| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kate Beishline, Jane Azizkhan-Cliffor. Sp1 and the 'hallmarks of cancer'. The FEBS journal. vol 282. issue 2. 2015-03-31. PMID:25393971. |
sp1 both activates and suppresses the expression of a number of essential oncogenes and tumor suppressors, as well as genes involved in essential cellular functions, including proliferation, differentiation, the dna damage response, apoptosis, senescence and angiogenesis. |
2015-03-31 |
2023-08-13 |
Not clear |
| Jung Jae Cho, Jung-Il Chae, Goo Yoon, Ka Hwi Kim, Jin Hyoung Cho, Seung-Sik Cho, Young Sik Cho, Jung-Hyun Shi. Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma. International journal of oncology. vol 45. issue 2. 2015-01-26. PMID:24858379. |
licochalcone a, a natural chalconoid isolated from glycyrrhiza inflata root, induces apoptosis via sp1 and sp1 regulatory proteins in oral squamous cell carcinoma. |
2015-01-26 |
2023-08-13 |
human |
| Ji-Ae Shin, Gyoonhee Han, Hyun-Jung Kim, Hwan-Mook Kim, Sung-Dae Ch. Chemopreventive and chemotherapeutic effect of a novel histone deacetylase inhibitor, by specificity protein 1 in MDA-MB-231 human breast cancer cells. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 23. issue 4. 2015-01-15. PMID:24871559. |
furthermore, the knockdown of sp1 protein by sp1-specific inhibitor, mithramycin a, and sirna resulted in the alteration of truncated bid and bim to induce apoptosis. |
2015-01-15 |
2023-08-13 |
human |
| Hang-Eun Lee, Eun-Sun Choi, Ji-Ae Shin, Lee-Han Kim, Nam-Pyo Cho, Sung-Dae Ch. Apoptotic effect of methanol extract of Picrasma quassioides by regulating specificity protein 1 in human cervical cancer cells. Cell biochemistry and function. vol 32. issue 3. 2014-12-01. PMID:24037733. |
the knock-down of sp1 by both sp1 interfering rna and mithramycin a, sp1 specific inhibitor clearly increased bad and t-bid expression to decrease cell viability and induce apoptosis. |
2014-12-01 |
2023-08-12 |
human |
| Indira Jutooru, Aaron S Guthrie, Gayathri Chadalapaka, Satya Pathi, KyoungHyun Kim, Robert Burghardt, Un-Ho Jin, Stephen Saf. Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Molecular and cellular biology. vol 34. issue 13. 2014-07-31. PMID:24732804. |
knockdown of sp1 alone by rna interference also induced apoptosis and decreased pancreatic cancer cell growth and invasion, indicating that downregulation of sp transcription factors is an important common mechanism of action for peitc and other ros-inducing anticancer agents. |
2014-07-31 |
2023-08-13 |
Not clear |
| Rong Jin, Fei Teng, Xi Xu, Yisha Yao, Shusong Zhang, Xiuyuan Sun, Yu Zhang, Qing G. Redox balance of mouse medullary CD4 single-positive thymocytes. Immunology and cell biology. vol 91. issue 10. 2014-07-24. PMID:24100390. |
an increase of ros in the most mature sp4 cells resulted in enhanced cytokine production upon stimulation, whereas an early increase of ros in the immature sp1 thymocytes resulted in enhanced apoptosis. |
2014-07-24 |
2023-08-12 |
mouse |
| Yingying Zhao, Wenjing Zhang, Zheng Guo, Feng Ma, Yao Wu, Yang Bai, Wei Gong, Ye Chen, Tianming Cheng, Fachao Zhi, Yali Zhang, Jide Wang, Bo Jian. Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23877322. |
inhibition of the transcription factor sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. |
2014-04-29 |
2023-08-12 |
mouse |
| Yingying Zhao, Wenjing Zhang, Zheng Guo, Feng Ma, Yao Wu, Yang Bai, Wei Gong, Ye Chen, Tianming Cheng, Fachao Zhi, Yali Zhang, Jide Wang, Bo Jian. Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23877322. |
this study investigated the role of sp1 in colon csc growth and apoptosis. |
2014-04-29 |
2023-08-12 |
mouse |
| Yingying Zhao, Wenjing Zhang, Zheng Guo, Feng Ma, Yao Wu, Yang Bai, Wei Gong, Ye Chen, Tianming Cheng, Fachao Zhi, Yali Zhang, Jide Wang, Bo Jian. Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23877322. |
furthermore, inhibition of sp1 expression using sp1 sirna or mithramycin a (mit) led to marked suppression of csc growth and induced apoptosis. |
2014-04-29 |
2023-08-12 |
mouse |
| Hang Do, Hey-Jin Park, Eun-Hwa Sohn, Byung-Oh Kim, Sung Hee Um, Jong-Hwan Kwak, Eun-Yi Moon, Dong-Kwon Rhee, Suhkneung Py. Ethanol induces cell cycle arrest and triggers apoptosis via Sp1-dependent p75NTR expression in human neuroblastoma cells. Cell biology and toxicology. vol 29. issue 5. 2014-04-21. PMID:24026251. |
furthermore, the inhibition of p75ntr expression or sp1 activity suppressed ethanol-induced p21 expression, cell cycle arrest, and apoptosis. |
2014-04-21 |
2023-08-12 |
human |
| Dong-Wook Kim, Seon Mi Ko, Young-Joo Jeon, Young-Woock Noh, Nag-Jin Choi, Sung-Dae Cho, Hong Seop Moon, Young Sik Cho, Jae-Chen Shin, Seon-Min Park, Kang Seok Seo, Ji-Young Choi, Jung-Il Chae, Jung-Hyun Shi. Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1. International journal of oncology. vol 43. issue 4. 2014-04-07. PMID:23877711. |
the important key regulators in the cell cycle such as p27 and p21 were up-regulated by hk-mediated down-regulation of sp1, whereas anti-apoptotic proteins including mcl-1 and survivin were decreased, resulting in caspase-dependent apoptosis. |
2014-04-07 |
2023-08-12 |
Not clear |
| Young-Joo Jeon, Seon Mi Ko, Jin Hyoung Cho, Jung-Il Chae, Jung-Hyun Shi. The HDAC inhibitor, panobinostat, induces apoptosis by suppressing the expresssion of specificity protein 1 in oral squamous cell carcinoma. International journal of molecular medicine. vol 32. issue 4. 2014-03-27. PMID:23877235. |
panobinostat (lbh589) induces apoptosis through the regulation of specificity protein 1 (sp1) in the oral squamous cell carcinoma (oscc) cell lines, hn22 and hsc4. |
2014-03-27 |
2023-08-12 |
Not clear |
| Young-Joo Jeon, Seon Mi Ko, Jin Hyoung Cho, Jung-Il Chae, Jung-Hyun Shi. The HDAC inhibitor, panobinostat, induces apoptosis by suppressing the expresssion of specificity protein 1 in oral squamous cell carcinoma. International journal of molecular medicine. vol 32. issue 4. 2014-03-27. PMID:23877235. |
taken together, our data demonstrate that lbh589 induces the apoptosis of oscc cells by suppressing sp1 expression, indicating that lbh589 may be a promising chemotherapeutic agent for the treatment of oscc. |
2014-03-27 |
2023-08-12 |
Not clear |
| Chen-fei Zhou, Jun Ji, Fei Yuan, Ying-yan Yu, Bing-ya Liu, Jun Zhang, Zheng-gang Zh. [Impacts of Bevacizumab on vascular endothelial growth factor and Sp1 expression in gastric cancer xenografts]. Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery. vol 15. issue 2. 2014-01-23. PMID:22368029. |
to evaluate the effects of bevacizumab on the tumor growth, proliferation and apoptosis of gastric cancer xenograft, and the impacts on the vegf and sp1 expression. |
2014-01-23 |
2023-08-12 |
Not clear |
| Eun-Sun Choi, Gyoonhee Han, Song-Kyu Park, Kiho Lee, Hyun-Jung Kim, Sung-Dae Cho, Hwan Mook Ki. A248, a novel synthetic HDAC inhibitor, induces apoptosis through the inhibition of specificity protein 1 and its downstream proteins in human prostate cancer cells. Molecular medicine reports. vol 8. issue 1. 2014-01-07. PMID:23685644. |
these data suggest that a248 has apoptotic activity in human prostate cancer cells and that sp1 may be the molecular target of a248 treatment for inducing apoptosis in prostate cancer cells. |
2014-01-07 |
2023-08-12 |
human |
| Chuan-Chou Tu, V Bharath Kumar, Cecilia Hsuan Day, Wei-Wen Kuo, Su-Peng Yeh, Ray-Jade Chen, Chen-Rong Liao, Hsiao-Yu Chen, Fuu-Jen Tsai, Wen-Jun Wu, Chih-Yang Huan. Estrogen receptor α (ESR1) over-expression mediated apoptosis in Hep3B cells by binding with SP1 proteins. Journal of molecular endocrinology. vol 51. issue 1. 2014-01-07. PMID:23733894. |
estrogen receptor α (esr1) over-expression mediated apoptosis in hep3b cells by binding with sp1 proteins. |
2014-01-07 |
2023-08-12 |
human |
| Chuan-Chou Tu, V Bharath Kumar, Cecilia Hsuan Day, Wei-Wen Kuo, Su-Peng Yeh, Ray-Jade Chen, Chen-Rong Liao, Hsiao-Yu Chen, Fuu-Jen Tsai, Wen-Jun Wu, Chih-Yang Huan. Estrogen receptor α (ESR1) over-expression mediated apoptosis in Hep3B cells by binding with SP1 proteins. Journal of molecular endocrinology. vol 51. issue 1. 2014-01-07. PMID:23733894. |
in general, we demonstrate that the overexpression of erα mediates apoptosis in erα-negative hep3b cells by the binding of erα to sp1 protein. |
2014-01-07 |
2023-08-12 |
human |
| Don Eslin, Chris Lee, Umesh T Sankpal, Pius Maliakal, Robert M Sutphin, Liz Abraham, Riyaz Bash. Anticancer activity of tolfenamic acid in medulloblastoma: a preclinical study. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23686785. |
specificity protein 1 (sp1) transcription factor regulates several genes involved in cell proliferation and cell survival including survivin, an inhibitor of apoptosis protein. |
2013-11-26 |
2023-08-12 |
mouse |
| Huaqi Wang, Min Li, Ren Zhang, Yuanyuan Wang, Wenqiao Zang, Yunyun Ma, Guoqiang Zhao, Guojun Zhan. Effect of miR-335 upregulation on the apoptosis and invasion of lung cancer cell A549 and H1299. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 5. 2013-11-26. PMID:23740614. |
these results indicated that upregulation of mir-335 can simultaneously suppress the invasiveness and promote apoptosis of lung cancer cell a549 and h1299 by targeting bcl-w and sp1. |
2013-11-26 |
2023-08-12 |
human |
| Jung-Il Chae, Young-Joo Jeon, Jung-Hyun Shi. Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. Oncology reports. vol 29. issue 6. 2013-10-29. PMID:23525508. |
downregulation of sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells. |
2013-10-29 |
2023-08-12 |
human |