| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrico Gringeri, Amedeo Carraro, Elena Tibaldi, Francesco E D'Amico, Mario Mancon, Antonio Toninello, Mario A Pagano, Claudia Vio, Umberto Cillo, Anna M Brunat. Lyn-mediated mitochondrial tyrosine phosphorylation is required to preserve mitochondrial integrity in early liver regeneration. The Biochemical journal. vol 425. issue 2. 2010-01-14. PMID:19832701. |
mitochondrial tyrosine phosphorylation, negligible in the quiescent liver, was detected in the early phases of lr with a trend similar to the events heralding mitochondrial apoptosis and was attributed to the tyrosine kinase lyn, a member of the src family. |
2010-01-14 |
2023-08-12 |
Not clear |
| V Mamidipudi, C A Cartwrigh. A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. Oncogene. vol 28. issue 50. 2010-01-07. PMID:19767770. |
here, we show that rack1 also induces apoptosis of the cells, partly by inhibiting src. |
2010-01-07 |
2023-08-12 |
human |
| V Mamidipudi, C A Cartwrigh. A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways. Oncogene. vol 28. issue 50. 2010-01-07. PMID:19767770. |
rack1 also induces apoptosis by blocking src activation of the akt cell survival pathway. |
2010-01-07 |
2023-08-12 |
human |
| Jianping Zhao, Yongjun Zhang, Sujay Subbayya Ithychanda, Yizeng Tu, Ka Chen, Jun Qin, Chuanyue W. Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling. The Journal of biological chemistry. vol 284. issue 49. 2009-12-22. PMID:19833732. |
consequently, the binding of migfilin activates src, resulting in suppression of apoptosis. |
2009-12-22 |
2023-08-12 |
Not clear |
| Ramachandran Rashmi, Barrie P Bode, Ninder Panesar, Sarah B King, James R Rudloff, Melisa R Gartner, Joyce M Koeni. Siglec-9 and SHP-1 are differentially expressed in neonatal and adult neutrophils. Pediatric research. vol 66. issue 3. 2009-10-27. PMID:19542910. |
receptors containing immunoreceptor tyrosine-based inhibitory motif (itim) domains promote apoptosis by activating inhibitory phosphatases, such as src homology domain 2-containing tyrosine phosphatase-1 (shp-1), that block survival signals. |
2009-10-27 |
2023-08-12 |
Not clear |
| Clementine Cailleteau, Bertrand Liagre, Jean-L Beneytou. A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation. Journal of cellular biochemistry. vol 107. issue 4. 2009-10-26. PMID:19415684. |
for the first time, we examined kinase activation and showed that kinases including src, tor, akt, creb, rsk and chk2 may be implicated in signalling of subsequent apoptosis of mature megakaryocytes after diosgenin-induced differentiation of hel cells. |
2009-10-26 |
2023-08-12 |
human |
| Salvador Harguindey, Jose Luis Arranz, Miriam L Wahl, Gorka Orive, Stephan J Reshki. Proton transport inhibitors as potentially selective anticancer drugs. Anticancer research. vol 29. issue 6. 2009-09-24. PMID:19528473. |
this basic specific abnormality of the relationship between the intracellular and the extracellular proton dynamics, a phenomenon that is increasingly considered to be one of the most differential hallmarks of cancer, has led to the formation of a unifying thermodynamic view of cancer research that embraces cancer fields from etiopathogenesis, cancer cell metabolism, multiple drug resistance (mdr), neovascularization and the metastatatic process to selective apoptosis, cancer chemotherapy and even the spontaneous regression of cancer (src). |
2009-09-24 |
2023-08-12 |
Not clear |
| Elaine Lai-Han Leung, Issan Yee-San Tam, Vicky Pui-Chi Tin, Daniel Tsin-Tien Chua, Alan Dart-Loon Sihoe, Lik-Cheung Cheng, James Chung-Man Ho, Lap-Ping Chung, Maria Pik Won. SRC promotes survival and invasion of lung cancers with epidermal growth factor receptor abnormalities and is a potential candidate for molecular-targeted therapy. Molecular cancer research : MCR. vol 7. issue 6. 2009-09-18. PMID:19491201. |
the results showed that ski-1 induced significant apoptosis in a dose-dependent manner in cancer cells with high basal src activation. |
2009-09-18 |
2023-08-12 |
Not clear |
| Hong-Yun Jia, Jiang-Xue Wu, Xiao-Feng Zhu, Jie-Min Chen, Shi-Ping Yang, Hai-Jiao Yan, Li Tan, Yi-Xin Zeng, Wenlin Huan. ZD6474 inhibits Src kinase leading to apoptosis of imatinib-resistant K562 cells. Leukemia research. vol 33. issue 11. 2009-09-03. PMID:19394692. |
zd6474 inhibits src kinase leading to apoptosis of imatinib-resistant k562 cells. |
2009-09-03 |
2023-08-12 |
Not clear |
| Hong-Yun Jia, Jiang-Xue Wu, Xiao-Feng Zhu, Jie-Min Chen, Shi-Ping Yang, Hai-Jiao Yan, Li Tan, Yi-Xin Zeng, Wenlin Huan. ZD6474 inhibits Src kinase leading to apoptosis of imatinib-resistant K562 cells. Leukemia research. vol 33. issue 11. 2009-09-03. PMID:19394692. |
zd6474 induces growth arrest and apoptosis of imatinib-resistant and parental k562 cells, as well as inhibition of src activity and its downstream effectors, the anti-apoptotic bcl-2 family. |
2009-09-03 |
2023-08-12 |
Not clear |
| Emil Rudolf, Miroslav Cervink. Trivalent chromium activates Rac-1 and Src and induces switch in the cell death mode in human dermal fibroblasts. Toxicology letters. vol 188. issue 3. 2009-07-20. PMID:19406221. |
we show that initially exposure of fibroblasts to cr (iii) induced membrane-dependent signaling including activation of rac1 gtpase, src and apoptosis signal-regulating kinase 1 (ask-1) kinases leading to increased activities of p38 and particularly jun n-terminal kinase (jnk) and subsequent activation of caspase-3. |
2009-07-20 |
2023-08-12 |
human |
| Patricio Godoy, Jan G Hengstler, Iryna Ilkavets, Christoph Meyer, Anastasia Bachmann, Alexandra Müller, Gregor Tuschl, Stefan O Mueller, Steven Doole. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology (Baltimore, Md.). vol 49. issue 6. 2009-07-01. PMID:19274752. |
apoptosis resistance is reversible by inhibiting akt or src, and emt can be abrogated by blocking the erk1/2 pathway. |
2009-07-01 |
2023-08-12 |
Not clear |
| Jinwoo Ahn, In-Ja L Byeon, Chang-Hyeock Byeon, Angela M Gronenbor. Insight into the structural basis of pro- and antiapoptotic p53 modulation by ASPP proteins. The Journal of biological chemistry. vol 284. issue 20. 2009-06-30. PMID:19246451. |
p53-dependent apoptosis is modulated by the aspp family of proteins (apoptosis-stimulating proteins of p53; also called ankyrin repeat-, src homology 3 domain-, and pro-rich region-containing proteins). |
2009-06-30 |
2023-08-12 |
Not clear |
| Jingfang Sun, Benjamin D Hopkins, Kaoru Tsujikawa, Carole Perruzzi, Irit Adini, Robert Swerlick, Paul Bornstein, Jack Lawler, Laura E Benjami. Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina. American journal of physiology. Heart and circulatory physiology. vol 296. issue 5. 2009-06-19. PMID:19304944. |
we find that tsp1(-/-), fyn(-/-), and double-mutant tsp1(-/-)/fyn(-/-) mice have a similar enhancement of capillary survival in oxygen, whereas in a tsp(-/-) background, the loss of only one allele of src restores the balance in survival and apoptosis to that of wild-type mice. |
2009-06-19 |
2023-08-12 |
mouse |
| Sheng-Huei Yang, Ching-Ming Chien, Jung-Chen Su, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Li. Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells. Journal of biochemical and molecular toxicology. vol 22. issue 6. 2009-04-08. PMID:19111001. |
taken together, these results indicate that iqdma causes significant induction of apoptosis in k562 cells via downregulation of egfr, src, bcr-abl, jak2, and stat5 signaling and modulation of p21, p27, cyclin d1, mcl-1, bcl-x(l), and vegf proteins. |
2009-04-08 |
2023-08-12 |
human |
| Naohiro Yano, Daisuke Suzuki, Masayuki Endoh, Andy Tseng, Joan P Stabila, Bethany G McGonnigal, Ting C Zhao, James F Padbury, Yi-Tang Tsen. Beta-adrenergic receptor mediated protection against doxorubicin-induced apoptosis in cardiomyocytes: the impact of high ambient glucose. Endocrinology. vol 149. issue 12. 2009-03-31. PMID:18719028. |
transfection of an active src cdna (y529f) alone was sufficient to render the cells resistant to apoptosis, and the resistance was blocked by wortmannin. |
2009-03-31 |
2023-08-12 |
Not clear |
| Naohiro Yano, Daisuke Suzuki, Masayuki Endoh, Andy Tseng, Joan P Stabila, Bethany G McGonnigal, Ting C Zhao, James F Padbury, Yi-Tang Tsen. Beta-adrenergic receptor mediated protection against doxorubicin-induced apoptosis in cardiomyocytes: the impact of high ambient glucose. Endocrinology. vol 149. issue 12. 2009-03-31. PMID:18719028. |
these data provide in vitro evidence supporting a signaling cascade by which beta2ar exerts a protective effect against doxorubicin-induced apoptosis via sequential involvement of galphai, gbetagamma, src, pdgfr, pi3k, and akt. |
2009-03-31 |
2023-08-12 |
Not clear |
| Sascha Jakob, Peter Schroeder, Margarete Lukosz, Nicole Büchner, Ioakim Spyridopoulos, Joachim Altschmied, Judith Haendele. Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. The Journal of biological chemistry. vol 283. issue 48. 2009-01-29. PMID:18829466. |
previously, we demonstrated that inhibition of oxidative stress-induced src kinase family-dependent nuclear export of tert results in delayed replicative senescence and reduced apoptosis sensitivity. |
2009-01-29 |
2023-08-12 |
Not clear |
| Masamitsu Tanaka, Kazuki Sasaki, Reiko Kamata, Yukari Hoshino, Kazuyoshi Yanagihara, Ryuichi Saka. A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis. Molecular and cellular biology. vol 29. issue 2. 2009-01-26. PMID:19015244. |
a novel rna-binding protein, ossa/c9orf10, regulates activity of src kinases to protect cells from oxidative stress-induced apoptosis. |
2009-01-26 |
2023-08-12 |
Not clear |
| Masamitsu Tanaka, Kazuki Sasaki, Reiko Kamata, Yukari Hoshino, Kazuyoshi Yanagihara, Ryuichi Saka. A novel RNA-binding protein, Ossa/C9orf10, regulates activity of Src kinases to protect cells from oxidative stress-induced apoptosis. Molecular and cellular biology. vol 29. issue 2. 2009-01-26. PMID:19015244. |
here we report that c9orf10 (designated ossa for oxidative stress-associated src activator) is a novel rna-binding protein that guards cancer cells from oxidative stress-induced apoptosis by activation of sfks. |
2009-01-26 |
2023-08-12 |
Not clear |