| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Cuadrado, Laura González, Yajaira Suárez, Teresa Martínez, Alberto Muño. JNK activation is critical for Aplidin-induced apoptosis. Oncogene. vol 23. issue 27. 2004-06-29. PMID:15122339. |
aplidin is an antitumor drug that induces apoptosis and activates egfr, src, jnk and p38mapk. |
2004-06-29 |
2023-08-12 |
mouse |
| Charlotte Gruber, Marco Henkel, Wilfried Budach, Claus Belka, Verena Jendrosse. Involvement of tyrosine kinase p56/Lck in apoptosis induction by anticancer drugs. Biochemical pharmacology. vol 67. issue 10. 2004-06-18. PMID:15130763. |
in contrast, retransfection of the cells with the p56/lck-related tyrosine kinase src could not restore sensitivity to the treatment with cytotoxic drugs indicating a specific role of the tyrosine kinase p56/lck in apoptosis signaling. |
2004-06-18 |
2023-08-12 |
human |
| Huang Shao, Xuejun Xu, Mary-Ann A Mastrangelo, Naijie Jing, Richard G Cook, Glen B Legge, David J Tweard. Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif. The Journal of biological chemistry. vol 279. issue 18. 2004-06-10. PMID:14966128. |
stat3 is an src homology (sh)2-containing protein constitutively activated in a wide variety of human cancers following its recruitment to yxxq-containing motifs, which results in resistance to apoptosis. |
2004-06-10 |
2023-08-12 |
human |
| Gayle M Smythe, Joshua C Eby, Marie-Helene Disatnik, Thomas A Rand. A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes. Journal of cell science. vol 116. issue Pt 23. 2004-06-09. PMID:14600260. |
a caveolin-3 mutant that causes limb girdle muscular dystrophy type 1c disrupts src localization and activity and induces apoptosis in skeletal myotubes. |
2004-06-09 |
2023-08-12 |
Not clear |
| Gayle M Smythe, Joshua C Eby, Marie-Helene Disatnik, Thomas A Rand. A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes. Journal of cell science. vol 116. issue Pt 23. 2004-06-09. PMID:14600260. |
along with these alterations of src localization and targeting, there was elevated src activation in myotubes expressing the tft mutation and an increased incidence of apoptosis in those cells compared with control myotubes. |
2004-06-09 |
2023-08-12 |
Not clear |
| Mario I Vega, Sara Huerta-Yepaz, Hermes Garban, Ali Jazirehi, Christos Emmanouilides, Benjamin Bonavid. Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: pivotal role of p38 MAPK in drug resistance. Oncogene. vol 23. issue 20. 2004-06-01. PMID:15077178. |
inhibition of the src ptks, mapk, and nf-kappab activities by rituximab or by specific chemical inhibitors sensitized the cells to cddp-mediated apoptosis. |
2004-06-01 |
2023-08-12 |
Not clear |
| Vita M Golubovskaya, Steven Gross, Aparna S Kaur, Richard I Wilson, Li-Hui Xu, Xi Hui Yang, William G Canc. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Molecular cancer research : MCR. vol 1. issue 10. 2004-04-02. PMID:12939401. |
simultaneous inhibition of focal adhesion kinase and src enhances detachment and apoptosis in colon cancer cell lines. |
2004-04-02 |
2023-08-12 |
Not clear |
| Vita M Golubovskaya, Steven Gross, Aparna S Kaur, Richard I Wilson, Li-Hui Xu, Xi Hui Yang, William G Canc. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Molecular cancer research : MCR. vol 1. issue 10. 2004-04-02. PMID:12939401. |
ad-fak-cd-induced apoptosis was significantly increased by pp2, an inhibitor of src family kinases. |
2004-04-02 |
2023-08-12 |
Not clear |
| Vita M Golubovskaya, Steven Gross, Aparna S Kaur, Richard I Wilson, Li-Hui Xu, Xi Hui Yang, William G Canc. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Molecular cancer research : MCR. vol 1. issue 10. 2004-04-02. PMID:12939401. |
activation of caspase-3, down-regulation of fak, and src and akt activities were demonstrated in ad-fak-cd + pp2-treated colon cancer cells undergoing apoptosis. |
2004-04-02 |
2023-08-12 |
Not clear |
| Vita M Golubovskaya, Steven Gross, Aparna S Kaur, Richard I Wilson, Li-Hui Xu, Xi Hui Yang, William G Canc. Simultaneous inhibition of focal adhesion kinase and SRC enhances detachment and apoptosis in colon cancer cell lines. Molecular cancer research : MCR. vol 1. issue 10. 2004-04-02. PMID:12939401. |
the results suggest that fak and src are both important survival factors, playing a role in protecting colon cancer cell lines from ad-fak-cd-induced apoptosis. |
2004-04-02 |
2023-08-12 |
Not clear |
| Justin M Summy, Gary E Gallic. Src family kinases in tumor progression and metastasis. Cancer metastasis reviews. vol 22. issue 4. 2004-03-26. PMID:12884910. |
exactly how src family kinases contribute to individual tumors remains to be defined completely, however they appear to be important for multiple aspects of tumor progression, including proliferation, disruption of cell/cell contacts, migration, invasiveness, resistance to apoptosis, and angiogenesis. |
2004-03-26 |
2023-08-12 |
human |
| Li Gong, Indira Unnikrishnan, Anuradha Raghavan, Kalindi Parmar, Naomi Rosenber. Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells. Journal of virology. vol 78. issue 4. 2004-03-05. PMID:14747529. |
these data indicate that an intact src homology 2 (sh2) domain is not critical for apoptosis suppression and suggest that signals transmitted through akt and p53 play an important role in the response. |
2004-03-05 |
2023-08-12 |
Not clear |
| Wen-Ling Shih, Min-Liang Kuo, Shuang-En Chuang, Ann-Lii Cheng, Shin-Lian Doon. Hepatitis B virus X protein activates a survival signaling by linking SRC to phosphatidylinositol 3-kinase. The Journal of biological chemistry. vol 278. issue 34. 2003-10-29. PMID:12805382. |
the src family kinase inhibitor pp2 and c-terminal src kinase (csk) both alleviated hbx-mediated pi 3-kinase activation and protection from tgf-beta-induced apoptosis. |
2003-10-29 |
2023-08-12 |
Not clear |
| Ramadevi Nimmanapalli, Erica O'Bryan, Deborah Kuhn, Hirohito Yamaguchi, Hong-Gang Wang, Kapil N Bhall. Regulation of 17-AAG-induced apoptosis: role of Bcl-2, Bcl-XL, and Bax downstream of 17-AAG-mediated down-regulation of Akt, Raf-1, and Src kinases. Blood. vol 102. issue 1. 2003-08-19. PMID:12623837. |
regulation of 17-aag-induced apoptosis: role of bcl-2, bcl-xl, and bax downstream of 17-aag-mediated down-regulation of akt, raf-1, and src kinases. |
2003-08-19 |
2023-08-12 |
human |
| Lanxi Song, James Turkson, James G Karras, Richard Jove, Eric B Haur. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene. vol 22. issue 27. 2003-08-01. PMID:12833138. |
treatment of a549 lung cancer cells with pd180970 or su6656, both pharmacological inhibitors of src-kinase, resulted in reduced src and stat3 activity, cell cycle arrest in g2, and reduced viability of cells accompanied by induction of apoptosis. |
2003-08-01 |
2023-08-12 |
human |
| Alireza Alavi, John D Hood, Ricardo Frausto, Dwayne G Stupack, David A Cheres. Role of Raf in vascular protection from distinct apoptotic stimuli. Science (New York, N.Y.). vol 301. issue 5629. 2003-07-14. PMID:12843393. |
in contrast, vegf activated raf-1 via src kinase, leading to phosphorylation of tyrosines 340 and 341 and mek1-dependent protection from extrinsic-mediated apoptosis. |
2003-07-14 |
2023-08-12 |
human |
| Takeshi Baba, Noemi Fusaki, Nobuko Shinya, Akihiro Iwamatsu, Nobumichi Hozum. Actin tyrosine dephosphorylation by the Src homology 1-containing protein tyrosine phosphatase is essential for actin depolymerization after membrane IgM cross-linking. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 7. 2003-07-08. PMID:12646642. |
src homology protein 1 (shp-1) plays an important role in b cell ag receptor (bcr) differentiation, proliferation, survival, and apoptosis. |
2003-07-08 |
2023-08-12 |
chicken |
| Aura S Kamiguti, Robert J Harris, Joseph R Slupsky, Peter K Baker, John C Cawley, Mirko Zuze. Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways. Oncogene. vol 22. issue 15. 2003-05-14. PMID:12700663. |
taken together, these results suggest that active p38/jnk make hcs susceptible to apoptosis, but the cells are effectively rescued by erk activation involving constitutively active pkc and src. |
2003-05-14 |
2023-08-12 |
Not clear |
| Vladimir Boudny, Shuji Nakan. Src tyrosine kinase but not activated Ras augments sensitivity to taxanes through apoptosis in human adenocarcinoma cells. Anticancer research. vol 23. issue 1A. 2003-05-01. PMID:12680188. |
src tyrosine kinase but not activated ras augments sensitivity to taxanes through apoptosis in human adenocarcinoma cells. |
2003-05-01 |
2023-08-12 |
human |
| Vladimir Boudny, Shuji Nakan. Src tyrosine kinase but not activated Ras augments sensitivity to taxanes through apoptosis in human adenocarcinoma cells. Anticancer research. vol 23. issue 1A. 2003-05-01. PMID:12680188. |
we investigated the mechanistic role of src and ras, important oncoproteins implicated in the pathogenesis of many human cancers, in taxane-induced apoptosis using v-src or c-h-ras transfected hag-1 human gallbladder epithelial cells. |
2003-05-01 |
2023-08-12 |
human |