Su Jin Kim, Tae Hwan Noh, Sujin Son, Do Hyun Kim, Wooseong Kim, Yunna Lee, Jieun Choo, Gwangbeom Heo, Min Jae Kim, Hae Young Chung, Yunjin Jung, Jee Hyung Jung, Hyung Ryong Moon, Eunok I. Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer. Cell death & disease. vol 9. issue 9. 2019-11-20. PMID:30158525. |
in addition, mhys generated reactive oxygen species and increased er stress, and pretreatment with antioxidant-inhibited mhy-induced er stress, src activation, and apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Su Jin Kim, Tae Hwan Noh, Sujin Son, Do Hyun Kim, Wooseong Kim, Yunna Lee, Jieun Choo, Gwangbeom Heo, Min Jae Kim, Hae Young Chung, Yunjin Jung, Jee Hyung Jung, Hyung Ryong Moon, Eunok I. Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer. Cell death & disease. vol 9. issue 9. 2019-11-20. PMID:30158525. |
collectively, src can play a key role in apoptosis induced by the novel egfr inhibitor mhys, suggesting that activation of src might prove effective in treating egfr/wild-type kras colon cancer. |
2019-11-20 |
2023-08-13 |
Not clear |
| Xinmei Zhao, Chaolan Lv, Shengbo Chen, Fachao Zh. A role for the non-receptor tyrosine kinase ACK1 in TNF-alpha-mediated apoptosis and proliferation in human intestinal epithelial caco-2 cells. Cell biology international. vol 42. issue 9. 2019-11-04. PMID:28921811. |
moreover, ack1 activated akt and src enhanced nuclear factor-кb (nf-кb) activity, suggesting a correlation between nf-кb signaling and tnf-alpha-mediated apoptosis in caco-2 cells. |
2019-11-04 |
2023-08-13 |
human |
| Panagiotis Kratimenos, Ioannis Koutroulis, Beamon Agarwal, Stamatios Theocharis, Maria Delivoria-Papadopoulo. Effect of Src Kinase inhibition on Cytochrome c, Smac/DIABLO and Apoptosis Inducing Factor (AIF) Following Cerebral Hypoxia-Ischemia in Newborn Piglets. Scientific reports. vol 7. issue 1. 2019-07-12. PMID:29192254. |
effect of src kinase inhibition on cytochrome c, smac/diablo and apoptosis inducing factor (aif) following cerebral hypoxia-ischemia in newborn piglets. |
2019-07-12 |
2023-08-13 |
Not clear |
| V A Lakunina, K M Burnysheva, V A Mitkevich, A A Makarov, I Y Petrushank. [Changes in the receptor function of Na,K-ATPase during hypoxia and ischemia]. Molekuliarnaia biologiia. vol 51. issue 1. 2019-04-30. PMID:28251981. |
binding of ouabain to na,k-atpase leads to the activation of src kinase and the subsequent initiation of intracellular signaling pathways, including the induction of apoptosis. |
2019-04-30 |
2023-08-13 |
Not clear |