| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jung-Il Chae, Young-Joo Jeon, Jung-Hyun Shi. Anti-proliferative properties of kahweol in oral squamous cancer through the regulation specificity protein 1. Phytotherapy research : PTR. vol 28. issue 12. 2015-08-21. PMID:25196544. |
in addition, kahweol modulated the protein expression level of the sp1 regulatory genes including cell cycle regulatory proteins and anti-apoptotic proteins, resulting in apoptosis. |
2015-08-21 |
2023-08-13 |
Not clear |
| Ra Ham Lee, Jae-Cheon Shin, Ka-Hwi Kim, Yung Hyun Choi, Jung-Il Chae, Jung-Hyun Shi. Apoptotic effects of 7,8-dihydroxyflavone in human oral squamous cancer cells through suppression of Sp1. Oncology reports. vol 33. issue 2. 2015-08-20. PMID:25434704. |
we demonstrated that 7,8-dhf decreased cell growth and induced apoptosis in the hn22 and hsc4 cells through regulation of specificity protein 1 (sp1) using the mts assay, dapi staining, annexin v, propidium iodide staining, reverse transcription-polymerase chain reaction, immunocytochemistry, pull-down assay and western blot analysis. |
2015-08-20 |
2023-08-13 |
human |
| Jin Hyoung Cho, Jae-Cheon Shin, Jung-Jae Cho, Yung Hyun Choi, Jung-Hyun Shim, Jung-Il Cha. Esculetin (6,7-dihydroxycoumarin): a potential cancer chemopreventive agent through suppression of Sp1 in oral squamous cancer cells. International journal of oncology. vol 46. issue 1. 2015-08-11. PMID:25310400. |
the treatment of hn22 and hsc4 cells with esculetin led to a significant reduction in growth and induced apoptosis, followed by the regulation of sp1 and sp1 regulatory protein. |
2015-08-11 |
2023-08-13 |
human |
| Jin Hyoung Cho, Jae-Cheon Shin, Jung-Jae Cho, Yung Hyun Choi, Jung-Hyun Shim, Jung-Il Cha. Esculetin (6,7-dihydroxycoumarin): a potential cancer chemopreventive agent through suppression of Sp1 in oral squamous cancer cells. International journal of oncology. vol 46. issue 1. 2015-08-11. PMID:25310400. |
this indicates that esculetin inhibited cell growth and induced apoptosis by suppressing sp1 in hn22 and hsc4 cells, suggesting it to be a potent anticancer drug candidate for oral cancer. |
2015-08-11 |
2023-08-13 |
human |
| Kyung-Jun Jang, Gi-Sun Kwon, Jin-Woo Jeong, Cheol-Hong Kim, Hyun-Min Yoon, Gi-Young Kim, Jung-Hyun Shim, Sung-Kwon Moon, Wun-Jae Kim, Yung Hyun Cho. Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT. Journal of bioscience and bioengineering. vol 119. issue 3. 2015-07-06. PMID:25282637. |
in this study, we found that cordycepin-induced apoptosis of human leukemia cells (h937 and thp-1 cells) was associated with inactivation of telomerase and downregulation of human telomerase reverse transcriptase (htert) as well as the transcription factors c-myc and sp1, which are required for basal transcription from the htert gene promoter. |
2015-07-06 |
2023-08-13 |
human |
| H Li, Y Zhang, A Ströse, D Tedesco, K Gurova, G Selivanov. Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis. Cell death and differentiation. vol 21. issue 9. 2015-04-22. PMID:24971482. |
integrated high-throughput analysis identifies sp1 as a crucial determinant of p53-mediated apoptosis. |
2015-04-22 |
2023-08-13 |
Not clear |
| H Li, Y Zhang, A Ströse, D Tedesco, K Gurova, G Selivanov. Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis. Cell death and differentiation. vol 21. issue 9. 2015-04-22. PMID:24971482. |
in the present study, we performed an integrated analysis of genome-wide short hairpin rna screen and gene expression data and uncovered a previously unrecognized role of sp1 as a central modulator of the transcriptional response induced by p53 that leads to robust induction of apoptosis. |
2015-04-22 |
2023-08-13 |
Not clear |
| H Li, Y Zhang, A Ströse, D Tedesco, K Gurova, G Selivanov. Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis. Cell death and differentiation. vol 21. issue 9. 2015-04-22. PMID:24971482. |
our study advances the understanding of the molecular basis of p53-mediated apoptosis and implicates sp1 as one of its key modulators. |
2015-04-22 |
2023-08-13 |
Not clear |
| Kate Beishline, Jane Azizkhan-Cliffor. Sp1 and the 'hallmarks of cancer'. The FEBS journal. vol 282. issue 2. 2015-03-31. PMID:25393971. |
sp1 both activates and suppresses the expression of a number of essential oncogenes and tumor suppressors, as well as genes involved in essential cellular functions, including proliferation, differentiation, the dna damage response, apoptosis, senescence and angiogenesis. |
2015-03-31 |
2023-08-13 |
Not clear |
| Jung Jae Cho, Jung-Il Chae, Goo Yoon, Ka Hwi Kim, Jin Hyoung Cho, Seung-Sik Cho, Young Sik Cho, Jung-Hyun Shi. Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma. International journal of oncology. vol 45. issue 2. 2015-01-26. PMID:24858379. |
licochalcone a, a natural chalconoid isolated from glycyrrhiza inflata root, induces apoptosis via sp1 and sp1 regulatory proteins in oral squamous cell carcinoma. |
2015-01-26 |
2023-08-13 |
human |
| Ji-Ae Shin, Gyoonhee Han, Hyun-Jung Kim, Hwan-Mook Kim, Sung-Dae Ch. Chemopreventive and chemotherapeutic effect of a novel histone deacetylase inhibitor, by specificity protein 1 in MDA-MB-231 human breast cancer cells. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 23. issue 4. 2015-01-15. PMID:24871559. |
furthermore, the knockdown of sp1 protein by sp1-specific inhibitor, mithramycin a, and sirna resulted in the alteration of truncated bid and bim to induce apoptosis. |
2015-01-15 |
2023-08-13 |
human |
| Hang-Eun Lee, Eun-Sun Choi, Ji-Ae Shin, Lee-Han Kim, Nam-Pyo Cho, Sung-Dae Ch. Apoptotic effect of methanol extract of Picrasma quassioides by regulating specificity protein 1 in human cervical cancer cells. Cell biochemistry and function. vol 32. issue 3. 2014-12-01. PMID:24037733. |
the knock-down of sp1 by both sp1 interfering rna and mithramycin a, sp1 specific inhibitor clearly increased bad and t-bid expression to decrease cell viability and induce apoptosis. |
2014-12-01 |
2023-08-12 |
human |
| Indira Jutooru, Aaron S Guthrie, Gayathri Chadalapaka, Satya Pathi, KyoungHyun Kim, Robert Burghardt, Un-Ho Jin, Stephen Saf. Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Molecular and cellular biology. vol 34. issue 13. 2014-07-31. PMID:24732804. |
knockdown of sp1 alone by rna interference also induced apoptosis and decreased pancreatic cancer cell growth and invasion, indicating that downregulation of sp transcription factors is an important common mechanism of action for peitc and other ros-inducing anticancer agents. |
2014-07-31 |
2023-08-13 |
Not clear |
| Rong Jin, Fei Teng, Xi Xu, Yisha Yao, Shusong Zhang, Xiuyuan Sun, Yu Zhang, Qing G. Redox balance of mouse medullary CD4 single-positive thymocytes. Immunology and cell biology. vol 91. issue 10. 2014-07-24. PMID:24100390. |
an increase of ros in the most mature sp4 cells resulted in enhanced cytokine production upon stimulation, whereas an early increase of ros in the immature sp1 thymocytes resulted in enhanced apoptosis. |
2014-07-24 |
2023-08-12 |
mouse |
| Yingying Zhao, Wenjing Zhang, Zheng Guo, Feng Ma, Yao Wu, Yang Bai, Wei Gong, Ye Chen, Tianming Cheng, Fachao Zhi, Yali Zhang, Jide Wang, Bo Jian. Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23877322. |
inhibition of the transcription factor sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. |
2014-04-29 |
2023-08-12 |
mouse |
| Yingying Zhao, Wenjing Zhang, Zheng Guo, Feng Ma, Yao Wu, Yang Bai, Wei Gong, Ye Chen, Tianming Cheng, Fachao Zhi, Yali Zhang, Jide Wang, Bo Jian. Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23877322. |
this study investigated the role of sp1 in colon csc growth and apoptosis. |
2014-04-29 |
2023-08-12 |
mouse |
| Yingying Zhao, Wenjing Zhang, Zheng Guo, Feng Ma, Yao Wu, Yang Bai, Wei Gong, Ye Chen, Tianming Cheng, Fachao Zhi, Yali Zhang, Jide Wang, Bo Jian. Inhibition of the transcription factor Sp1 suppresses colon cancer stem cell growth and induces apoptosis in vitro and in nude mouse xenografts. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23877322. |
furthermore, inhibition of sp1 expression using sp1 sirna or mithramycin a (mit) led to marked suppression of csc growth and induced apoptosis. |
2014-04-29 |
2023-08-12 |
mouse |
| Hang Do, Hey-Jin Park, Eun-Hwa Sohn, Byung-Oh Kim, Sung Hee Um, Jong-Hwan Kwak, Eun-Yi Moon, Dong-Kwon Rhee, Suhkneung Py. Ethanol induces cell cycle arrest and triggers apoptosis via Sp1-dependent p75NTR expression in human neuroblastoma cells. Cell biology and toxicology. vol 29. issue 5. 2014-04-21. PMID:24026251. |
furthermore, the inhibition of p75ntr expression or sp1 activity suppressed ethanol-induced p21 expression, cell cycle arrest, and apoptosis. |
2014-04-21 |
2023-08-12 |
human |
| Dong-Wook Kim, Seon Mi Ko, Young-Joo Jeon, Young-Woock Noh, Nag-Jin Choi, Sung-Dae Cho, Hong Seop Moon, Young Sik Cho, Jae-Chen Shin, Seon-Min Park, Kang Seok Seo, Ji-Young Choi, Jung-Il Chae, Jung-Hyun Shi. Anti-proliferative effect of honokiol in oral squamous cancer through the regulation of specificity protein 1. International journal of oncology. vol 43. issue 4. 2014-04-07. PMID:23877711. |
the important key regulators in the cell cycle such as p27 and p21 were up-regulated by hk-mediated down-regulation of sp1, whereas anti-apoptotic proteins including mcl-1 and survivin were decreased, resulting in caspase-dependent apoptosis. |
2014-04-07 |
2023-08-12 |
Not clear |
| Young-Joo Jeon, Seon Mi Ko, Jin Hyoung Cho, Jung-Il Chae, Jung-Hyun Shi. The HDAC inhibitor, panobinostat, induces apoptosis by suppressing the expresssion of specificity protein 1 in oral squamous cell carcinoma. International journal of molecular medicine. vol 32. issue 4. 2014-03-27. PMID:23877235. |
panobinostat (lbh589) induces apoptosis through the regulation of specificity protein 1 (sp1) in the oral squamous cell carcinoma (oscc) cell lines, hn22 and hsc4. |
2014-03-27 |
2023-08-12 |
Not clear |