| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinyi Liu, Indira Jutooru, Ping Lei, KyoungHyun Kim, Syng-Ook Lee, Lisa K Brents, Paul L Prather, Stephen Saf. Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Molecular cancer therapeutics. vol 11. issue 7. 2012-10-31. PMID:22553354. |
treatment of erbb2-overexpressing bt474 and mda-mb-453 breast cancer cells with 1 to 10 μmol/l betulinic acid inhibited cell growth, induced apoptosis, downregulated specificity protein (sp) transcription factors sp1, sp3, and sp4, and decreased expression of erbb2. |
2012-10-31 |
2023-08-12 |
Not clear |
| Chen Huang, Keping Xi. Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis. Cytokine & growth factor reviews. vol 23. issue 1-2. 2012-07-16. PMID:22342309. |
specificity protein 1 (sp1) and signal transducer and activator of transcription 3 (stat3) are central transcription factors that regulate a number of pathways important to tumorigenesis, including tumor cell-cycle progression, apoptosis, angiogenesis, metastasis, and evasion of the immune system. |
2012-07-16 |
2023-08-12 |
Not clear |
| Soichi Kojima, Ting-Fang Kuo, Hideki Tatsukaw. Regulation of transglutaminase-mediated hepatic cell death in alcoholic steatohepatitis and non-alcoholic steatohepatitis. Journal of gastroenterology and hepatology. vol 27 Suppl 2. 2012-06-06. PMID:22320917. |
we previously reported that tg2, induced in the nucleus of ethanol- or free fatty acids (ffas)-treated hepatic cells, crosslinks and inactivates a transcription factor sp1, leading to reduced expression of c-met and thereby caspase independent hepatic apoptosis in culture systems, animal models, and both alcoholic steatohepatitis (ash) and non-alcoholic steatohepatitis (nash) patients. |
2012-06-06 |
2023-08-12 |
Not clear |
| Ting-Fang Kuo, Hideki Tatsukawa, Tomokazu Matsuura, Keisuke Nagatsuma, Shigehisa Hirose, Soichi Kojim. Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways. Journal of cellular physiology. vol 227. issue 3. 2012-04-25. PMID:21567402. |
we previously reported that transglutaminase 2 (tg2), induced in the nuclei of ethanol-treated hepatocytes, crosslinks and inactivates the transcription factor sp1, leading to hepatic apoptosis. |
2012-04-25 |
2023-08-12 |
human |
| Ting-Fang Kuo, Hideki Tatsukawa, Tomokazu Matsuura, Keisuke Nagatsuma, Shigehisa Hirose, Soichi Kojim. Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways. Journal of cellular physiology. vol 227. issue 3. 2012-04-25. PMID:21567402. |
these results suggest that ffas could increase er stress and lead to nuclear nfκb activation and tg2 induction through perk-dependent pathways, resulting in tg2-mediated apoptosis accompanying crosslinking and inactivation of sp1, activation of aif, and release of cytochrome c. |
2012-04-25 |
2023-08-12 |
human |
| Dong-Oh Moon, Chang-Hee Kang, Sang-Hyuck Kang, Yung-Hyun Choi, Jin-Won Hyun, Weon-Young Chang, Hee-Kyoung Kang, Young-Sang Koh, Young-Hee Maeng, Young-Ree Kim, Gi-Young Ki. Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: involvement of Ca(2+) influx. Toxicology and applied pharmacology. vol 259. issue 1. 2012-04-16. PMID:22200406. |
taken together, our data suggest that capsaicin sensitizes trail-mediated hcc cell apoptosis by dr5 up-regulation via calcium influx-dependent sp1 activation. |
2012-04-16 |
2023-08-12 |
human |
| Hanrui Zhang, Cuihua Zhan. Vasoprotection by dietary supplements and exercise: role of TNFα signaling. Experimental diabetes research. vol 2012. 2012-03-25. PMID:22110483. |
tnfα induces vascular inflammation, monocyte adhesion to endothelial cells, vascular oxidative stress, apoptosis, and atherogenic response and participates in the regulation of thrombosis and coagulation through multiple signaling pathways involving nfκb, sp1, activator protein 1, jnk, p38, stat3, and so forth. |
2012-03-25 |
2023-08-12 |
Not clear |
| B Chhunchha, N Fatma, B Bhargavan, E Kubo, A Kumar, D P Sing. Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress. Cell death & disease. vol 2. 2012-03-16. PMID:22113199. |
curcumin enhanced sp1 and prdx6 mrna and protein expression in a concentration-dependent manner, as evidenced by western and real-time pcr analyses, and thereby negatively regulated ros-mediated apoptosis by blunting ros expression and lipid peroxidation. |
2012-03-16 |
2023-08-12 |
human |
| Qi Li, Ying Zhang, Yue Sheng, Rong Huo, Bo Sun, Xue Teng, Na Li, Jiu-Xin Zhu, Bao-Feng Yang, De-Li Don. Large T-antigen up-regulates Kv4.3 K⁺ channels through Sp1, and Kv4.3 K⁺ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase II. The Biochemical journal. vol 441. issue 3. 2012-03-15. PMID:22023388. |
large t-antigen up-regulates kv4.3 k⁺ channels through sp1, and kv4.3 k⁺ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase ii. |
2012-03-15 |
2023-08-12 |
human |
| Qi Li, Ying Zhang, Yue Sheng, Rong Huo, Bo Sun, Xue Teng, Na Li, Jiu-Xin Zhu, Bao-Feng Yang, De-Li Don. Large T-antigen up-regulates Kv4.3 K⁺ channels through Sp1, and Kv4.3 K⁺ channels contribute to cell apoptosis and necrosis through activation of calcium/calmodulin-dependent protein kinase II. The Biochemical journal. vol 441. issue 3. 2012-03-15. PMID:22023388. |
in summary, we establish: (i) the hek-293 and hek-293t cell model for kv4.3 k⁺ channel study; (ii) that large t-antigen up-regulates kv4.3 k⁺ channels through increasing sp1 levels; and (iii) that kv4.3 k⁺ channels contribute to cell apoptosis and necrosis through activating camkii. |
2012-03-15 |
2023-08-12 |
human |
| Umesh T Sankpal, Steven Goodison, Maen Abdelrahim, Riyaz Bash. Targeting Sp1 transcription factors in prostate cancer therapy. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 7. issue 5. 2012-02-21. PMID:22022994. |
sp1, sp3, and sp4 regulate a variety of cancer associated genes that are involved in cell cycle, proliferation, cell differentiation, and apoptosis. |
2012-02-21 |
2023-08-12 |
Not clear |
| Satya S Pathi, Ping Lei, Sandeep Sreevalsan, Gayathri Chadalapaka, Indira Jutooru, Stephen Saf. Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Nutrition and cancer. vol 63. issue 7. 2012-02-02. PMID:21919647. |
in this study, ascorbic acid (1-3 mm) decreased rko and sw480 colon cancer cell proliferation and induced apoptosis and necrosis, and this was accompanied by downregulation of sp1, sp3, and sp4 proteins. |
2012-02-02 |
2023-08-12 |
Not clear |
| Eun-Sun Choi, Sung-Dae Cho, Jae-Gyu Jeon, Nam-Pyo Ch. The Apoptotic Effect of the Hexane Extract of Rheum undulatum L. in Oral Cancer Cells through the Down-regulation of Specificity Protein 1 and Survivin. Laboratory animal research. vol 27. issue 1. 2011-11-10. PMID:21826155. |
therefore, our results suggest that the regulation of sp1 and survivin plays a critical role in herl-induced apoptosis in human oral cancer cells. |
2011-11-10 |
2023-08-12 |
human |
| Shiu Hwa Yeh, Wen Bin Yang, Po Wu Gean, Chung Yi Hsu, Joseph T Tseng, Tsung Ping Su, Wen Chang Chang, Jan Jong Hun. Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway. Nucleic acids research. vol 39. issue 13. 2011-10-03. PMID:21441538. |
short hairpin rna against sp1 exacerbates ogd-induced apoptosis in primary neurons. |
2011-10-03 |
2023-08-12 |
rat |
| Shiu Hwa Yeh, Wen Bin Yang, Po Wu Gean, Chung Yi Hsu, Joseph T Tseng, Tsung Ping Su, Wen Chang Chang, Jan Jong Hun. Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway. Nucleic acids research. vol 39. issue 13. 2011-10-03. PMID:21441538. |
while sp1 levels increase in the cortex in a rat model of stroke, inhibition of sp1 binding leads to enhanced apoptosis and cortical injury. |
2011-10-03 |
2023-08-12 |
rat |
| Soichi Kojima, Ting-Fang Kuo, Hideki Tatsukawa, Shigehisa Hiros. Induction of cross-linking and silencing of Sp1 by transglutaminase during liver injury in ASH and NASH via different ER stress pathways. Digestive diseases (Basel, Switzerland). vol 28. issue 6. 2011-08-24. PMID:21525755. |
we previously reported that transglutaminase 2 (tg2), a protein cross-linking enzyme, is induced in the nucleus of ethanol-treated hepatocytes, and cross-links and inactivates a general transcription factor sp1, which eventually leads to reduced expression of c-met and caspase-independent hepatic apoptosis [tatsukawa et al., gastroenterology 2009;136:1783-1795]. |
2011-08-24 |
2023-08-12 |
Not clear |
| Soichi Kojima, Ting-Fang Kuo, Hideki Tatsukawa, Shigehisa Hiros. Induction of cross-linking and silencing of Sp1 by transglutaminase during liver injury in ASH and NASH via different ER stress pathways. Digestive diseases (Basel, Switzerland). vol 28. issue 6. 2011-08-24. PMID:21525755. |
these results suggest that ffa and ethanol may increase er stress and lead to nuclear nfκb activation and tg2 induction through respectively distinctive pathways, leading to tg2-mediated apoptosis via cross-linking and inactivation of sp1 and reduction in c-met. |
2011-08-24 |
2023-08-12 |
Not clear |
| Yuqing Chen, Xiaojing Wang, Wei Li, Hailong Zhang, Chengling Zhao, Yan Li, Zhenhuan Wang, Changjie Che. Sp1 upregulates survivin expression in adenocarcinoma of lung cell line A549. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 5. 2011-07-29. PMID:21433308. |
we also found that sp1 could decrease capase-9 activity, which is shown to be suppressed by survivin during apoptosis inhibition. |
2011-07-29 |
2023-08-12 |
human |
| Eun-Sun Choi, Jung-Hyun Shim, Ji-Youn Jung, Hyeong-Jin Kim, Kyeong-Hee Choi, Ji-Ae Shin, Jeong-Seok Nam, Nam-Pyo Cho, Sung-Dae Ch. Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1. Cancer science. vol 102. issue 4. 2011-06-09. PMID:21241418. |
overall, tol downregulates the sp1 protein to inhibit growth and induce apoptosis in androgen-refractory prostate cancers, both in vitro and in vivo, that show resistance against many chemotherapeutic agents. |
2011-06-09 |
2023-08-12 |
mouse |
| Sonja Meemboor, Janina Mertens, Eva Flenner, Laura Groneck, Alessandra Zingarelli, Thomas Gamstätter, Martina Bessler, Jens M Seeger, Hamid Kashkar, Margarete Odenthal, Wiltrud Maria Kalka-Mol. Interleukin-6 is essential for zwitterionic polysaccharide-mediated abscess formation. Innate immunity. vol 16. issue 5. 2011-05-10. PMID:19897529. |
sp1 inhibits apoptosis of cd4+ t-cells and causes il-17 expression by cd4+ t-cells in an il-6-dependent manner. |
2011-05-10 |
2023-08-12 |
mouse |