| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jennifer S Waby, Haridasan Chirakkal, ChenWei Yu, Gareth J Griffiths, Roderick S P Benson, Colin D Bingle, Bernard M Corf. Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line. Molecular cancer. vol 9. 2011-01-20. PMID:20950428. |
sp1 is a ubiquitous transcription factor and sp1-regulated genes include those involved in cell cycle regulation, apoptosis and lipogenesis: all major pathways in cancer development. |
2011-01-20 |
2023-08-12 |
Not clear |
| Xue Bai, Hong Den. [Research progress on relationship between transcription factor Sp1 and tumor]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 39. issue 2. 2010-12-08. PMID:20387253. |
sp1 plays an extremely important role in growth and metastasis of many tumors by regulating oncogenes, tumor suppressor genes, cell cycle control molecules, growth-related signal transductions, angiogenesis-related factors, as well as apoptosis. |
2010-12-08 |
2023-08-12 |
Not clear |
| R C M Simmen, J M P Pabona, M C Velarde, C Simmons, O Rahal, F A Simme. The emerging role of Krüppel-like factors in endocrine-responsive cancers of female reproductive tissues. The Journal of endocrinology. vol 204. issue 3. 2010-03-15. PMID:19833720. |
while previously regarded to simply function as silencers of sp1 transactivity, many klfs are now shown to be relevant to human cancers by their newly identified abilities to mediate crosstalk with signaling pathways involved in the control of cell proliferation, apoptosis, migration, and differentiation. |
2010-03-15 |
2023-08-12 |
human |
| Aristotelis Astrinidis, Jiyoon Kim, Crystal M Kelly, Beatrix A Olofsson, Behzad Torabi, Elena M Sorokina, Jane Azizkhan-Cliffor. The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of rapamycin/raptor complex. Genes, chromosomes & cancer. vol 49. issue 3. 2010-02-24. PMID:20013896. |
specificity protein 1 (sp1) is an essential transcription factor implicated in the regulation of genes that control multiple cellular processes, including cell cycle, apoptosis, and dna damage. |
2010-02-24 |
2023-08-12 |
mouse |
| Emmanuelle Deniaud, Joël Baguet, Roxane Chalard, Bariza Blanquier, Lilia Brinza, Julien Meunier, Marie-Cécile Michallet, Aurélie Laugraud, Claudette Ah-Soon, Anne Wierinckx, Marc Castellazzi, Joël Lachuer, Christian Gautier, Jacqueline Marvel, Yann Leverrie. Overexpression of transcription factor Sp1 leads to gene expression perturbations and cell cycle inhibition. PloS one. vol 4. issue 9. 2010-02-01. PMID:19753117. |
the ubiquitous transcription factor sp1 regulates the expression of a vast number of genes involved in many cellular functions ranging from differentiation to proliferation and apoptosis. |
2010-02-01 |
2023-08-12 |
Not clear |
| Emmanuelle Deniaud, Joël Baguet, Roxane Chalard, Bariza Blanquier, Lilia Brinza, Julien Meunier, Marie-Cécile Michallet, Aurélie Laugraud, Claudette Ah-Soon, Anne Wierinckx, Marc Castellazzi, Joël Lachuer, Christian Gautier, Jacqueline Marvel, Yann Leverrie. Overexpression of transcription factor Sp1 leads to gene expression perturbations and cell cycle inhibition. PloS one. vol 4. issue 9. 2010-02-01. PMID:19753117. |
although sp1 deregulation might be beneficial for tumour cells, its overexpression induces apoptosis of untransformed cells. |
2010-02-01 |
2023-08-12 |
Not clear |
| Janina Mertens, Mario Fabri, Alessandra Zingarelli, Torsten Kubacki, Sonja Meemboor, Laura Groneck, Jens Seeger, Martina Bessler, Helena Hafke, Margarete Odenthal, Joan G Bieler, Christoph Kalka, Jonathan P Schneck, Hamid Kashkar, Wiltrud M Kalka-Mol. Streptococcus pneumoniae serotype 1 capsular polysaccharide induces CD8CD28 regulatory T lymphocytes by TCR crosslinking. PLoS pathogens. vol 5. issue 9. 2010-01-14. PMID:19779562. |
in cd8(+)cd28(-) t cells, sp1 enhances zap-70 phosphorylation and increasingly involves nf-kappab which ultimately results in protection versus apoptosis and cell death and promotes survival and accumulation of the cd8(+)cd28(-) population. |
2010-01-14 |
2023-08-12 |
mouse |
| Xiao-Bing Wang, Wei-Qiang Peng, Zhi-Jun Yi, Shu-Ling Zhu, Qi-Huan Ga. [Expression and prognostic value of transcriptional factor sp1 in breast cancer]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 9. 2009-12-03. PMID:17927860. |
transcriptional factor sp1 is involved in many biological processes, such as cell proliferation, apoptosis, differentiation and transformation, and plays an important role in invasion and metastasis of tumors. |
2009-12-03 |
2023-08-12 |
Not clear |
| Francesco Crea, Elisa Giovannetti, Filippo Cortesi, Valentina Mey, Sara Nannizzi, Marielle I Gallegos Ruiz, Simona Ricciardi, Mario Del Tacca, Godefridus J Peters, Romano Danes. Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines. Molecular cancer therapeutics. vol 8. issue 7. 2009-10-19. PMID:19531575. |
5-aza may enhance irinotecan cytotoxicity by at least one of the following mechanisms: (a) top-i promoter demethylation, (b) activation of genes involved in top-i transcriptional regulation (p16 or sp1), and (c) modulation of the cell cycle and apoptosis after dna damage. |
2009-10-19 |
2023-08-12 |
Not clear |
| Jian-Ying Chuang, Chien-Hsing Wu, Ming-Derg Lai, Wen-Chang Chang, Jan-Jong Hun. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19588484. |
overexpression of sp1 leads to p53-dependent apoptosis in cancer cells. |
2009-09-15 |
2023-08-12 |
human |
| Jian-Ying Chuang, Chien-Hsing Wu, Ming-Derg Lai, Wen-Chang Chang, Jan-Jong Hun. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19588484. |
to better understand the role and the mechanism of increased sp1 levels on apoptosis, we used adenovirus to ectopically express gfp-sp1 protein in various cancer cell lines. |
2009-09-15 |
2023-08-12 |
human |
| Jian-Ying Chuang, Chien-Hsing Wu, Ming-Derg Lai, Wen-Chang Chang, Jan-Jong Hun. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19588484. |
first, in hela and a549 cells, we found that sp1 overexpression suppressed the cell growth and increased the detection of sub-g1 fraction, caspase-3 cleavage, and annexin-v signal revealed that apoptosis occurred. |
2009-09-15 |
2023-08-12 |
human |
| Jian-Ying Chuang, Chien-Hsing Wu, Ming-Derg Lai, Wen-Chang Chang, Jan-Jong Hun. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19588484. |
furthermore, when cells entered the mitotic stage, the cell apoptosis was induced by sp1 overexpression through affecting mitotic chromatin packaging. |
2009-09-15 |
2023-08-12 |
human |
| Jian-Ying Chuang, Chien-Hsing Wu, Ming-Derg Lai, Wen-Chang Chang, Jan-Jong Hun. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19588484. |
in addition, a549 (p53(+/+)) cells could be protected from apoptosis under sp1 overexpression when p53 was knockdown by p53 shrna. |
2009-09-15 |
2023-08-12 |
human |
| Sabitha Papineni, Sudhakar Chintharlapalli, Maen Abdelrahim, Syng-ook Lee, Robert Burghardt, Ala Abudayyeh, Cheryl Baker, Luis Herrera, Stephen Saf. Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. Carcinogenesis. vol 30. issue 7. 2009-08-11. PMID:19406933. |
ta (20 mg/kg/day) also decreased tumor growth and weight in athymic nude mice bearing seg-1 cells as xenografts and this was accompanied by increased apoptosis and decreased sp1 and c-met staining in tumors from treated mice. |
2009-08-11 |
2023-08-12 |
mouse |
| Sebastian Sieber, Georg Gdynia, Wilfried Roth, Benjamin Bonavida, Thomas Effert. Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate. International journal of oncology. vol 35. issue 1. 2009-08-06. PMID:19513562. |
the transcription factors yy1 and sp1 are upstream regulators of apoptosis by controlling the expression of apoptosis-regulating genes. |
2009-08-06 |
2023-08-12 |
Not clear |
| Sebastian Sieber, Georg Gdynia, Wilfried Roth, Benjamin Bonavida, Thomas Effert. Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate. International journal of oncology. vol 35. issue 1. 2009-08-06. PMID:19513562. |
yy1 and sp1 were down-regulated and fas/cd95 was up-regulated by rituximab and artesunate indicating that artesunate activated the fas/cd95 pathway and that rituximab increased the susceptibility of tumor cells to artesunate-induced apoptosis. |
2009-08-06 |
2023-08-12 |
Not clear |
| Xinying Wang, Jing Wang, Shiyong Lin, Yan Geng, Jide Wang, Bo Jian. Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells. Journal of experimental & clinical cancer research : CR. vol 27. 2008-12-12. PMID:18811981. |
sp1 is involved in h2o2-induced puma gene expression and apoptosis in colorectal cancer cells. |
2008-12-12 |
2023-08-12 |
Not clear |
| Lihua Ming, Tsukasa Sakaida, Wen Yue, Anupma Jha, Lin Zhang, Jian Y. Sp1 and p73 activate PUMA following serum starvation. Carcinogenesis. vol 29. issue 10. 2008-10-14. PMID:18579560. |
our results suggest that transcription factors sp1 and p73 mediate p53-independent induction of puma following serum starvation to trigger apoptosis in human cancer cells. |
2008-10-14 |
2023-08-12 |
human |
| Jialin Shen, Jianhai Jiang, Yuanyan Wei, Lei Zhou, Dan Liu, Jin Zhou, Jianxin G. Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. Molecular and cellular biochemistry. vol 304. issue 1-2. 2008-02-05. PMID:17557191. |
however, the two pi3k inhibitors ly294002 and wortmannin treatment up-regulated beta1,4gt1 through enhancing sp1 protein expression and consequently increased chx-induced smmc-7721 cells apoptosis. |
2008-02-05 |
2023-08-12 |
human |