| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fan Fan, Susmita Ghosh, Reid Powell, Jason Roszik, Yongsun Park, Mary Sobieski, Alexey Sorokin, Clifford Stephan, Scott Kopetz, Lee M Ellis, Rajat Bhattachary. Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo. PloS one. vol 18. issue 3. 2023-03-23. PMID:36952536. |
analysis of markers for cell proliferation and apoptosis using fluorescence-activated cell sorting, reverse-phase protein array, or western blotting demonstrated decreased cell proliferation and increased cell death when targeting both src and mek as compared to single agents in multiple crc cell lines. |
2023-03-23 |
2023-08-14 |
mouse |
| Yvain Desplat, Jacob F Warner, Emily J Blake, Nidhi Vijayan, Marie Cuvelier, Patricia Blackwelder, Jose V Lope. Morphological and transcriptional effects of crude oil and dispersant exposure on the marine sponge Cinachyrella alloclada. The Science of the total environment. 2023-03-16. PMID:36924960. |
genes that were upregulated included heat shock proteins, apoptosis, oncogenes (rab/ras, src, cmyc), and several e3 ubiquitin ligases. |
2023-03-16 |
2023-08-14 |
Not clear |
| SanFei Peng, Yang F. FYN: emerging biological roles and potential therapeutic targets in cancer. Journal of translational medicine. vol 21. issue 1. 2023-02-05. PMID:36740671. |
src family protein kinases (sfks) play a key role in cell adhesion, invasion, proliferation, survival, apoptosis, and angiogenesis during tumor development. |
2023-02-05 |
2023-08-14 |
Not clear |
| Andra Fortner, Alexandra Chera, Antoanela Tanca, Octavian Bucu. Apoptosis regulation by the tyrosine-protein kinase CSK. Frontiers in cell and developmental biology. vol 10. 2022-12-29. PMID:36578781. |
c-terminal src kinase (csk) is a cytosolic tyrosine-protein kinase with an important role in regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation, cytoskeletal organization and many others. |
2022-12-29 |
2023-08-14 |
Not clear |
| Soyoung Im, Yu Kyung Cho, Donghoon Kang, Ga-Yeong Shin, Eun Sun Jung, Kyo Young Song, Sung Hak Lee, Jae Myung Par. Combined High NEDD9 Expression and E-cadherin Loss Correlate with Poor Clinical Outcome in Gastric Cancer. Journal of gastroenterology and hepatology. 2022-10-07. PMID:36203318. |
previous studies have revealed that nedd9 coordinates the focal adhesion kinase and src signaling cascades that are involved in integrin-dependent adhesion and migration, invasion, cell apoptosis and life cycle and survival, which may play a role in epithelial-mesenchymal transformation. |
2022-10-07 |
2023-08-14 |
Not clear |
| Wenjing Xiang, Wanchen Qi, Huayu Li, Jia Sun, Chao Dong, Haojie Ou, Bing Li. Palbociclib Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells via RB-Independent STAT3 Phosphorylation. Current oncology (Toronto, Ont.). vol 29. issue 8. 2022-08-25. PMID:36005200. |
we found that palbociclib induced lusc cell apoptosis through inhibition of src tyrosine kinase/signal transducers and activators of transcription 3 (stat3). |
2022-08-25 |
2023-08-14 |
human |
| Ming Zhao, Darren Finlay, Robert Liddington, Kristiina Vuor. SRC plays a specific role in the cross-talk between apoptosis and autophagy via phosphorylation of a novel regulatory site on AMPK. Autophagy reports. vol 1. issue 1. 2022-06-01. PMID:35647611. |
src plays a specific role in the cross-talk between apoptosis and autophagy via phosphorylation of a novel regulatory site on ampk. |
2022-06-01 |
2023-08-13 |
Not clear |
| Carlos Anerillas, Allison B Herman, Martina Rossi, Rachel Munk, Elin Lehrmann, Jennifer L Martindale, Chang-Yi Cui, Kotb Abdelmohsen, Supriyo De, Myriam Gorosp. Early SRC activation skews cell fate from apoptosis to senescence. Science advances. vol 8. issue 14. 2022-04-08. PMID:35394839. |
early src activation skews cell fate from apoptosis to senescence. |
2022-04-08 |
2023-08-13 |
mouse |
| Carlos Anerillas, Allison B Herman, Martina Rossi, Rachel Munk, Elin Lehrmann, Jennifer L Martindale, Chang-Yi Cui, Kotb Abdelmohsen, Supriyo De, Myriam Gorosp. Early SRC activation skews cell fate from apoptosis to senescence. Science advances. vol 8. issue 14. 2022-04-08. PMID:35394839. |
with high dna damage, failure to activate src led to elevation of p53, inhibition of p38, and apoptosis. |
2022-04-08 |
2023-08-13 |
mouse |
| Carlos Anerillas, Allison B Herman, Martina Rossi, Rachel Munk, Elin Lehrmann, Jennifer L Martindale, Chang-Yi Cui, Kotb Abdelmohsen, Supriyo De, Myriam Gorosp. Early SRC activation skews cell fate from apoptosis to senescence. Science advances. vol 8. issue 14. 2022-04-08. PMID:35394839. |
we propose that inhibiting src could be exploited to favor apoptosis over senescence in tissues to improve health outcomes. |
2022-04-08 |
2023-08-13 |
mouse |
| Yamei Li, Bo Peng, Yi Li, Airu Huang, Yinian Peng, Qian Yu, Yufeng L. MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke. Chemico-biological interactions. 2022-03-20. PMID:35305977. |
moreover, mir-203a-3p and mir-153-3p relieved the apoptosis, decreases nlrp3 inflammasome activity, decreases oxidative stress and inflammation in hippocampal neuron through targeting src. |
2022-03-20 |
2023-08-13 |
rat |
| Ya-Li Wu, Xiao-Yan Wang, Hui Zhang, Yu-Long Chen, Ming-Liang Zhang, Xiao-Fei Chen, Lu Niu, Wei-Xia Li, Jin-Fa Tan. [Study on alleviating effect of Glycyrrhizae Radix et Rhizoma on Psoraleae Fructus-induced liver injury based on network pharmacology and cell experiments]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 1. 2022-02-18. PMID:35178925. |
the predicted core targets were proto-oncogene tyrosine-protein kinase(src), phosphatidylinositol 4,5-bisphosphate 3-kinase subunit alpha(pik3 ca), rac-alpha serine/threonine-protein kinase(akt1), etc, with pi3 k-akt signaling pathway, mapk signaling pathway, apoptosis, toll-like receptor signaling pathway, and nf-κb signaling pathway mainly involved. |
2022-02-18 |
2023-08-13 |
Not clear |
| Henry Beetham, Billie G C Griffith, Olga Murina, Alexander Ep Loftus, David A Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H Sims, Adam Byron, Valerie G Brunto. Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors. Cancer research. 2021-12-18. PMID:34921014. |
increased sensitivity to src inhibition in ilk knockout cells was associated with defective adhesion, resulting in reduced cell number as well as increased g1 arrest and apoptosis. |
2021-12-18 |
2023-08-13 |
Not clear |
| Xing He, Jun Tang, He-Zhong Yan, Jiao-Xue Wang, Hai-Qing Li, Xiao-Wei Duan, Sen-Yuan Yu, Xi-Lu Hou, Guo-Bin Liao, Wei Li. Anemoside B4 sensitizes human colorectal cancer to fluorouracil-based chemotherapy through src-mediated cell apoptosis. Aging. vol 13. issue undefined. 2021-12-10. PMID:34890366. |
elevated src activity induced cell apoptosis and cancer stem cells elimination effects in ab4 treated colorectal cancer cells. |
2021-12-10 |
2023-08-13 |
human |
| Louise Pinet, Nadine Assrir, Carine van Heijenoor. Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs. Biomolecules. vol 11. issue 11. 2021-11-30. PMID:34827688. |
their phosphorylation triggers interaction with phosphotyrosine binding (ptb) or src homology 2 (sh2) domains and activates several signaling pathways controling cellular motility, proliferation, adhesion, and apoptosis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Shruti Patrick, Pruthvi Gowda, Kirti Lathoria, Vaishali Suri, Ellora Se. YAP1-mediated regulation of mitochondrial dynamics in IDH1 mutant gliomas. Journal of cell science. vol 134. issue 22. 2021-11-24. PMID:34651186. |
treatment with the src kinase inhibitor bosutinib, which prevents extranuclear shuttling of tert, further elevated ros in idh1 r132h cells and triggered apoptosis. |
2021-11-24 |
2023-08-13 |
Not clear |
| Ming Zhao, Darren Finlay, Elizabeth Kwong, Robert Liddington, Benoit Viollet, Norio Sasaoka, Kristiina Vuor. Cell adhesion suppresses autophagy via Src/FAK-mediated phosphorylation and inhibition of AMPK. Cellular signalling. vol 89. 2021-11-20. PMID:34673141. |
furthermore, we found that autophagy suppression by hydroxychloroquine promotes apoptosis in a cancer cell model that had been treated with src inhibitors. |
2021-11-20 |
2023-08-13 |
Not clear |
| Loukik Arora, Chakrabhavi Dhananjaya Mohan, Min Hee Yang, Shobith Rangappa, Amudha Deivasigamani, Alan Prem Kumar, Ajaikumar B Kunnumakkara, Manoj Garg, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Kanchugarakoppal S Rangappa, Kam Man Hui, Gautam Sethi, Kwang Seok Ah. Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway. Cancers. vol 13. issue 21. 2021-11-18. PMID:34771643. |
tris dba decreased cell viability, increased apoptosis, and inhibited il-6 induced/constitutive activation of stat3, jak1, jak2, and src in hcc and mm cells. |
2021-11-18 |
2023-08-13 |
mouse |
| Mohamed Ramadan, Yaseen A M M Elshaier, Ashraf A Aly, Mohamed Abdel-Aziz, Hazem M Fathy, Alan B Brown, Jacey R Pridgen, Kevin N Dalby, Tamer S Kaou. Development of 2'-aminospiro [pyrano[3,2-c]quinoline]-3'-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell migration and proliferation. Bioorganic chemistry. vol 116. 2021-11-15. PMID:34598088. |
noticeably, the cell growth suppression and apoptosis induction in the tested cell lines can be attributed to the ability of the new derivatives to suppress the erk and akt survival pathways downstream of src. |
2021-11-15 |
2023-08-13 |
Not clear |
| Nam-Sook Park, Yu-Kyung Park, Anil Kumar Yadav, Young-Min Shin, David Bishop-Bailey, Jong-Soon Choi, Jong Wook Park, Byeong-Churl Jan. Anti-growth and pro-apoptotic effects of dasatinib on human oral cancer cells through multi-targeted mechanisms. Journal of cellular and molecular medicine. vol 25. issue 17. 2021-11-04. PMID:34318593. |
strikingly, dasatinib at 10 µm strongly suppressed the growth and induced apoptosis of yd-38 cells and inhibited the phosphorylation of src, egfr, stat-3, stat-5, pkb and erk-1/2. |
2021-11-04 |
2023-08-13 |
human |