| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Young-Ho Kim, Jong-Wook Park, Jai-Youl Lee, Taeg Kyu Kwo. Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells. Carcinogenesis. vol 25. issue 10. 2004-11-09. PMID:15142888. |
sodium butyrate sensitizes trail-mediated apoptosis by induction of transcription from the dr5 gene promoter through sp1 sites in colon cancer cells. |
2004-11-09 |
2023-08-12 |
human |
| Yoshikazu Uchida, Mitsuru Itoh, Yoshimitsu Taguchi, Syohei Yamaoka, Hisanori Umehara, Shin-Ichi Ichikawa, Yoshio Hirabayashi, Walter M Holleran, Toshiro Okazak. Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells. Cancer research. vol 64. issue 17. 2004-10-05. PMID:15342415. |
because we reported that a gc-rich/sp1 promoter binding region was of importance in the regulation of gcs expression, the role of sp1 in dox-induced up-regulation of gcs and apoptosis was investigated. |
2004-10-05 |
2023-08-12 |
Not clear |
| Yoshikazu Uchida, Mitsuru Itoh, Yoshimitsu Taguchi, Syohei Yamaoka, Hisanori Umehara, Shin-Ichi Ichikawa, Yoshio Hirabayashi, Walter M Holleran, Toshiro Okazak. Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells. Cancer research. vol 64. issue 17. 2004-10-05. PMID:15342415. |
together, the results suggest that transcriptional up-regulation of gcs through dox-induced activation of sp1 is one potential mechanism to regulate ceramide increase and apoptosis in hl-60/adr cells. |
2004-10-05 |
2023-08-12 |
Not clear |
| Mohamed Kabbout, Asma Hatoum, Ghada Abou-Lteif, Imane Chakroun, Fadia R Homaidan, Nadine Darwich. Stage-specific effect of N-(4-hydroxyphenyl)retinamide on cell growth in squamous cell carcinogenesis. Molecular carcinogenesis. vol 40. issue 1. 2004-05-27. PMID:15108326. |
overexpression of rargamma in sp1 papilloma cells enhanced growth suppression and apoptosis induction by hpr. |
2004-05-27 |
2023-08-12 |
Not clear |
| Niall O'Donnell, Natasha E Zachara, Gerald W Hart, Jamey D Mart. Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Molecular and cellular biology. vol 24. issue 4. 2004-03-12. PMID:14749383. |
we show that ogt mutation results in the loss of o-glcnac and causes t-cell apoptosis, neuronal tau hyperphosphorylation, and fibroblast growth arrest with altered expression of c-fos, c-jun, c-myc, sp1, and p27. |
2004-03-12 |
2023-08-12 |
Not clear |
| Mary M Kavurma, Levon M Khachigia. Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation. The Journal of biological chemistry. vol 278. issue 35. 2003-10-02. PMID:12796485. |
sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21waf1/cip1 transcription and cyclin d1-cdk4-p21waf1/cip1 complex formation. |
2003-10-02 |
2023-08-12 |
Not clear |
| Mary M Kavurma, Levon M Khachigia. Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation. The Journal of biological chemistry. vol 278. issue 35. 2003-10-02. PMID:12796485. |
these findings, using complementary approaches, demonstrate the inverse relationship between sp1 and p21waf1/cip1 in smcs and the capacity of sp1 to regulate smc proliferation and apoptosis via its repression of p21waf1/cip1. |
2003-10-02 |
2023-08-12 |
Not clear |
| R D Watkin, T Nawrot, R J Potts, Beth A Har. Mechanisms regulating the cadmium-mediated suppression of Sp1 transcription factor activity in alveolar epithelial cells. Toxicology. vol 184. issue 2-3. 2003-03-18. PMID:12499119. |
this study demonstrates that in vitro exposure of adult rat alveolar epithelial cells to cdcl(2) decreases dna binding activity of specificity protein 1 (sp1), a zinc-finger transcription factor known to play a key role in eukaryotic gene expression, maintenance of homeostasis, cell cycle control, terminal differentiation, and apoptosis. |
2003-03-18 |
2023-08-12 |
human |
| G Koutsodontis, I Tentes, P Papakosta, A Moustakas, D Kardassi. Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein. The Journal of biological chemistry. vol 276. issue 31. 2001-09-13. PMID:11384995. |
in conclusion, sp1 must play a critical role in regulating important biological processes controlled by p53 via p21 gene activation such as dna repair, cell growth, differentiation, and apoptosis. |
2001-09-13 |
2023-08-12 |
human |
| M M Kavurma, F S Santiago, E Bonfoco, L M Khachigia. Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement. The Journal of biological chemistry. vol 276. issue 7. 2001-06-28. PMID:11053446. |
sp1 phosphorylation regulates apoptosis via extracellular fasl-fas engagement. |
2001-06-28 |
2023-08-12 |
Not clear |
| M M Kavurma, F S Santiago, E Bonfoco, L M Khachigia. Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement. The Journal of biological chemistry. vol 276. issue 7. 2001-06-28. PMID:11053446. |
in efforts to understand the molecular processes regulating apoptosis in this cell type, we have defined a novel mechanism involving the ubiquitously expressed transcription factor sp1. |
2001-06-28 |
2023-08-12 |
Not clear |
| M M Kavurma, F S Santiago, E Bonfoco, L M Khachigia. Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement. The Journal of biological chemistry. vol 276. issue 7. 2001-06-28. PMID:11053446. |
subtypes of smc expressing abundant levels of sp1 produce the death agonist, fas ligand (fasl) and undergo greater spontaneous apoptosis. |
2001-06-28 |
2023-08-12 |
Not clear |
| M M Kavurma, F S Santiago, E Bonfoco, L M Khachigia. Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement. The Journal of biological chemistry. vol 276. issue 7. 2001-06-28. PMID:11053446. |
increased smc apoptosis is preceded by sp1 phosphorylation, increased fasl transcription, and the autocrine/paracrine engagement of fasl with its cell-surface receptor, fas. |
2001-06-28 |
2023-08-12 |
Not clear |
| M M Kavurma, F S Santiago, E Bonfoco, L M Khachigia. Sp1 phosphorylation regulates apoptosis via extracellular FasL-Fas engagement. The Journal of biological chemistry. vol 276. issue 7. 2001-06-28. PMID:11053446. |
inducible fasl transcription and apoptosis are blocked by dominant-negative protein kinase c-zeta, whose wild-type counterpart phosphorylates sp1. |
2001-06-28 |
2023-08-12 |
Not clear |
| A Rickers, N Peters, V Badock, R Beyaert, P Vandenabeele, B Dörken, K Bommer. Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis. European journal of biochemistry. vol 261. issue 1. 1999-05-19. PMID:10103059. |
cleavage of transcription factor sp1 by caspases during anti-igm-induced b-cell apoptosis. |
1999-05-19 |
2023-08-12 |
human |
| A Rickers, N Peters, V Badock, R Beyaert, P Vandenabeele, B Dörken, K Bommer. Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis. European journal of biochemistry. vol 261. issue 1. 1999-05-19. PMID:10103059. |
we report here the cleavage of the transcription factor sp1 in the human burkitt lymphoma cell line bl60 during anti-igm-induced apoptosis. |
1999-05-19 |
2023-08-12 |
human |
| A Rickers, N Peters, V Badock, R Beyaert, P Vandenabeele, B Dörken, K Bommer. Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis. European journal of biochemistry. vol 261. issue 1. 1999-05-19. PMID:10103059. |
the time course of sp1 cleavage during anti-igm-induced apoptosis is paralleled by an increase of caspase activity measured by devd-p-nitroanilide (devd-pna) cleavage. |
1999-05-19 |
2023-08-12 |
human |
| A Rickers, N Peters, V Badock, R Beyaert, P Vandenabeele, B Dörken, K Bommer. Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis. European journal of biochemistry. vol 261. issue 1. 1999-05-19. PMID:10103059. |
our results show the cleavage of the human transcription factor sp1 in vivo and in vitro, underlining the central role of caspase 3-like proteases during the process of anti-igm-induced apoptosis. |
1999-05-19 |
2023-08-12 |
human |
| M Seve, A Favier, M Osman, D Hernandez, G Vaitaitis, N C Flores, J M McCord, S C Flore. The human immunodeficiency virus-1 Tat protein increases cell proliferation, alters sensitivity to zinc chelator-induced apoptosis, and changes Sp1 DNA binding in HeLa cells. Archives of biochemistry and biophysics. vol 361. issue 2. 1999-02-11. PMID:9882443. |
the human immunodeficiency virus-1 tat protein increases cell proliferation, alters sensitivity to zinc chelator-induced apoptosis, and changes sp1 dna binding in hela cells. |
1999-02-11 |
2023-08-12 |
human |
| M Seve, A Favier, M Osman, D Hernandez, G Vaitaitis, N C Flores, J M McCord, S C Flore. The human immunodeficiency virus-1 Tat protein increases cell proliferation, alters sensitivity to zinc chelator-induced apoptosis, and changes Sp1 DNA binding in HeLa cells. Archives of biochemistry and biophysics. vol 361. issue 2. 1999-02-11. PMID:9882443. |
these redox changes enhance proliferation and apoptosis and alter the activity of zinc thiolate-containing proteins such as sp1. |
1999-02-11 |
2023-08-12 |
human |