| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Silvia Cursi, Alessandra Rufini, Venturina Stagni, Ivano Cond\\xc3\\xb2, Vittoria Matafora, Angela Bachi, Antonio Panicci\\xc3\\xa0 Bonifazi, Luigi Coppola, Giulio Superti-Furga, Roberto Testi, Daniela Baril\\xc3\\xa. Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. The EMBO journal. vol 25. issue 9. 2006-06-21. PMID:16619028.' |
src kinase phosphorylates caspase-8 on tyr380: a novel mechanism of apoptosis suppression. |
2006-06-21 |
2023-08-12 |
human |
| b' Silvia Cursi, Alessandra Rufini, Venturina Stagni, Ivano Cond\\xc3\\xb2, Vittoria Matafora, Angela Bachi, Antonio Panicci\\xc3\\xa0 Bonifazi, Luigi Coppola, Giulio Superti-Furga, Roberto Testi, Daniela Baril\\xc3\\xa. Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. The EMBO journal. vol 25. issue 9. 2006-06-21. PMID:16619028.' |
src activation triggers caspase-8 phosphorylation on tyr380 and impairs fas-induced apoptosis. |
2006-06-21 |
2023-08-12 |
human |
| b' Silvia Cursi, Alessandra Rufini, Venturina Stagni, Ivano Cond\\xc3\\xb2, Vittoria Matafora, Angela Bachi, Antonio Panicci\\xc3\\xa0 Bonifazi, Luigi Coppola, Giulio Superti-Furga, Roberto Testi, Daniela Baril\\xc3\\xa. Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression. The EMBO journal. vol 25. issue 9. 2006-06-21. PMID:16619028.' |
remarkably, src activation upon egf-receptor stimulation triggers endogenous caspase-8 phosphorylation and prevents fas-induced apoptosis. |
2006-06-21 |
2023-08-12 |
human |
| Benjamin Y Klein, Zohar Kerem, Nathan Rojansk. LDL induces Saos2 osteoblasts death via Akt pathways responsive to a neutral sphingomyelinase inhibitor. Journal of cellular biochemistry. vol 98. issue 3. 2006-06-14. PMID:16440306. |
taken together, the results indicate that nldl has induced apoptosis in saos2 osteoblasts by inactivation of the pathway downstream to akt using nsmase, and by involvement of src kinase. |
2006-06-14 |
2023-08-12 |
Not clear |
| Eriko Fujimoto, Hiromi Sato, Sumiko Shirai, Yoji Nagashima, Nantiga Virgona, Kiyokazu Hagiwara, Hiroshi Yamasaki, Etsuko Negishi, Koichi Ueno, Tomohiro Yan. Inhibition of Src activity enhances the tumor-suppressive effect of the connexin 32 gene in Caki-1 renal cancer cells. Oncology reports. vol 15. issue 5. 2006-06-13. PMID:16596211. |
the in vitro reinforcement of the cytotoxic effect depended not only on control of cell-cycle transition but also on the induction of apoptosis, and the occurrence of the event was mostly caused by potential inhibition of src activity in caki-1t. |
2006-06-13 |
2023-08-12 |
mouse |
| Anupama Kotha, Madhavi Sekharam, Lucia Cilenti, Khandaker Siddiquee, Annette Khaled, Antonis S Zervos, Bradford Carter, James Turkson, Richard Jov. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Molecular cancer therapeutics. vol 5. issue 3. 2006-05-26. PMID:16546976. |
resveratrol inhibits src and stat3 signaling and induces the apoptosis of malignant cells containing activated stat3 protein. |
2006-05-26 |
2023-08-12 |
mouse |
| Fabio Carraro, Antonella Naldini, Annalisa Pucci, Giada A Locatelli, Giovanni Maga, Silvia Schenone, Olga Bruno, Angelo Ranise, Francesco Bondavalli, Chiara Brullo, Paola Fossa, Giulia Menozzi, Luisa Mosti, Michele Modugno, Cristina Tintori, Fabrizio Manetti, Maurizio Bott. Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation. Journal of medicinal chemistry. vol 49. issue 5. 2006-04-25. PMID:16509573. |
several of them were found to be more active than the reference compound (1-(tert-butyl)-3-(4-chlorophenyl)-4-aminopyrazolo[3,4-d]pyrimidine, pp2) in inhibiting cell proliferation and in inducing apoptosis, and as active as pp2 in the inhibition of the phosphorylation of isolated src. |
2006-04-25 |
2023-08-12 |
Not clear |
| Sophie Tamareille, Olivier Mignen, Thierry Capiod, Catherine Rücker-Martin, Danielle Feuvra. High glucose-induced apoptosis through store-operated calcium entry and calcineurin in human umbilical vein endothelial cells. Cell calcium. vol 39. issue 1. 2006-03-21. PMID:16243395. |
blocking hydrogen peroxide production using catalase or inhibiting the tyrosine kinase pp60(src) during prolonged exposure to hg, resulted in a marked decrease in apoptosis and was further associated with a significant reduction in cn-a phosphatase activity. |
2006-03-21 |
2023-08-12 |
human |
| S Liu, H Ishikawa, N Tsuyama, F-J Li, S Abroun, K-I Otsuyama, X Zheng, Z Ma, Y Maki, M S Iqbal, M Obata, M M Kawan. Increased susceptibility to apoptosis in CD45(+) myeloma cells accompanied by the increased expression of VDAC1. Oncogene. vol 25. issue 3. 2006-03-02. PMID:16247487. |
the activation of the src family kinases associated with cd45 phosphatase played an important role in the augmented apoptosis in cd45(+) u266 by oxidative stress. |
2006-03-02 |
2023-08-12 |
human |
| Masahiro Sugano, Keiko Tsuchida, Tomoji Hata, Naoki Makin. RNA interference targeting SHP-1 attenuates myocardial infarction in rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 14. 2006-02-27. PMID:16223786. |
the src homology domain 2 (sh2)-containing tyrosine phosphatase-1 (shp-1) plays a key role in apoptosis and decreases phosphorylation of akt. |
2006-02-27 |
2023-08-12 |
rat |
| Y Itoh, T Yano, T Sendo, M Sueyasu, K Hirano, H Kanaide, R Oish. Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury. Kidney international. vol 69. issue 2. 2006-02-23. PMID:16408118. |
like ioversol, c2 ceramide and the akt inhibitor src homology-6 induced apoptosis by reducing pakt and pcreb-like immunoreactivities, lowering bcl-2 expression and enhancing caspase-3 activity. |
2006-02-23 |
2023-08-12 |
mouse |
| A K Samraj, C Stroh, U Fischer, K Schulze-Osthof. The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expression. Oncogene. vol 25. issue 2. 2006-02-16. PMID:16116473. |
here, we provide evidence that p56(lck), a lymphoid-specific src kinase, is involved in the activation of the mitochondrial apoptosis pathway. |
2006-02-16 |
2023-08-12 |
Not clear |
| Kelly Carney Harris, Bohua Hu, David Hangauer, Donald Henderso. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hearing research. vol 208. issue 1-2. 2006-01-25. PMID:15950415. |
the src protein tyrosine kinase (ptk) signaling cascade may be involved in both metabolic and mechanically induced initiation of apoptosis in sensory cells of the cochlea. |
2006-01-25 |
2023-08-12 |
human |
| Jessica A George, Ting Chen, Christopher C Taylo. SRC tyrosine kinase and multidrug resistance protein-1 inhibitions act independently but cooperatively to restore paclitaxel sensitivity to paclitaxel-resistant ovarian cancer cells. Cancer research. vol 65. issue 22. 2006-01-18. PMID:16288028. |
inhibition of src enhanced microtubule stabilization in paclitaxel-resistant ovarian cancer cells treated with paclitaxel without affecting expression of beta-tubulin isotypes and resulted in multipolar spindle formation and apoptosis. |
2006-01-18 |
2023-08-12 |
mouse |
| Adina Vultur, Rozanne Arulanandam, James Turkson, Guilian Niu, Richard Jove, Leda Rapti. Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen. Molecular biology of the cell. vol 16. issue 8. 2005-12-12. PMID:15917293. |
inhibition of src activity led to stat3 down-regulation as well as apoptosis of sparsely growing, tag-transformed cells. |
2005-12-12 |
2023-08-12 |
Not clear |
| Tammy L Unruh, Haidong Li, Cathlin M Mutch, Neda Shariat, Lana Grigoriou, Ratna Sanyal, Christopher B Brown, Julie P Dean. Cholesterol depletion inhibits src family kinase-dependent calcium mobilization and apoptosis induced by rituximab crosslinking. Immunology. vol 116. issue 2. 2005-11-10. PMID:16162271. |
cholesterol depletion inhibits src family kinase-dependent calcium mobilization and apoptosis induced by rituximab crosslinking. |
2005-11-10 |
2023-08-12 |
Not clear |
| Tammy L Unruh, Haidong Li, Cathlin M Mutch, Neda Shariat, Lana Grigoriou, Ratna Sanyal, Christopher B Brown, Julie P Dean. Cholesterol depletion inhibits src family kinase-dependent calcium mobilization and apoptosis induced by rituximab crosslinking. Immunology. vol 116. issue 2. 2005-11-10. PMID:16162271. |
apoptosis induced by rituximab hypercrosslinking has been shown to require src family kinases (sfk), which are enriched in rafts. |
2005-11-10 |
2023-08-12 |
Not clear |
| Stephen S Leonard, Gabriel K Harris, Xianglin Sh. Metal-induced oxidative stress and signal transduction. Free radical biology & medicine. vol 37. issue 12. 2005-11-03. PMID:15544913. |
this review covers recent advances in (1) metal-induced generation of reactive oxygen species; (2) the receptors, kinases, and nuclear transcription factors affected by metals and metal-induced oxidative stress, including growth factor receptors, src kinase, ras signaling, mitogen-activated protein kinases, the phosphoinositide 3-phosphate/akt pathway, nuclear transcription factor kappab, activator protein 1, p53, nuclear factor of activated t cells, and hypoxia-inducible factor 1; and (3) global cellular phenomena (signal transduction, cell cycle regulation, and apoptosis) associated with metal-induced ros production and gene expression. |
2005-11-03 |
2023-08-12 |
Not clear |
| Salvador Harguindey, Gorka Orive, José Luis Pedraz, Angelo Paradiso, Stephan J Reshki. The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single nature. Biochimica et biophysica acta. vol 1756. issue 1. 2005-11-01. PMID:16099110. |
seen in that light, different fields of cancer research, from etiopathogenesis, cancer cell metabolism and neovascularization, to multiple drug resistance (mdr), selective apoptosis, modern cancer chemotherapy and the spontaneous regression of cancer (src) all appear to have in common a pivotal characteristic, the aberrant regulation of hydrogen ion dynamics [s. harguindey, j.l. |
2005-11-01 |
2023-08-12 |
Not clear |
| L I Plotkin, I Mathov, J I Aguirre, A M Parfitt, S C Manolagas, T Bellid. Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs. American journal of physiology. Cell physiology. vol 289. issue 3. 2005-09-23. PMID:15872009. |
mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, src kinases, and erks. |
2005-09-23 |
2023-08-12 |
Not clear |