| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Young-Joo Jeon, Seon Mi Ko, Jin Hyoung Cho, Jung-Il Chae, Jung-Hyun Shi. The HDAC inhibitor, panobinostat, induces apoptosis by suppressing the expresssion of specificity protein 1 in oral squamous cell carcinoma. International journal of molecular medicine. vol 32. issue 4. 2014-03-27. PMID:23877235. |
taken together, our data demonstrate that lbh589 induces the apoptosis of oscc cells by suppressing sp1 expression, indicating that lbh589 may be a promising chemotherapeutic agent for the treatment of oscc. |
2014-03-27 |
2023-08-12 |
Not clear |
| Chen-fei Zhou, Jun Ji, Fei Yuan, Ying-yan Yu, Bing-ya Liu, Jun Zhang, Zheng-gang Zh. [Impacts of Bevacizumab on vascular endothelial growth factor and Sp1 expression in gastric cancer xenografts]. Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery. vol 15. issue 2. 2014-01-23. PMID:22368029. |
to evaluate the effects of bevacizumab on the tumor growth, proliferation and apoptosis of gastric cancer xenograft, and the impacts on the vegf and sp1 expression. |
2014-01-23 |
2023-08-12 |
Not clear |
| Eun-Sun Choi, Gyoonhee Han, Song-Kyu Park, Kiho Lee, Hyun-Jung Kim, Sung-Dae Cho, Hwan Mook Ki. A248, a novel synthetic HDAC inhibitor, induces apoptosis through the inhibition of specificity protein 1 and its downstream proteins in human prostate cancer cells. Molecular medicine reports. vol 8. issue 1. 2014-01-07. PMID:23685644. |
these data suggest that a248 has apoptotic activity in human prostate cancer cells and that sp1 may be the molecular target of a248 treatment for inducing apoptosis in prostate cancer cells. |
2014-01-07 |
2023-08-12 |
human |
| Chuan-Chou Tu, V Bharath Kumar, Cecilia Hsuan Day, Wei-Wen Kuo, Su-Peng Yeh, Ray-Jade Chen, Chen-Rong Liao, Hsiao-Yu Chen, Fuu-Jen Tsai, Wen-Jun Wu, Chih-Yang Huan. Estrogen receptor α (ESR1) over-expression mediated apoptosis in Hep3B cells by binding with SP1 proteins. Journal of molecular endocrinology. vol 51. issue 1. 2014-01-07. PMID:23733894. |
estrogen receptor α (esr1) over-expression mediated apoptosis in hep3b cells by binding with sp1 proteins. |
2014-01-07 |
2023-08-12 |
human |
| Chuan-Chou Tu, V Bharath Kumar, Cecilia Hsuan Day, Wei-Wen Kuo, Su-Peng Yeh, Ray-Jade Chen, Chen-Rong Liao, Hsiao-Yu Chen, Fuu-Jen Tsai, Wen-Jun Wu, Chih-Yang Huan. Estrogen receptor α (ESR1) over-expression mediated apoptosis in Hep3B cells by binding with SP1 proteins. Journal of molecular endocrinology. vol 51. issue 1. 2014-01-07. PMID:23733894. |
in general, we demonstrate that the overexpression of erα mediates apoptosis in erα-negative hep3b cells by the binding of erα to sp1 protein. |
2014-01-07 |
2023-08-12 |
human |
| Don Eslin, Chris Lee, Umesh T Sankpal, Pius Maliakal, Robert M Sutphin, Liz Abraham, Riyaz Bash. Anticancer activity of tolfenamic acid in medulloblastoma: a preclinical study. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23686785. |
specificity protein 1 (sp1) transcription factor regulates several genes involved in cell proliferation and cell survival including survivin, an inhibitor of apoptosis protein. |
2013-11-26 |
2023-08-12 |
mouse |
| Huaqi Wang, Min Li, Ren Zhang, Yuanyuan Wang, Wenqiao Zang, Yunyun Ma, Guoqiang Zhao, Guojun Zhan. Effect of miR-335 upregulation on the apoptosis and invasion of lung cancer cell A549 and H1299. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23740614. |
these results indicated that upregulation of mir-335 can simultaneously suppress the invasiveness and promote apoptosis of lung cancer cell a549 and h1299 by targeting bcl-w and sp1. |
2013-11-26 |
2023-08-12 |
human |
| Jung-Il Chae, Young-Joo Jeon, Jung-Hyun Shi. Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23525508. |
downregulation of sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. |
2013-10-29 |
2023-08-12 |
human |
| Jung-Il Chae, Young-Joo Jeon, Jung-Hyun Shi. Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23525508. |
hnk reduced the transcriptional activity of sp1 regulatory proteins, including cyclin d1, mcl-1 and survivin, and, thus, induced apoptosis signaling pathways by increasing bax, reducing bid and bcl-xl and activating caspase-3 and parp in mesothelioma cells. |
2013-10-29 |
2023-08-12 |
human |
| Jung-Il Chae, Young-Joo Jeon, Jung-Hyun Shi. Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23525508. |
the results suggest that sp1, a novel molecular target of hnk, may be related to cell cycle arrest and apoptosis induction through the modulation of signal transduction pathways in mpm. |
2013-10-29 |
2023-08-12 |
human |
| Kyung-Ae Lee, Sang-Han Lee, Yong-Jin Lee, Seung Mi Baeg, Jung-Hyun Shi. Hesperidin Induces Apoptosis by Inhibiting Sp1 and Its Regulatory Protein in MSTO-211H Cells. Biomolecules & therapeutics. vol 20. issue 3. 2013-10-16. PMID:24130923. |
hesperidin induces apoptosis by inhibiting sp1 and its regulatory protein in msto-211h cells. |
2013-10-16 |
2023-08-12 |
human |
| Don Eslin, Umesh T Sankpal, Chris Lee, Robert M Sutphin, Pius Maliakal, Erika Currier, Giselle Sholler, Moeez Khan, Riyaz Bash. Tolfenamic acid inhibits neuroblastoma cell proliferation and induces apoptosis: a novel therapeutic agent for neuroblastoma. Molecular carcinogenesis. vol 52. issue 5. 2013-06-03. PMID:22213339. |
these results show that ta effectively inhibits neuroblastoma cell growth potentially through suppressing mitosis, sp1, and survivin expression, and inducing apoptosis. |
2013-06-03 |
2023-08-12 |
human |
| N Amodio, M T Di Martino, U Foresta, E Leone, M Lionetti, M Leotta, A M Gullà, M R Pitari, F Conforti, M Rossi, V Agosti, M Fulciniti, G Misso, F Morabito, M Ferrarini, A Neri, M Caraglia, N C Munshi, K C Anderson, P Tagliaferri, P Tasson. miR-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor Sp1. Cell death & disease. vol 3. 2013-05-31. PMID:23190608. |
mir-29b sensitizes multiple myeloma cells to bortezomib-induced apoptosis through the activation of a feedback loop with the transcription factor sp1. |
2013-05-31 |
2023-08-12 |
Not clear |
| Satya Pathi, Indira Jutooru, Gayathri Chadalapaka, Vijayalekshmi Nair, Syng-Ook Lee, Stephen Saf. Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. PloS one. vol 7. issue 10. 2013-04-26. PMID:23110215. |
aspirin induced nuclear caspase-dependent cleavage of sp1, sp3 and sp4 proteins and this response was related to sequestration of zinc ions since addition of zinc sulfate blocked aspirin-mediated apoptosis and repression of sp proteins. |
2013-04-26 |
2023-08-12 |
mouse |
| Jiansha Li, Lubing Gu, Hailong Zhang, Tao Liu, Dan Tian, Muxiang Zhou, Sheng Zho. Berberine represses DAXX gene transcription and induces cancer cell apoptosis. Laboratory investigation; a journal of technical methods and pathology. vol 93. issue 3. 2013-04-17. PMID:23295648. |
our results reveal a novel possible mechanism: by competitively binding to the sp1 and ets1 consensus sequences, bbr inhibits the transcription of daxx, thus inducing cancer cell apoptosis through a p53-dependent pathway. |
2013-04-17 |
2023-08-12 |
Not clear |
| Wen-Chang Chang, Jan-Jong Hun. Functional role of post-translational modifications of Sp1 in tumorigenesis. Journal of biomedical science. vol 19. 2013-04-03. PMID:23148884. |
specific protein 1 (sp1), the first transcription factor to be isolated, regulates the expression of numerous genes involved in cell proliferation, apoptosis, and differentiation. |
2013-04-03 |
2023-08-12 |
Not clear |
| Pham Thi Thu Huong, Nak Kyun Soung, Jae Hyuk Jang, Hyun Joo Cha-Molstad, Krisada Sakchaisri, Sun Ok Kim, Jun Min Jang, Kyoon Eon Kim, Kyung Sang Lee, Yong Tae Kwon, Raymond Leo Erikson, Jong Seog Ahn, Bo Yeon Ki. Regulation of CEP131 gene expression by SP1. Gene. vol 513. issue 1. 2013-02-19. PMID:23137637. |
specificity protein 1 (sp1), known as a centrosome regulator, is an essential transcription factor regulating the genes involved in multiple cellular processes such as cell cycle, apoptosis, and dna damages. |
2013-02-19 |
2023-08-12 |
Not clear |
| J-Y Chuang, S-A Wang, W-B Yang, H-C Yang, C-Y Hung, T-P Su, W-C Chang, J-J Hun. Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. Oncogene. vol 31. issue 47. 2013-01-24. PMID:22266860. |
mutation of thr739 to alanine resulted in sp1 remaining in the chromosomes, delayed cell-cycle progression, and eventually led to apoptosis. |
2013-01-24 |
2023-08-12 |
Not clear |
| Kyung-Ae Lee, Jung-Il Chae, Jung-Hyun Shi. Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma. Journal of biomedical science. vol 19. 2013-01-04. PMID:22734486. |
regarding to the cancer-related functions, in this study, suppression of sp1 protein level followed by induction of msto-211h cell apoptosis by cafestol and kahweol were investigated in oreder to determine sp1's potential as a significant target for human mpm therapy as well. |
2013-01-04 |
2023-08-12 |
human |
| Yong Fang, Yonghui Yu, Qi Hou, Xiao Zheng, Min Zhang, Dongyun Zhang, Jingxia Li, Xue-Ru Wu, Chuanshu Huan. The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP. The Journal of biological chemistry. vol 287. issue 42. 2012-12-31. PMID:22896709. |
collectively, current studies, for the first time to the best of our knowledge, identify iso as a major active compound for the anti-cancer activity of g. cleistostachyum by down-regulation of xiap expression and induction of apoptosis through specific targeting of a sp1 pathway, and cast new light on the treatment of the cancer patients with xiap overexpression. |
2012-12-31 |
2023-08-12 |
human |