| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesco Crea, Elisa Giovannetti, Filippo Cortesi, Valentina Mey, Sara Nannizzi, Marielle I Gallegos Ruiz, Simona Ricciardi, Mario Del Tacca, Godefridus J Peters, Romano Danes. Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines. Molecular cancer therapeutics. vol 8. issue 7. 2009-10-19. PMID:19531575. |
5-aza may enhance irinotecan cytotoxicity by at least one of the following mechanisms: (a) top-i promoter demethylation, (b) activation of genes involved in top-i transcriptional regulation (p16 or sp1), and (c) modulation of the cell cycle and apoptosis after dna damage. |
2009-10-19 |
2023-08-12 |
Not clear |
| Jian-Ying Chuang, Chien-Hsing Wu, Ming-Derg Lai, Wen-Chang Chang, Jan-Jong Hun. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19588484. |
overexpression of sp1 leads to p53-dependent apoptosis in cancer cells. |
2009-09-15 |
2023-08-12 |
human |
| Jian-Ying Chuang, Chien-Hsing Wu, Ming-Derg Lai, Wen-Chang Chang, Jan-Jong Hun. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19588484. |
to better understand the role and the mechanism of increased sp1 levels on apoptosis, we used adenovirus to ectopically express gfp-sp1 protein in various cancer cell lines. |
2009-09-15 |
2023-08-12 |
human |
| Jian-Ying Chuang, Chien-Hsing Wu, Ming-Derg Lai, Wen-Chang Chang, Jan-Jong Hun. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19588484. |
first, in hela and a549 cells, we found that sp1 overexpression suppressed the cell growth and increased the detection of sub-g1 fraction, caspase-3 cleavage, and annexin-v signal revealed that apoptosis occurred. |
2009-09-15 |
2023-08-12 |
human |
| Jian-Ying Chuang, Chien-Hsing Wu, Ming-Derg Lai, Wen-Chang Chang, Jan-Jong Hun. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19588484. |
furthermore, when cells entered the mitotic stage, the cell apoptosis was induced by sp1 overexpression through affecting mitotic chromatin packaging. |
2009-09-15 |
2023-08-12 |
human |
| Jian-Ying Chuang, Chien-Hsing Wu, Ming-Derg Lai, Wen-Chang Chang, Jan-Jong Hun. Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells. International journal of cancer. vol 125. issue 9. 2009-09-15. PMID:19588484. |
in addition, a549 (p53(+/+)) cells could be protected from apoptosis under sp1 overexpression when p53 was knockdown by p53 shrna. |
2009-09-15 |
2023-08-12 |
human |
| Sabitha Papineni, Sudhakar Chintharlapalli, Maen Abdelrahim, Syng-ook Lee, Robert Burghardt, Ala Abudayyeh, Cheryl Baker, Luis Herrera, Stephen Saf. Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. Carcinogenesis. vol 30. issue 7. 2009-08-11. PMID:19406933. |
ta (20 mg/kg/day) also decreased tumor growth and weight in athymic nude mice bearing seg-1 cells as xenografts and this was accompanied by increased apoptosis and decreased sp1 and c-met staining in tumors from treated mice. |
2009-08-11 |
2023-08-12 |
mouse |
| Sebastian Sieber, Georg Gdynia, Wilfried Roth, Benjamin Bonavida, Thomas Effert. Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate. International journal of oncology. vol 35. issue 1. 2009-08-06. PMID:19513562. |
the transcription factors yy1 and sp1 are upstream regulators of apoptosis by controlling the expression of apoptosis-regulating genes. |
2009-08-06 |
2023-08-12 |
Not clear |
| Sebastian Sieber, Georg Gdynia, Wilfried Roth, Benjamin Bonavida, Thomas Effert. Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunate. International journal of oncology. vol 35. issue 1. 2009-08-06. PMID:19513562. |
yy1 and sp1 were down-regulated and fas/cd95 was up-regulated by rituximab and artesunate indicating that artesunate activated the fas/cd95 pathway and that rituximab increased the susceptibility of tumor cells to artesunate-induced apoptosis. |
2009-08-06 |
2023-08-12 |
Not clear |
| Xinying Wang, Jing Wang, Shiyong Lin, Yan Geng, Jide Wang, Bo Jian. Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells. Journal of experimental & clinical cancer research : CR. vol 27. 2008-12-12. PMID:18811981. |
sp1 is involved in h2o2-induced puma gene expression and apoptosis in colorectal cancer cells. |
2008-12-12 |
2023-08-12 |
Not clear |
| Lihua Ming, Tsukasa Sakaida, Wen Yue, Anupma Jha, Lin Zhang, Jian Y. Sp1 and p73 activate PUMA following serum starvation. Carcinogenesis. vol 29. issue 10. 2008-10-14. PMID:18579560. |
our results suggest that transcription factors sp1 and p73 mediate p53-independent induction of puma following serum starvation to trigger apoptosis in human cancer cells. |
2008-10-14 |
2023-08-12 |
human |
| Jialin Shen, Jianhai Jiang, Yuanyan Wei, Lei Zhou, Dan Liu, Jin Zhou, Jianxin G. Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. Molecular and cellular biochemistry. vol 304. issue 1-2. 2008-02-05. PMID:17557191. |
however, the two pi3k inhibitors ly294002 and wortmannin treatment up-regulated beta1,4gt1 through enhancing sp1 protein expression and consequently increased chx-induced smmc-7721 cells apoptosis. |
2008-02-05 |
2023-08-12 |
human |
| Zhenzhong Zhang, Baiyan Wang, Huixiang Li, Tianyang Zhou, Lan Zhan. The inhibitory effects of nanosize delivery system for antisense oligonucleotide of hTERT on EC9706 cells. Cancer biology & therapy. vol 6. issue 3. 2007-09-25. PMID:17438368. |
the asodns complementary to the sites to which sp1 and c-myc bind had stronger effects on ec9706 cell proliferation and apoptosis. |
2007-09-25 |
2023-08-12 |
Not clear |
| Jianhai Jiang, Jialin Shen, Tao Wu, Yuanyan Wei, Xiaoning Chen, Hongliang Zong, Si Zhang, Maoyun Sun, Jianhui Xie, Xiangfei Kong, Yanzhong Yang, Aiguo Shen, Hanzhou Wang, Jianxin G. Down-regulation of beta1,4-galactosyltransferase V is a critical part of etoposide-induced apoptotic process and could be mediated by decreasing Sp1 levels in human glioma cells. Glycobiology. vol 16. issue 11. 2007-03-16. PMID:16873896. |
collectively, our results suggest that the down-regulation of beta1,4galt v expression plays an important role in etoposide-induced apoptosis and could be mediated by a decreasing level of sp1 in shg44 cells, indicating that inhibitors of beta1,4galt v may enhance the therapeutic efficiency of etoposide for malignant glioma. |
2007-03-16 |
2023-08-12 |
human |
| Tae-Jin Lee, Eun Mi Jung, Jung Tae Lee, Shin Kim, Jong-Wook Park, Kyeong Sook Choi, Taeg Kyu Kwo. Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites. Molecular cancer therapeutics. vol 5. issue 11. 2007-02-15. PMID:17121920. |
mithramycin a sensitizes cancer cells to trail-mediated apoptosis by down-regulation of xiap gene promoter through sp1 sites. |
2007-02-15 |
2023-08-12 |
Not clear |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
overexpression of sp1 transcription factor induces apoptosis. |
2006-12-13 |
2023-08-12 |
human |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
sp1 regulates the expression of a number of genes participating in multiple aspects of tumorigenesis such as angiogenesis, cell growth and apoptosis resistance. |
2006-12-13 |
2023-08-12 |
human |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
to better understand the role of increased sp1 levels on apoptosis regulation we have used retroviruses to overexpress this protein in haematopoietic baf-3 cells and in 3t3 fibroblasts. |
2006-12-13 |
2023-08-12 |
human |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
surprisingly, sp1 overexpression on its own induces apoptosis in all the cellular models tested. |
2006-12-13 |
2023-08-12 |
human |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
finally, using a truncated form of sp1, we show that sp1-induced apoptosis requires its dna-binding domain. |
2006-12-13 |
2023-08-12 |
human |