| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Seve, A Favier, M Osman, D Hernandez, G Vaitaitis, N C Flores, J M McCord, S C Flore. The human immunodeficiency virus-1 Tat protein increases cell proliferation, alters sensitivity to zinc chelator-induced apoptosis, and changes Sp1 DNA binding in HeLa cells. Archives of biochemistry and biophysics. vol 361. issue 2. 1999-02-11. PMID:9882443. |
these results suggest that the tat protein, via direct or indirect mechanisms, increases proliferation, sensitizes cells to apoptosis, and changes the conformation of sp1, affecting its ability to bind to its cognate dna sequence and to retain its zinc. |
1999-02-11 |
2023-08-12 |
human |
| C Liu, V M Rangnekar, E Adamson, D Mercol. Suppression of growth and transformation and induction of apoptosis by EGR-1. Cancer gene therapy. vol 5. issue 1. 1998-03-10. PMID:9476963. |
although cloned as an "immediate-early gene," recent studies show that egr-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor beta-1 (tgf-beta1) gene and cooperation with sp1, jun-b, p21waf1/cip1, and stimulates apoptosis by transactivation of the p53 gene. |
1998-03-10 |
2023-08-12 |
Not clear |
| F J Piedrafita, M Pfah. Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation. Molecular and cellular biology. vol 17. issue 11. 1997-11-21. PMID:9343396. |
retinoid-induced apoptosis and sp1 cleavage occur independently of transcription and require caspase activation. |
1997-11-21 |
2023-08-12 |
Not clear |
| F J Piedrafita, M Pfah. Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation. Molecular and cellular biology. vol 17. issue 11. 1997-11-21. PMID:9343396. |
we found that the dna binding activity of the general transcription factor sp1 is lost in retinoid-treated t cells undergoing apoptosis. |
1997-11-21 |
2023-08-12 |
Not clear |
| F J Piedrafita, M Pfah. Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation. Molecular and cellular biology. vol 17. issue 11. 1997-11-21. PMID:9343396. |
the peptide inhibitors also blocked retinoid-induced apoptosis, as well as processing of caspases and proteolysis of sp1 and poly(adp-ribose) polymerase in intact cells. |
1997-11-21 |
2023-08-12 |
Not clear |
| F J Piedrafita, M Pfah. Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation. Molecular and cellular biology. vol 17. issue 11. 1997-11-21. PMID:9343396. |
degradation of sp1 occurs early during apoptosis and is therefore likely to have profound effects on the basal transcription status of the cell. |
1997-11-21 |
2023-08-12 |
Not clear |
| F Borellini, R I Glaze. Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1. The Journal of biological chemistry. vol 268. issue 11. 1993-05-06. PMID:8463313. |
formation of this complex was dependent on the level of p53 since p53 was more abundant in proliferating cells and decreased upon induction of growth arrest and apoptosis by withdrawal of gm-csf while sp1 levels remained unchanged. |
1993-05-06 |
2023-08-12 |
human |