| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenzhong Zhang, Baiyan Wang, Huixiang Li, Tianyang Zhou, Lan Zhan. The inhibitory effects of nanosize delivery system for antisense oligonucleotide of hTERT on EC9706 cells. Cancer biology & therapy. vol 6. issue 3. 2007-09-25. PMID:17438368. |
the asodns complementary to the sites to which sp1 and c-myc bind had stronger effects on ec9706 cell proliferation and apoptosis. |
2007-09-25 |
2023-08-12 |
Not clear |
| Jianhai Jiang, Jialin Shen, Tao Wu, Yuanyan Wei, Xiaoning Chen, Hongliang Zong, Si Zhang, Maoyun Sun, Jianhui Xie, Xiangfei Kong, Yanzhong Yang, Aiguo Shen, Hanzhou Wang, Jianxin G. Down-regulation of beta1,4-galactosyltransferase V is a critical part of etoposide-induced apoptotic process and could be mediated by decreasing Sp1 levels in human glioma cells. Glycobiology. vol 16. issue 11. 2007-03-16. PMID:16873896. |
collectively, our results suggest that the down-regulation of beta1,4galt v expression plays an important role in etoposide-induced apoptosis and could be mediated by a decreasing level of sp1 in shg44 cells, indicating that inhibitors of beta1,4galt v may enhance the therapeutic efficiency of etoposide for malignant glioma. |
2007-03-16 |
2023-08-12 |
human |
| Tae-Jin Lee, Eun Mi Jung, Jung Tae Lee, Shin Kim, Jong-Wook Park, Kyeong Sook Choi, Taeg Kyu Kwo. Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites. Molecular cancer therapeutics. vol 5. issue 11. 2007-02-15. PMID:17121920. |
mithramycin a sensitizes cancer cells to trail-mediated apoptosis by down-regulation of xiap gene promoter through sp1 sites. |
2007-02-15 |
2023-08-12 |
Not clear |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
overexpression of sp1 transcription factor induces apoptosis. |
2006-12-13 |
2023-08-12 |
human |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
sp1 regulates the expression of a number of genes participating in multiple aspects of tumorigenesis such as angiogenesis, cell growth and apoptosis resistance. |
2006-12-13 |
2023-08-12 |
human |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
to better understand the role of increased sp1 levels on apoptosis regulation we have used retroviruses to overexpress this protein in haematopoietic baf-3 cells and in 3t3 fibroblasts. |
2006-12-13 |
2023-08-12 |
human |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
surprisingly, sp1 overexpression on its own induces apoptosis in all the cellular models tested. |
2006-12-13 |
2023-08-12 |
human |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
finally, using a truncated form of sp1, we show that sp1-induced apoptosis requires its dna-binding domain. |
2006-12-13 |
2023-08-12 |
human |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
our results highlight that sp1 levels in untransformed cells must be tightly regulated as sp1 overexpression leads to the induction of apoptosis. |
2006-12-13 |
2023-08-12 |
human |
| E Deniaud, J Baguet, A-L Mathieu, G Pagès, J Marvel, Y Leverrie. Overexpression of Sp1 transcription factor induces apoptosis. Oncogene. vol 25. issue 53. 2006-12-13. PMID:16715126. |
our results also suggest that cancer cells overexpressing sp1 can avoid sp1-induced apoptosis. |
2006-12-13 |
2023-08-12 |
human |
| Veronica Albertini, Aklank Jain, Sara Vignati, Sara Napoli, Andrea Rinaldi, Ivo Kwee, Mohammad Nur-e-Alam, Julia Bergant, Francesco Bertoni, Giuseppina M Carbone, Jürgen Rohr, Carlo V Catapan. Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy. Nucleic acids research. vol 34. issue 6. 2006-04-06. PMID:16571899. |
rt-pcr and microarray analysis showed that sdk repressed transcription of multiple genes implicated in critical aspects of cancer development and progression, including cell cycle, apoptosis, migration, invasion and angiogenesis, consistent with the pleiotropic role of sp1 family transcription factors. |
2006-04-06 |
2023-08-12 |
Not clear |
| Antonella Zannetti, Silvana Del Vecchio, Alessandra Romanelli, Stefania Scala, Michele Saviano, Gaetano Cali', M Patrizia Stoppelli, Carlo Pedone, Marco Salvator. Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells. Biochemical pharmacology. vol 70. issue 9. 2005-11-30. PMID:16143315. |
sp1 regulates the activation of many genes involved in tumor growth, apoptosis, and angiogenesis. |
2005-11-30 |
2023-08-12 |
Not clear |
| J Savickiene, G Treigyte, K-E Magnusson, R Navakauskien. p21 (Waf1/Cip1) and FasL gene activation via Sp1 and NFkappaB is required for leukemia cell survival but not for cell death induced by diverse stimuli. The international journal of biochemistry & cell biology. vol 37. issue 4. 2005-06-30. PMID:15694838. |
herein, the role of transcription factors, sp1 and nfkappab in differentiation-related and etoposide-induced apoptosis was examined in a number of human leukemia cell lines (hl-60, nb4, hel, thp-1, k562). |
2005-06-30 |
2023-08-12 |
human |
| J Savickiene, G Treigyte, K-E Magnusson, R Navakauskien. p21 (Waf1/Cip1) and FasL gene activation via Sp1 and NFkappaB is required for leukemia cell survival but not for cell death induced by diverse stimuli. The international journal of biochemistry & cell biology. vol 37. issue 4. 2005-06-30. PMID:15694838. |
using electrophoretic mobility shift assay (emsa), we consistently observed sp1 and nfkappab binding activity to the promoter of either gene during cell differentiation and the decrease associated with apoptosis upon long-term treatment with differentiation inducers in hl-60, nb4 and hel cells. |
2005-06-30 |
2023-08-12 |
human |
| J Savickiene, G Treigyte, K-E Magnusson, R Navakauskien. p21 (Waf1/Cip1) and FasL gene activation via Sp1 and NFkappaB is required for leukemia cell survival but not for cell death induced by diverse stimuli. The international journal of biochemistry & cell biology. vol 37. issue 4. 2005-06-30. PMID:15694838. |
by contrast, sp1 and nfkappab binding capacities were lost in all myeloid cell lines undergoing etoposide-induced fast apoptosis. |
2005-06-30 |
2023-08-12 |
human |
| Jurate Savickiene, Grazina Treigyte, Augustas Pivoriunas, Ruta Navakauskiene, Karl-Eric Magnusso. Sp1 and NF-kappaB transcription factor activity in the regulation of the p21 and FasL promoters during promyelocytic leukemia cell monocytic differentiation and its associated apoptosis. Annals of the New York Academy of Sciences. vol 1030. 2005-06-16. PMID:15659839. |
sp1 and nf-kappab transcription factor activity in the regulation of the p21 and fasl promoters during promyelocytic leukemia cell monocytic differentiation and its associated apoptosis. |
2005-06-16 |
2023-08-12 |
human |
| Jurate Savickiene, Grazina Treigyte, Augustas Pivoriunas, Ruta Navakauskiene, Karl-Eric Magnusso. Sp1 and NF-kappaB transcription factor activity in the regulation of the p21 and FasL promoters during promyelocytic leukemia cell monocytic differentiation and its associated apoptosis. Annals of the New York Academy of Sciences. vol 1030. 2005-06-16. PMID:15659839. |
here we have studied sp1 and nuclear factor kappab (nf-kappab) transcription factor activity in controlling promoters of cell cycle-regulating (p21/waf1/cip1) and cell death (fasl) genes during monocytic differentiation and apoptosis of the human acute promyelocytic leukemia cell lines nb4 and hl-60. |
2005-06-16 |
2023-08-12 |
human |
| Joel Blush, Jun Lei, Wenjun Ju, Sharon Silbiger, James Pullman, Joel Neugarte. Estradiol reverses renal injury in Alb/TGF-beta1 transgenic mice. Kidney international. vol 66. issue 6. 2005-04-21. PMID:15569304. |
estrogen negatively regulates sp1 activity and reverses the stimulatory effects of tgf-beta on type iv collagen synthesis and cellular apoptosis in cultured mesangial cells. |
2005-04-21 |
2023-08-12 |
mouse |
| Kwang S Suh, Michihiro Mutoh, Michael Gerdes, John M Crutchley, Tomoko Mutoh, Lindsay E Edwards, Rebecca A Dumont, Pooja Sodha, Christina Cheng, Adam Glick, Stuart H Yusp. Antisense suppression of the chloride intracellular channel family induces apoptosis, enhances tumor necrosis factor {alpha}-induced apoptosis, and inhibits tumor growth. Cancer research. vol 65. issue 2. 2005-03-02. PMID:15695400. |
reducing clic proteins in tumor grafts of sp1 cells expressing a tetracycline-regulated clic4-antisense substantially inhibited tumor growth and induced tumor apoptosis. |
2005-03-02 |
2023-08-12 |
mouse |
| F Blasco, S Peñuelas, M Cascalló, J L Hernández, C Alemany, M Masa, J Calbó, M Soler, M Nicolás, S Pérez-Torras, A Gómez, G Tarrasón, V Noé, A Mazo, C J Ciudad, J Piulat. Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy. Oncology. vol 67. issue 3-4. 2004-12-17. PMID:15557790. |
inhibition of hdac activity, sp1 binding and dna primase expression led to an increase in the level of apoptosis, both in parental cells and in doxorubicin-resistant cells. |
2004-12-17 |
2023-08-12 |
human |